Simulation of the Taylor impact test and analysis of damage evolution using a nucleation and growth based approach

International audienceComputational modeling of the Taylor impact test, using OFHC copper rods are carried out for two impact velocities (260 m/s and 365 m/s). The aim of this work is to demonstrate the efficiency of the recently proposed material model for dynamic plasticity and failure for metals. This model combines the use of a damage approach based on void nucleation and growth, with the Mechanical Threshold Stress (MTS) model for the evolution of the flow stress in isotropic plasticity. The proposed approach is implemented in the finite element code ABAQUS/Explicit via a user material subroutine and the symmetric Taylor impact test, using copper rods, is simulated. The predicted results are compared to the experimental results reported in the open literature and good agreement is found for both shape change and damage distribution

Granular Jamming as Controllable Stiffness Mechanism for Endoscopic and Catheter Applications

Context During minimally invasive procedures, most of the devices (endoscopes, catheters, guidewires, etc.) need to be sufficiently flexible to avoid damaging patient tissues or causing pain, but have to be stiff enough to transmit force for support or for puncture. In the case of vascular stenosis, the guidewire has to be flexible to reach the stenosis (through the blood vessels), but it requires a rigid support to pass through the occlusion for treatment, to avoid buckling or deformation due to the force application. In order to solve this duality on the rigidity, controllable stiffness mechanisms can be used. Various mechanisms to control the stiffness can be found in the literature [1]. One of the promising solutions to achieve this objective is based on granular material jamming [2]. This research aims at studying the scaling laws of such solutions for miniaturized applications (with diameters below 3mm), the mechanical rules of design and the optimization based on the stiffness performances. Granular jamming The granular jamming is based on the locking of granular material. In this study, a flexible membrane is filled with a granular material (glass beads). When the pressure difference between outside and inside the membrane is low, the grains are free to move with respect to each other. In this configuration, the system is very flexible. Once the difference of pressure is increased, the grains are locked to each other due to the inter-grain friction. In this configuration, the system is more rigid. It is possible to adjust the stiffness of the device by controlling the pressure difference across the membrane. Materials and methods In this work, the performances of the stiffness change thanks to the granular jamming are quantified by mechanical testing. On the one hand, three point bending and cantilever beam tests are performed to quantify the flexural stiffness EI (product of the Young Modulus, E, and the second moment of area, I) of the solutions. Various granular materials and diameters of the samples are studied. On the other hand, triaxial compression tests are performed to observe the influence of the pressure difference on the rigidity obtained via granular jamming, using different granular materials. Results and discussion The tests described previously provide information on the performances of the granular jamming solution as well as an indication of the most important parameters to optimize. An optimal size of grains is highlighted by the results of these mechanical tests. The results of the triaxial compression tests show that the pressure difference is the most important parameter influencing the Young Modulus. The bending tests show that the second moment of area greatly impacts this stiffness. Removing the influence of the geometry, the equivalent Young Modulus is positively influenced for smaller diameters which is promising for the applications targeted in this work. Some of these results, as well as pictures and conclusions are illustrated in the poster file available in the following link : https://dipot.ulb.ac.be/dspace/bitstream/2013/239703/3/20161125PosterNCBMElblanc.pdf. One of the perspectives of this work is to develop a model for linking the results obtained from the different mechanical tests and to observe the optimization of the grains (shape and size) and cross-section of the samples with respect to the change of stiffness obtained. Further studies on stimulation method and on materials should be performed. References - [1] Kuder, I. K. et Al., ?Variable stiffness material and structural concepts for morphing applications?, Progress in Aerospace Sciences, pp.33-55, 2013. - [2] Loeve, A. J. et Al., ?Vacuum packed particles as flexible endoscope guides with controllable rigidity?, Granular Matter, pp. 543-554, 2010

Surgically created double-orifice left atrioventricular valve: A valve-sparing repair in selected atrioventricular septal defects

AbstractObjectives: Some features of the left atrioventricular valve (large mural leaflet, dystrophic tissue) represent a challenge for repair of atrioventricular septal defects without postoperative regurgitation. A retrospective study was conducted to evaluate the results of surgically creating a double-orifice left atrioventricular valve in such circumstances. Clinical results were analyzed according to valvular and subvalvular left atrioventricular valve measurements in pathologic specimens with atrioventricular septal defects. Methods: Among 157 patients operated on for atrioventricular septal defect since October 1989, 10 patients underwent primary repair (n = 8) or reoperation (n = 2) by this procedure. Median age at repair was 3.3 years (0.1-33 years). Anatomic types were complete (n = 3), intermediate (n = 5), and partial (n = 2). Preoperative moderate to severe left atrioventricular valve regurgitation was present in 6 patients. After the repair (two-patch technique in complete atrioventricular septal defect, cleft closed in each case), these 10 patients were found to have moderate to severe residual regurgitation not amenable to repair by annuloplasty. The top edge of the mural leaflet was anchored to the facing free edge of the cleft. Results: No hospital death or morbidity was observed. Left atrioventricular valve regurgitation was absent or trivial (8 patients) and mild (2 patients). Color-coded echocardiography did not show significant left atrioventricular valve stenosis. The mean diastolic pressure gradient across the left atrioventricular valve was 3.2 ± 1.1 mm Hg (1.4-4.5 mm Hg). At a median follow-up of 72 months (6-91 months), there was 1 late death, unrelated to left atrioventricular valve malfunction, due to pulmonary vascular obstructive disease. Left atrioventricular valve regurgitation did not increase over time, except in 1 patient in whom regurgitation recently progressed from mild to moderate. At rest, the mean diastolic pressure gradient across the left atrioventricular valve was 3.8 ± 2.9 mm Hg (1.5-11.2 mm Hg). One child had an early moderate stenosis without pulmonary hypertension. Studies on pathologic specimens (n = 34) indicated that long chordal lengths and large mural leaflet size are essential independent anatomic features to assess its feasibility. Conclusions: Surgical creation of a double-orifice left atrioventricular valve is an effective additional procedure for repair of atypical cases of atrioventricular septal defect. The operation may decrease the need for reoperation or left atrioventricular valve replacement. (J Thorac Cardiovasc Surg 2001;121:352-65

Low frequency high resolution optical inertial sensors

Nowadays, sensors’ resolution limits their performance at low frequency which reduces their operating range. Sensors with a good resolution at low frequency are required to improve the performance of gravitational wave detectors in the sub-Hz frequency range. We are currently developing an inertial sensor with a sufficient resolution at low frequency from 10 mHz to 100 Hz. We are focusing on the improvement of different characteristics of the sensor, among others, its compactness and its thermal noise mitigation. The readout consists of a long-range Michelson interferometer fed by a 1550 nm laser and whose signal is measured by InGaS photodetectors. The use of InGaS photodetector in our interferometer will allow better resolution for future sensor projects. The inertial mass is connected to the frame by a fused silica flexure joint to limit internal damping. Then, translational guidance is implemented to allow the use of a flat mirror. The actual sensor developed at the Precision Mechatronics Laboratory has a resolution of 2x10^(-13) m/√Hz at 1 Hz. Our goal is to reach the same resolution with a compact version: 10x10x10 cm^3

Investigating Fused Silica Bending Strength and Damping Characteristics on Resonators Fabricated through Femtosecond Laser-Assisted Wet Etching: An Experimental Analysis

peer reviewe

High resolution compact vertical inertial sensor for atomic quantum gravimeter hybridization

peer reviewedInertial sensors are devices capable of measuring the absolute motion of the support they are fixed onto. The advance of very high-end scientific instruments such as gravitational wave detectors, always pursuing ever greater sensitivities and performance, puts a large demand on ultra-high-resolution inertial sensors, capable of measuring very low-frequency and small-amplitude motions. Our group has a long experience in the design of low-frequency inertial sensors intended to be used in active isolation systems. The latest horizontal and vertical interferometric inertial sensors that have been designed have performance that competes with industry standards. They were shown to reach a resolution of 2×10−13 m/Hz−−−√ at 1 Hz and are capable of measuring ground motion from 0.1 to 100 Hz. However, they are large and heavy, measuring approximately 20 × 20 × 30 cm3 each, which makes their integration into practical systems tedious. In addition, experimental characterization of these sensors revealed three main limitations to their resolution. They are: (i) thermal noise, (ii) electronic readout noise and (iii) broadband white noise caused by mechanical and optical nonlinearities. The present paper presents a revised version of the vertical sensor, where the size of the device has been made to fit a 10 × 10 × 10 cm3 while simultaneously addressing the aforementioned sources of noise. The mechanics of the compact sensor is made of a leaf-spring supported pendulum, connected to the frame using a flexure hinge. A moving mirror is connected to the mass and guided using a so-called "4-bar" mechanism, providing the moving mirror with linear translation motion (iii). The joints of the mechanics are made of fused silica, allowing to reach a low natural frequency of ≈1 Hz with a compact design, in addition to significantly reducing structural thermal noise (i) due to the low dissipation rate of fused-silica. On the other hand, the readout system used in this sensor is a homemade design of a Michelson interferometer. The optical scheme features numerous polarizing elements that allow the propagation of two laser beams in phase quadrature, and custom hardware is developed for minimizing electronic noise (ii). Lastly, the vertical sensor is operating in closed-loop, using a homemade actuator design, so as to reduce non-linear effects related to either the mechanics or the optical readout (iii). The sensor frequency response is characterized using a test bench that has been specifically developed for testing low-frequency sensor response. The noise floor is extracted using a Huddle Test

Real-Time Online Monitoring of the Ion Range by Means of Prompt Secondary Radiations

International audiencePrompt secondary radiations such as gamma rays and protons can be used for ion-range monitoring during ion therapy either on an energy-slice basis or on a pencil-beam basis. We present a review of the ongoing activities in terms of detector developments, imaging, experimental and theoretical physics issues concerning the correlation between the physical dose and hadronic processe

An atlas of genetic scores to predict multi-omic traits

The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics. Here we examine a large cohort (the INTERVAL study; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores

Electron population dynamics in resonant non-linear x-ray absorption in nickel at a free-electron laser

Free-electron lasers provide bright, ultrashort, and monochromatic x-ray pulses, enabling novel spectroscopic measurements not only with femtosecond temporal resolution: The high fluence of their x-ray pulses can also easily enter the regime of the non-linear x-ray–matter interaction. Entering this regime necessitates a rigorous analysis and reliable prediction of the relevant non-linear processes for future experiment designs. Here, we show non-linear changes in the L3-edge absorption of metallic nickel thin films, measured with fluences up to 60 J/cm2. We present a simple but predictive rate model that quantitatively describes spectral changes based on the evolution of electronic populations within the pulse duration. Despite its simplicity, the model reaches good agreement with experimental results over more than three orders of magnitude in fluence, while providing a straightforward understanding of the interplay of physical processes driving the non-linear changes. Our findings provide important insights for the design and evaluation of future high-fluence free-electron laser experiments and contribute to the understanding of non-linear electron dynamics in x-ray absorption processes in solids at the femtosecond timescale

2012 Activity Report of the Regional Research Programme on Hadrontherapy for the ETOILE Center

2012 is the penultimate year of financial support by the CPER 2007-2013 for ETOILE's research program, sustained by the PRRH at the University Claude Bernard. As with each edition we make the annual review of the research in this group, so active for over 12 years now. Over the difficulties in the decision-making process for the implementation of the ETOILE Center, towards which all our efforts are focussed, some "themes" (work packages) were strengthened, others have progressed, or have been dropped. This is the case of the eighth theme (technological developments), centered around the technology for rotative beam distribution heads (gantries) and, after being synchronized with the developments of ULICE's WP6, remained so by ceasing its activities, coinciding also with the retirement of its historic leader at IPNL, Marcel Bajard. Topic number 5 ("In silico simulations") has suffered the departure of its leader, Benjamin Ribba, although the work has still been provided by Branka Bernard, a former postdoctoral fellow in Lyon Sud, and now back home in Croatia, still in contract with UCBL for the ULICE project. Aside from these two issues (and the fact that the theme "Medico-economical simulations" is now directly linked to the first one ("Medical Project"), the rest of the teams are growing, as evidenced by the publication statistics at the beginning of this report. This is obviously due to the financial support of our always faithful regional institutions, but also to the synergy that the previous years, the European projects, the arrival of the PRIMES LabEx, and the national France Hadron infrastructure have managed to impulse. The Rhone-Alpes hadron team, which naturally includes the researchers of LPC at Clermont, should also see its influence result in a strong presence in France Hadron's regional node, which is being organized. The future of this regional research is not yet fully guaranteed, especially in the still uncertain context of ETOILE, but the tracks are beginning to emerge to allow past and present efforts translate into a long future that we all want to see established. Each of the researchers in PRRH is aware that 2013 will be (and already is) the year of great challenge : for ETOILE, for the PRRH, for hadron therapy in France, for French hadrontherapy in Europe (after the opening and beginning of treatments in the German [HIT Heidelberg, Marburg], Italian [CNAO, Pavia] and Austrian [MedAustron, Wien Neuerstadt]) centers. Let us meet again in early 2014 for a comprehensive review of the past and a perspective for the future ..