3,937 research outputs found
Chaotic Mixing in Three Dimensional Porous Media
Under steady flow conditions, the topological complexity inherent to all
random 3D porous media imparts complicated flow and transport dynamics. It has
been established that this complexity generates persistent chaotic advection
via a three-dimensional (3D) fluid mechanical analogue of the baker's map which
rapidly accelerates scalar mixing in the presence of molecular diffusion. Hence
pore-scale fluid mixing is governed by the interplay between chaotic advection,
molecular diffusion and the broad (power-law) distribution of fluid particle
travel times which arise from the non-slip condition at pore walls. To
understand and quantify mixing in 3D porous media, we consider these processes
in a model 3D open porous network and develop a novel stretching continuous
time random walk (CTRW) which provides analytic estimates of pore-scale mixing
which compare well with direct numerical simulations. We find that chaotic
advection inherent to 3D porous media imparts scalar mixing which scales
exponentially with longitudinal advection, whereas the topological constraints
associated with 2D porous media limits mixing to scale algebraically. These
results decipher the role of wide transit time distributions and complex
topologies on porous media mixing dynamics, and provide the building blocks for
macroscopic models of dilution and mixing which resolve these mechanisms.Comment: 36 page
Scaling forms of particle densities for LĂ©vy walks and strong anomalous diffusion
International audienceWe study the scaling behavior of particle densities for LĂ©vy walks whose transition length r is coupled with the transition time t as |r| â t α with an exponent α > 0. The transition-time distribution behaves as Ï(t) â t â1âÎČ with ÎČ > 0. For 1 q c. These results give insight into the possible origins of strong anomalous diffusion and anomalous behaviors in disordered systems in general
An evaluation of metal removal during wastewater treatment: The potential to achieve more stringent final effluent standards
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 Taylor & Francis.Metals are of particular importance in relation to water quality, and concern regarding the impact of these contaminants on biodiversity is being encapsulated within the latest water-related legislation such as the Water Framework Directive in Europe and criteria revisions to the Clean Water Act in the United States. This review undertakes an evaluation of the potential of 2-stage wastewater treatment consisting of primary sedimentation and biological treatment in the form of activated sludge processes, to meet more stringent discharge consents that are likely to be introduced as a consequence. The legislation, sources of metals, and mechanisms responsible for their removal are discussed, to elucidate possible pathways by which the performance of conventional processes may be optimized or enhanced. Improvements in effluent quality, achievable by reducing concentrations of suspended solids or biochemical oxygen demand, may also reduce metal concentrations although meeting possible requirements for the removal of copper my be challenging
Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study
Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and simultaneous radiotherapy. Patients and Methods: Previously untreated patients with stage IIIB NSCLC received concurrent chemoradiotherapy with 66 Gy and 2 cycles of cisplatin and oral vinorelbine which was administered at 3 different levels (40, 50 and 60 mg/m(2)). This was to be followed by 2 cycles of cisplatin/vinorelbine oral consolidation chemotherapy. The study goal was to determine the maximal recommended dose of oral vinorelbine during concurrent treatment. Results: 11 stage IIIB patients were entered into the study. The median radiotherapy dose was 66 Gy. Grade 3-4 toxicity included neutropenia, esophagitis, gastritis and febrile neutropenia. The dose-limiting toxicity for concurrent chemoradiotherapy was esophagitis. 9 patients received consolidation chemotherapy, with neutropenia and anemia/thrombocytopenia grade 3 being the only toxicities. The overall response was 73%. Conclusion: Oral vinorelbine 50 mg/m(2) (days 1, 8, 15 over 4 weeks) in combination with cisplatin 20 mg/m2 (days 1-4) is the recommended dose in combination with radiotherapy (66 Gy) and will be used for concurrent chemoradiotherapy in a forthcoming phase III trial testing the efficacy of consolidation chemotherapy in patients not progressing after chemoradiotherapy
The impact of the ATLAS zero-lepton, jets and missing momentum search on a CMSSM fit
Recent ATLAS data significantly extend the exclusion limits for
supersymmetric particles. We examine the impact of such data on global fits of
the constrained minimal supersymmetric standard model (CMSSM) to indirect and
cosmological data. We calculate the likelihood map of the ATLAS search, taking
into account systematic errors on the signal and on the background. We validate
our calculation against the ATLAS determinaton of 95% confidence level
exclusion contours. A previous CMSSM global fit is then re-weighted by the
likelihood map, which takes a bite at the high probability density region of
the global fit, pushing scalar and gaugino masses up.Comment: 16 pages, 7 figures. v2 has bigger figures and fixed typos. v3 has
clarified explanation of our handling of signal systematic
Interpreting a 1 fb^-1 ATLAS Search in the Minimal Anomaly Mediated Supersymmetry Breaking Model
Recent LHC data significantly extend the exclusion limits for supersymmetric
particles, particularly in the jets plus missing transverse momentum channels.
The most recent such data have so far been interpreted by the experiment in
only two different supersymmetry breaking models: the constrained minimal
supersymmetric standard model (CMSSM) and a simplified model with only squarks
and gluinos and massless neutralinos. We compare kinematical distributions of
supersymmetric signal events predicted by the CMSSM and anomaly mediated
supersymmetry breaking (mAMSB) before calculating exclusion limits in mAMSB. We
obtain a lower limit of 900 GeV on squark and gluino masses at the 95%
confidence level for the equal mass limit, tan(beta)=10 and mu>0.Comment: 18 pages, 11 figure
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors
Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinsonâs disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this up-regulation of α6* or α4* nAChRs but does not participate in basal trafficking. We show that α6ÎČ2ÎČ3 nAChR up-regulation is prevented by mutating a putative COPI-binding motif in the ÎČ3 subunit or by inhibiting COPI. Similarly, a COPI-dependent process is required for up-regulation of α4ÎČ2 nAChRs by chronic nicotine but not for basal trafficking. Mutation of the putative COPI-binding motif or inhibition of COPI also results in reduced normalized Förster resonance energy transfer between α6ÎČ2ÎČ3 nAChRs and ΔCOP subunits. The discovery that nicotine exploits a COPI-dependent process to chaperone high sensitivity nAChRs is novel and suggests that this may be a common mechanism in the up-regulation of nAChRs in response to chronic nicotine
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