Health information: a case of saturation or 57 channels and nothing on?

The claim is made by many that we have reached a point where we are exposed to too much information. This potential phenomenon is particularly prominent in the health field where there is a suggestion that the volume of available information has increased significantly and more importantly that such volume has had detrimental effects on both the overall quality of such information and the ability of people to process and use it. This paper explores the nature and validity of these claims. Within the context of the notion of an `information society', it outlines a range of concerns that have been expressed in relation to this increase, including the simple problem of overload, the potential for less robust information to enter the system and thus the overall quality of available information to decline. This excess of information is seen to act against the benefits that are sought — information can be invalid and people may not have time to reflect and act on excessive information loads. This can result in irrationality or disinformation.<p></p> The suggestion is made, however, that these concerns are largely unsupported by empirical evidence and are potentially the basis of a panic over the entry of alternative perspectives on health. The pessimistic perspectives are thus balanced by more constructive and optimistic views on this growth and opening up of information production and potential consumption. Seeing information creation as organic and pluralistic, it is suggested that increased information volume can actually be a constructive phenomenon.<p></p> The paper concludes with the contention that it is unrealistic to expect a return to former circumstances of controlled and limited information flows. Rather, a series of more pragmatic suggestions is offered within existing circumstances, including differentiating between information rich and poor health areas, addressing structural issues like information access and health literacy, and working towards organizing health information so that it is of a high quality, is physically accessible, relevant to the needs and literacy of groups, and in a usable form

Perceptions and practices of dress-related leisure: shopping, sorting, making and mending

This article explores the attitudes of seven women to four dress-related activities: shopping for new garments; sorting clothes within the wardrobe; making - specifically knitting - clothes for themselves; and mending damaged items. This topic is of particular interest within the field of fashion and sustainability, because clothing consumption could be reduced if activity were to be diverted from shopping to alternative fashion practices. Positioning these practices as intrinsically rewarding leisure activities may encourage such a shift. The research demonstrates that all four of the dress-related activities occupy a grey area between leisure and chore. However, because perceptions are personal, context dependent and flexible, there is scope for attitudes to be changed. An experimental project indicates that it is possible to reframe mending as a desirable leisure activity by integrating attributes such as social interaction and creativity. This reframing is aided by individuals' concerns about wasting resources, but can also be limited by concerns about wasting time. © 2015 Australia and New Zealand Association of Leisure Studie

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

PurposeTo evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).DesignProspective cohort study within a randomized clinical trial.ParticipantsThe 1185 CATT participants.MethodsMasked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm(2), or outside the center 1mm(2) were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks.Main outcome measuresPresence of SHRM, as well as location and size, and associations with VA, scar, and GA.ResultsAmong CATT participants, the percentage with SHRM at enrollment was 77%, decreasing to 68% at 4 weeks after treatment and to 54% at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved (64% vs. 31%; P < 0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n = 76) and 104 (n = 66), mean VA letter score was 73.5 (standard error [SE], 2.8), 73.1 (SE, 3.4), 65.3 (SE, 3.5), and 63.9 (SE, 3.7) when SHRM was absent, present outside the central 1 mm(2), present within the central 1 mm(2) but not the foveal center, or present at the foveal center (P = 0.02), respectively. When SHRM was present, the median maximum height under the fovea, within the central 1 mm(2) including the fovea and anywhere within the scan, was 86 μm, 120 μm, and 122 μm, respectively. Visual acuity was decreased with greater SHRM height and width (P < 0.05).ConclusionsIn eyes with neovascular age-related macular degeneration (AMD), SHRM is common and often persists after anti-vascular endothelial growth factor treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM dimensions were associated with worse VA. In eyes with neovascular AMD, SHRM is an important morphologic biomarker

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer