Microencapsulation Yield Assessment Using TGA

In this study, microcapsules containing different contents of different kinds of fragrances and with a regular spherical shape, 2,0–8,0 µm diameter, were synthesized in various core:shell ratios. Mint and cuir fragrances were successfully encapsulated in poly(urea-formaldehyde) (PUF) shell via in-situ polymerization. This was confirmed by optical microscope, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR) studies. By observation from thermogravimetric analysis (TGA), it was found a relation between thermal gravimetric curves and the amount of fragrance encapsulated, which was later contrasted by ultraviolet-visible spectroscopy. In this way, comparatively, the yield percentage values can be quantitatively defined with a sufficient degree of accuracy by TGA methodPostprint (author's final draft

Uso de los recursos digitales y desempeño docente en una institución educativa pública del distrito de La Unión, Huánuco, 2022

La presente investigación tuvo como objetivo: determinar la relación que existe entre recursos digitales y desempeño docente en una institución educativa del distrito de La Unión, Huánuco, 2022; se ubica en el enfoque cuantitativo, de tipo aplicada, diseño no experimental de corte transeccional, nivel correlacional. Se utilizó el método hipotético deductivo. Se contó con una población y muestra censal de 80 docentes. Para el proceso de recolección de datos se empleó la técnica de la encuesta y como instrumento los cuestionarios para así determinar la relación entre recursos digitales y desempeño docente, con una fiabilidad de Cronbach de 0,960 y 0,917 respectivamente. El resultado obtenido fue un valor de coeficiente de Rho de spearman de 0,645 y un valor de significancia bilateral de p= 0,001 menor que 0,05, por ello se concluye que existe una correlación positiva moderada entre las variables consideradas, refutando la hipótesis nula

Por que não ouvimos mais falar em Gestão pela Qualidade Total (GQT)?

A Gestão pela Qualidade Total (GQT) alcançou grande visibilidade e popularidade nas décadas de 80 e 90 no mundo ocidental. Porém, a partir da segunda metade da década de 90, esse modelo entrou em crise, perdendo destaque no meio acadêmico e empresarial. Atualmente, o esgotamento da GQT é amplamente reconhecido pela literatura. Considerando a relevância de tal abordagem para o campo da administração, esta pesquisa busca aclarar as causas da aparente exaustão. Visando atingir esse objetivo, este artigo utilizase de pesquisa bibliográfica para apresentar, com base na literatura, hipóteses que procuram explicar as motivações que culminaram na crise (ou declínio) do modelo de Gestão baseado na Qualidade Total nos países ocidentais e, consequentemente, no Brasil. Ao todo, foram apresentadas vinte hipóteses levantadas por nove autores. A mais plausível, formulada na execução deste trabalho bibliográfico, é que não há propriamente uma “crise” dos programas de GQT, pois muitos dos seus aspectos estão bem sedimentados na gestão atual das empresas. Eles continuam sendo implementados por meio de práticas ou programas gerenciais com nomenclaturas diferenciadas, porém ainda guardam muitas semelhanças com os antigos programas de Gestão pela Qualidade Total do estilo japonês

Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis.

Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A. marginale strains based on N-terminal tandem repeats and a 5'-UTR microsatellite located in the msp1a gene. The MSP1a tandem repeats contain immune relevant elements and functional domains that bind to bovine erythrocytes and tick cells, thus providing information about the evolution of host-pathogen and vector-pathogen interactions. Here we propose one nomenclature for A. marginale strain classification based on MSP1a. All tandem repeats among A. marginale strains were classified and the amino acid variability/frequency in each position was determined. The sequence variation at immunodominant B cell epitopes was determined and the secondary (2D) structure of the tandem repeats was modeled. A total of 224 different strains of A. marginale were classified, showing 11 genotypes based on the 5'-UTR microsatellite and 193 different tandem repeats with high amino acid variability per position. Our results showed phylogenetic correlation between MSP1a sequence, secondary structure, B-cell epitope composition and tick transmissibility of A. marginale strains. The analysis of MSP1a sequences provides relevant information about the biology of A. marginale to design vaccines with a cross-protective capacity based on MSP1a B-cell epitopes

Identidad Urbana y su influencia en el paisaje cultural del barrio Santa Ana, en el distrito de Ayacucho, Ayacucho, 2022

Este estudio tiene como objetivo determinar la influencia de la identidad urbana en el paisaje cultural del barrio Santa Ana del centro histórico de Ayacucho, desde un contexto físico espacial donde se evidencia construcciones a expensas de los patrones y perfiles urbanos históricos, que impulsa el discurso sobre la perdida de la identidad de la población con respecto a la ciudad. La metodología utilizada parte desde el enfoque cualitativo de diseño fenomenológico de tipo explicativo, en función a las variables de estudio. A partir del mapeo y 14 entrevistas, donde se revelo los resultados, que muestran las capas urbanas y sociales sobre la pérdida del patrimonio cultural que son cruciales para la identidad urbanas debido a las características físicas del entorno urbano y su relación identitaria con el barrio. En conclusión, la propuesta de un nuevo enfoque que define a la identidad urbana como la composición del espacio físico y la memoria colectiva tradicional, examina las capas urbanas, sociales y tradicionales como elementos representativos del barrio para determinar la relación identitaria de la población con respecto al barrio son importantes para su prevalencia

Brucella abortus induces TNF-á-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases

Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology.Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Scian, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Est.de la Inmunidad Humoral Prof.r.a.margni;Fil: Garcia Samartino, Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Barrionuevo, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Baldi, Pablo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Cassataro, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; ArgentinaFil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Giambartolomei, Guillermo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Rodríguez, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martin; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ibañez, Andres Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Coria, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; ArgentinaFil: Velasquez, Lis Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. R. A. Margni; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentin

A falta de efetividade na proteção aos transexuais nas prisões brasileiras / A falta de efetividade na proteção aos transexuais nas prisões brasileiras

Neste trabalho investigaremos a falta de efetividade dos direitos humanos e de políticas de amparo às pessoas transexuais que estão inseridas no sistema prisional brasileiro, analisando as condições desumanas que vivenciam diariamente. Para embasar este artigo será utilizada a metodologia de pesquisa documental e qualitativa, com a análise de pesquisas que apontam e refletem o dia a dia nas cadeias do país e o mapeamento dos índices quantitativos e qualitativos acerca dos transexuais que estão cumprindo a pena de privação de liberdade. Isto posto, será possível cumprir o objetivo de compreender se os direitos fundamentais, declarações internacionais, leis e resoluções que embasam as políticas públicas de amparo estão sendo violados, deixando os transexuais em cárcere carentes de proteções que atendam suas peculiaridades.

Hsp21potentiates antifungal drug tolerance in Candida albicans

Peer reviewedPublisher PD

Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome: ABESO 2022

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Obesity is a chronic disease resulting from multifactorial causes mainly related to lifestyle (sedentary lifestyle, inadequate eating habits) and to other conditions such as genetic, hereditary, psychological, cultural, and ethnic factors. The weight loss process is slow and complex, and involves lifestyle changes with an emphasis on nutritional therapy, physical activity practice, psychological interventions, and pharmacological or surgical treatment. Because the management of obesity is a long-term process, it is essential that the nutritional treatment contributes to the maintenance of the individual's global health. The main diet-related causes associated with excess weight are the high consumption of ultraprocessed foods, which are high in fats, sugars, and have high energy density; increased portion sizes; and low intake of fruits, vegetables, and grains. In addition, some situations negatively interfere with the weight loss process, such as fad diets that involve the belief in superfoods, the use of teas and phytotherapics, or even the avoidance of certain food groups, as has currently been the case for foods that are sources of carbohydrates. Individuals with obesity are often exposed to fad diets and, on a recurring basis, adhere to proposals with promises of quick solutions, which are not supported by the scientific literature. The adoption of a dietary pattern combining foods such as grains, lean meats, low-fat dairy, fruits, and vegetables, associated with an energy deficit, is the nutritional treatment recommended by the main international guidelines. Moreover, an emphasis on behavioral aspects including motivational interviewing and the encouragement for the individual to develop skills will contribute to achieve and maintain a healthy weight. Therefore, this Position Statement was prepared based on the analysis of the main randomized controlled studies and meta-analyses that tested different nutrition interventions for weight loss. Topics in the frontier of knowledge such as gut microbiota, inflammation, and nutritional genomics, as well as the processes involved in weight regain, were included in this document. This Position Statement was prepared by the Nutrition Department of the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO), with the collaboration of dietitians from research and clinical fields with an emphasis on strategies for weight loss.info:eu-repo/semantics/publishedVersio

Suicide prevention in primary care: General practitioners' views on service availability

BackgroundPrimary care may be a key setting for suicide prevention. However, comparatively little is known about the services available in primary care for suicide prevention. The aims of the current study were to describe services available in general practices for the management of suicidal patients and to examine GPs views on these services. We carried out a questionnaire and interview study in the North West of England. We collected data on GPs views of suicide prevention generally as well as local mental health service provision.FindingsDuring the study period (2003-2005) we used the National Confidential Inquiry Suicide database to identify 286 general practitioners (GPs) who had registered patients who had died by suicide. Data were collected from GPs and practice managers in 167 practices. Responses suggested that there was greater availability of services and training for general mental health issues than for suicide prevention specifically. The three key themes which emerged from GP interviews were: barriers accessing primary or secondary mental health services; obstacles faced when referring a patient to mental health services; managing change within mental health care servicesConclusionsHealth professionals have an important role to play in preventing suicide. However, GPs expressed concerns about the quality of primary care mental health service provision and difficulties with access to secondary mental health services. Addressing these issues could facilitate future suicide prevention in primary care