121 research outputs found
Status and perspectives of the CAST experiment
Arık, Metin (Dogus Author) -- The conference paper was firstly submitted to 12th International Conference on Topics in Astroparticle and Underground Physics.The CERN Axion Solar Telescope (CAST) is currently the most sensitive axion helioscope designed to search for axions produced by the Primakoff process in the solar core. CAST is using a Large Hadron Collider (LHC) test magnet where axions could be converted into X-rays with energies up to 10 keV. During the phase I, the experiment operated with vacuum inside the magnet bores and covered axion masses up to 0.02 eV. In the phase II, the magnet bores were filled with a buffer gas (first 4He and later 3He) at various densities in order to extend the sensitivity to higher axion masses (up to f .18 eV). The phase II data taking was completed in 2011. So far, no evidence of axion signal has been found and CAST set the most restrictive experimental limit on the axion-photon coupling constant over a broad range of axion masses. The latest CAST results with 3He data in the mass range 0.39 eV < m a < 0.64 eV will be presented
Towards a new generation axion helioscope
We study the feasibility of a new generation axion helioscope, the most
ambitious and promising detector of solar axions to date. We show that large
improvements in magnetic field volume, x-ray focusing optics and detector
backgrounds are possible beyond those achieved in the CERN Axion Solar
Telescope (CAST). For hadronic models, a sensitivity to the axion-photon
coupling of \gagamma\gtrsim {\rm few} \times 10^{-12} GeV is
conceivable, 1--1.5 orders of magnitude beyond the CAST sensitivity. If axions
also couple to electrons, the Sun produces a larger flux for the same value of
the Peccei-Quinn scale, allowing one to probe a broader class of models. Except
for the axion dark matter searches, this experiment will be the most sensitive
axion search ever, reaching or surpassing the stringent bounds from SN1987A and
possibly testing the axion interpretation of anomalous white-dwarf cooling that
predicts of a few meV. Beyond axions, this new instrument will probe
entirely unexplored ranges of parameters for a large variety of axion-like
particles (ALPs) and other novel excitations at the low-energy frontier of
elementary particle physics.Comment: 37 pages, 11 figures, accepted for publication in JCA
The International Axion Observatory (IAXO)
The International Axion Observatory (IAXO) is a new generation axion
helioscope aiming at a sensitivity to the axion-photon coupling of a few
10 GeV, i.e. 1 - 1.5 orders of magnitude beyond the one currently
achieved by CAST. The project relies on improvements in magnetic field volume
together with extensive use of x-ray focusing optics and low background
detectors, innovations already successfully tested in CAST. Additional physics
cases of IAXO could include the detection of electron-coupled axions invoked to
solve the white dwarfs anomaly, relic axions, and a large variety of more
generic axion-like particles (ALPs) and other novel excitations at the
low-energy frontier of elementary particle physics. This contribution is a
summary of our paper [1] to which we refer for further details.Comment: 4 pages, 2 figures. To appear in the proceedings of the 7th Patras
Workshop on Axions, WIMPs and WISPs, Mykonos, Greece, 201
CAST constraints on the axion-electron coupling
In non-hadronic axion models, which have a tree-level axion-electron
interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton
scattering, and axio-recombination, the "BCA processes." Based on a new
calculation of this flux, including for the first time axio-recombination, we
derive limits on the axion-electron Yukawa coupling g_ae and axion-photon
interaction strength g_ag using the CAST phase-I data (vacuum phase). For m_a <
10 meV/c2 we find g_ag x g_ae< 8.1 x 10^-23 GeV^-1 at 95% CL. We stress that a
next-generation axion helioscope such as the proposed IAXO could push this
sensitivity into a range beyond stellar energy-loss limits and test the
hypothesis that white-dwarf cooling is dominated by axion emission
Legumain in acute coronary syndromes: A substudy of the PLATO (Platelet Inhibition and Patient Outcomes) trial
Background
The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the association of legumain with clinical outcome in a large cohort of patients with acute coronary syndrome.
Methods and Results
Serum levels of legumain were analyzed in 4883 patients with acute coronary syndrome from a substudy of the PLATO (Platelet Inhibition and Patient Outcomes) trial. Levels were analyzed at admission and after 1 month followâup. Associations between legumain and a composite of cardiovascular death, spontaneous myocardial infarction or stroke, and its individual components were assessed by multivariable Cox regression analyses. At baseline, a 50% increase in legumain level was associated with a hazard ratio (HR) of 1.13 (95% CI, 1.04â1.21), P=0.0018, for the primary composite end point, adjusted for randomized treatment. The association remained significant after adjustment for important clinical and demographic variables (HR, 1.10; 95% CI, 1.02â1.19; P=0.013) but not in the fully adjusted model. Legumain levels at 1 month were not associated with the composite end point but were negatively associated with stroke (HR, 0.62; 95% CI, 0.44â0.88; P=0.0069), including in the fully adjusted model (HR, 0.57; 95% CI, 0.37â0.88; P=0.0114).
Conclusions
Baseline legumain was associated with the primary outcome in patients with acute coronary syndrome, but not in the fully adjusted model. The association between high levels of legumain at 1 month and decreased occurrence of stroke could be of interest from a mechanistic point of view, illustrating the potential dual role of legumain during atherogenesis and acute coronary syndrome.
Registration
URL: https://www.cliniâcaltrâials.gov; Unique identifier: NCT00391872
Solar axion search with the CAST experiment
The CAST (CERN Axion Solar Telescope) experiment is searching for solar
axions by their conversion into photons inside the magnet pipe of an LHC
dipole. The analysis of the data recorded during the first phase of the
experiment with vacuum in the magnet pipes has resulted in the most restrictive
experimental limit on the coupling constant of axions to photons. In the second
phase, CAST is operating with a buffer gas inside the magnet pipes in order to
extent the sensitivity of the experiment to higher axion masses. We will
present the first results on the data taking as well as the
system upgrades that have been operated in the last year in order to adapt the
experiment for the data taking. Expected sensitivities on the
coupling constant of axions to photons will be given for the recent run just started in March 2008.Comment: Proceedings of the ICHEP 2008 conferenc
Interleukinâ18 in patients with acute coronary syndromes
Background
We aimed to assess associations between circulating ILâ18 concentrations and cardiovascular outcomes in patients with acute coronary syndromes (ACS).
Hypothesis and Methods
Plasma ILâ18 concentrations were measured at admission, discharge, 1 month, and 6 months in patients with ACS in the PLATelet inhibition and patient Outcomes (PLATO) trial. Associations with outcomes were evaluated with Cox regression models on the composite of CV death, spontaneous myocardial infarction (sMI), or stroke; and on CV death or sMI separately, including adjustment for clinical risk factors and biomarkers (cTnTâhs, NTâproBNP, cystatin C, CRPâhs, and GDFâ15).
Results
Median ILâ18 concentrations at baseline, discharge, 1 month, and 6 months were 237, 283, 305, and 320âng/L (n = 16â636). Male sex, obesity, diabetes, and plasma levels of cystatin C, GDFâ15, and CRPâhs were independently associated with higher ILâ18 levels. Higher baseline ILâ18 levels were associated with the composite endpoint and with CV death (hazard ratio [HR] 1.05, 95% confidence interval [95% CI] 1.02â1.07 and HR 1.10, 95% CI 1.06â1.14, respectively, per 25% increase of ILâ18 levels). Associations remained significant after adjustment for clinical variables but became nonâsignificant after adjustment for all biomarkers (HR 1.01, 95% CI 0.98â1.04 and HR 1.04, 95% CI 1.00â1.08, respectively). There were no associations with sMI.
Conclusions
In ACS patients, ILâ18 concentrations increased after the acute event and remained increased for 6 months. Baseline ILâ18 levels were significantly associated with CV mortality, independent of clinical characteristics and indicators of renal/cardiac dysfunction but this association was attenuated after adjustment for multiple biomarkers
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Objectives
Biomarker concentrations and their changes during acute coronary syndrome (ACS) provide clinically useful information on pathophysiological processes, e.g. myocardial necrosis, hemodynamic stress and inflammation. However, current evidence on temporal biomarker patterns early during ACS is limited, and studies investigating multiple biomarkers are lacking.
Methods
We measured concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI), NT-terminal pro-B-type natriuretic peptide, C-reactive protein, and growth-differentiation factor-15 (GDF-15) in plasma samples obtained at randomization in ACS patients from the PLATelet inhibition and patient Outcomes (PLATO) trial. Linear regressions with interaction analyses were used to investigate the associations of biomarker concentrations with the time from symptom onset and to model temporal biomarker concentration patterns.
Results
The study population consisted of 16,944 patients (median age 62 years; 71.3âŻ% males) with 6,853 (40.3âŻ%) having ST-elevation myocardial infarction (STEMI) and 10,141 (59.7âŻ%) having non-ST-elevation ACS (NSTE-ACS). Concentrations of all biomarkers were associated with time from symptom onset (pinteraction<0.001), apart for GDF-15 (pinteraction=0.092). Concentration increases were more pronounced in STEMI compared to NSTE-ACS. Temporal biomarker patterns for hs-cTnT and hs-cTnI were different depending on sex whereas biomarker patterns for the other biomarkers were similar in cohorts defined by age and sex.
Conclusions
Temporal concentration patterns differ for various biomarkers early during ACS, reflecting the variability in the activation and duration of different pathophysiological processes, and the amount of injured myocardium. Our data emphasize that the time elapsed from symptom onset should be considered for the interpretation of biomarker results in ACS
CAST solar axion search with 3^He buffer gas: Closing the hot dark matter gap
The CERN Axion Solar Telescope (CAST) has finished its search for solar
axions with 3^He buffer gas, covering the search range 0.64 eV < m_a <1.17 eV.
This closes the gap to the cosmological hot dark matter limit and actually
overlaps with it. From the absence of excess X-rays when the magnet was
pointing to the Sun we set a typical upper limit on the axion-photon coupling
of g_ag < 3.3 x 10^{-10} GeV^{-1} at 95% CL, with the exact value depending on
the pressure setting. Future direct solar axion searches will focus on
increasing the sensitivity to smaller values of g_a, for example by the
currently discussed next generation helioscope IAXO.Comment: 5 pages, 2 figures. Last version uploade
Production properties of K*(892) vector mesons and their spin alignment as measured in the NOMAD experiment
First measurements of K*(892) mesons production properties and their spin
alignment in nu_mu charged current (CC) and neutral current (NC) interactions
are presented. The analysis of the full data sample of the NOMAD experiment is
performed in different kinematic regions. For K*+ and K*- mesons produced in
nu_mu CC interactions and decaying into K0 pi+/- we have found the following
yields per event: (2.6 +/- 0.2 (stat.) +/- 0.2 (syst.))% and (1.6 +/- 0.1
(stat.) +/- 0.1 (syst.))% respectively, while for the K*+ and K*- mesons
produced in nu NC interactions the corresponding yields per event are: (2.5 +/-
0.3 (stat.) +/- 0.3 (syst.))% and (1.0 +/- 0.3 (stat.) +/- 0.2 (syst.))%. The
results obtained for the rho00 parameter, 0.40 +/- 0.06 (stat) +/- 0.03 (syst)
and 0.28 +/- 0.07 (stat) +/- 0.03 (syst) for K*+ and K*- produced in nu_mu CC
interactions, are compared to theoretical predictions tuned on LEP measurements
in e+e- annihilation at the Z0 pole. For K*+ mesons produced in nu NC
interactions the measured rho00 parameter is 0.66 +/- 0.10 (stat) +/- 0.05
(syst).Comment: 20 p
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