Alix Therese Coste

B Enjalbert

B Wachtler

Bernhard Hube

C Fradin

C Onyewu

D Harcus

Duncan Wilson

F Abe

F Ritossa

FL Mayer

François L. Mayer

G Kappe

H Senn

HJ Lo

ID Jacobsen

J Buchner

JA Lewis

K Richter

K Zakikhany

L Whitesell

LE Cowen

M Lis

M Ramsdale

M Taipale

MA Pfaller

MC Cruz

MC Lorenz

MS Fu

N Booth

N Robbins

P Uppuluri

RK Swoboda

RS Shapiro

S Diezmann

S Hodgetts

S Lindquist

S Nicholls

S Thewes

SD Singh

SL LaFayette

WJ Steinbach

PLoS ONE

English

PubMed

Crossref

Hsp21 Potentiates Antifungal Drug Tolerance in Candida albicans

Mayer François L.

Wilson Duncan

Hube Bernhard

Public Library of Science (PLOS)

Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs. We recently identified the small heat shock protein Hsp21 in C. albicans and demonstrated its fundamental role for environmental stress adaptation and fungal virulence. Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. albicans mutant strain. Our results indicate that combinatorial therapy targeting Hsp21, together with specific antifungal drug targets, has strong synergistic potential. In addition, we demonstrate that Hsp21 is required for tolerance to ethanol-induced stress and induction of filamentation in response to pharmacological inhibition of Hsp90. These findings might pave the way for the development of new treatment strategies against Candida infections

François L Mayer

Directory of Open Access Journals

Hsp21 potentiates antifungal drug tolerance in Candida albicans.

Mayer, François L

Wilson, Duncan

Hube, Bernhard

The Open University

Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.

Antimicrobial peptide MUC7 12-mer activates the calcium/calcineurin pathway in Candida albicans.

Calcineurin is essential for survival during membrane stress in Candida albicans.

Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.

Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10: 85–

Candida and Candidosis: Bailliere Tindall,

Candida: What Should Clinicians and Scientists Be Talking About? In:

Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans.

Discovery of the heat shock response.

Epidemiology of invasive candidiasis: a persistent public health problem.

Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata,a n dCandida krusei.

Exploiting natural variation in Saccharomyces cerevisiae to identify genes for increased ethanol resistance.

Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress.

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood.

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Heat-shock proteins and stress tolerance in microorganisms.

HSP90 and the chaperoning of cancer.

HSP90 at the hub of protein homeostasis: emerging mechanistic insights.

Hsp90 governs dispersion and drug resistance of fungal biofilms.

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS

Hsp90 orchestrates stress response signaling governing fungal drug resistance.

Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion.

In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination.

Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry.

Mechanistic role of ergosterol in membrane rigidity and cycloheximide resistance in Saccharomyces cerevisiae.

MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.M o l

Nonfilamentous C. albicans mutants are avirulent.

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of

Quantitative analysis of hsp90-client interactions reveals principles of substrate recognition.

Regulatory circuitry governing fungal development, drug resistance, and disease.

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.

Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.

Stress-induced gene expression in Candida albicans: absence of a general stress response.

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans.

Supervising the fold: functional principles of molecular chaperones.

Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.

The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.

The denaturation of proteins: Denaturation in the presence of alcohol.

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

The heat shock response: life on the verge of death.

The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10.

Transcription profiling of cyclic AMP signaling in Candida albicans.

Transcriptional response of Candida albicans upon internalization by macrophages.

Hsp21potentiates antifungal drug tolerance in Candida albicans

file:///data/remote/core/dit/data/public_library_of_science/pdf/d15/ZnRwOi8vZnRwLm5jYmkubmxtLm5paC5nb3YvcHViL3BtYy9vYV9wYWNrYWdlL2MyLzhkL1BNQzM2MDYxOTMudGFyLmd6.pdf

Hsp21potentiates antifungal drug tolerance in Candida albicans

Abstract

Similar works

Full text

Available Versions

Crossref

Public Library of Science (PLOS)

Directory of Open Access Journals

Public Library of Science (PLOS)

The Open University