Numerical simulations of kink instability in line-tied coronal loops

The results from numerical simulations carried out using a new shock-capturing, Lagrangian-remap, 3D MHD code, Lare3d are presented. We study the evolution of the m=1 kink mode instability in a photospherically line-tied coronal loop that has no net axial current. During the non-linear evolution of the kink instability, large current concentrations develop in the neighbourhood of the infinite length mode rational surface. We investigate whether this strong current saturates at a finite value or whether scaling indicates current sheet formation. In particular, we consider the effect of the shear, defined by where is the fieldline twist of the loop, on the current concentration. We also include a non-uniform resistivity in the simulations and observe the amount of free magnetic energy released by magnetic reconnection

Charge State Evolution in the Solar Wind. II. Plasma Charge State Composition in the Inner Corona and Accelerating Fast Solar Wind

In the present work, we calculate the evolution of the charge state distribution within the fast solar wind. We use the temperature, density, and velocity profiles predicted by Cranmer et al. to calculate the ionization history of the most important heavy elements in the solar corona and solar wind: C, N, O, Ne, Mg, Si, S, and Fe. The evolution of each charge state is calculated from the source region in the lower chromosphere to the final freeze-in point. We show that the solar wind velocity causes the plasma to experience significant departures from equilibrium at very low heights, well inside the field of view (within 0.6 R sun from the solar limb) of nearly all the available remote-sensing instrumentation, significantly affecting observed spectral line intensities. We also study the evolution of charge state ratios with distance from the source region, and the temperature they indicate if ionization equilibrium is assumed. We find that virtually every charge state from every element freezes in at a different height, so that the definition of freeze-in height is ambiguous. We also find that calculated freeze-in temperatures indicated by charge state ratios from in situ measurements have little relation to the local coronal temperature of the wind source region, and stop evolving much earlier than their correspondent charge state ratio. We discuss the implication of our results on plasma diagnostics of coronal holes from spectroscopic measurements as well as on theoretical solar wind models relying on coronal temperatures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98586/1/0004-637X_761_1_48.pd

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

Background: Psychological distress (PD) has a major impact on quality of life. We studied the incidence of PD before and after radiotherapy for painful bone metastases. Furthermore, we aimed to identify factors predictive for PD.Methods: Between 1996 and 1998, the Dutch Bone Metastasis Study included 1157 patients with painful bone metastases. Patients were randomized between two fractionation schedules. The study showed a pain response of 74% in both groups. Patients filled out weekly questionnaires for 13 weeks, then monthly for two years. The questionnaires included a subscale for PD on the Rotterdam Symptom Checklist. We used generalized estimating equations and multivariable logistic regression analyses.Results: At baseline, 290 patients (27%) had a high level of PD. For the entire group, the level of PD remained constant over time. The majority of patients with a low level of PD at baseline remained at a low level during follow-up. In patients with a high level of PD at baseline, the mean level of PD decreased after treatment and stabilized around the cutoff level. Female patients, higher age, worse performance, lower pain score and worse self-reported QoL were associated with an increased chance of PD, although the model showed moderate discriminative power.Conclusions: A substantial proportion of patients had a high level of PD before and after radiotherapy for painful bone metastases. Most patients who reported high levels of PD when referred for palliative radiotherapy remained at high levels thereafter. Therefore, screening of PD prior to treatment seems appropriate, in order to select patients requiring intervention.</p

The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial

Objective To determine whether early initiated anti-inflammatory therapy with prolonged high dose inhaled glucocorticoids influences the occurrence and severity of recurrent wheeze after respiratory syncytial virus related lower respiratory tract infections

Solar winds along curved magnetic field lines

Both remote-sensing measurements using the interplanetary scintillation (IPS) technique and in situ measurements by the Ulysses spacecraft show a bimodal structure for the solar wind at solar minimum conditions. At present what makes the fast wind fast and the slow wind slow still remains to be answered. While a robust empirical correlation exists between the coronal expansion rate $f_c$ of the flow tubes and the speeds $v$ measured in situ, further data analysis suggests that $v$ depends on more than just $f_c$. We examine whether the non-radial shape of field lines, which naturally accompanies any non-radial expansion, could be an additional geometrical factor. We solved the transport equations incorporating the heating due to turbulent Alfv\'en waves for an electron-proton solar wind along curved field lines given by an analytical magnetic field model, representative of a solar minimum corona. The field line shape is found to influence substantially the solar wind parameters, reducing the asymptotic speed by up to $\sim 130$ km s$^{-1}$, or by $\sim 28$ in relative terms, compared with the case neglecting the field line curvature. This effect was interpreted in the general framework of energy addition in the solar wind: Relative to the straight case, the field line curvature enhances the effective energy deposition to the subsonic flow, resulting in a higher proton flux and a lower terminal proton speed. Our computations suggest that the field line curvature could be a geometrical factor which, in addition to the tube expansion, substantially influences the solar wind speed. Furthermore, at solar minima although the field line curvature unlikely affects the polar fast solar wind, it does help make the wind at low latitudes slow, thereby helping better reproduce the Ulysses measurements.Comment: 7 pages, 3 figures, accepted by Astronomy and Astrophysic

The Possibility of Thermal Instability in Early-Type Stars Due to Alfven Waves

It was shown by dos Santos et al. the importance of Alfv\'en waves to explain the winds of Wolf-Rayet stars. We investigate here the possible importance of Alfv\'en waves in the creation of inhomogeneities in the winds of early-type stars. The observed infrared emission (at the base of the wind) of early-type stars is often larger than expected. The clumping explains this characteristic in the wind, increasing the mean density and hence the emission measure, making possible to understand the observed infrared, as well as the observed enhancement in the blue wing of the $H_\alpha$ line. In this study, we investigate the formation of these clumps a via thermal instability. The heat-loss function used, $H(T,n)$, includes physical processes such as: emission of (continuous and line) recombination radiation; resonance line emission excited by electron collisions; thermal bremsstrahlung; Compton heating and cooling; and damping of Alfv\'en waves. As a result of this heat-loss function we show the existence of two stable equilibrium regions. The stable equilibrium region at high temperature is the diffuse medium and at low temperature the clumps. Using this reasonable heat-loss function, we show that the two stable equilibrium regions can coexist over a narrow range of pressures describing the diffuse medium and the clumps.Comment: 21 pages (psfig.sty), 5 figures (included), ApJ accepted. Also available at http://www.iagusp.usp.br/preprints/preprint.htm

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

Paul Verweij and colleagues show that azole resistance has emerged inAspergillus fumigatus in The Netherlands and that a dominant resistance mechanism is present in clinical isolates

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age