Can we define a best estimator in simple one-dimensional cases?

International audienceWhat is the best estimator for assessing a parameter of a probability distribution from a small number of measurements? Is the same answer valid for a location parameter like the mean as for a scale parameter like the variance? It is sometimes argued that it is better to use a biased estimator with low dispersion than an unbiased estimator with a higher dispersion. In which cases is this assertion correct? To answer these questions, we will compare, on a simple example, the determination of a location parameter and a scale parameter with three "optimal" estimators: the minimum-variance unbiased estimator, the minimum square error estimator, and the a posteriori mean

Mouvement et voies de communication en Asie centrale. L’avènement d’une colonie

De 1839 à 1907, la Russie a étendu sa domination sur l’Asie centrale, réorganisant en même temps qu’elle le colonisait un espace réputé nomade et infini. Cette « marche en avant » de plus d’un demi-siècle ne peut se concevoir sans aborder la question des voies de communication. L’article développe une approche de la colonisation russe en termes de mouvement et montre combien les voies de communication ont participé – en particulier le chemin de fer Transcaspien – à la formation du Turkestan russe, en tant qu’instrument de conquête morale et militaire, mais aussi en imposant un ordre et une circulation nouvelle à travers la steppe. Terre de mouvement et circulation ferroviaire, ces deux termes se sont forcément heurtés et ont modifié avec le courant des hommes, des idées et des marchandises la définition même de l’espace centrasiatique.From 1839 to 1907, Russia extended its domination all over Central Asia, restructuring and colonising a supposedly nomadic land with no limits. This “forward movement” that lasted for over half a century cannot be understood without addressing the communication lines’ status. This paper intends to analyse Russian colonisation in terms of motion, establishing how the lines of communication, and in particular the Transcaspian railway, played a major role in the making of Russian Turkestan, not only as an instrument of moral and military conquest, but even more essentially, in imposing a new system of order and circulation throughout the Steppes. A land in motion and railway traffic: these two categories inevitably clashed and, together with the streams of people, ideas and goods, changed the very definition of the Central Asiatic space

The OURSE model: Simulating the World Refining Sector to 2030

The development of a model of the World Refining for the POLES model ( Contract n°151559-2009 A08 FR – with the Joint Research Centre Institute for Prospective Technological Studies of Commission of the European Communities) aims to represent the oil product's supply at a world-wide level in a global energy model. The World oil refining industry faces to several challenges such as the increasing oil derivatives demand in the transport sector, the improvement of the specifications of these products, the crude oil availability and the limitation of carbon emissions. An aggregated refining model linked to the POLES energy model has been developed to study these questions. The OURSE (Oil is Used in Refineries to Supply Energy) model is a world-wide aggregated refining model which is designed to simulate the world oil product supply for the POLES (Prospective Outlook for the Long-term Energy System) model. OURSE is able to simulate the impact on the world refining industry of changes in the crude oil supply (in costs and qualities) as well as in the oil product demand (in terms of level, structure and specifications). OURSE also enables to assess the consequences of a carbon emission regulation (caps and taxes) as the adoption of various kinds of alternative fuel policies. More precisely, these impacts are evaluated as regards the world refining structure (investments), but also its balance (production and trade of petroleum products), its pollutant emissions (CO2 and SO2) and its costs (of production, investments, etc.). Simulations for 2030 were performed. Thus, the paper presents the results of a prospective exercise for the oil refining industry which has been carried out with the worldwide refining model OURSE according to the oil product demand projections of European Commission for Europe with the PRIMES model (European Commission, 2010) and the IFP projections for the rest of the World.JRC.J.1-Economics of Climate Change, Energy and Transpor

Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection

Background Urogenital schistosomiasis is caused by the helminth parasite Schistosoma haematobium. In high transmission areas, children acquire schistosome infection early in life with infection levels peaking in early childhood and subsequently declining in late childhood. This age-related infection profile is thought to result from the gradual development of protective acquired immunity. Age-related differences in schistosome-specific humoral and cellular responses have been reported from several field studies. However there has not yet been a systematic study of the age-related changes in human dendritic cells, the drivers of T cell polarisation. Methods Peripheral blood mononuclear cells were obtained from a cohort of 61 Zimbabwean aged 5–45 years with a S. haematobium prevalence of 47.5%. Two subsets of dendritic cells, myeloid and plasmacytoid dentritic cells (mDCs and pDCs), were analyzed by flow cytometry. Findings In this population, schistosome infection levels peaked in the youngest age group (5–9 years), and declined in late childhood and adulthood (10+ years). The proportions of both mDCs and pDCs varied with age. However, for mDCs the age profile depended on host infection status. In the youngest age group infected people had enhanced proportions of mDCs as well as lower levels of HLA-DR on mDCs than un-infected people. In the older age groups (10–13 and 14–45 years) infected people had lower proportions of mDCs compared to un-infected individuals, but no infection status-related differences were observed in their levels of HLA-DR. Moreover mDC proportions correlated with levels of schistosome-specific IgG, which can be associated with protective immunity. In contrast proportions of pDCs varied with host age, but not with infection status. Conclusions Our results show that dendritic cell proportions and activation in a human population living in schistosome-endemic areas vary with host age reflecting differences in cumulative history of exposure to schistosome infection.World Health Organisation (grant no. RPC264), the Wellcome Trust (grant no. WT082028MA; www.wellcome.co.uk) and by Thrasher Research Funds (www.thrasherresearch.org)

An essential role for decorin in bladder cancer invasiveness

Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours.Fil: El Behi, Mohamed. Institute Curie; Francia. Centre de Recherche de I; Francia. Inserm; FranciaFil: Krumeich, Sophie. Institute Curie; Francia. Inserm; FranciaFil: Lodillinsky, Catalina. Institute Curie; Francia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Kamoun, Aurélie. Institute Curie; FranciaFil: Tibaldi, Lorenzo. Institute Curie; Francia. Inserm; FranciaFil: Sugano, Gaël. Institute Curie; Francia. Inserm; FranciaFil: de Reynies, Aurélien. Ligue Nationale Contre le Cancer; FranciaFil: Chapeaublanc, Elodie. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Laplanche, Agnès. Centre National de la Recherche Scientifique; Francia. Institut de Cancérologie Gustave Roussy; FranciaFil: Lebret, Thierry. Hôpital Foch. Service d; Francia. Université de Versailles; FranciaFil: Allory, Yves. Inserm; FranciaFil: Radvanyi, François. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Lantz, Olivier. Institute Curie; Francia. Inserm; FranciaFil: Eijan, Ana Maria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bernard Pierrot, Isabelle. Institute Curie; Francia. Centre National de la Recherche Scientifique; FranciaFil: Théery, Clotilde. Institute Curie; Francia. Inserm; Franci

Observation of out-of-plane vibrations in few-layer graphene

We report the observation of layer breathing mode (LBM) vibrations in few-layer graphene (FLG) samples of thickness from 2 to 6 layers, exhibiting both Bernal (AB) and rhombohedral (ABC) stacking order. The LBM vibrations are identified using a Raman combination band lying around 1720 cm-1. From double resonance theory, we identify the feature as the LOZO' combination mode of the out-of-plane LBM (ZO') and the in-plane longitudinal optical mode (LO). The LOZO' Raman band is found to exhibit multiple peaks, with a unique line shape for each layer thickness and stacking order. These complex line shapes of the LOZO'-mode arise both from the material-dependent selection of different phonons in the double-resonance Raman process and from the detailed structure of the different branches of LBM in FLG.Comment: 17 pages, 7 figures, supplemental material include

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.

ABSTRACT: A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome Project (EBP), which plans to sequence and assemble high-quality reference genomes for all ∼1.5 million recognized eukaryotic species through a stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are to be sequenced in just four years, worldwide participation in the project will be fundamental to success. As the European node of the EBP, the European Reference Genome Atlas (ERGA) seeks to implement a new decentralised, accessible, equitable and inclusive model for producing high-quality reference genomes, which will inform EBP as it scales. To embark on this mission, ERGA launched a Pilot Project to establish a network across Europe to develop and test the first infrastructure of its kind for the coordinated and distributed reference genome production on 98 European eukaryotic species from sample providers across 33 European countries. Here we outline the process and challenges faced during the development of a pilot infrastructure for the production of reference genome resources, and explore the effectiveness of this approach in terms of high-quality reference genome production, considering also equity and inclusion. The outcomes and lessons learned during this pilot provide a solid foundation for ERGA while offering key learnings to other transnational and national genomic resource projects.info:eu-repo/semantics/publishedVersio