Branhamella catarrhalis septicemia in a granulocytopenic patient

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Polarized deep inelastic scattering at high energies and parity violating structure functions

A comprehensive analysis of deep inelastic scattering of polarized charged leptons on polarized nucleons is presented; weak interaction contributions, both in neutral and charged current processes, are taken into account and the parity violating polarized nucleon structure functions are studied. Possible ways of their measurements and their interpretations in the parton model are discussed.Comment: (slightly modified version, includes a few new references and corrects few misprints for publication), 14 pages in TeX (needs harvmac) no figure, DFTT 80/9

Precise determination of the Wtb couplings at LHC

Top pair production at LHC is the ideal place to search for nonstandard Wtb couplings in t -> W b -> l nu b decays. The lb forward-backward asymmetry in the W rest frame is very sensitive to sigma_{mu nu} couplings, and can spot one-loop QCD corrections to the decay vertex with more than 5 sigma statistical significance. We discuss the potential of this asymmetry to signal nonstandard gamma_mu and sigma_{mu nu} couplings and compare with top-antitop spin correlation asymmetries, which have a lower sensitivity. We also briefly summarise the results for Tevatron.Comment: LaTeX, 12 pages, 2 PS figures. One reference added. To be published in PR

Zebrafish models of collagen VI-related myopathies

Collagen VI is an integral part of the skeletal muscle extracellular matrix, providing mechanical stability and facilitating matrix-dependent cell signaling. Mutations in collagen VI result in either Ullrich congenital muscular dystrophy (UCMD) or Bethlem myopathy (BM), with UCMD being clinically more severe. Recent studies demonstrating increased apoptosis and abnormal mitochondrial function in Col6a1 knockout mice and in human myoblasts have provided the first mechanistic insights into the pathophysiology of these diseases. However, how loss of collagen VI causes mitochondrial dysfunction remains to be understood. Progress is hindered in part by the lack of an adequate animal model for UCMD, as knockout mice have a mild motor phenotype. To further the understanding of these disorders, we have generated zebrafish models of the collagen VI myopathies. Morpholinos designed to exon 9 of col6a1 produced a severe muscle disease reminiscent of UCMD, while ones to exon 13 produced a milder phenotype similar to BM. UCMD-like zebrafish have increased cell death and abnormal mitochondria, which can be attenuated by treatment with the proton pump modifier cyclosporin A (CsA). CsA improved the motor deficits in UCMD-like zebrafish, but failed to reverse the sarcolemmal membrane damage. In all, we have successfully generated the first vertebrate model matching the clinical severity of UCMD and demonstrated that CsA provides phenotypic improvement, thus corroborating data from knockout mice supporting the use of mitochondrial permeability transition pore modifiers as therapeutics in patients, and providing proof of principle for the utility of the zebrafish as a powerful preclinical model

Collider aspects of flavour physics at high Q

This review presents flavour related issues in the production and decays of heavy states at LHC, both from the experimental side and from the theoretical side. We review top quark physics and discuss flavour aspects of several extensions of the Standard Model, such as supersymmetry, little Higgs model or models with extra dimensions. This includes discovery aspects as well as measurement of several properties of these heavy states. We also present public available computational tools related to this topic.Comment: Report of Working Group 1 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 200

ATLAS sensitivity to Wtb anomalous couplings in top quark decays

Abstract We study the sensitivity of the ATLAS experiment to Wtb anomalous couplings in top pair production with semileptonic decay, pp?tt̄?W+bW-b̄ with one of the W bosons decaying leptonically and the other hadronically. Several observables are examined, including the W helicity fractions and new quantities recently introduced, such as the ratios of helicity fractions and some angular asymmetries defined in the W rest frame. The dependence on anomalous couplings of all these observables has been previously obtained. In this work we show that some of the new observables also have smaller systematic uncertainties than the helicity fractions, with a similar or stronger dependence on anomalous couplings. Consequently, their measurement can significantly improve the limits on anomalous couplings. Moreover, the most sensitive measurements can be combined. In this case, the precision achieved in the determination of Wtb anomalous couplings can be of a few percent in the semileptonic channel alone