Research recruitment: A case study on women with substance use disorder.

This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International License.Women with substance use disorder may evade research participation because of individual and societal factors. Limited information exists on recruitment of women with substance use disorder. The purpose of this study was to delineate recruitment challenges among women with substance use disorder and identify successful recruitment strategies. An exploratory case study was used to examine recruitment of women with substance use disorder. This case study was informed by a pilot study in 2017-2018, where data were generated from 25 direct observations and three key informants from a drug rehabilitation treatment agency. Analysis took an explanation-building approach, which incorporated chronological field notes from direct observations, memos from key informant conversations, and the extant literature to revise our initial proposition. Macro-level contextual factors influencing recruitment were: (a) establishment of a triage system, (b) reactivation of agency ethics committee, (c) scheduled accreditation site visits, (d) varied guidelines, and (e) required treatment regimen. Recruitment may benefit from multiple sites, staff training in protocol, increased researcher presence, and the opportunity for women’s voices to be heard. This study advances knowledge of macro-level challenges faced during recruitment of women with substance use disorder in southeast USA. Indirect and direct recruitment, when combined, could maximize participation.ECU Open Access Publishing Support Fun

The embedding theorem in Hurwitz-Brill-Noether Theory

We generalize the Embedding Theorem of Eisenbud-Harris from classical Brill-Noether theory to the setting of Hurwitz-Brill-Noether theory. More precisely, in classical Brill-Noether theory, the embedding theorem states that a general linear series of degree d and rank r on a general curve of genus g is an embedding if r is at least 3. If $f \colon C \to \mathbb{P}^1$ is a general cover of degree k, and L is a line bundle on C, recent work of the authors shows that the splitting type of $f_* L$ provides the appropriate generalization of the pair (r, d) in classical Brill--Noether theory. In the context of Hurwitz-Brill-Noether theory, the condition that r is at least 3 is no longer sufficient to guarantee that a general such linear series is an embedding. We show that the additional condition needed to guarantee that a general linear series |L| is an embedding is that the splitting type of $f_* L$ has at least three nonnegative parts. This new extra condition reflects the unique geometry of k-gonal curves, which lie on scrolls in $\mathbb{P}^r$

Operation of a Tritium Glovebox Clean-Up System Using Zirconium Manganese Iron and Zirconium Two Iron Metal Getters

A metal hydride-based tritium clean-up system has been successfully operated for more than four years on an 11 m{sup 3} helium/nitrogen glovebox which was used for handling metal tritide powders. The clean-up system consists of two beds: (1) a Zr-Mn-Fe (in a 10% by weight Al binder, SAES ST909) bed operating at 675 C followed by (2) a Zr{sub 2}Fe (SAES ST198) bed operating at 250 C. The Zr-Mn-Fe bed serves to condition the gas stream by cracking hydrogenous impurities (such as H{sub 2}O and hydrocarbons) and absorbing oxygen and carbon. The Zr{sub 2}Fe bed absorbs the hydrogen isotopes from the flowing stream by forming a solid hydride compound. These beds contain 3 kilograms of Zr{sub 2}Fe and have been loaded routinely with 230-250 STP liters of hydrogen isotopes in earlier trials. The Zr-Mn-Fe alloy exhibits an anomaly during activation, namely an exotherm upon initial exposure to nitrogen. The purpose of this work is to better understand this reaction. Nitrogen absorption studies were done in order to quantify the nitrogen taken up by the getter and to characterize the reaction kinetics. In addition, ST909 phases before and after the reaction were studied with x-ray diffraction

Research Recruitment: A Case Study on Women with Substance Use Disorder

Women with substance use disorder may evade research participation because of individual and societal factors. Limited information exists on recruitment of women with substance use disorder. The purpose of this study was to delineate recruitment challenges among women with substance use disorder and identify successful recruitment strategies. An exploratory case study was used to examine recruitment of women with substance use disorder. This case study was informed by a pilot study in 2017-2018, where data were generated from 25 direct observations and three key informants from a drug rehabilitation treatment agency. Analysis took an explanation-building approach, which incorporated chronological field notes from direct observations, memos from key informant conversations, and the extant literature to revise our initial proposition. Macro-level contextual factors influencing recruitment were: (a) establishment of a triage system, (b) reactivation of agency ethics committee, (c) scheduled accreditation site visits, (d) varied guidelines, and (e) required treatment regimen. Recruitment may benefit from multiple sites, staff training in protocol, increased researcher presence, and the opportunity for women’s voices to be heard. This study advances knowledge of macro-level challenges faced during recruitment of women with substance use disorder in southeast USA. Indirect and direct recruitment, when combined, could maximize participation

Inferred summer precipitation for southern Ontario back to AD 610, as reconstructed from ring widths of Thuja occidentalis

We present a network of seven ring-width chronologies of eastern white-cedar (Thuja occidentalis L.) from the Niagara Escarpment in southern Ontario, Canada. Using principal component regression, a 350-year June-July precipitation reconstruction (SOR) is developed for the region. Prior to the 20th century, the SOR series shows reasonable coherence, particularly at the decadal scale, with an independent tree-ring-based reconstruction of the Palmer drought severity index (PDSI) for roughly the same region. A weakening of the tree-growth – climate relationship in recent decades results in a regression model explaining 21% of the variance in the original climate series when the recent data are used for calibration. We therefore compromise with a model, calibrated for the period 1900–1960, which explains 33% of the variance. The model, while not terribly strong, does pass verification tests, indicating some degree of predictive skill. The longest chronology in our network, the 2787-year Flowerpot Island (FLOW) chronology, also exhibits common variability with the PDSI reconstruction, particularly on decadal and longer time scales and was used to infer hydroclimatic conditions back to AD 610. The combined information of the SOR, PDSI, and FLOW series suggests that dry conditions existed for the periods 1700–1725, 1750–1800, and 1840–1900, and wet conditions for the periods 1675–1700, 1730–1750, and 1810–1840. Over longer time scales, the FLOW chronology shows that summer precipitation was particularly variable during the 7th, 9th, 13th, and 16th centuries

Star-forming Clumps in Local Luminous Infrared Galaxies

We present HST narrowband near-infrared imaging of Paα and Paβ emission of 48 local luminous infrared galaxies (LIRGs) from the Great Observatories All-Sky LIRG Survey. These data allow us to measure the properties of 810 spatially resolved star-forming regions (59 nuclei and 751 extranuclear clumps) and directly compare their properties to those found in both local and high-redshift star-forming galaxies. We find that in LIRGs the star-forming clumps have radii ranging from ~90 to 900 pc and star formation rates (SFRs) of ~1 × 10⁻³ to 10 M⊙ yr⁻¹, with median values for extranuclear clumps of 170 pc and 0.03 M⊙ yr⁻¹. The detected star-forming clumps are young, with a median stellar age of 8.7 Myr, and have a median stellar mass of 5 × 10⁵ M ⊙. The SFRs span the range of those found in normal local star-forming galaxies to those found in high-redshift star-forming galaxies at z = 1–3. The luminosity function of the LIRG clumps has a flatter slope than found in lower-luminosity, star-forming galaxies, indicating a relative excess of luminous star-forming clumps. In order to predict the possible range of star-forming histories and gas fractions, we compare the star-forming clumps to those measured in the MassiveFIRE high-resolution cosmological simulation. The star-forming clumps in MassiveFIRE cover the same range of SFRs and sizes found in the local LIRGs and have total gas fractions that extend from 10% to 90%. If local LIRGs are similar to these simulated galaxies, we expect that future observations with ALMA will find a large range of gas fractions, and corresponding star formation efficiencies, among the star-forming clumps in LIRGs

The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey.

BACKGROUND: Public trust in immunization is an increasingly important global health issue. Losses in confidence in vaccines and immunization programmes can lead to vaccine reluctance and refusal, risking disease outbreaks and challenging immunization goals in high- and low-income settings. National and international immunization stakeholders have called for better monitoring of vaccine confidence to identify emerging concerns before they evolve into vaccine confidence crises. METHODS: We perform a large-scale, data-driven study on worldwide attitudes to immunizations. This survey - which we believe represents the largest survey on confidence in immunization to date - examines perceptions of vaccine importance, safety, effectiveness, and religious compatibility among 65,819 individuals across 67 countries. Hierarchical models are employed to probe relationships between individual- and country-level socio-economic factors and vaccine attitudes obtained through the four-question, Likert-scale survey. FINDINGS: Overall sentiment towards vaccinations is positive across all 67 countries, however there is wide variability between countries and across world regions. Vaccine-safety related sentiment is particularly negative in the European region, which has seven of the ten least confident countries, with 41% of respondents in France and 36% of respondents in Bosnia & Herzegovina reporting that they disagree that vaccines are safe (compared to a global average of 13%). The oldest age group (65+) and Roman Catholics (amongst all faiths surveyed) are associated with positive views on vaccine sentiment, while the Western Pacific region reported the highest level of religious incompatibility with vaccines. Countries with high levels of schooling and good access to health services are associated with lower rates of positive sentiment, pointing to an emerging inverse relationship between vaccine sentiments and socio-economic status. CONCLUSIONS: Regular monitoring of vaccine attitudes - coupled with monitoring of local immunization rates - at the national and sub-national levels can identify populations with declining confidence and acceptance. These populations should be prioritized to further investigate the drivers of negative sentiment and to inform appropriate interventions to prevent adverse public health outcomes

Probing shear-banding transitions of the VCM model for entangled wormlike micellar solutions using large amplitude oscillatory shear (LAOS) deformations

We explore the use of large amplitude oscillatory shear (LAOS) deformation to probe the dynamics of shear-banding in soft entangled materials, primarily wormlike micellar solutions which are prone to breakage and disentanglement under strong deformations. The state of stress in these complex fluids is described by a class of viscoelastic constitutive models which capture the key linear and nonlinear rheological features of wormlike micellar solutions, including the breakage and reforming of an entangled network. At a frequency-dependent critical strain, the imposed deformation field localizes to form a shear band, with a phase response that depends on the frequency and amplitude of the forcing. The different material responses are compactly represented in the form of Lissajous (phase plane) orbits and a corresponding strain-rate and frequency-dependent Pipkin diagram. Comparisons between the full network model predictions and those of a simpler, limiting case are presented.National Science Foundation (U.S.) (NSF DMS-0807395)National Science Foundation (U.S.) (NSF DMS-0807330

Developing second language oral ability in foreign language classrooms: the role of the length and focus of instruction and individual differences

The current study aimed to examine how instruction can impact the global, segmental, prosodic, and temporal qualities of second language (L2) oral ability in foreign language (FL) settings (i.e., a few hours of target language input per week). Spontaneous speech was elicited via a timed picture description task from 56 Japanese freshman college students who had studied English through FL instruction from Grades 7 to 12 without any experience abroad. The tokens were rated for global accentedness and then submitted to segmental, prosodic, and temporal analyses. According to statistical analyses, (a) the participants' oral performance widely varied in relation to the length and focus of FL instruction, the frequency of their conversations in the L2, and aptitude; and (b) their diverse proficiency levels were predicted in particular by the amount of extra FL activities inside (i.e., pronunciation training) and outside (i.e., cram school) of high school (but not junior high) classrooms. The results in turn suggest that whereas extensive FL instruction (>875 hr) itself does make some difference in L2 oral ability development, its pedagogical potential can be increased by how students optimize their most immediate FL experience beyond the regular syllabus