115 research outputs found
Deuteron Electroweak Disintegration
We study the deuteron electrodisintegration with inclusion of the neutral
currents focusing on the helicity asymmetry of the exclusive cross section in
coplanar geometry. We stress that a measurement of this asymmetry in the quasi
elastic region is of interest for an experimental determination of the weak
form factors of the nucleon, allowing one to obtain the parity violating
electron neutron asymmetry. Numerically, we consider the reaction at low
momentum transfer and discuss the sensitivity of the helicity asymmetry to the
strangeness radius and magnetic moment. The problems coming from the finite
angular acceptance of the spectrometers are also considered.Comment: 30 pages, Latex, 7 eps figures, submitted to Phys.Rev.C e-mail:
[email protected] , [email protected]
Nuclear medium modification of the F2 structure function
We study the nuclear effects in the electromagnetic structure function
F2(x,Q^2) in nuclei in the deep inelastic lepton nucleus scattering process by
taking into account Fermi motion, binding, pion and rho meson cloud
contributions. Calculations have been done in a local density approximation
using relativistic nuclear spectral functions which include nucleon
correlations for nuclear matter. The ratios over deuteron structure function
are obtained and compared with the recent JLAB results for light nuclei with
special attention to the slope of the x distributions. This magnitude shows a
non trivial A dependence and it is insensitive to possible normalization
uncertainties. The results have also been compared with some of the older
experiments using intermediate mass nuclei.Comment: 19 pages, 8 figures. This version matches accepted version to be
published in Nuclear Physics
Relativistic Structure of the Deuteron: 1.Electro-disintegration and y-scaling
Realistic solutions of the spinor-spinor Bethe-Salpeter equation for the
deuteron with realistic interaction kernel including the exchange of pi, sigma,
omega, rho, eta and delta mesons, are used to systematically investigate
relativistic effects in inclusive quasi-elastic electron-deuteron scattering
within the relativistic impulse approximation. Relativistic y-scaling is
considered by generalising the non relativistic scaling function to the
relativistic case, and it is shown that y-scaling does occur in the usual
relativistic scaling variable resulting from the energy conservation in the
instant form of dynamics. The present approach of y-scaling is fully covariant,
with the deuteron being described by eight components, viz. the 3S_1^{++},
3S_1^{--}, 3D_1^{++}, 3D_1^{--}, 3P_1^{+-}, 3P_1^{-+}, 1P_1^{+-}, 1P_1^{-+}
waves. It is demonstrated that if the negative relative energy states 1P_1,
3P_1 are disregarded, the concept of covariant momentum distributions N(p_0,p),
with p_0=M_D/2-\sqrt{p^2+m^2}, can be introduced, and that calculations of
lectro-disintegration cross section in terms of these distributions agree
within few percents with the exact calculations which include the 1P_1, 3P_1
states, provided the nucleon three momentum |p|\<= 1 GeV/c; in this momentum
range, the asymptotic relativistic scaling function is shown to coincide with
the longitudinal covariant momentum distribution.Comment: 32 LaTeX pages, 18 eps-figures. Final version to appear in Phys. Rev.
Reaction and Axial Vector Coupling
The reaction is studied in the region of low
to investigate the effect of deuteron structure and width of the
resonance on the differential cross section. The results are used to extract
the axial vector coupling from the experimental data on
this reaction. The possibility to determine this coupling from electroweak
interaction experiments with high intensity electron accelerators is discussed.Comment: 14 pages, REVTEX, 5 figure
European Organization for Research and Treatment of Cancer (EORTC) open label phase II study on glufosfamide administered as a 60-minute infusion every 3 weeks in recurrent glioblastoma multiforme
BACKGROUND: Glufosfamide is a new alkylating agent in which the active
metabolite of isophosphoramide mustard is covalently linked to
beta-D-glucose to target the glucose transporter system and increase
intracellular uptake in tumor cells. We investigated this drug in a
multicenter prospective phase II trial in recurrent glioblastoma
multiforme (GBM). PATIENTS AND METHODS: Eligible patients had recurrent
GBM following surgery, radiotherapy and no more than one prior line of
chemotherapy. Patients were treated with glufosfamide 5000 mg/m(2)
administered as a 1-h intravenous infusion. Treatment success was defined
as patients with either an objective response according to Macdonald's
criteria or 6 months progression-free survival. Toxicity was assessed with
the Common Toxicity Criteria (CTC) version 2.0. RESULTS: Thirty-one
eligible patients were included. Toxicity was modest, the main clinically
relevant toxicities being leukopenia (CTC grade >3 in five patients) and
hepatotoxicity (in three patients). No responses were observed; one
patient (3%; 95% confidence interval 0 to 17%) was free from progression
at 6 months. Pharmacokinetic analysis showed a 15% decrease in area under
the curve and glufosfamide clearance in patients treated with
enzyme-inducing antiepileptic drugs, but no effect of these drugs on
maximum concentration and plasma half-life. CONCLUSION: Glufosfamide did
not show significant clinical antitumor activity in patients with
recurrent GBM
MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status
The methylation status of the O6-methylguanine- DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Recent studies in anaplastic glioma suggest a prognostic value for MGMT methylation. Investigation of pathogenetic and epigenetic features of this intriguingly distinct behavior requires accurate MGMT classification to assess high throughput molecular databases. Promoter methylation-mediated gene silencing is strongly dependent on the location of the methylated CpGs,
CREBBP mutations in individuals without Rubinstein-Taybi syndrome phenotype
Item does not contain fulltextMutations in CREBBP cause Rubinstein-Taybi syndrome. By using exome sequencing, and by using Sanger in one patient, CREBBP mutations were detected in 11 patients who did not, or only in a very limited manner, resemble Rubinstein-Taybi syndrome. The combined facial signs typical for Rubinstein-Taybi syndrome were absent, none had broad thumbs, and three had only somewhat broad halluces. All had apparent developmental delay (being the reason for molecular analysis); five had short stature and seven had microcephaly. The facial characteristics were variable; main characteristics were short palpebral fissures, telecanthi, depressed nasal ridge, short nose, anteverted nares, short columella, and long philtrum. Six patients had autistic behavior, and two had self-injurious behavior. Other symptoms were recurrent upper airway infections (n = 5), feeding problems (n = 7) and impaired hearing (n = 7). Major malformations occurred infrequently. All patients had a de novo missense mutation in the last part of exon 30 or beginning of exon 31 of CREBBP, between base pairs 5,128 and 5,614 (codons 1,710 and 1,872). No missense or truncating mutations in this region have been described to be associated with the classical Rubinstein-Taybi syndrome phenotype. No functional studies have (yet) been performed, but we hypothesize that the mutations disturb protein-protein interactions by altering zinc finger function. We conclude that patients with missense mutations in this specific CREBBP region show a phenotype that differs substantially from that in patients with Rubinstein-Taybi syndrome, and may prove to constitute one (or more) separate entities. (c) 2016 Wiley Periodicals, Inc
Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
BACKGROUND: Outcome of low-grade glioma (WHO grade II) is highly variable, reflecting molecular heterogeneity of the disease. We compared two different, single-modality treatment strategies of standard radiotherapy versus primary temozolomide chemotherapy in patients with low-grade glioma, and assessed progression-free survival outcomes and identified predictive molecular factors.
METHODS: For this randomised, open-label, phase 3 intergroup study (EORTC 22033-26033), undertaken in 78 clinical centres in 19 countries, we included patients aged 18 years or older who had a low-grade (WHO grade II) glioma (astrocytoma, oligoastrocytoma, or oligodendroglioma) with at least one high-risk feature (aged >40 years, progressive disease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HIV infection, chronic hepatitis B or C virus infection, or any condition that could interfere with oral drug administration. Eligible patients were randomly assigned (1:1) to receive either conformal radiotherapy (up to 50·4 Gy; 28 doses of 1·8 Gy once daily, 5 days per week for up to 6·5 weeks) or dose-dense oral temozolomide (75 mg/m(2) once daily for 21 days, repeated every 28 days [one cycle], for a maximum of 12 cycles). Random treatment allocation was done online by a minimisation technique with prospective stratification by institution, 1p deletion (absent vs present vs undetermined), contrast enhancement (yes vs no), age (<40 vs ≥40 years), and WHO performance status (0 vs ≥1). Patients, treating physicians, and researchers were aware of the assigned intervention. A planned analysis was done after 216 progression events occurred. Our primary clinical endpoint was progression-free survival, analysed by intention-to-treat; secondary outcomes were overall survival, adverse events, neurocognitive function (will be reported separately), health-related quality of life and neurological function (reported separately), and correlative analyses of progression-free survival by molecular markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/IDH2 mutations). This trial is closed to accrual but continuing for follow-up, and is registered at the European Trials Registry, EudraCT 2004-002714-11, and at ClinicalTrials.gov, NCT00182819.
FINDINGS: Between Sept 23, 2005, and March 26, 2010, 707 patients were registered for the study. Between Dec 6, 2005, and Dec 21, 2012, we randomly assigned 477 patients to receive either radiotherapy (n=240) or temozolomide chemotherapy (n=237). At a median follow-up of 48 months (IQR 31-56), median progression-free survival was 39 months (95% CI 35-44) in the temozolomide group and 46 months (40-56) in the radiotherapy group (unadjusted hazard ratio [HR] 1·16, 95% CI 0·9-1·5, p=0·22). Median overall survival has not been reached. Exploratory analyses in 318 molecularly-defined patients confirmed the significantly different prognosis for progression-free survival in the three recently defined molecular low-grade glioma subgroups (IDHmt, with or without 1p/19q co-deletion [IDHmt/codel], or IDH wild type [IDHwt]; p=0·013). Patients with IDHmt/non-codel tumours treated with radiotherapy had a longer progression-free survival than those treated with temozolomide (HR 1·86 [95% CI 1·21-2·87], log-rank p=0·0043), whereas there were no significant treatment-dependent differences in progression-free survival for patients with IDHmt/codel and IDHwt tumours. Grade 3-4 haematological adverse events occurred in 32 (14%) of 236 patients treated with temozolomide and in one (<1%) of 228 patients treated with radiotherapy, and grade 3-4 infections occurred in eight (3%) of 236 patients treated with temozolomide and in two (1%) of 228 patients treated with radiotherapy. Moderate to severe fatigue was recorded in eight (3%) patients in the radiotherapy group (grade 2) and 16 (7%) in the temozolomide group. 119 (25%) of all 477 patients had died at database lock. Four patients died due to treatment-related causes: two in the temozolomide group and two in the radiotherapy group.
INTERPRETATION: Overall, there was no significant difference in progression-free survival in patients with low-grade glioma when treated with either radiotherapy alone or temozolomide chemotherapy alone. Further data maturation is needed for overall survival analyses and evaluation of the full predictive effects of different molecular subtypes for future individualised treatment choices.
FUNDING: Merck Sharpe & Dohme-Merck & Co, Canadian Cancer Society, Swiss Cancer League, UK National Institutes of Health, Australian National Health and Medical Research Council, US National Cancer Institute, European Organisation for Research and Treatment of Cancer Cancer Research Fund
CHIRAL BACKGROUND FOR THE TWO PION EXCHANGE NUCLEAR POTENTIAL: A PARAMETRIZED VERSION
We argue that the minimal chiral background for the two-pion exchange
nucleon-nucleon interaction has nowadays a rather firm conceptual basis, which
entitles it to become a standard ingredient of any modern potential. In order
to facilitate applications, we present a parametrized version of a
configuration space potential derived previously. We then use it to assess the
phenomenological contents of some existing NN potentials.Comment: REVTEX style, 16 pages, 5 PostScript figures compressed, tarred and
uuencode
Measurement of the Nucleon Structure Function F2 in the Nuclear Medium and Evaluation of its Moments
We report on the measurement of inclusive electron scattering off a carbon
target performed with CLAS at Jefferson Laboratory. A combination of three
different beam energies 1.161, 2.261 and 4.461 GeV allowed us to reach an
invariant mass of the final-state hadronic system W~2.4 GeV with four-momentum
transfers Q2 ranging from 0.2 to 5 GeV2. These data, together with previous
measurements of the inclusive electron scattering off proton and deuteron,
which cover a similar continuous two-dimensional region of Q2 and Bjorken
variable x, permit the study of nuclear modifications of the nucleon structure.
By using these, as well as other world data, we evaluated the F2 structure
function and its moments. Using an OPE-based twist expansion, we studied the
Q2-evolution of the moments, obtaining a separation of the leading-twist and
the total higher-twist terms. The carbon-to-deuteron ratio of the leading-twist
contributions to the F2 moments exhibits the well known EMC effect, compatible
with that discovered previously in x-space. The total higher-twist term in the
carbon nucleus appears, although with large systematic uncertainites, to be
smaller with respect to the deuteron case for n<7, suggesting partial parton
deconfinement in nuclear matter. We speculate that the spatial extension of the
nucleon is changed when it is immersed in the nuclear medium.Comment: 37 pages, 15 figure
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