176 research outputs found
Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5-90 years
The recent development of assays that accurately quantify neurofilament light, a neuronal cytoskeleton protein, in plasma has generated a vast literature supporting that it is a sensitive, dynamic, and robust biomarker of neuroaxonal damage. As a result, efforts are now made to introduce plasma neurofilament light into clinical routine practice, making it an easily accessible complement to its cerebrospinal fluid counterpart. An increasing literature supports the use of plasma neurofilament light in differentiating neurodegenerative diseases from their non-neurodegenerative mimics and suggests it is a valuable biomarker for the evaluation of the effect of putative disease-modifying treatments (e.g. in multiple sclerosis). More contexts of use will likely emerge over the coming years. However, to assist clinical interpretation of laboratory test values, it is crucial to establish normal reference intervals. In this study, we sought to derive reliable cut-offs by pooling quantified plasma neurofilament light in neurologically healthy participants (5-90 years) from eight cohorts. A strong relationship between age and plasma neurofilament light prompted us to define the following age-partitioned reference limits (upper 95th percentile in each age category): 5-17 years = 7 pg/mL; 18-50 years = 10 pg/mL; 51-60 years = 15 pg/mL; 61-70 years = 20 pg/mL; 70 + years = 35 pg/mL. The established reference limits across the lifespan will aid the introduction of plasma neurofilament light into clinical routine, and thereby contribute to diagnostics and disease-monitoring in neurological practice
Double parton interactions in photon+3 jet events in ppbar collisions sqrt{s}=1.96 TeV
We have used a sample of photon+3 jets events collected by the D0 experiment
with an integrated luminosity of about 1 fb^-1 to determine the fraction of
events with double parton scattering (f_DP) in a single ppbar collision at
sqrt{s}=1.96 TeV. The DP fraction and effective cross section (sigma_eff), a
process-independent scale parameter related to the parton density inside the
nucleon, are measured in three intervals of the second (ordered in pT) jet
transverse momentum pT_jet2 within the range 15 < pT_jet2 < 30 GeV. In this
range, f_DP varies between 0.23 < f_DP < 0.47, while sigma_eff has the average
value sigma_eff_ave = 16.4 +- 0.3(stat) +- 2.3(syst) mb.Comment: 15 pages, 13 figure
Measurement of the B0_s semileptonic branching ratio to an orbitally excited D_s** state, Br(B0_s -> Ds1(2536) mu nu)
In a data sample of approximately 1.3 fb-1 collected with the D0 detector
between 2002 and 2006, the orbitally excited charm state D_s1(2536) has been
observed with a measured mass of 2535.7 +/- 0.6 (stat) +/- 0.5 (syst) MeV via
the decay mode B0_s -> D_s1(2536) mu nu X. A first measurement is made of the
branching ratio product Br(b(bar) -> D_s1(2536) mu nu X).Br(D_s1(2536)->D*
K0_S). Assuming that D_s1(2536) production in semileptonic decay is entirely
from B0_s, an extraction of the semileptonic branching ratio Br(B0_s ->
D_s1(2536) mu nu X) is made.Comment: 7 pages, 2 figures, LaTeX, version with minor changes as accepted by
Phys. Rev. Let
Search for R-parity violating supersymmetry via the LLE couplings lambda_{121}, lambda_{122} or lambda_{133} in ppbar collisions at sqrt(s)=1.96 TeV
A search for gaugino pair production with a trilepton signature in the
framework of R-parity violating supersymmetry via the couplings lambda_121,
lambda_122, or lambda_133 is presented. The data, corresponding to an
integrated luminosity of L~360/pb, were collected from April 2002 to August
2004 with the D0 detector at the Fermilab Tevatron Collider, at a
center-of-mass energy of sqrt(s)=1.96 TeV. This analysis considers final states
with three charged leptons with the flavor combinations eel, mumul, and eetau
(l=e or mu). No evidence for supersymmetry is found and limits at the 95%
confidence level are set on the gaugino pair production cross section and lower
bounds on the masses of the lightest neutralino and chargino are derived in two
supersymmetric models.Comment: 9 pages, 4 figures (fig2 includes 3 subfigures
Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV
We present cross section measurements for Z/gamma*+jets+X production,
differential in the transverse momenta of the three leading jets. The data
sample was collected with the D0 detector at the Fermilab Tevatron proton
anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to
an integrated luminosity of 1 fb-1. Leading and next-to-leading order
perturbative QCD predictions are compared with the measurements, and agreement
is found within the theoretical and experimental uncertainties. We also make
comparisons with the predictions of four event generators. Two
parton-shower-based generators show significant shape and normalization
differences with respect to the data. In contrast, two generators combining
tree-level matrix elements with a parton shower give a reasonable description
of the the shapes observed in data, but the predicted normalizations show
significant differences with respect to the data, reflecting large scale
uncertainties. For specific choices of scales, the normalizations for either
generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure
Measurement of the t-channel single top quark production cross section
The D0 collaboration reports direct evidence for electroweak production of
single top quarks through the t-channel exchange of a virtual W boson. This is
the first analysis to isolate an individual single top quark production
channel. We select events containing an isolated electron or muon, missing
transverse energy, and two, three or four jets from 2.3 fb^-1 of ppbar
collisions at the Fermilab Tevatron Collider. One or two of the jets are
identified as containing a b hadron. We combine three multivariate techniques
optimized for the t-channel process to measure the t- and s-channel cross
sections simultaneously. We measure cross sections of 3.14 +0.94 -0.80 pb for
the t-channel and 1.05 +-0.81 pb for the s-channel. The measured t-channel
result is found to have a significance of 4.8 standard deviations and is
consistent with the standard model prediction.Comment: 7 pages, 6 figure
Dependence of the production cross section on the transverse momentum of the top quark
We present a measurement of the differential cross section for
events produced in collisions at TeV as a function
of the transverse momentum () of the top quark. The selected events
contain a high- lepton (), four or more jets, and a large imbalance
in , and correspond to 1 fb of integrated luminosity recorded
with the D0 detector. Each event must have at least one candidate for a
jet. Objects in the event are associated through a constrained kinematic fit to
the process. Results
from next-to-leading-order perturbative QCD calculations agree with the
measured differential cross section. Comparisons are also provided to
predictions from Monte Carlo event generators using QCD calculations at
different levels of precision.Comment: 8 pages, 6 figures, 4 tables, updated to reflect the published
versio
Measurement of the W boson mass
We present a measurement of the W boson mass in W -> ev decays using 1 fb^-1
of data collected with the D0 detector during Run II of the Fermilab Tevatron
collider. With a sample of 499830 W -> ev candidate events, we measure M_W =
80.401 +- 0.043 GeV. This is the most precise measurement from a single
experiment.Comment: As published in PR
Search for resonant diphoton production with the D0 detector
We present a search for a narrow resonance in the inclusive diphoton final
state using 2.7 fb-1 of data collected with the D0 detector at the Fermilab
Tevatron ppbar Collider. We observe good agreement between the data and the
background prediction, and set the first 95% C.L. upper limits on the
production cross section times the branching ratio for decay into a pair of
photons for resonance masses between 100 and 150 GeV. This search is also
interpreted in the context of several models of electroweak symmetry breaking
with a Higgs boson decaying into two photons.Comment: 7 pages, 3 figures
Search for charged massive long-lived particles with the D0 detector
We search for charged massive long-lived particles using 1.1 fb of
data collected by the D0 detector at the Fermilab Tevatron Collider.
Time-of-flight information is used to search for pair produced long-lived tau
sleptons, gaugino-like charginos, and higgsino-like charginos. We find no
evidence of a signal and set 95% C.L. cross section upper limits for staus,
which vary from 0.31pb to 0.04pb for stau masses between 60 GeV and 300 GeV. We
also set lower mass limits of 206 GeV (171 GeV) for pair produced charged
gauginos (higgsinos).Comment: To be submitted to Phys. Rev. Letters, V2: updated the figures and
references, V3: final version submitted to PRL and changes in title and
abstracts from "stable" to "long-lived
- …