El pensar del alma: un regalo de la madre

No puedo evitar, al plantearme una conferencia en el seminario de Duoda, una reflexión sobre las atribuciones ideológicas -ideológicas, sí- que se hacen a quienes en él colaboran. Digo ideológicas por cuanto, si bien todo pensamiento o todo discurso es un sistema de ideas y el mío por supuesto lo será o tratará de serlo, también se usa este adjetivo para totalizar en uno sólo cualquier sistema de ideas que quiera expresar un pensamiento. Mi primera reflexión pues, es la de que mi intento de sistematizar mis ideas en torno a ese materno tema del Gratis et amare, se produce en una práctica de libertad de pensar, que poco a poco y no sin dificultad, he ido construyéndome a lo largo de mi experiencia personal y profesional, en distintos espacios institucionales y sociales, entre Jos cuajes se ha podido contar éste de Ouoda

CASP-12 as a measure of quality of life at older ages: comparing near and older elderly

It is well known that European governments face to an ageing society as result of the increasing life expectancy and the decreasing birth rates in recent decades. A growing part of the European population is living their “Third age”, and this new paradigm has become increasingly important and has become a major concern in public policy. It stands to reason that better conditions at these ages (health, economic status, happiness, family, etc.) surely influence this approach. The aim of this paper is to determinate the key factors that affect the Quality of Life (QoL) of the elderly in the European countries. Additionally, we try to identify if significant differences are resulted in QoL of the elderly in regions across Europe (southern, northern and eastern). We have used data from the most recent wave released in SHARE (Survey of Health, Ageing and Retirement in Europe, wave 7) for all European countries participants in the survey. Then, we used the SHARE version of the CASP-12 scale to determinate if there are significant discrepancies between European countries. Despcritive results shown significant differences raised in QoL of the elderly by regions across Europe (northern and eastern) if life satisfaction is self-reported. However, using CASP-12 as key indicator of quality of life and life satisfaction the results are more heterogenous.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Reviure en relació a l'altre: fer de les classes un inici

El text que us presentem té origen en una experiència viscuda per dues professores de Coeducació que, a la mateixa hora i en aules veines, es trobaven amb un grup de noies i nois. Les paraules que segueixen valen continuar reprenent el fil de les que ens dèiem en els minuts que precedien i seguien a les sessions de classe. Així és com les prenem per tal que iniciïn un assaig d'escriure els diàlegs que, primer casuals i després imprescindibles, manteníem amb lànim de compartir l'experiència de ser mestres, d'intercanviar receptes que a una o altra ens anaven bé per a encetar, aprofundir o revisar les possibilitats creadores que porta en sí el partir de la diferència sexual

How genomics has informed our understanding of the pathogenesis of osteoporosis

Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes a person to an increased risk of fracture. Osteoporosis is a complex trait that involves multiple genes, environmental factors, and gene-gene and gene-environment interactions. Twin and family studies have indicated that between 25% and 85% of the variation in bone mass and other skeletal phenotypes is heritable, but our knowledge of the underlying genes is limited. Bone mineral density is the most common assessment for diagnosing osteoporosis and is the most often used quantitative value in the design of genetic studies. In recent years, our understanding of the pathophysiology of osteoporosis has been greatly facilitated by advances brought about by the Human Genome Project. Genetic approaches ranging from family studies of monogenic traits to association studies with candidate genes, to whole-genome scans in both humans and animals have identified a small number of genes that contribute to the heritability of bone mass. Studies with transgenic and knockout mouse models have revealed major new insights into the biology of many of these identified genes, but much more needs to be learned. Ultimately, we hope that by revealing the underlying genetics and biology driving the pathophysiology of osteoporosis, new and effective treatment can be developed to combat and possibly cure this devastating disease. Here we review the rapidly evolving field of the genomics of osteoporosis with a focus on important gene discoveries, new biological/physiological paradigms that are emerging, and many of the unanswered questions and hurdles yet to be overcome in the field

Economía colaborativa en el sector alojativo: El impacto de Airbnb en Gandía

[EN] Past economic crises, especially the financial one in 2007-2008, have shown the unsustainability of the consumer capitalist system that prevails today. In this context, the so-called collaborative economy was born as a more sustainable economy, where the access to goods and services shifts the private property of them. The accommodation sector hasn't been indifferent to this new tendency of collaborative consumption. Therefore, this work's object of study is focused on checking, through different tools, its impact in Gandia city. Keywords: sharing economy, accommodation sector, collaborative consumption, Gandia.[ES] Las numerosas crisis económicas acontecidas, y en especial la financiera de 2007-2008, no han hecho nada más que evidenciar la insostenibilidad del sistema capitalista consumista que impera en la actualidad. En este contexto surge la llamada economía colaborativa, una economía más sostenible, donde el acceso a los bienes y servicios desplaza a la propiedad privada de los mismos. El sector alojativo no ha sido indiferente ante estos nuevos patrones de consumo colaborativo. Es por ello, que el objeto de estudio de este trabajo se encuentra enfocado en comprobar, mediante diferentes herramientas, su impacto en la ciudad de Gandía.[EN] Past economic crises, especially the financial one in 2007-2008, have shown the unsustainability of the consumer capitalist system that prevails today. In this context, the so-called collaborative economy was born as a more sustainable economy, where the access to goods and services shifts the private property of them. The accommodation sector hasn't been indifferent to this new tendency of collaborative consumption. Therefore, this work's object of study is focused on checking, through different tools, its impact in Gandia cityAlberca Lara, N. (2021). Economía colaborativa en el sector alojativo: El impacto de Airbnb en Gandía. Universitat Politècnica de València. http://hdl.handle.net/10251/175212TFG

Acromegàlia : test sobre el seu impacte en la qualitat de vida

L'acromegàlia, denominada també popularment gegantisme, és una malaltia que causa un creixement anormal en algunes parts i òrgans del cos. Per valorar-ne l'impacte sobre la qualitat de vida de les persones que la pateixen, especialistes de diferents hospitals espanyols han desenvolupat un senzill test: l'AcroQol.La acromegalia, también denominada popularmente gigantismo, es una enfermedad que causa un crecimiento anormal en algunas partes y órganos del cuerpo. Para valorar su impacto sobre la calidad de vida de las personas que la padecen, especialistas de diferentes hospitales españoles han desarrollado un sencillo test, denominado AcroQol

Le « geste esthétique » dans le domaine de l'art : étude sur l'expression corporelle dans la peinture gestuelle, le mime et la danse contemporaine

L'objet d'étude de ce mémoire est le « geste esthétique », c'est-à-dire la valeur de l'acte gestuel dans le domaine des arts. L'idée du « geste anthropologique » est le point de départ pour comprendre son caractère utilitaire, social et dialogique. Sa faculté d'être, à travers le « mimage », un moyen de connaissance par l'appréhension du réel a permis à l'homme de créer au fil de son existence des outils et des techniques efficaces. Le geste est donc un moyen qui a facilité le développement de nos connaissances en matérialisant l'évolution du savoir-faire humain. Cependant, en plus de cette fonction utilitaire, il possède également une valeur affective qui manifeste l'expression de l'être humain. L'homme se communique avec ses semblables en s'exprimant par le langage autant que par son corps, à travers le geste. L'interaction par le dialogue, qui se compose aussi bien de la parole que de l'engagement corporel, nous transforme en une espèce sociale et nous différencie des animaux. Je définis le « geste esthétique » comme un acte possédant une valeur expressive auquel s'incorpore une dimension créative. Dans ce sens, le geste n'est plus seulement un accomplissement communicatif envers quelqu'un d'autre ou bien un acte utilitaire pour produire quelque chose, mais un « vouloir faire » innovateur, une intervention artistique qui nous met en représentation et établie un dialogue avec le spectateur. Le « geste esthétique » peut fonctionner de plusieurs manières dans le contexte de la production de l'oeuvre d'art. Je distingue trois modes d'engagement gestuel: 1) la représentation libre et spontanée qui n'est pas définie a priori par un sujet; 2) la représentation mimétique du geste qui est résolument construite a posteriori par une idée; 3) et un troisième processus qui se situe dans une synthèse de « l'entre-deux ». Afin d'exemplifier ces trois modes expressifs, je reprends diverses manifestations artistiques qui exposent le fonctionnement de la gestuelle esthétique. En premier lieu, je reprends l'idée de la libération expressive du geste à travers l'automatisme pictural dans la peinture moderne de Jackson Pollock, passant par le style performatif de l'automatiste québécois Marcel Barbeau pour arriver à l'interprétation dansée du geste pictural d'Henri Michaux par la chorégraphe Marie Chouinard. Ensuite, je travaille sur la question de la fonction mimétique de la gestuelle chez le mime. D'abord je précise le concept de la « mimésis » chez Platon et Aristote et postérieurement je l'applique aux conditions des deux figures principales du mime contemporain: Marcel Marceau et Étienne Decroux. Finalement, j'analyse le cas de la danse contemporaine à partir de la mise en scène « Luna » de la chorégraphe Ginette Laurin, comme une synthèse de l' « entre-deux » gestuel, car la danse se situe entre le geste « aisthétique » qui explore les capacités kinesthésiques du corps et la théâtralisation du geste dansé. Julia Kristeva a signalé la domination du discours verbal qui exclut la portée expressive du geste, ce mémoire tente précisément de constater l'importance du système sémantique gestuel à partir d'une étude interdisciplinaire sur l'art. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Geste, Esthétique, Expression corporelle, Automatisme et mimésis

Aplicación de la Dignity Therapy en pacientes oncológicos en situación avanzada.

The Dignity Therapy was designed to cope with suffering, psychosocial and existential distress among patients with advanced or terminal disease. This paper is a cuasi experimental study with sixteen cancer patients in advanced stages of the disease. The aim of the study is to apply, in our context, the Dignity Therapy as a proposal for intervention for the relief of suffering such patients, in order to assess whether there is pre and post intervention changes. The results of Wilcoxon’s test, show statistically significant differences comparing the pre-intervention and the post-intervention for the variables Anxiety and Well-being. Nevertheless, statistically significant differences are not observed for the variables Depression and Serenity. The subjects agreed to participate voluntarily, and all the subjects felt satisfied after the application of the Dignity Therapy and noted that they found it useful enough or very useful. These results suggest that it is an appropriate therapeutic approach to these patients.La Dignity Therapy fue diseñada para hacer frente al sufrimiento, la angustia psicosocial y existencial entre los pacientes con enfermedad avanzada o terminal. El presente trabajo es un estudio cuasi experimental con dieciséis pacientes oncológicos en estado avanzado de la enfermedad. El objetivo del estudio fue aplicar, en nuestro contexto, la Dignity Therapy como propuesta de intervención para el alivio del sufrimiento a dichos pacientes, evaluando si existen cambios pre y post intervención. Tras obtener resultados mediante la prueba de Wilcoxon, se obtienen diferencias estadísticamente significativas comparando la pre-intervención y la post-intervención para las variables Ansiedad y Bienestar. Sin embargo, no se observa diferencias estadísticamente significativas para las variables Depresión y Serenidad. Los sujetos accedieron a participar de forma voluntaria y todos se sintieron satisfechos tras la aplicación de la Dignity Therapy, destacando que les había resultado bastante útil o muy útil. Estos resultados apuntan a que se trata de un acercamiento terapéutic

Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells

Background: Our prior characterization of RasGrf1 deficient mice uncovered significant defects in pancreatic islet count and size as well as beta cell development and signaling function, raising question about the mechanisms linking RasGrf1 to the generation of those"pancreatic" phenotypes. Results: Here, we compared the transcriptional profile of highly purified pancreatic islets from RasGrf1 KO mice to that of WT control animals using commercial oligonucleotide microarrays. RasGrf1 elimination resulted in differential gene expression of numerous components of MAPK- and Calcium-signaling pathways,suggesting a relevant contribution of this GEF to modulation of cellular signaling in the cell lineages integrating the pancreatic islets. Whereas the overall transcriptional profile of pancreatic islets was highly specific in comparison to other organs of the same KO mice, a significant specific repression of Pttg1 was a common transcriptional alteration shared with other tissues of neuroectodermal origin. This observation,together with the remarkable pancreatic phenotypic similarities between RasGrf1 KO and Pttg1 KO mice suggested the possibility of proximal functional regulatory links between RasGrf1 and Pttg1 in pancreatic cell lineages expressing these proteins. Analysis of the mPttg1 promoter region identified specific recognition sites for numerous transcription factors which were also found to be differentially expressed in RasGrf1 KO pancreatic islets and are known to be relevant for Ras-ERK signaling as well as beta cell function. Reporter luciferase assays in BT3 insulinoma cells demonstrated the ability of RasGrf1 to modulate mPttg1 promoter activity through ERK-mediated signals. Analysis of the phenotypic interplay between RasGrf1 and Pttg1 in double knockout RasGrf1/Pttg1 mice showed that combined elimination of the two loci resulted in dramatically reduced values of islet and beta cell count and glucose homeostasis function which neared those measured in single Pttg1 KO mice and were significantly lower than those observed in individual RasGrf1 KO mice. Conclusions: The specific transcriptional profile and signaling behavior of RasgGrf1 KO pancreatic islets, together with the dominance of Pttg1 over RasGrf1 with regards to the generation of these phenotypes in mouse pancreas, suggest that RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological response

Rye (Secale cereale L.) and squarrose clover (Trifolium squarrosum L.) cover crops can increase their allelopathic potential for weed control when used mixed as dead mulch

Cover crops are essential tools in agro-ecosystems for reduc- ing the reliance on synthetic inputs and associated environmental risks. Alongside their benefits to soil fertility, cover crops can con- trol weeds by their competitive and allelopathic attributes. Laboratory and field experiments were conducted to assess the allelopathic potential of two cover crop species, rye (Secale cereale L.) and squarrose clover (Trifolium squarrosum L.), alone or in a mixture, on seed germination and growth of arable weeds. Aqueous extracts of the two cover crops and their mixture were tested in a bioassay on Conyza canadensis (L). Cronq., Amaranthus retroflexus L. and Digitaria sanguinalis (L.) Scop. In vitro effects of aqueous extracts varied in a dose-dependent manner, with cover crops and weed species. All three extracts were able to reduce the germination of A. retroflexus (–87%) consider- ably. Inhibitory effects by rye and mixture extracts on radicle growth of all weed species ranged between 51 and 82%. Rye extract was the best at reducing shoot length of C. canadensis and D. sanguinalis (–39 to 44%), while squarrose clover was more effective on A. retroflexus (–79%). Plant extracts also delayed the germination time of weed species with a substantial effect of the mixture on C. canadensis seeds. In the field experiment, no signif- icant weed suppression was provided by cover crop residues incorporated as green manure compared to control plots, despite tillage being more effective in reducing weed density than no-till. Still, the mulch of the mixture controlled weed emergence signif- icantly better than single cover crop mulches. The chemical char- acterization of cover crop residues, both shoots and roots, revealed a notable richness of allelopathic phenolic acids and flavonoids, which may constitute potential natural herbicides through slow decomposition. From the analysis of the aqueous extracts, other non-analysed and/or unidentified water-soluble allelopathic com- pounds should underlie the phytotoxicity observed in vitro, at least for rye. For cover crop mixture, positive interactions among plant materials leading to a better release of allelochemicals and weed- ing effectiveness are discussed according to chemical profiles and field data. Our study demonstrated the allelopathic activity of the cover crops and their potential to be included in weed manage- ment strategies according to cropping system needs. Additional trials are needed to confirm the performance of cover crop residues under field conditions