Ideología, economía y matemáticas: la hipótesis de racionalidad

The object of this work is to bring into light the contradictions that appear if one admits, without previous criticism, the concept of rationality. This is a polysemous concept that has to be analyzed and discussed in each human and social context, either individual or social. In the introduction we first analyze the concepts of truth and coherence, and subsequently we turn to analyze ideas that are opposite to rationalism like dogmatism and fundamentalism. Then we relate rationality to mathematical knowledge, to information theory, to decision theory and finally to economy.Con este trabajo se pretende poner de manifiesto las contradicciones que surgen al admitir, sin criticar, el concepto de racionalidad. Es un concepto polisémico que hay que analizar y discutir en cada contexto científico y humano, bien individual o bien social. En la introducción se analizan los conceptos de verdad y coherencia, para posteriormente analizar ideas opuestas a la racionalidad, como son el dogmatismo y el fundamentalismo. A continuación se relaciona el concepto que nos ocupa con el conocimiento matemático, con la teoría de la Información, de la Decisión y, por último, con la Economía

Análisis de la opinión de los alumnos de la Diplomatura de CCs. Empresariales de la E.U. de Estudios Empresariales de Oviedo acerca de los Planes de Estudios de 1973, 1992 y 1999

En este trabajo trataremos de analizar la opinión que los alumnos de la Escuela Universitaria de Estudios Empresariales de Oviedo, tienen acerca del desarrollo de las actividades docentes en la misma. En concreto, compararemos la opinión de los alumnos que se diplomaron en Ciencias Empresariales según el plan de estudios de 1973, la de aquellos que lo hicieron de acuerdo con el plan de estudios de 1992 o con el Plan de Estudios de 1999. Centraremos nuestra atención en la opinión que los alumnos manifiestan sobre las asignaturas de carácter obligatorio impartidas por los profesores del departamento de Economía Cuantitativa de la Universidad de Oviedo

Ideología y matemáticas: el cero, la nada y el conjunto vacío

Con estas reflexiones se pretende poner de manifiesto las dificultades de diferente ámbito que existen en conceptos, habituales y aparentemente sencillos, en los que no solemos pararnos a pensar sobre ellos. La aceptación de estas tres ideas está impregnada de una gran carga ideológica, en su sentido más amplio de la palabra, desde sus aspectos religiosos a los filosóficos pasando por la concepción de la Física

El precio de la vivienda en Asturias. Una modelización econometrica

Variables económicas, demográficas y urbanísticas son algunos de los factores que, con distinta ponderación, explican el comportamiento de la demanda de vivienda. Dicho aspecto ha sido, hasta el momento, objeto de un tratamiento teórico, en cierta forma, residual a pesar de la influencia que el sector de la vivienda ejerce sobre las principales macromagnitudes económicas. Nuestro estudio se centrará en la modelización econométrica de los factores que explican el comportamiento de la función de demanda de vivienda en el Principado de Asturias para el periodo 1980-1997. Su conocimiento resulta imprescindible, entre otros aspectos, en la adopción de medidas de política económica

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal chemistry programs. The data for all of these assays are presented and analyzed to show how outstanding leads for many indications can be selected. These results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications. Another lesson is that when multiple screens from different groups are run on the same library, results can be integrated quickly to select the most valuable starting points for subsequent medicinal chemistry efforts

On Cartan matrices with two parameters (Cohomology theory of finite groups and related topics)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. This paper reports for the first time on 236 screens that have been carried out against the Malaria Box and compares these results with 55 assays that were previously published, in a format that allows a meta-analysis of the combined dataset. The combined biochemical and cellular assays presented here suggest mechanisms of action for 135 (34%) of the compounds active in killing multiple life-cycle stages of the malaria parasite, including asexual blood, liver, gametocyte, gametes and insect ookinete stages. In addition, many compounds demonstrated activity against other pathogens, showing hits in assays with 16 protozoa, 7 helminths, 9 bacterial and mycobacterial species, the dengue fever mosquito vector, and the NCI60 human cancer cell line panel of 60 human tumor cell lines. Toxicological, pharmacokinetic and metabolic properties were collected on all the compounds, assisting in the selection of the most promising candidates for murine proof-of-concept experiments and medicinal chemistry programs. The data for all of these assays are presented and analyzed to show how outstanding leads for many indications can be selected. These results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications. Another lesson is that when multiple screens from different groups are run on the same library, results can be integrated quickly to select the most valuable starting points for subsequent medicinal chemistry efforts

Antiprotozoal Malaria Box compounds with activity in biological assays and lacking toxicity at therapeutic levels.

<p>Selectivity Index, SI, is toxicity level/activity level; p, probe-like; d, drug-like.</p

Malaria Box Heatmap.

<p>Shown are selected data from the HeatMap (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005763#ppat.1005763.s002" target="_blank">S1 Table</a>) for the 400 Malaria Box compounds. Each column represents an assay (grouped by category), compounds are represented in rows. The red-green gradient represents higher to lower activity. Favorable PK activities are scored green. <i>Pf</i>: <i>Plasmodium falciparum</i>, <i>Pb</i>: <i>Plasmodium berghei</i>, PK: pharmacokinetics, sol.: solubility, hERG: human ether-a-go-go channel inhibition, DDI: drug-drug interactions (predicted).</p