Bottomonium spectroscopy with mixing of eta_b states and a light CP-odd Higgs

The mass of the eta_b(1S), measured recently by BABAR, is significantly lower than expected from QCD predictions for the Upsilon(1S) - eta_b(1S) hyperfine splitting. We suggest that the observed eta_b(1S) mass is shifted downwards due to a mixing with a CP-odd Higgs scalar A with a mass m_A in the range 9.4 - 10.5 GeV compatible with LEP, CLEO and BABAR constraints. We determine the resulting predictions for the spectrum of the eta_b(nS) - A system and the branching ratios into tau^+ tau^- as functions of m_A.Comment: 4 pages, 4 figures, submitted to PRL, misprint correcte

Waiting for Data Journalism

Data journalism has emerged as a trend worthy of attention in newsrooms the world over. Previous research has highlighted how elite media, journalism education institutions, and other interest groups take part in the emergence and evolution of data journalism. But has it equally gained momentum in smaller, less-scrutinized media markets? This paper looks at the ascent of data journalism in the French-speaking part of Belgium. It argues that journalism, and hence data journalism, can be understood as a socio-discursive practice: it is not only the production of (data-driven) journalistic artefacts that shapes the notion of (data) journalism, but also the discursive efforts of all the actors involved, in and out of the newsrooms. A set of qualitative inquiries allowed us to examine the phenomenon by first establishing a cartography of who and what counts as data journalism. It uncovers an overall reliance on a handful of passionate individuals, only partly backed up institutionally, and a limited amount of consensual references that could foster a shared interpretive community. A closer examination of the definitions reveal a sharp polyphony that is particularly polarized around the duality of the term itself, divided between a focus on data and a focus on journalism, and torn between the co-existing notions of “ordinary” and “thorough” data journalism. We also describe what is perceived as obstacles, which mostly pertain to broader traits that shape contemporary newsmaking; and explain why, if data journalism clearly exists as a matter of concern, it has not transformed in concrete undertakings

Sustainable Refurbishment for School Buildings:A Literature Review

Purpose: Any building refurbishment is challenging and school buildings offer no exception. They are increasingly in need of refurbishment due to their age and evolving teaching and learning. The purpose of this paper is to present an overview of literature on sustainable refurbishment so as to identify key lessons from selected successful refurbishment projects. The review findings are expected to contribute to the development of refurbishment plans in an effective and innovative manner that should extend building’s service life, focus on resource efficiency, and comfort their users. It will also contribute to knowledge base of refurbishment and suggest future directions for research. Design/methodology/approach: The paper has undertaken a literature review on the sustainability assessment of buildings and frameworks for sustainable refurbishment. Besides, the work also provides a review of recent successful refurbishment projects to collect and structure systems experiences which can be adopted in developing a sustainable refurbishment strategy for school buildings. Findings: Findings include three groups of lessons in terms of reasons, process and barriers in the selected refurbishment projects that assist stakeholders to prepare a suitable refurbishment plan for their school buildings. The potential of 3D scanners and BIM applications in the refurbishment process will also be reviewed in order to develop a proposed framework of 3D scanner vs BIM for the refurbishment process. Recommendations highlight the role of a national strategy as a driving factor for applying the advantages of information technology to enhance optimal solution selection processes to get better and more sustainable results. Originality/value: The conceptual framework for 3D scanner and BIM applications within sustainable refurbishment for school buildings is currently under researched, and the findings aimed to address such a gap when considering 3D scanners and BIM applications in the refurbishment process

Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2′-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties

Benzohydroxamic acids, such as 4-hydroxy-(2H)- 1,4-benzoxazin-3(4H)-one (D-DIBOA), exhibit interesting herbicidal, fungicidal and bactericidal properties. Recently, the chemical synthesis of D-DIBOA has been simplified to only two steps. In a previous paper, we demonstrated that the second step could be replaced by a biotransformation using Escherichia coli to reduce the nitro group of the precursor, ethyl 2-(2′-nitrophenoxy)acetate and obtain D-DIBOA. The NfsA and NfsB nitroreductases and the NemA xenobiotic reductase of E. coli have the capacity to reduce one or two nitro groups from a wide variety of nitroaromatic compounds, which are similar to the precursor. By this reason, we hypothesised that these three enzymes could be involved in this biotransformation. We have analysed the biotransformation yield (BY) of mutant strains in which one, two or three of these genes were knocked out, showing that only in the double nfsA/nfsB and in the triple nfsA/nfsB/nemA mutants, the BY was 0%. These results suggested that NfsA and NfsB are responsible for the biotransformation in the tested conditions. To confirm this, the nfsA and nfsB open reading frames were cloned into the pBAD expression vector and transformed into the nfsA and nfsB single mutants, respectively. In both cases, the biotransformation capacity of the strains was recovered (6.09±0.06% as in the wild-type strain) and incremented considerably when NfsA and NfsB were overexpressed (40.33%±9.42% and 59.68%±2.0% respectively)

Small-scale mobility fostering the interaction networks of Patagonia (Argentina) hunter-gatherers during the Late Holocene: Perspectives from strontium isotopes and exotic items

During the Late Holocene, hunter-gatherer interaction networks significantly grew in intensity and extension across Patagonia. Although this growth is evidenced by the increased flow of exotic items across the region, the mechanisms behind these strengthening social networks remain unclear. Since evidence suggests that some individuals might have performed long-distance trips, this article aims to address the potential relationship between these individuals and the flows of exotic items in North Patagonia. We analyzed 54 enamel teeth for strontium isotopes and reconstructed their probable mobility using mixed-effect models and isotope-based geographic assignments. We inferred population and individual mobility trends and compared them against the flow of exotic items built from a standardized compilation. Our results indicate that most individuals have isotopic composition compatible with residence within their burial and surrounding areas. However, a few individuals show isotopic composition incompatible with their burial areas, which suggests axes -from the burial location to the most likely isotope integration area- of extraordinary mobility. At the same time, the flows of exotic items overlap with these axes around the eastern sector of the study area suggesting that this location could have been a central point of convergence for people and items. We argue that small-scale socially driven mobility could have played a relevant role as a general mechanism of interaction that fostered and materialized Patagonian interaction networks during the Late Holocene

The solar wind disappearance event of 11 May 1999: source region evolution

Context. A recent, detailed study of the well-known solar wind disappearance event of 11 May 1999 traced its origin to a coronal hole (CH) lying adjacent to a large active region (AR), AR8525 in Carrington rotation 1949. The AR was located at central meridian on 05 May 1999 when the flows responsible for this event began. We examine the evolution of the AR-CH complex during 5-6 May 1999 to study the changes that apparently played a key role in causing this disappearance event. Aims. To study the evolution of the solar source region of the disappearance event of 11 May 1999. Methods. Using images from the Soft X-ray Telescope (SXT), the Extreme-ultraviolet Imaging Telescope (EIT) and the Michelson Doppler Imager (MDI) to examine the evolution of the CH and AR complex at the source region of the disappearance event. Results. We find a dynamic evolution taking place in the CH-AR boundary at the source region of the disappearance event of 11 May 1999. This evolution, which is found to reduce the area of the CH, is accompanied by the formation of new loops in EUV images that are spatially and temporally correlated with emerging flux regions as seen in MDI data. Conclusions. In the period leading up to the disappearance event of 11 May 1999, our observations, during quiet solar conditions and in the absence of CMEs, provide the first clear evidence for Sun-Earth connection originating from an evolving AR-CH region located at central meridian. With the exception of corotating interacting regions (CIR), these observations provide the first link between the Sun and space weather effects at 1 AU, arising from non-explosive solar events.Comment: The paper has recently been accepted in A&A letters and this version is an 8 page article with 4 figure

Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer: a phase III randomised study

BACKGROUND:10%-15% of early-stage colon cancers harbour either deficient mismatch repair (dMMR), microsatellite instability high (MSI-H) or POLE exonuclease domain mutations, and are characterised by high tumour mutational burden and increased lymphocytic infiltrate. Metastatic dMMR colon cancers are highly sensitive to immune checkpoint inhibition, and recent data show POLE-mutant tumours are similarly responsive. We are conducting a phase III randomised trial to determine if the addition of the anti-PD-L1 antibody avelumab following adjuvant chemotherapy improves disease-free survival (DFS) in patients with stage III dMMR/MSI-H or POLE mutant colon cancer and is a cost-effective approach for the UK National Health Service (NHS). METHODS:We are recruiting patients with completely resected, stage III colon cancer confirmed to have dMMR/MSI-H, locally or POLE exonuclease domain mutation on central testing. Eligible patients are randomised in a 1:1 ratio to standard fluoropyrimidine-based chemotherapy (capecitabine, oxaliplatin for 12 weeks or capecitabine for 24 weeks) or chemotherapy, followed by avelumab (10 mg/kg, 2 weekly for 24 weeks). Stratification is by chemotherapy received and MMR/MSI-H status. The primary endpoint is DFS. Secondary endpoints include overall survival, toxicity, quality of life and health resource use. The 3-year DFS rate in the control arm is expected to be ~75%. Avelumab is expected to improve the 3-year DFS rate by 12% (ie, 87%). Target accrual is 402 patients, which provides 80% power to detect an HR of 0.48 for DFS at a two-sided alpha of 0.05. This national, multicentre phase III trial is sponsored by the Royal Marsden NHS Foundation Trust and it is anticipated that approximately 40 centres in the UK will participate. This study opened to recruitment in August 2018. TRIAL REGISTRATION NUMBER:NCT03827044

Maturity model of building maintenance management for New Zealand’s state schools

In New Zealand (NZ), state school properties are owned by the Ministry of Education and operated by school managers with the assistance of external consultants. This study aims to explore relationships of key stakeholders to propose a set of improvement actions for building maintenance management (BMM) in NZ’s state schools. The research employed a sequential mixed-methods approach encompassing interviews with school managers at the exploratory stage and questionnaire surveys completed by school managers and the Ministry staff to identify the maturity level of BMM. The interviews’ findings were used to map roles and responsibilities of people involved in BMM and develop the measurement model used in this study. Based on data from the questionnaire, relationships among key stakeholders in BMM were examined using Partial Least Squares Structural Equation Modelling (PLS-SEM). The research hypotheses of correlation among the stakeholders were tested and validated. The questionnaire results were also analysed to identify the maturity level of stakeholders’ responsibilities in BMM. Suggestions were made for improving BMM for NZ’s state schools focusing on training programmes, reporting system, performance evaluation, and lesson sharing. The results could assist stakeholders to review their current BMM and identify the areas in need of improvement

Mental health screening using the MINI test in medical students

Introducción: Los trastornos de salud mental constituyen un problema prevalente en alumnos de educación superior, siendo los estudiantes de medicina una población especialmente vulnerable. Objetivos: Determinar la frecuencia de trastornos de salud mental en los alumnos de una escuela de medicina. Diseño: Estudio descriptivo, transversal. Institución: Escuela de Medicina, Universidad Católica Santo Toribio de Mogrovejo, Chiclayo, Lambayeque, Perú. Participantes: Alumnos de una escuela de medicina. Intervenciones: En el semestre académico 2010-I, se evaluó la frecuencia de trastornos de salud mental en los alumnos utilizando el test Mini International Neuropsychiatric Interview (MINI), validado en español, como método de tamizaje. Principales medidas de resultados: Frecuencia de problemas de salud mental. Resultados: Se evaluó 159 estudiantes, 94 del sexo femenino (59,1%) y 65 de sexo masculino (40,8%); la media de la edad fue de 18,6+/- 2,1 años; 35 alumnos (22%) tuvieron al menos un trastorno mental. Los diagnósticos más frecuentes fueron: episodio hipomaniaco pasado (16 alumnos; 10,2%), riesgo suicida (11; 6,9%), trastorno depresivo actual (9; 5,6%), trastorno de angustia actual (8; 5%), agorafobia (8; 5%). En 20 (12,6%) y 11 estudiantes (6,9%), respectivamente, algún profesional de la salud le había diagnosticado previamente ansiedad y depresión. Conclusiones: Los problemas de salud mental fueron frecuentes en esta población de estudiantes, siendo el episodio hipomaniaco pasado, el riesgo suicida y el episodio depresivo actual los más frecuentes.Introduction: Mental health disorders are prevalent in higher education students and medical students are especially vulnerable. Objectives: To determine mental health problems frequency in students of Medicine. Design: Descriptive, transversal study. Setting: School of Medicine, Universidad Catolica Santo Toribio de Mogrovejo, Chiclayo, Lambayeque, Peru. Participants: Medical students. Interventions: During the 2010-I academic semester, frequency of mental health problems were determined using the Mini International Neuropsychiatric Interview (MINI) test, validated in Spanish, as a screening test for mental health. Main outcome measures: Frequency of mental health problems. Results: From 159 students interviewed, 94 were women (59,1%) and 65 men (40,8%). Average age was 18,7+/- 2,1 years; 35 students (22%) had at least one mental disorder. There were 16 (10,2%) students with history of hypomania episode, 11 with suicide risk (6,9%), 9 with current depressive disorder (5,6%), 8 with agoraphobia (4,8%), 8 with current anxiety disorder (4,8%); 20 (12,6%) and 11 (6,9%) students respectively mentioned that a health care provider had previously diagnosed anxiety and depression. Conclusions: Mental health disorders were frequent in these medical students; past hypomania episode, suicidal risk and current depressive disorder were the most frequently diagnosed mental health disorders

Host Alternation Is Necessary to Maintain the Genome Stability of Rift Valley Fever Virus

Arthropod-borne viruses are transmitted among vertebrate hosts by insect vectors. Unusually, Rift Valley fever virus (RVFV) can also be transmitted by direct contacts of animals/humans with infectious tissues. What are the molecular mechanisms and evolutionary events leading to adopt one mode of transmission rather than the other? Viral replication is implied to be different in a vertebrate host and an invertebrate host. The alternating host cycle tends to limit virus evolution by adopting a compromise fitness level for replication in both hosts. To test this hypothesis, we used a cell culture model system to study the evolution of RVFV. We found that freeing RVFV from alternating replication in mammalian and mosquito cells led to large deletions in the NSs gene carrying the virulence factor. Resulting NSs-truncated viruses were able to protect mice from a challenge with a virulent RVFV. Thus, in nature, virulence is likely maintained by continuous alternating passages between vertebrates and insects. Thereby, depending on the mode of transmission adopted, the evolution of RVFV will be of major importance to predict the outcome of outbreaks