375 research outputs found
Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mutations in Protein-Binding Hot-Spots on the Hub Protein Smad3 Differentially Affect Its Protein Interactions and Smad3-Regulated Gene Expression
- Author
- A Moustakas
- A Moustakas
- A Sultana
- AA Bogan
- B Ma
- BM Chacko
- BM Zhao
- BY Qin
- Chateen Krueger
- CJ Tsai
- D Goto
- D Javelaud
- D Koinuma
- D Liu
- D Liu
- D Reichmann
- Dhyan Chandra
- E Cukuroglu
- E Piek
- E Wiercinska
- EN Olson
- F. Michael Hoffmann
- G Fibbi
- G Kennedy
- G Wu
- G Xu
- GJ Prud'homme
- GR Warnes
- H Ikushima
- HJ Lee
- II Nagy
- IM van de Laar
- IS Moreira
- IW Taylor
- J Dzwonek
- J Gupta
- J He
- J Massague
- J Massague
- J Massague
- J Rosenbloom
- J Seoane
- J Webber
- J Webber
- J Xu
- JE Lai-Cheong
- JE Lai-Cheong
- JE Lai-Cheong
- JF Rual
- JM Hernandez-Hernandez
- JW Wu
- JW Wu
- JW Wu
- K Eppert
- K Verschueren
- KA Brown
- Kenneth A. Satyshur
- L Izzi
- L Vardouli
- L Xu
- L Xu
- L Zheng
- M Barrios-Rodiles
- M Furuhashi
- M Kioulafa
- M Kondo
- M Mizuide
- M Shiroishi
- M Tyagi
- M Weinstein
- MB Sporn
- Michael A. Newton
- Michelle M. Schiro
- N Nakaya
- NJ Burgoyne
- NL Malinin
- Norman R. Drinkwater
- O Keskin
- P Bernasconi
- P ten Dijke
- P Uetz
- PA Chong
- PL Zeeuwen
- Q Cui
- R Chen
- R Derynck
- R Janknecht
- RA Randall
- RD Cohn
- RM Simpson
- S Birtalan
- S Dennler
- S Germain
- Sara E. Stauber
- SK Lim
- SM Pulukuri
- Steven J. Darnell
- SZ Zhang
- T Clackson
- T Tsukazaki
- Tami L. Peterson
- W Chen
- WC Chou
- X Lin
- Y Kang
- Y Kang
- Y Shi
- Y Shi
- Y Shi
- Y Zhang
- YG Chen
- Publication venue
- Public Library of Science
- Publication date
- 19/09/2011
- Field of study
Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-ÎČ), serves as a hub protein for over 50 protein-protein interactions. Different cellular responses mediated by Smad3 are the product of cell-type and context dependent Smad3-nucleated protein complexes acting in concert. Our hypothesis is that perturbation of this spectrum of protein complexes by mutation of single protein-binding hot-spots on Smad3 will have distinct consequences on Smad3-mediated responses.We mutated 28 amino acids on the surface of the Smad3 MH2 domain and identified 22 Smad3 variants with reduced binding to subsets of 17 Smad3-binding proteins including Smad4, SARA, Ski, Smurf2 and SIP1. Mutations defective in binding to Smad4, e.g., D408H, or defective in nucleocytoplasmic shuttling, e.g., W406A, were compromised in modulating the expression levels of a Smad3-dependent reporter gene or six endogenous Smad3-responsive genes: Mmp9, IL11, Tnfaip6, Fermt1, Olfm2 and Wnt11. However, the Smad3 mutants Y226A, Y297A, W326A, K341A, and E267A had distinct differences on TGF-ÎČ signaling. For example, K341A and Y226A both reduced the Smad3-mediated activation of the reporter gene by âŒ50% but K341A only reduced the TGF-ÎČ inducibilty of Olfm2 in contrast to Y226A which reduced the TGF-ÎČ inducibility of all six endogenous genes as severely as the W406A mutation. E267A had increased protein binding but reduced TGF-ÎČ inducibility because it caused higher basal levels of expression. Y297A had increased TGF-ÎČ inducibility because it caused lower Smad3-induced basal levels of gene expression.Mutations in protein binding hot-spots on Smad3 reduced the binding to different subsets of interacting proteins and caused a range of quantitative changes in the expression of genes induced by Smad3. This approach should be useful for unraveling which Smad3 protein complexes are critical for specific biological responses
Structural Characterization of Minor Ampullate Spidroin Domains and Their Distinct Roles in Fibroin Solubility and Fiber Formation
- Author
- A Bhattacharya
- A Rising
- A Rising
- AC Zhao
- AP Pawar
- B Xue
- C La Mattina
- C Zwahlen
- Chong Cheong Lai
- CY Hayashi
- D Bittencourt
- Daiwen Yang
- DH Hijirida
- DW Yang
- F Hagn
- F Teule
- FG Omenetto
- G Askarieh
- IW Davis
- JE Garb
- Jing-song Fan
- K Beena
- K Spiess
- M Hedhammar
- M Heim
- M Stark
- MA Colgin
- MA Roseman
- Markus J. Buehler
- MJ Greenwood
- MZ Tian
- RA Laskowski
- RJ Challis
- RV Lewis
- S Wang
- SA Yang
- T Herrmann
- W Huang
- Weidong Huang
- YQ Xu
- YQ Xu
- Z Lin
- Zhenwei Gao
- Zhi Lin
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2012
- Field of study
10.1371/journal.pone.0056142PLoS ONE82
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
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- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
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- Anjos N
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- Anulli F
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâ„20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60â€pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â€{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Abbott B
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- Abdesselam A
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- Tipton P
- Tisserant S
- Tobias J
- Toczek B
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- Tojo J
- Tokar S
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- Tokushuku K
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- Tomoto M
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- Tonazzo A
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- Tonoyan A
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- Topilin ND
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- Torregrosa EF
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- Tseng JC-L
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- Tsukerman II
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- Tuggle JM
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- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Typaldos D
- Tyrvainen H
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- Ueno R
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- Underwood DG
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- Valenta J
- Valente P
- Valentinetti S
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- van der Graaf H
- van der Kraaij E
- van der Poel E
- van der Ster D
- Van Eijk B
- van Eldik N
- van Gemmeren P
- van Kesteren Z
- van Vulpen I
- Vandelli W
- Vandoni G
- Vaniachine A
- Vankov P
- Vannucci F
- Vari R
- Varnes EW
- Varouchas D
- Vartapetian A
- Varvell KE
- Vassilakopoulos VI
- Vazeille F
- Vegni G
- Veillet JJ
- Vellidis C
- Veloso F
- Veness R
- Veneziano S
- Ventura A
- Ventura D
- Ventura S
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vertogardov L
- Vest A
- Vetterli MC
- Vichou I
- Vickey T
- Viegas FJTA
- Viehhauser GHA
- Viel S
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
- Virchaux M
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- Virzi J
- Vitale A
- Vitells O
- Vivarelli I
- Vives Vaque F
- Vlachos S
- Vlasak M
- Vlasov N
- Vogel A
- Vokac P
- Volpi M
- Volpini G
- von der Schmitt H
- von Loeben J
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobiev AP
- Vorwerk V
- Vos M
- Voss R
- Voss TT
- Vossebeld JH
- Vovenko AS
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wahlen H
- Wakabayashi J
- Walbersloh J
- Walch S
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Wang C
- Wang H
- Wang J
- Wang JC
- Wang SM
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- Warsinsky M
- Watkins PM
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- Watson MF
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- Watts S
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- Waugh BM
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- Weber MS
- Weber P
- Weidberg AR
- Weingarten J
- Weiser C
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- Wenaus T
- Wendler S
- Weng Z
- Wengler T
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Whalen K
- Wheeler-Ellis SJ
- Whitaker SP
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik LAM
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wolter MW
- Wolters H
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wraight K
- Wright C
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wunstorf R
- Wynne BM
- Xaplanteris L
- Xella S
- Xie S
- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang S
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao W-M
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema PF
- Zemla A
- Zendler C
- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Cutaneous tuberculosis: epidemiologic, etiopathogenic and clinical aspects - Part I
- Author
- Abebe F
- Almagro M
- Almaguer-ChĂĄvez J
- Ana Roberta Figueiredo
- Barbagallo J
- Baron JM
- Behar SM
- Bellet JS
- Bravo FG
- ClĂĄudia Elise Ferraz
- Daikos GL
- Forrellad MA
- Fortaleza GTM
- Frankel A
- Freiman A
- Fukamachi S
- Gaikwad AN
- Gilchrist H
- Gooptu C
- Gruber PC
- Handog EB
- Hu Y
- Inoue T
- Jacobsen G
- Josemir Belo dos Santos
- Kim GW
- Lai-Cheong JE
- MacGregor RR
- Marcela Concha R
- MascarĂł JM Jr
- Motta A
- MĂĄrcia Helena de Oliveira
- Park YM
- Perla Gomes da Silva
- Puri N
- Raja A
- Ramesh V
- Rossetti ML
- Saritha M
- Sehgal VN
- Sehgal VN
- Smith I
- Tappeiner G
- Vanessa LucĂlia Silveira de Medeiros
- Vashisht P
- Wong HW
- Wong S
- Yates VM
- Zawirska A
- Zuñiga J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Olmsted syndrome: clinical, molecular and therapeutic aspects
- Author
- A Georgii
- A Haghighi
- A Kariminejad
- A Nofal
- AC Inamadar
- Alain Hovnanian
- AM Attia
- AP Armstrong
- B Mevorah
- B Nilius
- B Nilius
- CA Raskin
- CS Sirka
- D Danso-Abeam
- D Dogra
- DJ Atherton
- DW Kress
- E Fonseca
- F Ogawa
- FN Bergonse
- G Ferone
- GK Tharini
- GP Lucker
- H Megarbane
- H Xu
- H Ziaaddini
- HC Olmsted
- HJ Wang
- HO Perry
- I Hausser
- J Dessureault
- J Frias-Iniesta
- J Tao
- JE Lai-Cheong
- JH Barnett
- JK Rivers
- L Requena
- L Tang
- M Harms
- M Keir
- M Larregue
- M Ueda
- ME Ali
- MR Judge
- MS Bedard
- N Al-Mutairi
- O Costa
- O Eytan
- OL Santos
- P Batra
- P Koch
- P Kumar
- R Elise Tonoli
- R Michalowski
- R Ruiz-Maldonado
- R Yaghoobi
- S Cambiaghi
- S Duchatelet
- S Duchatelet
- Sabine Duchatelet
- SM Huang
- T Yamamoto
- V Vosynioti
- X Cheng
- Y He
- Y Poulin
- Y Yoshizaki
- Z Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cutaneous mosaicisms: concepts, patterns and classifications
- Author
- Almeida AS
- Devillers C
- Froes GC
- Goldberg I
- Grzeschik KH
- Hamm H
- Happle R
- Happle R
- Happle R
- Happle R
- Happle R
- Happle R
- Izelda Maria Carvalho Costa
- Kiritsi D
- Lai-Cheong JE
- Lipsker D
- LlanoRivasa I
- Marcela Sena Teixeira Mendes
- Molho-Pessach V
- Paller AS
- Pasmooij AM
- Pereira MAC
- Samara Silva Kouzak
- Siegel DH
- Siegel DH
- Souza e Souza I
- Torrelo A
- Urbano LMF
- Wang X
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Study of the skin anatomy with high-frequency (22 MHz) ultrasonography and histological correlation
- Author
- Alves MPT
- Antonio Carlos Pires Carvalho
- Araujo JĂșnior E
- Arend CF
- Arend CF
- Calixto AC
- Campos AG
- Carlos Baptista Barcaui
- Eifler RV
- Elder DE
- Elisa de Oliveira Barcaui
- Fernandes DA
- Gniadecka M
- Heleno Moraes
- Juan Piñeiro-Maceira
- Kleinerman R
- Lai-Cheong JE
- Martins FP
- Resende DAQP
- Sakuno T
- SimĂŁo MN
- Solha RS
- Souza LRMF
- Terazaki CRT
- Venus M
- Wortsman X
- Wortsman X
- Wortsman X
- Wortsman X
- Wortsman X
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Targeting Huntingtonâs disease through histone deacetylases
- Author
- A Bithell
- A Brunet
- A Carnemolla
- A Edwards
- A Kazantsev
- A Khoshnan
- A Khoshnan
- A Kuzmichev
- A Liu
- A Roopra
- A Wyce
- A Yanai
- A You
- AD Hollenbach
- AJ Paquette
- AK Mankan
- AL Boutillier
- AN Packer
- B Chen
- B Lakowski
- B Li
- B Schilling
- BP Ashburner
- BS Mann
- BS Mann
- BT Scroggins
- C Boyault
- C Boyault
- C Conaco
- C Hubbert
- C Pelegri
- C Saft
- C Schwab
- C Xu
- C Zibetti
- C Zuccato
- CA Johnson
- CA Lyssiotis
- CD Allis
- CD Bown
- CJ Maynard
- CL Benn
- CT Aiken
- D Ron
- D Schaft
- D Zadori
- D Zala
- DJ Greenway
- DN Hebert
- DS Bachman
- DT Rutkowski
- E Battaglioli
- E Colin
- E Fossale
- E Hockly
- E Kontopoulos
- E Lai
- E Roze
- E Taherzadeh-Fard
- E Trushina
- EA Bates
- EA Thomas
- EC Stack
- EJ Bennett
- EN Ebbel
- F Ajamian
- F Bardag-Gorce
- F Borovecki
- F Dangond
- F Saudou
- F Yeung
- FC Nucifora Jr
- FO Walker
- G Bonapace
- G Donati
- G Gardian
- G Hoffner
- G Sadri-Vakili
- G Sun
- G Thiel
- GH Yam
- GH Yam
- GJ Yohrling
- GM Doody
- GR Symington
- Group THsDCR
- GW Humphrey
- H Daub
- H Hayashi
- H Jeong
- H Jiang
- H Jiang
- H Li
- H Liu
- H Rangone
- H Ryu
- H Ryu
- H Watanabe
- H Yang
- HI Sarkander
- HL Pahl
- HV Che
- HY Kuo
- I Bach
- I Pearce
- IA Klement
- IC Weaver
- IS Seong
- IT Yu
- J Cui
- J Lee
- J Park
- J Tapia-Ramirez
- J Wang
- J Wang
- J Wu
- J Yu
- J Zhang
- JA Burrows
- JA Grimes
- JE Hoberg
- JE Hoberg
- JF Wang
- JF Wang
- JF Wang
- JJ Abrajano
- JJ Abrajano
- JJ Kovacs
- JK Wiencke
- JL MacDonald
- JM Boutell
- JP Dompierre
- JS Lee
- JS Steffan
- JS Steffan
- JS Steffan
- JW Edmunds
- JY Noh
- K Esposito
- K Kubota
- K Moser
- K Saijo
- K Sharma
- KA Seth
- KA Sieradzan
- KB Hymes
- KB Kegel
- L Cui
- L Shao
- L Shao
- L Wu
- LM Brill
- LM Thompson
- LR Choo-Kang
- M Albert
- M Calao
- M DiFiglia
- M Dokmanovic
- M Hoshino
- M Lim
- M Perez
- M Vilatoba
- MA Curtis
- MC Keogh
- ME Andres
- ME Caruso
- ME Gerritsen
- ML Mulhern
- MM Esiri
- MO Kim
- MT Lorincz
- MW Lawless
- MW Lawless
- MW Lawless
- N Ballas
- N Cheong
- N Dephoure
- N Khan
- N Ohoka
- N Sirianni
- N Vij
- N Watanabe
- ND Belyaev
- ND Perkins
- NJ Krogan
- OV Singh
- P Bali
- P Baumeister
- P Dandona
- P Dandona
- P Gaub
- P Hogarth
- P Hublitz
- P Matthias
- P Weydt
- P Weydt
- PJ Muchowski
- PL Zeitlin
- Q Jiang
- Q Xia
- R Cao
- R Datta
- R Johnson
- R Pardo
- R Vidal
- R Wadgaonkar
- RC Rubenstein
- RC Rubenstein
- RC Rubenstein
- RC Rubenstein
- RE Hughes
- RJ Ferrante
- RJ Sims 3rd
- RK Chaturvedi
- RL Montgomery
- RS Atwal
- RS Atwal
- RV Rao
- S Bahn
- S Camelo
- S Carra
- S Carra
- S Carra
- S Carra
- S Hanada
- S Humbert
- S Kwon
- S Kyrylenko
- S Luo
- S Reijonen
- S Subramaniam
- S Waelter
- SA Morris
- SC Warby
- SF Almeida de
- SG Gray
- SI Grivennikov
- SL Anne
- SS Vembar
- ST Hou
- ST Lee
- ST Lee
- SY Cong
- T Prozorovski
- T Suzuki
- T Xiao
- TA Rapoport
- TK Said
- TW Corson
- U Ozcan
- UB Pandey
- V Balasubramaniyan
- V Menendez-Benito
- VE Grove Jr
- W Fiskus
- W Renthal
- W Vanden Berghe
- W Yuan
- X Gu
- X Kong
- X Qi
- X Su
- X Yao
- XJ Sun
- XL Liu
- Y Cherasse
- Y He
- Y Horio
- Y Huang
- Y Kawaguchi
- Y Konishi
- Y Naruse
- Y Wang
- YM Sun
- YS Gao
- Z Salazar
- ZF Chen
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Huntingtonâs disease (HD) is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite extensive research, treatment options for patients with this condition remain limited. Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD. These PTMs include acetylation, phosphorylation, methylation, sumoylation and ubiquitination. Several families of proteins are involved with the regulation of these PTMs. In this review, I discuss the current evidence linking aberrant PTMs and/or aberrant regulation of the cellular machinery regulating these PTMs to HD pathogenesis. Finally, I discuss the evidence suggesting that pharmacologically targeting one of these protein families the histone deacetylases may be of potential therapeutic benefit in the treatment of HD
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