Zero leakage design for ducts and tube connections for deep space travel. Volume 5 - Tube connector design principles and evaluation Final report, 5 Jul. 1963 - 30 Jun. 1967

Principles of connector testing, design evaluation of commercial connectors, and assessment of design rules for threaded connector

Angular Distribution of Electrons in Extensive Air Showers

Electrons are the main products of an extensive air shower and comprise approximately 90% of the shower. Since these electrons are the most numerous particles near the axis of a large shower and are not easily detected, extensive air showers are most easily studied by means of the electronic component. Thus, whatever concern there may be about the nucleonic cascade of which the electron is an outgrowth, it is necessary first to understand the development of the electronic component and is lateral and angular distribution. Also, for the correct analysis of any experimental data, it is of particular importance to know something about the angular distribution of the particles at the prescribed distance from the axis of the shower. Since the actual tracks left by the electronic component can be photographed and analyzed, a cloud chamber was used [as] the principle place of equipment in this experiment. The results of this investigation furnished the basis of this paper. Details of the experiment, analysis of data, interpretation of results, and comparison of these results with those other experiments and theories are treated in subsequent parts of the paper

Diffusion bonding makes strong seal at flanged connector

Copper strip seals a high pressure fluid system connector so that it is insensitive to relaxation of the bolt loads. The copper strip is diffusion bonded to the surfaces of the connector flange by application of high pressure and temperature

Świadek młodociany

Digitalizacja i deponowanie archiwalnych zeszytów RPEiS sfinansowane przez MNiSW w ramach realizacji umowy nr 541/P-DUN/201

Operationszeit der Mindener Technik der minimalinvasiven suprapubischen Cholezystektomie im Vergleich zur Standart Cholezystektomie

Vergleich der konventionellen laparoskopischen Cholezystektomie versus der Cholezystektomie in "Mindener Technik" ergab keine Unterschiede hinsichtlich der Operationszeiten. Die MI-CHE ist, im Gegensatz zu anderen neuen laparoskopischen Techniken, bei einem sehr guten kosmetischen Ergebnis in ähnlicher Zeit durchführbar wie die Standard-CHE. Da nur die Zugangsorte an der Bauchdecke in einen nicht sichtbaren Bereich verlagert wurden, nehmen wir an, dass dies durch die Ähnlichkeit des Operationsablaufs mit der Standard-CHE ohne Erhöhung der Komplexität des Eingriffes zu erklären ist. Offensichtlich waren beide Operationstechniken für die Jungchirurgen gleich schnell erlernbar

Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T cell Responses

Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in cellular responses. However, the effect of increased H2O2on an antigen-specific CD8+ T cell response was unknown. Following T cell receptor (TCR) stimulation, the expression and oxidation of peroxiredoxin II (PrdxII), a critical antioxidant enzyme, increased in CD8+ T cells. Deletion of PrdxII increased ROI, S phase entry, division, and death during in vitro division. During primary acute viral and bacterial infection, the number of effector CD8+ T cells in PrdxII-deficient mice was increased, while the number of memory cells were similar to those of the wild-type cells. Adoptive transfer of P14 TCR transgenic cells demonstrated that the increased expansion of effector cells was T cell autonomous. After rechallenge, effector CD8+ T cells in mutant animals were more skewed to memory phenotype than cells from wild-type mice, resulting in a larger secondary memory CD8+ T cell pool. During chronic viral infection, increased antigen-specific CD8+ T cells accumulated in the spleens of PrdxII mutant mice, causing mortality. These results demonstrate that PrdxII controls effector CD8+ T cell expansion, secondary memory generation, and immunopathology

The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions

Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 adolescent and young women aged 16–26 years with histologically confirmed, untreated CIN2 lesions to determine whether VMB composition affects rates of regression over 24 months. We show that women with a Lactobacillus-dominant microbiome at baseline are more likely to have regressive disease at 12 months. Lactobacillus spp. depletion and presence of specific anaerobic taxa including Megasphaera, Prevotella timonensis and Gardnerella vaginalis are associated with CIN2 persistence and slower regression. These findings suggest that VMB composition may be a future useful biomarker in predicting disease outcome and tailoring surveillance, whilst it may offer rational targets for the development of new prevention and treatment strategies

Advances in structure elucidation of small molecules using mass spectrometry

The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as hybrid mass spectrometric and orthogonal chromatographic approaches. The latter part discusses mass spectral data handling strategies, which includes background and noise subtraction, adduct formation and detection, charge state determination, accurate mass measurements, elemental composition determinations, and complex data-dependent setups with ion maps and ion trees. The importance of mass spectral library search algorithms for tandem mass spectra and multiple-stage MS(n) mass spectra as well as mass spectral tree libraries that combine multiple-stage mass spectra are outlined. The successive chapter discusses mass spectral fragmentation pathways, biotransformation reactions and drug metabolism studies, the mass spectral simulation and generation of in silico mass spectra, expert systems for mass spectral interpretation, and the use of computational chemistry to explain gas-phase phenomena. A single chapter discusses data handling for hyphenated approaches including mass spectral deconvolution for clean mass spectra, cheminformatics approaches and structure retention relationships, and retention index predictions for gas and liquid chromatography. The last section reviews the current state of electronic data sharing of mass spectra and discusses the importance of software development for the advancement of structure elucidation of small molecules