Primary Caregivers of Children Affected by Disorders of Sex Development: Mental Health and Caregiver Characteristics in the Context of Genital Ambiguity and Genitoplasty

Purpose. To determine the relationship between having a child with a DSD including ambiguous external genitalia, as well as the decision of whether or not to have early genitoplasty for that child, on the mental health and parenting characteristics of caregivers. Materials and Methods. Caregivers were recruited from centers that specialize in DSD medicine and completed the Beck Depression Inventory 2nd Edition (BDI-2), Beck Anxiety Index (BAI), Parent Protection Scale (PPS), Child Vulnerability Scale (CVS) and Parenting Stress Index/Short Form (PSI/SF). Results and Conclusions. Sixty-eight caregivers provided informed consent and completed the study. Among female caregivers whose children never received genitoplasty, greater parenting stress was reported (F(1, 40) = 5.08, p = .03). For male caregivers, those whose children received genitoplasty within the first year of life reported more overprotective parenting and parenting stress than those whose children received genitoplasty later than 12 months of age (F(1, 13) = 6.16, p = 0.28); F(1, 15) = 6.70, p = .021), respectively)

Differences in adjustment by child developmental stage among caregivers of children with disorders of sex development

<p>Abstract</p> <p>Background</p> <p>The current study sought to compare levels of overprotection and parenting stress reported by caregivers of children with disorders of sex development at four different developmental stages.</p> <p>Methods</p> <p>Caregivers (<it>N </it>= 59) of children with disorders of sex development were recruited from specialty clinics and were asked to complete the Parent Protection Scale and Parenting Stress Index/Short Form as measures of overprotective behaviors and parenting stress, respectively.</p> <p>Results</p> <p>Analyses of covariance (ANCOVAs) were conducted to examine differences between caregiver report of overprotection and parenting stress. Results revealed that caregivers of infants and toddlers exhibited more overprotective behaviors than caregivers of children in the other age groups. Further, caregivers of adolescents experienced significantly more parenting stress than caregivers of school-age children, and this effect was driven by personal distress and problematic parent-child interactions, rather than having a difficult child.</p> <p>Conclusions</p> <p>These results suggest that caregivers of children with disorders of sex development may have different psychosocial needs based upon their child's developmental stage and based upon the disorder-related challenges that are most salient at that developmental stage.</p

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Mission Planning for the CHANDRA X-Ray Observatory

The CHANDRA x-ray observatory started life as the Advanced X-ray Facility (AXAF) but was renamed Chandra in December of 1998 at the of a nationwide contest by NASA to name the new observatory. The honors the Nobel Prize winning astrophysicist S. Chandrasekar who astrophysics at the University of Chicago for more than 50 years, following graduate studies at Cambridge University in England. The observatory has been under construction for a decade under the management of the Observatory observatory, Projects office at the Marshall Space Flight Center; the same office that oversaw the construction of the Hubble Space Telescope and the Compton Gamma Ray Observatory. This observatory is a member of NASA's great observatory series of missions of which Hubble and Compton are members. This paper describes the mission planning that was conducted at MSFC to design the orbit and launch window that would permit the new observatory to function properly

INTELLECTUAL FUNCTIONING AND LONG-TERM SOCIAL FUNCTIONING IN SURVIVORS OF PEDIATRIC CANCER

ii ACKNOWLEDGEMENTS I would first like to thank my primary advisor and mentor, Dr. Larry L. Mullins, for his ongoing support and encouragement. You have changed the person I want to become both personally and professionally and have showed me by example that it is completely possible to be successful in your career while still maintaining a balanced life. You have taught me so much about myself and have helped to strengthen any weaknesses I have felt during graduate school. I do not think I could ever really thank you for all you have done! I would also like to extend a special thank you to the other members of my committee, Drs. Jennifer L. Callahan and John M. Chaney. Thank you both for your support and guidance throughout my graduate school experience. I have relied on you so much and I truly appreciate you “giving me a home ” at OSU. At this time, I would also like to thank my family for their love and encouragement. Mom, Dad, and Jordan, I would not be where I am today without the three of you. You all loved me and believed in me when I did not believe in myself. Although many miles separate us, I know you are all only a phone call or plane rid

Psychosocial Risk Profiles Among American and Dutch Families Affected by Pediatric Cancer

OBJECTIVE: Little is known about relations between domains of psychosocial risk among pediatric cancer populations. The Psychosocial Assessment Tool 2.0 (PAT2.0) is one internationally validated screening measure that can examine these relations. This study aimed to examine risk profiles and predictors of these patterns exhibited by American and Dutch families. METHODS: Caregivers of children newly diagnosed with cancer (N = 262; nUSA=145, nNL=117) completed the PAT2.0 as part of larger studies conducted in the United States and the Netherlands. Latent profile analysis and multinomial logistic regression examined differences in demographic and medical variables across risk profiles. Domains assessed included Family Structure/Resources, Child Problems, Sibling Problems, Family Problems, Caregiver Stress Reactions, and Family Beliefs. RESULTS: Four groups were identified: "Low-Risk" (n = 162) defined by generally low risk across domains; "Moderate-Caregiver" (n = 55) defined by elevated Caregiver Stress Reactions domain; "Moderate-Children" (n = 25) defined by elevated Child Problems and/or Sibling Problems, and "Elevated-Risk" (n = 20) marked by generally high overall risk. Dutch families had higher odds of being in the Elevated-Risk group, compared to the Low-Risk group. Caregiver age, gender, and educational attainment predicted group membership. Families classified as Targeted or Clinical had higher odds of being in the Moderate or Elevated risk groups. CONCLUSION: The PAT2.0 appears to identify largely similar patterns of risk, suggesting that families experience common psychosocial difficulties in both American and Dutch societies. The two Moderate groups demonstrated specific risk sources, suggesting that evaluation of domain patterns, rather than reliance on PAT2.0 risk level, could be of clinical benefit