728 research outputs found
Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models
Suppose that we are interested in establishing simple, but reliable rules for predicting future t-year survivors via censored regression models. In this article, we present inference procedures for evaluating such binary classification rules based on various prediction precision measures quantified by the overall misclassification rate, sensitivity and specificity, and positive and negative predictive values. Specifically, under various working models we derive consistent estimators for the above measures via substitution and cross validation estimation procedures. Furthermore, we provide large sample approximations to the distributions of these nonsmooth estimators without assuming that the working model is correctly specified. Confidence intervals, for example, for the difference of the precision measures between two competing rules can then be constructed. All the proposals are illustrated with two real examples and their finite sample properties are evaluated via a simulation study
General Brane Geometries from Scalar Potentials: Gauged Supergravities and Accelerating Universes
We find broad classes of solutions to the field equations for d-dimensional
gravity coupled to an antisymmetric tensor of arbitrary rank and a scalar field
with non-vanishing potential. Our construction generates these configurations
from the solution of a single nonlinear ordinary differential equation, whose
form depends on the scalar potential. For an exponential potential we find
solutions corresponding to brane geometries, generalizing the black p-branes
and S-branes known for the case of vanishing potential. These geometries are
singular at the origin with up to two (regular) horizons. Their asymptotic
behaviour depends on the parameters of the model. When the singularity has
negative tension or the cosmological constant is positive we find
time-dependent configurations describing accelerating universes. Special cases
give explicit brane geometries for (compact and non-compact) gauged
supergravities in various dimensions, as well as for massive 10D supergravity,
and we discuss their interrelation. Some examples lift to give new solutions to
10D supergravity. Limiting cases with a domain wall structure preserve part of
the supersymmetries of the vacuum. We also consider more general potentials,
including sums of exponentials. Exact solutions are found for these with up to
three horizons, having potentially interesting cosmological interpretation. We
give several additional examples which illustrate the power of our techniques.Comment: 54 pages, 6 figures. Uses JHEP3. Published versio
Removing the Big Bang Singularity: The role of the generalized uncertainty principle in quantum gravity
The possibility of avoiding the big bang singularity by means of a
generalized uncertainty principle is investigated. In relation with this
matter, the statistical mechanics of a free-particle system obeying the
generalized uncertainty principle is studied and it is shown that the entropy
of the system has a finite value in the infinite temperature limit. It is then
argued that negative temperatures and negative pressures are possible in this
system. Finally, it is shown that this model can remove the big bang
singularity.Comment: 8 pages, Accepted for publication in Astrophysics & Space Scienc
Possible Supersymmetric Effects on Angular Distributions in Decays
We investigate the angular distributions of the rare B decay, , in general supersymmetric extensions of the standard
model. We consider the new physics contributions from the operators
in small invariant mass region of lepton pair. We show that the
azimuthal angle distribution of the decay can tell us the new physics effects
clearly from the behavior of the distribution, even if new physics does not
change the decay rate substantially from the standard model prediction
The transition form factors for semi-leptonic weak decays of in QCD sum rules
Within the Standard Model, we investigate the semi-leptonic weak decays of
. The various form factors of transiting to a single charmed
meson () are studied in the framework of the QCD sum rules.
These form factors fully determine the rates of the weak semi-leptonic decays
of and provide valuable information about the non-perturbative QCD
effects. Our results indicate that the decay rate of the semi-leptonic weak
decay mode is at order of .Comment: 28 pages, 6 figures, revised version to be published in Eur.Phys.J.
Global Fluctuation Spectra in Big Crunch/Big Bang String Vacua
We study Big Crunch/Big Bang cosmologies that correspond to exact world-sheet
superconformal field theories of type II strings. The string theory spacetime
contains a Big Crunch and a Big Bang cosmology, as well as additional
``whisker'' asymptotic and intermediate regions. Within the context of free
string theory, we compute, unambiguously, the scalar fluctuation spectrum in
all regions of spacetime. Generically, the Big Crunch fluctuation spectrum is
altered while passing through the bounce singularity. The change in the
spectrum is characterized by a function , which is momentum and
time-dependent. We compute explicitly and demonstrate that it arises
from the whisker regions. The whiskers are also shown to lead to
``entanglement'' entropy in the Big Bang region. Finally, in the Milne orbifold
limit of our superconformal vacua, we show that and, hence, the
fluctuation spectrum is unaltered by the Big Crunch/Big Bang singularity. We
comment on, but do not attempt to resolve, subtleties related to gravitational
backreaction and light winding modes when interactions are taken into account.Comment: 68 pages, 1 figure; typos correcte
Depletion of Trp53 and Cdkn2a does not promote self-renewal in the mammary gland but amplifies proliferation induced by TNF-α
Dermatology-oncolog
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (β-site amyloid precursor protein-cleaving enzyme 1), which regulates production of toxic amyloid peptides. However, whether BACE1 also plays a role in glucose homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1−/− mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild-type littermates. BACE1−/− mice are also protected from diet-induced obesity. BACE1-deficient skeletal muscle and liver exhibit improved insulin sensitivity. In a skeletal muscle cell line, BACE1 inhibition increased glucose uptake and enhanced insulin sensitivity. The loss of BACE1 is associated with increased levels of UCP1 (uncoupling protein 1) in BAT (brown adipose tissue) and UCP2 and UCP3 mRNA in skeletal muscle, indicative of increased uncoupled respiration and metabolic inefficiency. Thus BACE1 levels may play a critical role in glucose and lipid homoeostasis in conditions of chronic nutrient excess. Therefore strategies that ameliorate BACE1 activity may be important novel approaches for the treatment of diabetes
Asymmetric Dark Matter and Dark Radiation
Asymmetric Dark Matter (ADM) models invoke a particle-antiparticle asymmetry,
similar to the one observed in the Baryon sector, to account for the Dark
Matter (DM) abundance. Both asymmetries are usually generated by the same
mechanism and generally related, thus predicting DM masses around 5 GeV in
order to obtain the correct density. The main challenge for successful models
is to ensure efficient annihilation of the thermally produced symmetric
component of such a light DM candidate without violating constraints from
collider or direct searches. A common way to overcome this involves a light
mediator, into which DM can efficiently annihilate and which subsequently
decays into Standard Model particles. Here we explore the scenario where the
light mediator decays instead into lighter degrees of freedom in the dark
sector that act as radiation in the early Universe. While this assumption makes
indirect DM searches challenging, it leads to signals of extra radiation at BBN
and CMB. Under certain conditions, precise measurements of the number of
relativistic species, such as those expected from the Planck satellite, can
provide information on the structure of the dark sector. We also discuss the
constraints of the interactions between DM and Dark Radiation from their
imprint in the matter power spectrum.Comment: 22 pages, 5 figures, to be published in JCAP, minor changes to match
version to be publishe
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