The Vehicle, Fall 1993

Table of Contents 7/10ths SynthesisPeter F. Essigpage 5 Aug 1992 (My Small Catechism)Jon Montgomerypage 6 Chaos Is-J. Dylan McNeillpage 7 UntouchedTraci Williamspage 8 The JustificationJohn C. Carminepage 8 LincolnJon Montgomerypage 9 Untitled (Photo)Nicole Niemanpage 10 Park PoemJohn Brillhartpage 11 SmokeJulia Ann Canhampage 12 Warming the BenchAnn Moutraypage 12 Cereal KillerJay Harnackpage 13 The Dutiful SonsTom McGrathpage 14 UntitledCatherine DeGraafpage 17 7-up bottleWalt Howardpage 17 BreedDan Trutterpage 18 An Argument Against LoveTony Martinezpage 19 UntitledT. Scott Laniganpage 19 Glassblowers BallStephanie Franzenpage 20 Portrait of a Young GirlJohn C. Carminepage 20 Untitled (artwork)Dan Trutterpage 21 Death of a FriendLizabeth Kulkapage 22 Submission BluesMartin Paul Brittpage 23 To the Fourteen Year Old SuicideScott Langenpage 23 The Flabby PilgrimTom McGrathpage 24 The Fall of ImmortalityBrian Wheelerpage 25 Merging with AirThom Schnarrepage 26 UntitledCatherine DeGraafpage 27 Tree FishSandra Beauchamppage 28 Country SlumberJ. Dylan McNeillpage 29 Untitled (artwork)Dan Trutterpage 33 Authors\u27 Pagepage 34https://thekeep.eiu.edu/vehicle/1060/thumbnail.jp

The Vehicle, Spring 1993

Table of Contents The Shape of Things to Come.Peter F. Essigpage 6 SaxophoneWalt Howardpage 6 Gravity BedSue Songerpage 7 UntitledJennifer Gutowskipage 8 uncertaintyWalt Howardpage 9 Ruth Ann, et. al.Susan Eisenhourpage 9 Failed IndustryScott Langenpage 10 UntitledKaren Wisspage 10 wanted:Walt Howardpage 10 Dida; 1978Diana Matijaspage 11 UntitledJennifer Gutowskipage 12 The Lesson in NovemberSue Songerpage 13 Coal MinerJames P. Tangpage 16 Christmas CrueltySue Songerpage 17 Astral ProjectionSusan Eisenhourpage 18 UntitledBen Hausmannpage 19 Into Zagreb\u27s Evening*Diana Matjaspage 20 UntitledJennifer Gutowskipage 22 The AnniversaryJennifer Moropage 23 NudeDan Trutterpage 24 death for saleWalt Howardpage 24 JudgedKevin St. Angelpage 25 Nature\u27s RefugeeScott Langenpage 25 Arrowhead Hunting at TippecanoeJennifer Moropage 26 UntitledKimberly Foxpage 27 TAINTED LOVESarah C. Patiencepage 28 cemeteryWalt Howardpage 28 Cow GameSusan Eisenhourpage 29 UntitledJennifer Gutowskipage 31 ReflectionsPeter F. Essigpage 32 Destination U.S.A.Dan Trutterpage 33 UntitledMario Letopage 33 Authors\u27 Pagepage 34https://thekeep.eiu.edu/vehicle/1061/thumbnail.jp

The Vehicle, Spring 1993

Table of Contents The Shape of Things to Come.Peter F. Essigpage 6 SaxophoneWalt Howardpage 6 Gravity BedSue Songerpage 7 UntitledJennifer Gutowskipage 8 uncertaintyWalt Howardpage 9 Ruth Ann, et. al.Susan Eisenhourpage 9 Failed IndustryScott Langenpage 10 UntitledKaren Wisspage 10 wanted:Walt Howardpage 10 Dida; 1978Diana Matijaspage 11 UntitledJennifer Gutowskipage 12 The Lesson in NovemberSue Songerpage 13 Coal MinerJames P. Tangpage 16 Christmas CrueltySue Songerpage 17 Astral ProjectionSusan Eisenhourpage 18 UntitledBen Hausmannpage 19 Into Zagreb\u27s Evening*Diana Matjaspage 20 UntitledJennifer Gutowskipage 22 The AnniversaryJennifer Moropage 23 NudeDan Trutterpage 24 death for saleWalt Howardpage 24 JudgedKevin St. Angelpage 25 Nature\u27s RefugeeScott Langenpage 25 Arrowhead Hunting at TippecanoeJennifer Moropage 26 UntitledKimberly Foxpage 27 TAINTED LOVESarah C. Patiencepage 28 cemeteryWalt Howardpage 28 Cow GameSusan Eisenhourpage 29 UntitledJennifer Gutowskipage 31 ReflectionsPeter F. Essigpage 32 Destination U.S.A.Dan Trutterpage 33 UntitledMario Letopage 33 Authors\u27 Pagepage 34https://thekeep.eiu.edu/vehicle/1061/thumbnail.jp

The Vehicle, Fall 1994

Table of Contents Poetry Noah\u27s WifeJennifer Moropage 8-9 The Intensity of a BreathHeather Anne Winterspage 10-11 When I Was RainNicole Moonpage 11 Wreckage at Low Tide, After a Storm On Cape FearMatt Parkspage 12-14 two belowKeith Spearpage 16 HeatScott Langrenpage 17 Plastic Shard WordsMatthew J. Nelsonpage 18 Mr. Snowplow ManMartin Paul Brittpage 19 Carpe DiemMichael Lairpage 19 untitledWalt Howardpage 20 The GameKellie J. Olsenpage 21 AT PEACEJennifer Surmanpage 22 SawdustSue Songerpage 23 Photography Unbound RealitiesKris Quiriconipage 26 untitled Mark Porter page 27 untitled Mark Porter page 28 untitled Mark Porter page 29 Prose I am Here...RememberingJ. Dylan McNeillpage 32-34 RecognitionSue Songerpage 35-36 SACCADICSteve Beinpage 37-40 The BurnBryan Levekpage 41-45 Biographiespage 46-48https://thekeep.eiu.edu/vehicle/1063/thumbnail.jp

The Vehicle, Fall 1994

Table of Contents Poetry Noah\u27s WifeJennifer Moropage 8-9 The Intensity of a BreathHeather Anne Winterspage 10-11 When I Was RainNicole Moonpage 11 Wreckage at Low Tide, After a Storm On Cape FearMatt Parkspage 12-14 two belowKeith Spearpage 16 HeatScott Langrenpage 17 Plastic Shard WordsMatthew J. Nelsonpage 18 Mr. Snowplow ManMartin Paul Brittpage 19 Carpe DiemMichael Lairpage 19 untitledWalt Howardpage 20 The GameKellie J. Olsenpage 21 AT PEACEJennifer Surmanpage 22 SawdustSue Songerpage 23 Photography Unbound RealitiesKris Quiriconipage 26 untitled Mark Porter page 27 untitled Mark Porter page 28 untitled Mark Porter page 29 Prose I am Here...RememberingJ. Dylan McNeillpage 32-34 RecognitionSue Songerpage 35-36 SACCADICSteve Beinpage 37-40 The BurnBryan Levekpage 41-45 Biographiespage 46-48https://thekeep.eiu.edu/vehicle/1063/thumbnail.jp

The Vehicle, Spring 1994

Table of Contents Thoughts in the IGASue Songerpage 6 The Cries of an Innocent Tea BagWojnarowski Yvonnepage 7 Proud HarpySusan Eisenhourpage 8 Bus Number TwoMindy Glazepage 9 My Home TownScott Langenpage 10 MemoriesMaggie Willpage 11 Vase (Artwork)Gail Valkerpage 12 The Last HuntMark Kannmacherpage 13 Corn DanceJulia A. Canhampage 14 Untitled (Photography)Rachel Corbettpage 14 Paradise (Artwork)Gail Valkerpage 15 Holding Back A ScreamElise Kirarpage 16 poetry isJonathan W. Iwanskipage 17 loveCatherine DeGraafpage 18 The OneTim Rileypage 18 Reading His Words on a Frosty EveningTom McGrathpage 19 UntitledBob Newellpage 19 The Ice StormMindy Glazepage 20 UntitledJonathan W. Iwanskipage 21 Untitled (Photography)Rachel Corbettpage 23 cityscapeChris Pomeroypage 24 Untitled (Photography)Rachel Corbettpage 25 Quarter Pound TemptationBryan Levekpage 26 Photograph (Artwork)Gail Valkerpage 29 Don\u27t Talk to StrangersJon Montgomerypage 30 Untitled (Photography)Rachel Corbettpage 33 Charleston, U.S.A. (Artwork)Gail Valkerpage 34 Fun With Nature (Artwork)Gail Valkerpage 34https://thekeep.eiu.edu/vehicle/1064/thumbnail.jp

Interventions to reduce the time to diagnosis of brain tumours

BACKGROUND: Brain tumours are recognised as one of the most difficult cancers to diagnose because presenting symptoms, such as headache, cognitive symptoms, and seizures, may be more commonly attributable to other, more benign conditions. Interventions to reduce the time to diagnosis of brain tumours include national awareness initiatives, expedited pathways, and protocols to diagnose brain tumours, based on a person's presenting symptoms and signs; and interventions to reduce waiting times for brain imaging pathways. If such interventions reduce the time to diagnosis, it may make it less likely that people experience clinical deterioration, and different treatment options may be available. OBJECTIVES: To systematically evaluate evidence on the effectiveness of interventions that may influence: symptomatic participants to present early (shortening the patient interval), thresholds for primary care referral (shortening the primary care interval), and time to imaging diagnosis (shortening the secondary care interval and diagnostic interval). To produce a brief economic commentary, summarising the economic evaluations relevant to these interventions. SEARCH METHODS: For evidence on effectiveness, we searched CENTRAL, MEDLINE, and Embase from January 2000 to January 2020; Clinicaltrials.gov to May 2020, and conference proceedings from 2014 to 2018. For economic evidence, we searched the UK National Health Services Economic Evaluation Database from 2000 to December 2014. SELECTION CRITERIA: We planned to include studies evaluating any active intervention that may influence the diagnostic pathway, e.g. clinical guidelines, direct access imaging, public health campaigns, educational initiatives, and other interventions that might lead to early identification of primary brain tumours. We planned to include randomised and non-randomised comparative studies. Included studies would include people of any age, with a presentation that might suggest a brain tumour. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed titles identified by the search strategy, and the full texts of potentially eligible studies. We resolved discrepancies through discussion or, if required, by consulting another review author. MAIN RESULTS: We did not identify any studies for inclusion in this review. We excluded 115 studies. The main reason for exclusion of potentially eligible intervention studies was their study design, due to a lack of control groups. We found no economic evidence to inform a brief economic commentary on this topic. AUTHORS' CONCLUSIONS: In this version of the review, we did not identify any studies that met the review inclusion criteria for either effectiveness or cost-effectiveness. Therefore, there is no evidence from good quality studies on the best strategies to reduce the time to diagnosis of brain tumours, despite the prioritisation of research on early diagnosis by the James Lind Alliance in 2015. This review highlights the need for research in this area

SHANK3 controls maturation of social reward circuits in the VTA.

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects specific neural circuits and how this is related to specific symptoms remains elusive. Here we used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice. We identified dopamine (DA) and GABA cell-type-specific changes in excitatory synapse transmission that converge to reduce DA neuron activity and generate behavioral deficits, including impaired social preference. Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference. Collectively, these data reveal the contribution of impaired ventral tegmental area function to social behaviors and identify mGluR1 modulation during postnatal development as a potential treatment strategy