EVALUATION OF RIGHT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH CHRONIC BRONCHOPULMONARY PATHOLOGY

Background Early recognition of right ventricular (RV) failure in patients with chronic lung diseases is still challenging. In this regard, the study of RV diastolic function as an early marker of subclinical RV dysfunction is of significant practical interest.Objective We sought to evaluate the influence of chronic lung pathology and age on the RV relaxation properties and to identify the criteria for differential diagnosis of age-related changes in RV diastolic function and increased myocardial stiffness in case of chronic lung disease.Material and Methods This was a study of 80 patients aged 31 to 68 (40 patients with chronic lung  pathology and 40 healthy controls) being treated at the Research Institute – Ochapovsky Regional Hospital no. 1. All subjects underwent echocardiography with transtricuspidal and transmitral blood flow assessment and spectral tissue Doppler of the mitral and tricuspid annuli.Results 32 (80%) patients with lung disease demonstrated RV diastolic dysfunction. Of them, 18 (81%) patients are older than 60 years, and 14 (78%) patients are younger than 60 years. The indicators of RV filling were significantly lower compared to the control group not only in older patients but also in patients < 60.Conclusion The majority of patients with chronic lung pathology exhibited impaired RV diastolic function.The RV diastolic function was detected more often in older patients, but it also occurred in patients of the middle age group. Thus, we arrive at the conclusion that the RV myocardial stiffness is being increased in the  case of chronic lung diseases

The Interrelationship between Coping Strategies and Socio-Psychological Competency of University Students’ Personality

In contemporary society characterized by socio-economic and political instability, the problem of studying the factors and mechanisms that contribute to the constructive resolution of life difficulties and counteracting their negative consequences is very important. This paper contains the results of an empirical study of the characteristics and relationships of students’ coping behavior with different levels of their socio-psychological competency. The research methods comprised the following: theoretical analysis, empirical research (testing), qualitative analysis of the obtained data, mathematical and statistical data processing (SPSS Statistics, Excel). The characteristics of indicators of socio-psychological competency were determined with the use of the technique for assessing socio-communicative competency, as well as a questionnaire that reveals the possibility of using socio-psychological skills by a person in difficult life situations. To study coping behavior, the following were used: “The ways of coping questionnaire” and “The youth coping scale”. The validity and reliability of the research results was ensured by the initial methodological positions, the use of tested tools, representativeness of the research sample, as well as mathematical processing of data with the help of software package for statistical analysis. The conclusions have been drawn that the basis of constructive mechanisms to overcome difficult life situations is a high level of formation of professional skills and abilities, introversion, motivation to achieve success, high intellectual development, moral standards, a high level of development of communication skills. It is these mechanisms that make it possible to resolve problem situations and tasks at work in a productive way. Their absence or a low level of development contributes to the dominance of situational methods of overcoming difficult life situations that impede professional formation and personal development

Experimental studies of energy characteristics of mixer with deformable camera

Currently the development of new machine designs and methods of their engineering calculation is one of the most priority areas of construction industry. It allows one to carry out research at the stage of theoretical calculations in order to predict the expected result. One of the promising constructive solutions for economic profitability increase of mixing equipment is the use of deformable working chamber

Diamond-inclusion system recording old deep lithosphere conditions at Udachnaya (Siberia)

Diamonds and their inclusions are unique fragments of deep Earth, which provide rare samples from inaccessible portions of our planet. Inclusion-free diamonds cannot provide information on depth of formation, which could be crucial to understand how the carbon cycle operated in the past. Inclusions in diamonds, which remain uncorrupted over geological times, may instead provide direct records of deep Earth’s evolution. Here, we applied elastic geothermobarometry to a diamond-magnesiochromite (mchr) host-inclusion pair from the Udachnaya kimberlite (Siberia, Russia), one of the most important sources of natural diamonds. By combining X-ray diffraction and Fourier-transform infrared spectroscopy data with a new elastic model, we obtained entrapment conditions, Ptrap = 6.5(2) GPa and Ttrap = 1125(32)–1140(33) °C, for the mchr inclusion. These conditions fall on a ca. 35 mW/m2 geotherm and are colder than the great majority of mantle xenoliths from similar depth in the same kimberlite. Our results indicate that cold cratonic conditions persisted for billions of years to at least 200 km in the local lithosphere. The composition of the mchr also indicates that at this depth the lithosphere was, at least locally, ultra-depleted at the time of diamond formation, as opposed to the melt-metasomatized, enriched composition of most xenoliths

Влияние гуминовых веществ угля и биокомпозиций с наночастицами серебра на их основе на баланс аргинина в перитонеальных макрофагах интактных мышей

Background. Antigen-presenting cells (APCs), especially macrophages, play an important role in the body defense against various pathogens. Their dysfunction and polarization are associated with most inflammatory and autoimmune diseases. The inflammatory process is regulated by activation and / or inhibition of genes differentially expressed by macrophages. Successful correction of inflammation leads firstly to elimination of inflammatory stimuli and then to remodeling and restoration of tissues and organs. It was experimentally confirmed that silvercontaining bionanocomposites based on natural humic substances (HS) obtained from coal of different origin, as well as initial matrices of these HS, are capable of activating pro- and anti-inflammatory properties of macrophages.Aim. To study cytotoxic, pyrogenic, and immunomodulatory properties (arginine balance) of initial HS samples and samples of silver nanoparticles ultradispersed in these HS matrices (HS-AgNPs) in the cell culture of peritoneal macrophages, as well as their effect on pro- and anti-inflammatory properties of APCs.Materials and methods. Cultural and biochemical methods were used in the study.Results. The study showed that the samples CHE-K, CHE-AgNPs, CHS-K, and CHP-K increased M1 macrophage polarization due to stimulation of the NO-synthase activity and inhibition of arginase. The samples CHI-K, CHIAgNPs, CHP-AgNPs, and CHS-AgNPs modulated an alternative M2 or M2-like state of macrophage activation. At the same time, HS are not cytotoxic at effective concentrations, and three out of four studied samples did not contain pyrogenic impurities.Conclusion. The use of HS and their silver-containing bionanocomposites, which have the ability to greatly affect the polarization of antigen-presenting cells, is a promising research area in correction of the inflammatory response for solving an important social and medical problem of treating chronic wounds. Введение. Антигенпрезентирующие клетки, особенно макрофаги, играют важную роль в защите организма от различных патогенов, их дисфункции, и поляризация связана с большинством воспалительных и аутоиммунных заболеваний. Воспалительный процесс жестко регулируется активацией и (или) ингибированием дифференциально экспрессируемых макрофагами генов. Успешная коррекция воспалительного процесса приводит к устранению воспалительных стимулов и далее ремоделированию и восстановлению тканей и органов. Экспериментально доказано, что биокомпозиции с наночастицами серебра на основе природных гуминовых веществ (ГВ) угля различного генеза, а также исходные матрицы данных ГВ способны активировать про- и противовоспалительные свойства макрофагов.Цель. Исследование в культуре клеток перитонеальных макрофагов цитотоксических, пирогенных и иммуномодулирующих свойств (баланс аргинина) исходных образцов ГВ и образцов наночастиц серебра, ультрадиспергированных в данных матрицах гуминовых веществ (ГВ-AgNPs),а также их влияния на про- и противовоспалительные свойства антигенпрезентирующих клеток. Материалы и методы. Использовались культуральные и биохимические методы.Результаты. Показано, что образцы CHE-K, CHE-AgNPs, CHS-K, CHP-K за счет усиления активности NOсинтазы и ингибиции аргиназы способствуют поляризации перитонеальных макрофагов по классическому типу (М1). Образцы CHI-K, CHI-AgNPs, CHP-AgNPs и CHS-AgNPs модулируют альтернативный М2 или M2-подобный тип (M2-like state) активации макрофагов. При этом ГВ не цитотоксичны в эффективных концентрациях, а также три из четырех исследуемых образцов не содержат пирогенных примесей.Заключение. Применение ГВ и серебросодержащих бионанокомпозиций на основе ГВ, обладающих способностью широко влиять на поляризацию антигенпрезентирующих клеток, является перспективным направлением исследований коррекции воспалительной реакции и, в частности, для решения острой социальной и медицинской проблемы – лечения хронических ран.

Crna Prst und Terglou-Seen : Touristische und botanische Notizen

Diamond is a material of immense technological importance and an ancient signifier for wealth and societal status. In geology, diamond forms as part of the deep carbon cycle and typically displays a highly ordered cubic crystal structure. Impact diamonds, however, often exhibit structural disorder in the form of complex combinations of cubic and hexagonal stacking motifs. The structural characterization of such diamonds remains a challenge. Here, impact diamonds from the Popigai crater were characterized with a range of techniques. Using the MCDIFFaX approach for analysing X-ray diffraction data, hexagonality indices up to 40% were found. The effects of increasing amounts of hexagonal stacking on the Raman spectra of diamond were investigated computationally and found to be in excellent agreement with trends in the experimental spectra. Electron microscopy revealed nanoscale twinning within the cubic diamond structure. Our analyses lead us to propose a systematic protocol for assigning specific hexagonality attributes to the mineral designated as lonsdaleite among natural and synthetic samples

Organic matter from Artic sea ice loss alters bacterial community structure and function

Continuing losses of multi-year sea ice (MYI) across the Arctic are resulting in first-year ice (FYI) dominating the Arctic ice pack. Melting FYI provides a strong seasonal pulse of dissolved organic matter (DOM) into surface waters; however, the biological impact of this DOM input is unknown. Here we show that DOM additions cause significant and contrasting changes in under-ice bacterioplankton abundance, production and species composition. Utilization of DOM was influenced by molecular size, with 10-100 kDa and >100 kDa DOM fractions promoting rapid growth of particular taxa, while uptake of sulfur and nitrogen-rich low molecular weight organic compounds shifted bacterial community composition. These results demonstrate the ecological impacts of DOM released from melting FYI, with wideranging consequences for the cycling of organic matter across regions of the Arctic Ocean transitioning from multi-year to seasonal sea ice as the climate continues to warm

Polarization features of acoustic spectra in Uniaxial and biaxial nematic liquid crystals

yesThe results of investigation of uniaxial and biaxial nematic liquid crystals dynamics with molecules of the various forms are presented. These condensed matters possess internal spatial anisotropy and for their adequate description introduction of additional dynamic quantities is necessary. They are vectors of spatial anisotropy and conformational degrees of freedom. Investigation of dynamics of the given condensed matters is based on Hamiltonian formalism in which framework the nonlinear dynamic equations for uniaxial and biaxial nematic liquid crystals are derivedBelgorod State Universit

Polarization features of acoustic spectra in Uniaxial and biaxial nematic liquid crystals

The results of investigation of uniaxial and biaxial nematic liquid crystals dynamics with molecules of the various forms are presented. These condensed matters possess internal spatial anisotropy and for their adequate description introduction of additional dynamic quantities is necessary. They are vectors of spatial anisotropy and conformational degrees of freedom. Investigation of dynamics of the given condensed matters is based on Hamiltonian formalism in which framework the nonlinear dynamic equations for uniaxial and biaxial nematic liquid crystals are derivedyesBelgorod State Universit