An intercomparison of measured pressure-broadening, pressure shifting parameters of carbon dioxide and their temperature dependence

International audienceAn intercomparison of measured pressure-broadening and pressure-shifting coefficients for carbon dioxide absorption lines was done. The work focuses on collision systems where a significant number of data can be found (CO2-N2, CO2-O2, CO2-air, and CO2-CO2) and yield information important to applications related to Earth's atmosphere. The literature was searched for measured line shape parameter data for the collision systems mentioned above. Databases were created for each perturbing gas with the ro-vibrational transition as the key. Using these databases intercomparisons of the measurements of half-widths, their temperature dependence, and line shifts were made. The data allow the investigations of trends in the data with respect to the vibrational and the rotational quantum numbers, various line shape models, and isotopologue effects

Roles of regional hydrodynamic and trophic contamination in cadmium bioaccumulation by Pacific oysters in the Marennes-Oléron Bay (France)

International audienceThe Marennes-Oléron Bay, hosting the largest oyster production in France, is influenced by the historic polymetallic pollution of the Gironde Estuary. Despite management efforts and decreasing emissions in the Gironde watershed, cadmium levels in oysters from the bay are close to the consumption limit (5 lg g À1 dw, EC). From mid April to mid July 2009, we investigated the role of tidal resuspension and regional hydrodynamics on Cd speciation (seawater, SPM, phytoplankton, sediment, microphytobenthos) and bioaccumulation in 18 month-old oysters (gills, digestive glands, rests of tissues) reared under natural conditions (i) at $60 cm above the sediment and (ii) on the sediment surface. Dissolved and particulate Cd concentrations in surface and bottom waters were similar and constant over tidal cycle suggesting the absence of Cd release during sediment resuspension. Temporal dissolved and particulate Cd concentrations were closely related to Gironde Estuary water discharges, showing increasing concentrations during flood situations and decreasing concentrations afterwards. Cd depletion in the water column was associated with increasing Cd in the [20-100 lm] plankton fraction, suggesting Cd bioaccumulation. After 3 months, enrichment factors of Cd in tissues of oysters exposed in the water column and directly on the sediment were respectively 3.0 and 2.2 in gills, 4.7 and 3.2 in digestive glands and 4.9 and 3.4 in remaining tissues. Increasing Cd bioaccumulation in gills, digestive glands and remaining tissues can be related to elevated dissolved Cd in the bay, suggesting gill contamination via the direct pathway and subsequent internal redistribution of Cd to other organs and tissues. Elevated Cd contents in oysters reared on tables could be attributed to different trophic Cd transfer (phytoplankton versus micro-phytobenthos) or to different oyster metabolisms between the rearing conditions as suggested by metal-lothionein concentrations

Cobi: A Community-Informed Conference Scheduling Tool

Effectively planning a large multi-track conference requires an understanding of the preferences and constraints of organizers, authors, and attendees. Traditionally, the onus of scheduling the program falls on a few dedicated organizers. Resolving conflicts becomes difficult due to the size and complexity of the schedule and the lack of insight into community members ’ needs and desires. Cobi presents an alternative approach to conference scheduling that engages the entire community in the planning process. Cobi comprises (a) communitysourcing applications that collect preferences, constraints, and affinity data from community members, and (b) a visual scheduling interface that combines communitysourced data and constraint-solving to enable organizers to make informed improvements to the schedule. This paper describes Cobi’s scheduling tool and reports on a live deployment for planning CHI 2013, where organizers considered input from 645 authors and resolved 168 scheduling conflicts. Results show the value of integrating community input with an intelligent user interface to solve complex planning tasks. Author Keywords Cobi; conference scheduling; mixed-initiative; constrain

Single-mode Fiber and Few-Mode Fiber Photonic Lanterns Performance Evaluated for Use in a Scalable Real-Time Photon Counting Ground Receiver

Photonic lanterns provide an efficient way of coupling light from a single large-core fiber to multiple small-core fibers. This capability is of interest for space to ground communication applications. In these applications, the optical ground receivers require high-efficiency coupling from an atmospherically distorted focus spot to multiple fiber coupled single pixel super-conducting nanowire detectors. This paper will explore the use of photonic lanterns in a real-time ground receiver that is scalable and constructed with commercial parts. The number of small-core fibers that make a photonic lantern determines the number of spatial modes that they couple. For instance, lanterns made with n number of single-mode fibers can couple n number of spatial modes. Although the laser transmitted from a spacecraft originates as a Gaussian shape, the atmosphere distorts the beam profile by scattering energy into higher-order spatial modes. Therefore, if a ground receiver is sized for a target data rate with n number of detectors, the corresponding lantern made with single-mode fibers will couple n number of spatial modes. The energy of the transmitted beam scattered into spatial modes higher than n will be lost. This paper shows this loss may be reduced by making lanterns with few-mode fibers instead of single-mode fibers, increasing the number of spatial modes that can be coupled and therefore increasing the coupling efficiency to single pixel, single photon detectors. The free space to fiber coupling efficiency of these two types of photonic lanterns are compared over a range of the free-space coupling numerical apertures and mode field diameters. Results indicate the few mode fiber lantern has higher coupling efficiency for telescopes with longer focal lengths under higher turbulent conditions. Also presented is analysis of the jitter added to the system by the lanterns, showing the few-mode fiber photonic lantern adds more jitter than the single-mode fiber lantern, but less than a multimode fiber

A low density of 0.8 g/cc for the Trojan binary asteroid 617 Patroclus

The Trojan population consists of two swarms of asteroids following the same orbit as Jupiter and located at the L4 and L5 Lagrange points of the Jupiter-Sun system (leading and following Jupiter by 60 degrees). The asteroid 617 Patroclus is the only known binary Trojan (Merline et al. 2001). The orbit of this double system was hitherto unknown. Here we report that the components, separated by 680 km, move around the system centre of mass, describing roughly a circular orbit. Using the orbital parameters, combined with thermal measurements to estimate the size of the components, we derive a very low density of 0.8 g/cc. The components of Patroclus are therefore very porous or composed mostly of water ice, suggesting that they could have been formed in the outer part of the solar system.Comment: 10 pages, 3 figures, 1 tabl

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.

Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation

Understanding the nature of atmospheric acid processing of mineral dusts in supplying bioavailable phosphorus to the oceans

Acidification of airborne dust particles can dramatically increase the amount of bioavailable phosphorus (P) deposited on the surface ocean. Experiments were conducted to simulate atmospheric processes and determine the dissolution behaviour of phosphorus compounds in dust and dust precursors oils. Acid dissolution occurs rapidly (seconds to minutes) and is controlled by the amount of H + ions present. For H + 10-4 mol per gram of dust, the amount of phosphorus (and Ca) released follows a power law dependent on the amount of H + consumed until all inorganic phosphorus minerals are exhausted and the final pH remains acidic. Once dissolved, phosphorus will stay in solution due to slow precipitation kinetics. Dissolution of apatite-P, the major mineral phase in dust (79-96%), occurs whether CaCO 3 is present or not, though the increase in dissolved phosphorus is greater if CaCO 3 is absent or if the particles are externally mixed. The system was modelled adequately as a simple mixture of apatite-P and calcite. Phosphorus dissolves readily by acid processes in the atmosphere in contrast to iron, which dissolves slower and is subject to re-precipitation at cloud water pH. We show that acidification can increase bioavailable phosphorus deposition over large areas of the globe, and may explain much of the previously observed patterns of variability in leachable phosphorus in oceanic areas where primary productivity is limited by this nutrient (e.g. Mediterranean)

In-vivo Imaging of Magnetic Fields Induced by Transcranial Direct Current Stimulation (tDCS) in Human Brain using MRI

Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation technique that applies mA currents at the scalp to modulate cortical excitability. Here, we present a novel magnetic resonance imaging (MRI) technique, which detects magnetic fields induced by tDCS currents. This technique is based on Ampere’s law and exploits the linear relationship between direct current and induced magnetic fields. Following validation on a phantom with a known path of electric current and induced magnetic field, the proposed MRI technique was applied to a human limb (to demonstrate invivo feasibility using simple biological tissue) and human heads (to demonstrate feasibility in standard tDCS applications). The results show that the proposed technique detects tDCS induced magnetic fields as small as a nanotesla at millimeter spatial resolution. Through measurements of magnetic fields linearly proportional to the applied tDCS current, our approach opens a new avenue for direct in-vivo visualization of tDCS target engagement

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015

Establishing the baseline level of repetitive element expression in the human cortex

Background: Although nearly half of the human genome is comprised of repetitive sequences, the expression profile of these elements remains largely uncharacterized. Recently developed high throughput sequencing technologies provide us with a powerful new set of tools to study repeat elements. Hence, we performed whole transcriptome sequencing to investigate the expression of repetitive elements in human frontal cortex using postmortem tissue obtained from the Stanley Medical Research Institute. Results: We found a significant amount of reads from the human frontal cortex originate from repeat elements. We also noticed that Alu elements were expressed at levels higher than expected by random or background transcription. In contrast, L1 elements were expressed at lower than expected amounts. Conclusions: Repetitive elements are expressed abundantly in the human brain. This expression pattern appears to be element specific and can not be explained by random or background transcription. These results demonstrate that our knowledge about repetitive elements is far from complete. Further characterization is required to determine the mechanism, the control, and the effects of repeat element expression