A Gradient-Based Approach for Breast DCE-MRI Analysis

Breast cancer is the main cause of female malignancy worldwide. Effective early detection by imaging studies remains critical to decrease mortality rates, particularly in women at high risk for developing breast cancer. Breast Magnetic Resonance Imaging (MRI) is a common diagnostic tool in the management of breast diseases, especially for high-risk women. However, during this examination, both normal and abnormal breast tissues enhance after contrast material administration. Specifically, the normal breast tissue enhancement is known as background parenchymal enhancement: it may represent breast activity and depends on several factors, varying in degree and distribution in different patients as well as in the same patient over time. While a light degree of normal breast tissue enhancement generally causes no interpretative difficulties, a higher degree may cause difficulty to detect and classify breast lesions at Magnetic Resonance Imaging even for experienced radiologists. In this work, we intend to investigate the exploitation of some statistical measurements to automatically characterize the enhancement trend of the whole breast area in both normal and abnormal tissues independently from the presence of a background parenchymal enhancement thus to provide a diagnostic support tool for radiologists in the MRI analysis

Energy reconstruction of electromagnetic showers from [Pi 0] decays with the ICARUS T600 liquid argon TPC

We discuss the ICARUS T600 detector capabilities in electromagnetic shower reconstruction through the analysis of a sample of 212 events, coming from the 2001 Pavia surface test run, of hadronic interactions leading to the production of 0 mesons. Methods of shower energy and shower direction measurements were developed and the invariant mass of the photon pairs was reconstructed. The ( ) invariant mass was found to be consistent with the value of the 0 mass. The resolution of the reconstructed 0 mass was found to be equal to 27.3%. An improved analysis, carried out in order to clean the full event sample from the events measured in the crowded environment, mostly due to the trigger conditions, gave a 0 mass resolution of 16.1%, significantly better than the one evaluated for the full event sample. The trigger requirement of the coincidence of at least four photo-multiplier signals favored the selection of events with a strong pile up of cosmic ray tracks and interactions. Hence a number of candidate 0 events were heavily contaminated by other tracks and had to be rejected. Monte Carlo simulations of events with 0 production in hadronic and neutrino interactions confirmed the validity of the shower energy and shower direction reconstruction methods applied to the real data

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

A survey of clinical features of allergic rhinitis in adults

Background: Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden. Material/Methods: The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18\u201345 years). For each patient, the attending physician had to fill in a standardized questionnaire, covering, in particular, some issues such as the ARIA classification of allergic rhinitis (AR), the results of skin prick test (SPT), the kind of treatment, the response to treatment, and the satisfaction with treatment. Results: Out of the 3383 patients with rhinitis, 2788 (82.4%) had AR: 311 (11.5%) had a mild intermittent, 229 (8.8%) a mild persistent, 636 (23.5%) a moderate-severe intermittent, and 1518 (56.1%) a moderate-severe persistent form. The most frequently used drugs were oral antihistamines (77.1%) and topical corticosteroids (60.8%). The response to treatment was judged as excellent in 12.2%, good in 41.3%, fair in 31.2%, poor in 14.5%, and very bad in 0.8% of subjects. The rate of treatment dissatisfaction was significantly higher in patients with moderate-to-severe AR than in patients with mild AR (p<0.0001). Indication to allergen immunotherapy (AIT) was significantly more frequent (p<0.01) in patients with severe AR than with mild AR. . Conclusions: These fndings confirm the appropriateness of ARIA guidelines in classifying the AR patients and the association of severe symptoms with unsuccessful drug treatment. The optimal targeting of patients to be treated with AIT needs to be reassessed

TURNER SYNDROME WITH DENTAL STRUCTURAL ABNORMALITIES : HISTOLOGICAL AND MORPHOSTRUCTURAL FEATURES BY CONFOCAL LASER MICROSCOPY

Turner syndrome is a genetic disorder characterized by the total or partial absence of the X chromosome. There are different types of karyotypes although the most frequent is the 45X (57%). Mosaicisms such as 46 XX/45X, 45X/46XX/47XXX (29%), the presence of the isochromosome X or the chromosome X-ring (14%) may occur. The main clinical features are: short stature, gonadal dysfunction, congenital heart disease, renal and skeletal anomalies, endocrine disorders and hypoplasia of the fingernails and toenails. Craniofacial features are due to retarded development of the cranialfacial complex with reduced growth of the skull base, hypertelorism, retrognathic profile, maloclussion Class II (60%), hypoplasia of the maxilla, bilateral cross-bite (9%) with or without cleft palate, anterior open bite (17%). The teeth are altered in shape and structure. A patient AA 9 years old, suffering from Turner syndrome karyotype 45Xq; the Rx OPT has highlighted the presence of agenesis of 2.2 and a mesiodens in the region between the upper central incisors with the inclusion of 1.1. We proceeded to the extraction of the pre-orthodontic mesiodens and subsequent orthodontic treatment for the correction of Class II malocclusion. The mesiodens, fixed in formalin, decalcified, and half was embedded in paraffin and stained with hematoxylin-eosin and half including resin-ground sections. Histological examination to the confocal laser scanning microscopy showed: - Alternation of zones of hypo and over calcification; - Inhomogeneous structure of dentin and abnormalities of the dentinal tubules; - Reduced enamel thickness and irregular arrangement of the striae of Retzius. - The pulp and root systems are characterized by the presence of foci of ectomesenchymal dentinogenetic multifocal differentiation that cause irregularities in the shape and structure of the root by an irregular, neoplastical-like growth (odontoma-like)

Primary hyperoxaluria: Orthodontic management in a pediatric patient: A case report

Aims: The aim of this study is to report the case of the orthodontic treatment in a patient affected by primary hyperoxaluria type 1 and subjected to a combinate liver-kidney transplant. Methods and results: The 9-year patient was admitted to our department for the presence of facial dysmorphism. The patient was affected by primary hyperoxaluria type 1 and has undergone a combined liver-kidney transplantation. At the time of the visit, he was in treatment with immunosuppressive drugs and received a corticosteroid and an antibiotic therapy monthly. An intraoral and extraoral examination, as well as radiographic and model analysis, was performed in order to define an accurate diagnosis and a proper rehabilitation planning. An orthopedic-orthodontic treatment was performed and satisfactory final results obtained. A laser gingivectomy was also realized for eliminate the gengival hyperplasia probably induced by cyclosporine assumption. Both skeletal and dental relationships were improved by the treatment, reaching a good dental arches alignment. Conclusion: An early diagnosis, as well as a multidisciplinary approach, is very important in patients with rare diseases. An appropriate treatment allowed us to achieve acceptable results and improve the patient quality of life