Deep and Shallow-Water Mollusks from the Central Pacific

Recent shelled mollusks were trawled from deep water on four guyots in the Mid-Pacific Mountains and were dredged from shallow waters on Nero Bank and the lee shelf of Kure Island in Hawaii. Seven species of mollusks, six of which are new, have been identified from the deep waters on the guyots : two are trochids, Calliotropis hataii n. sp., and C. abyssicola n. sp., three are turrids, Comitas powelli n. sp., Pleurotomella dubia Schepman and P. allisoni n. sp., one is a bullid, Bulla argoblysis n. sp., and one a scaphopod, Dentalium mediopacificensis n. sp. Five of the seven species are identical or closely related to Indo-Pacific forms, one belongs to a small but cosmopolitan group, one is related to a species living near the Galapagos Islands in the eastern Pacific. Nine species of mollusks are identified from Nero Bank and 41 from Kure\u27s shelf, one being new. A total of 101 species are listed as occurring on these two sites and the Kure beaches and lagoon. More than one-third of the total listed appear to be endemic to Hawaii

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Letter to H.B. Stenzel from Harry S. Ladd on 1945-08-03

Jackson School of Geoscience

Letter to Henry B. Stenzel from Harry S. Ladd on 1943-04-26

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1950-12-07

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1950-03-22

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1944-05-11

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1954-03-30

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1948-08-16

Jackson School of Geoscience

Letter to H.B. Stenzel from Harry S. Ladd on 1951-11-16

Jackson School of Geoscience