13 research outputs found
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats
Implication de la protĂ©ine Sirt1 dans la stimulation de l'apoptose des cellules bĂȘta pancrĂ©atiques par la voie des hexosamines
L'apoptose des cellules bĂȘta pancrĂ©atiques est une cause du diabĂšte de type 2. La glycosylation par la voie des hexosamines modifie l'activitĂ© de protĂ©ines rĂ©gulatrices. La dĂ©acĂ©tylase Sirt1 est connue pour son rĂŽle dans la survie cellulaire et pour sa sensibilitĂ© face au mĂ©tabolisme glucidique. Cette Ă©tude visait Ă montrer que l'activation directe de la voie des hexosamines stimule la mort de ces cellules par l'implication de Sirt-1. Le traitement des cellules Nit-1 avec la glucosamine a causĂ© une augmentation temporelle significative de l'apoptose, jumelĂ©e Ă l'expression de facteurs pro-apoptotiques, la rĂ©duction des niveaux protĂ©iques de Sirt-1 ainsi que sa glycosylation. De plus, l'atttĂ©nuation gĂ©nĂ©tique de Sirt1 a accentuĂ© la vulnĂ©rabilitĂ© des cellules Ă l'apoptose. Ces rĂ©sultats montrent pour la premiĂšre fois que Sirt1 joue un rĂŽle important dans la survie de la cellule bĂȘta et que sa glycosylation serait impliquĂ©e dans la perturbation de son rĂŽle protecteur
Health literacy and use of healthcare services among community-dwelling older adults living with chronic conditions
Objective: Only 12% of the Canadian older adults have adequate health literacy (HL) to understand and handle health information sufficiently. A descriptive correlation study was conducted to describe HL and to examine its relationship with healthcare services use among community-dwelling older adults living with chronic conditions in a distant region of Quebec, Canada.
Methods: Data was collected through self-report instruments including the Health Literacy Questionnaire (HLQ), which assesses HL on nine dimensions.
Results: Based on health characteristics of the nine HLQ dimensions, the results showed significant differences between subgroups of participants as well as a negative association between the HLQ dimension Appraisal of Health Information and the number of consultations with healthcare professionals (incidence rate ratio: 0.66; p = .027).
Conclusions: The results highlight the need to improve older adults HL, in order to improve their health status and use of healthcare services