Tau-p mapping and interpretation of seismic reflection data from the western Isles region of Scotland

Seismic data are conventionally recorded, processed and displayed in the X-T domain, where X is the source-receiver. offset and T is the two-way traveltime. There are advantages, however, in mapping the same data in a different domain; that of intercept time T and horizontal ray parameter p. Computer programs .written for performing the transformation from X-T to -p were adapted for use with marine data acquired in the western Isles region of Scotland in order to obtain information about the velocity structure in that area. The results obtained are compared with those produced by the more conventional methods of refraction surveying and it is found that the data are of insufficient quality to facilitate a geological interpretation to be made with the -p method alone and that the method is of no use with the poorest quality data. Recourse to the conventional methods is found to be necessary, and the results obtained verify previous results from other work

Nowcasting Thunderstorm Anvil Clouds Over KSC/CCAFS

Electrified thunderstorm anvil clouds extend the threat of natural and triggered lightning to space launch and landing operations far beyond the immediate vicinity of thunderstorm cells. The deep convective updrafts of thunderstorms transport large amounts of water vapor, super-cooled water droplets and ice crystals into the upper troposphere, forming anvil clouds, which are then carried downstream by the prevailing winds in the anvil formation layer. Electrified anvil clouds have been observed over the space launch and landing facilities of Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS), emanating from thunderstorm activity more than 200 km distant. Space launch commit criteria and flight rules require launch and landing vehicles to avoid penetration of the non-transparent portion of anvil clouds. The life cycles of 167 anvil clouds over the Florida peninsula and its coastal waters were documented using GOES-8 visible imagery on 50 anvil case days during the months of May through July 2001. Anvil clouds were found to propagate at the speed and direction of upper-tropospheric winds in the layer from 300-to-l50 mb, approximately 9.4 km to 14 km, with an effective average transport lifetime of 2 hours and a standard deviation of approximately 30 minutes. The effective lifetime refers to the time required for the nontransparent leading edge of an anvil cloud to reach its maximum extent before beginning to dissipate. The propagation and lifetime information was incorporated into the design, construction and implementation of an objective short-range anvil forecast tool based on upper-air observations, for use on the Meteorological Interactive Data Display System within the Range Weather Operations facility of the 45th Weather Squadron at CCAFS and the Spaceflight Meteorology Group at Johnson Space Center

Establishing Chlamydomonas reinhardtii as an industrial biotechnology host.

Microalgae constitute a diverse group of eukaryotic unicellular organisms that are of interest for pure and applied research. Owing to their natural synthesis of value-added natural products microalgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including but not limited to those that could replace compounds currently made from fossil fuels. For the model microalga, Chlamydomonas reinhardtii, this has prompted a period of rapid development so that this organism is poised for exploitation as an industrial biotechnology platform. The question now is how best to achieve this? Highly advanced industrial biotechnology systems using bacteria and yeasts were established in a classical metabolic engineering manner over several decades. However, the advent of advanced molecular tools and the rise of synthetic biology provide an opportunity to expedite the development of C. reinhardtii as an industrial biotechnology platform, avoiding the process of incremental improvement. In this review we describe the current status of genetic manipulation of C. reinhardtii for metabolic engineering. We then introduce several concepts that underpin synthetic biology, and show how generic parts are identified and used in a standard manner to achieve predictable outputs. Based on this we suggest that the development of C. reinhardtii as an industrial biotechnology platform can be achieved more efficiently through adoption of a synthetic biology approach.M.A.S and J.R were funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I00680X/1, M.A.S was also funded by the European Commission 7th Framework Programme (FP7) project SPLASH (Sustainable PoLymers from Algae Sugars and Hydrocarbons), grant agreement number 311956. G.T.D.T.N was funded in part by Murray Edwards College and the Cambridge Philosophical Society. D.L. was funded by the Bill and Melinda Gates Foundation, and K.E.H was funded by BBSRC grant BB/I013164/1.This paper was originally published in The Plant Journal (Scaife MA, Nguyen GTDT, Rico J, Lambert D, Helliwell KE, Smith AG, The Plant Journal 2015, doi:10.1111/tpj.12781)

The oral microbiome of denture wearers is influenced by natural dentition

Objectives: The composition of dental plaque has been well defined, whereas currently there is limited understanding of the composition of denture plaque and how it directly influences denture related stomatitis (DS). The aims of this study were to compare the microbiomes of denture wearers, and to understand the implications of these towards inter-kingdom and host-pathogen interactions within the oral cavity. Methods: Swab samples were obtained from 123 participants wearing either a complete or partial denture; the bacterial composition of each sample was determined using bar-coded illumina MiSeq sequencing of the bacterial hypervariable V4 region of 16S rDNA. Sequencing data processing was undertaken using QIIME, clustered in Operational Taxonomic Units (OTUs) and assigned to taxonomy. The dentures were sonicated to remove the microbial flora residing on the prosthesis, sonicate was then cultured using diagnostic colorex Candida media. Samples of unstimulated saliva were obtained and antimicrobial peptides (AMP) levels were measured by ELISA. Results: We have shown that dental and denture plaques are significantly distinct both in composition and diversity and that the oral microbiome composition of a denture wearer is variable and is influenced by the location within the mouth. Dentures and mucosa were predominantly made up of Bacilli and Actinobacteria. Moreover, the presence of natural teeth has a significant impact on the overall microbial composition, when compared to the fully edentulous. Furthermore, increasing levels of Candida spp. positively correlate with Lactobacillus spp. AMPs were quantified, though showed no specific correlations. Conclusions: This is the first study to provide a detailed understanding of the oral microbiome of denture wearers and has provided evidence that DS development is more complex than simply a candidal infection. Both fungal and bacterial kingdoms clearly play a role in defining the progression of DS, though we were unable to show a defined role for AMPs

Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services:A controlled before-and-after study

Background: The Health and Social Care Act 2012 has mandated research use as a core consideration of health service commissioning arrangements. We evaluated whether or not access to a demand-led evidence briefing service improved use of research evidence by commissioners compared with less intensive and less targeted alternatives. Design: Controlled before-and-after study. Setting: Clinical Commissioning Groups (CCGs) in the north of England. Main outcome measures: Change at 12 months from baseline of a CCG’s ability to acquire, assess, adapt and apply research evidence to support decision-making. Secondary outcomes measured individual clinical leads’ and managers’ intentions to use research evidence in decision-making. Methods: Nine CCGs received one of three interventions: (1) access to an evidence briefing service; (2) contact plus an unsolicited push of non-tailored evidence; or (3) an unsolicited push of non-tailored evidence. Data for the primary outcome measure were collected at baseline and 12 months post intervention, using a survey instrument devised to assess an organisation’s ability to acquire, assess, adapt and apply research evidence to support decision-making. In addition, documentary and observational evidence of the use of the outputs of the service was sought and interviews with CCG participants were undertaken. Results: Most of the requests were conceptual; they were not directly linked to discrete decisions or actions but intended to provide knowledge about possible options for future actions. Symbolic use to justify existing decisions and actions were less frequent and included a decision to close a walk-in centre and to lend weight to a major initiative to promote self-care already under way. The opportunity to impact directly on decision-making processes was limited to work to establish disinvestment policies. In terms of impact overall, the evidence briefing service was not associated with increases in CCGs’ capacity to acquire, assess, adapt and apply research evidence to support decision-making, individual intentions to use research findings or perceptions of CCGs’ relationships with researchers. Regardless of the intervention received, at baseline participating CCGs indicated that it felt it was inconsistent in its research-seeking behaviours and its capacity to acquire research remained so at follow-up. The informal nature of decision-making processes meant that there was little or no traceability of the use of evidence. Limitations: Low baseline and follow-up response rates (of 68% and 44%, respectively) and missing data limit the reliability of these findings. Conclusions: Access to a demand-led evidence briefing service did not improve the uptake and use of research evidence by NHS commissioners compared with less intensive and less targeted alternatives. Commissioners appear to be well intentioned but ad hoc users of research. Future work: Further research is required on the effects of interventions and strategies to build individual and organisational capacity to use research. Resource-intensive approaches to providing evidence may best be employed to support instrumental decision-making. Comparative evaluation of the impact of less intensive but targeted strategies on the uptake and use of research by commissioners is warranted. Funding: National Institute for Health Research Health Services and Delivery Research programme

Evaluation of the Emergency Response Dose Assessment System(ERDAS)

The emergency response dose assessment system (ERDAS) is a protype software and hardware system configured to produce routine mesoscale meteorological forecasts and enhanced dispersion estimates on an operational basis for the Kennedy Space Center (KSC)/Cape Canaveral Air Station (CCAS) region. ERDAS provides emergency response guidance to operations at KSC/CCAS in the case of an accidental hazardous material release or an aborted vehicle launch. This report describes the evaluation of ERDAS including: evaluation of sea breeze predictions, comparison of launch plume location and concentration predictions, case study of a toxic release, evaluation of model sensitivity to varying input parameters, evaluation of the user interface, assessment of ERDA's operational capabilities, and a comparison of ERDAS models to the ocean breeze dry gultch diffusion model

Four problems with global carbon markets: a critical review

This article offers a critique of global carbon markets and trading, with a special focus on the Clean Development Mechanism of the Kyoto Protocol. It explores problems with the use of tradable permits to address climate change revolving around four areas: homogeneity, justice, gaming, and information. Homogeneity problems arise from the non-linear nature of climate change and sensitivity of emissions, which complicate attempts to calculate carbon offsets. Justice problems involve issues of dependency and the concentration of wealth among the rich, meaning carbon trading often counteracts attempts to reduce poverty. Gaming problems include pressures to promote high-volume, least-cost projects and the consequences of emissions leakage. Information problems encompass transaction costs related to carbon trading and market participation and the comparatively weak institutional capacity of project evaluators

Built Environment and Its Influences on Walking among Older Women: Use of Standardized Geographic Units to Define Urban Forms

Consensus is lacking on specific and policy-relevant measures of neighborhood attributes that may affect health outcomes. To address this limitation, we created small standardized geographic units measuring the transit, commercial, and park area access, intersection, and population density for the Portland, Oregon metropolitan area. Cluster analysis was used to identify six unique urban forms: central city, city periphery, suburb, urban fringe with poor commercial access, urban fringe with pool park access, and satellite city. The urban form information was linkable to the detailed physical activity, health, and socio-demographic data of 2,005 older women without the use of administrative boundaries. Evaluation of the relationship between urban forms and walking behavior indicates that older women residing in city center were more likely to walk than those living in city periphery, suburb communities, and urban fringe with poor commercial access; however, these women were not significantly more likely to walk compared to those residing in urban fringe with poor park access or satellite city. Utility of small standardized geographic units and clusters to measure and define built environment support research investigating the impact of built environment and health. The findings may inform environmental/policy interventions that shape communities and promote active living

Analytic Metaphysics versus Naturalized Metaphysics: The Relevance of Applied Ontology

The relevance of analytic metaphysics has come under criticism: Ladyman & Ross, for instance, have suggested do discontinue the field. French & McKenzie have argued in defense of analytic metaphysics that it develops tools that could turn out to be useful for philosophy of physics. In this article, we show first that this heuristic defense of metaphysics can be extended to the scientific field of applied ontology, which uses constructs from analytic metaphysics. Second, we elaborate on a parallel by French & McKenzie between mathematics and metaphysics to show that the whole field of analytic metaphysics, being useful not only for philosophy but also for science, should continue to exist as a largely autonomous field

Counting Yang-Mills Dyons with Index Theorems

We count the supersymmetric bound states of many distinct BPS monopoles in N=4 Yang-Mills theories and in pure N=2 Yang-Mills theories. The novelty here is that we work in generic Coulombic vacua where more than one adjoint Higgs fields are turned on. The number of purely magnetic bound states is again found to be consistent with the electromagnetic duality of the N=4 SU(n) theory, as expected. We also count dyons of generic electric charges, which correspond to 1/4 BPS dyons in N=4 theories and 1/2 BPS dyons in N=2 theories. Surprisingly, the degeneracy of dyons is typically much larger than would be accounted for by a single supermultiplet of appropriate angular momentum, implying many supermutiplets of the same charge and the same mass.Comment: 34 pages, 1 figure, LaTe