Using an ontology for interoperability and browsing of museum, library and archive information

Ontologies play an important part in the development of the future ‘semantic web’; the CIDOC conceptual reference model (CRM) is an ontology aimed at the cultural heritage domain. This paper describes a Concept Browser, developed for the EU/IST-funded SCULPTEUR project (semantic and content-based multimedia exploitation for European benefit environment (programme IST-2001-no. 35372); May 2002 to May 2005), which is able to access different museum information systems through a common ontology, the CRM. The development of this Concept Browser has required mappings from the legacy museum database systems to the CRM. The crucial process of creating the mappings is described, using the C2RMF catalogue (EROS) and library databases as a case study

Tricritical scaling at the N_t=6 chiral phase transition for 2 flavour lattice QCD with staggered quarks

We have simulated lattice QCD directly in the chiral limit of zero quark mass by adding an additional, irrelevant 4-fermion interaction to the standard action. Using lattices having temporal extent of six and spatial extents of twelve and eighteen, we find that the theory with 2 massless staggered quark flavors has a second order finite temperature phase transition. The critical exponents $\beta_{mag}$, $\delta$ and $\nu$ are measured and favour tricritical behaviour over that expected by universality arguments. The pion screening mass is consistent with zero below the transition, but is degenerate with the nonzero $\sigma(f_0)$ mass above the transition, indicating the restoration of chiral symmetry.Comment: 12 pages, 3 postscript figures Letter has been rewritten to reflect a reinterpretation of our results as indicating tricritical critical indices rather than those predicted by standard universality arguments. Some additional analysis which supports this interpretation is included. The comparison of our methods with those of others has been expande

Field Emission Dark Current of Technical Metallic Electrodes

In the framework of the Low Emittance Gun (LEG) project, high gradient acceleration of a low emittance electron beam will be necessary. In order to achieve this acceleration a -500 kV, 250 ns FWHM, pulse will be applied in between two electrodes. Those electrodes should sustain the pulsed field without arcing, must not outgass and must not emit electrons. Ion back bombardment, and dark current will be damageable to the electron source as well as for the low emittance beam. Electrodes of commercially available OFE copper, aluminium, stainless steel, titanium and molybdenum were tested following different procedures including plasma glow discharge cleaning.Comment: 22 pages, 6 tables, 10 figures Vs 2 : graphics more readable, enhanced content Vs 3 : typo correcte

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction leads to early onset airway diseases, remain unclear. In this study, we systematically characterized the developmental landscape of the mouse airway using single-cell RNA sequencing and identified remarkably conserved cellular programs operating during human fetal development. We demonstrated that in mouse, genetic inactivation of chloride channel Ano1/Tmem16a compromises airway barrier function, results in early signs of inflammation, and alters the airway cellular landscape by depleting epithelial progenitors. Mouse Ano1-/-mutants exhibited mucus obstruction and abnormal mucociliary clearance that resemble the airway defects associated with cystic fibrosis. The data reveal critical and non-redundant roles for Ano1 in organogenesis, and show that chloride channels are essential for mammalian airway formation and function

Pathologies of Quenched Lattice QCD at non--zero Density and its Effective Potential

We simulate lattice QCD at non--zero baryon density and zero temperature in the quenched approximation, both in the scaling region and in the infinite coupling limit. We investigate the nature of the forbidden region -- the range of chemical potential where the simulations grow prohibitively expensive, and the results, when available, are puzzling if not unphysical. At weak coupling we have explored the sensitivity of these pathologies to the lattice size, and found that using a large lattice ($64 \times 16^3$) does not remove them. The effective potential sheds considerable light on the problems in the simulations, and gives a clear interpretation of the forbidden region. The strong coupling simulations were particularly illuminating on this point.Comment: 49 pages, uu-encoded expanding to postscript;also available at ftp://hlrz36.hlrz.kfa-juelich.de/pub/mpl/hlrz72_95.p

Empirical comparison of high gradient achievement for different metals in DC and pulsed mode

For the SwissFEL project, an advanced high gradient low emittance gun is under development. Reliable operation with an electric field, preferably above 125 MV/m at a 4 mm gap, in the presence of an UV laser beam, has to be achieved in a diode configuration in order to minimize the emittance dilution due to space charge effects. In the first phase, a DC breakdown test stand was used to test different metals with different preparation methods at voltages up to 100 kV. In addition high gradient stability tests were also carried out over several days in order to prove reliable spark-free operation with a minimum dark current. In the second phase, electrodes with selected materials were installed in the 250 ns FWHM, 500 kV electron gun and tested for high gradient breakdown and for quantum efficiency using an ultra-violet laser.Comment: 25 pages, 13 figures, 5 tables. Follow up from FEL 2008 conference (Geyongju Korea 2008) New Title in JVST A (2010) : Vacuum breakdown limit and quantum efficiency obtained for various technical metals using DC and pulsed voltage source

Highly multimode memory in a crystal

We experimentally demonstrate the storage of 1060 temporal modes onto a thulium-doped crystal using an atomic frequency comb (AFC). The comb covers 0.93 GHz defining the storage bandwidth. As compared to previous AFC preparation methods (pulse sequences i.e. amplitude modulation), we only use frequency modulation to produce the desired optical pumping spectrum. To ensure an accurate spectrally selective optical pumping, the frequency modulated laser is self-locked on the atomic comb. Our approach is general and should be applicable to a wide range of rare-earth doped material in the context of multimode quantum memory

The Dixmier property and tracial states for C*-algebras

A.T. was partially supported by an NSERC Postdoctoral Fellowship and through the EPSRC grant EP/N00874X/1. Acknowledgements We are grateful to Luis Santiago for helpful discussions at an early stage of this investigation. We would also like to thank the referee for providing helpful comments, which have led to a number of improvements.Peer reviewedPublisher PD

Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents.

A small library of cryptolepine analogues were synthesised incorporating halogens and/or nitrogen containing side chains to optimise their interaction with the sugar-phosphate backbone of DNA to give improved binding, interfering with topoisomerase II hence enhancing cytotoxicity. Cell viability, DNA binding and Topoisomerase II inhibition is discussed for these compounds. Fluorescence microscopy was used to investigate the uptake of the synthesised cryptolepines into the nucleus. We report the synthesis and anti-cancer biological evaluation of nine novel cryptolepine analogues, which have greater cytotoxicity than the parent compound and are important lead compounds in the development of novel potent and selective indoloquinone anti-neoplastic agents