Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells

Nano-sized metal oxides are currently the most manufactured nanomaterials (NMs), and are increasingly used in consumer products. Recent exposure data reveal a genuine potential for adverse health outcomes for a vast array of NMs, however the underlying mechanisms are not fully understood. To elucidate size-related molecular effects, differentiated THP-1 cells were exposed to nano-sized materials (n-TiO2, n-ZnO and n-Ag), or their bulk-sized (b-ZnO and b-TiO2) or ionic (i-Ag) counterparts, and genome-wide gene expression changes were studied at low-toxic concentrations (Peer reviewe

Variation of Absorption Angstrom Exponent in Aerosols From Different Emission Sources

The absorption Angstrom exponent (AAE) describes the spectral dependence of light absorption by aerosols. AAE is typically used to differentiate between different aerosol types for example., black carbon, brown carbon, and dust particles. In this study, the variation of AAE was investigated mainly in fresh aerosol emissions from different fuel and combustion types, including emissions from ships, buses, coal-fired power plants, and residential wood burning. The results were assembled to provide a compendium of AAE values from different emission sources. A dual-spot aethalometer (AE33) was used in all measurements to obtain the light absorption coefficients at seven wavelengths (370-950 nm). AAE(470/950) varied greatly between the different emission sources, ranging from -0.2 +/- 0.7 to 3.0 +/- 0.8. The correlation between the AAE(470/950) and AAE(370-950) results was good (R-2 = 0.95) and the mean bias error between these was 0.02. In the ship engine exhaust emissions, the highest AAE(470/950) values (up to 2.0 +/- 0.1) were observed when high sulfur content heavy fuel oil was used, whereas low sulfur content fuels had the lowest AAE(470/950) (0.9-1.1). In the diesel bus exhaust emissions, AAE(470/950) increased in the order of acceleration (0.8 +/- 0.1), deceleration (1.1 +/- 0.1), and steady driving (1.2 +/- 0.1). In the coal-fired power plant emissions, the variation of AAE(470/950) was substantial (from -0.1 +/- 2.1 to 0.9 +/- 1.6) due to the differences in the fuels and flue gas cleaning conditions. Fresh wood-burning derived aerosols had AAE(470/950) from 1.1 +/- 0.1 (modern masonry heater) to 1.4 +/- 0.1 (pellet boiler), lower than typically associated with wood burning, while the burn cycle phase affected AAE variation.Peer reviewe

Economic and environmental analysis of energy efficiency measures in agriculture. Case Studies and trade offs.

This report is the result of the collaboration of the partners of the AGREE work-package “Economic and environmental analysis”, which is based on case study analyses of the partners in seven countries of the EU. The case studies show economic and environmental trade-offs in the different regions in the EU, for which each partner is responsible. Nevertheless prior to the reporting of the case studies an intensive discussion on a common methodological approach has been accomplished and applied to the case studies. The case studies show a wide range of different perspectives of energy efficiency in agriculture, but they are all based on the common methodology presented in Chapter 3. In Chapter 4, the case studies are presented, with authors indicated at the beginning of each section. Each section of Chapter 4 ends with a synthesis analysis of the results from the different case studies. Chapter 5 summarizes and concludes the report by highlighting the major findings of the analyses. The report builds upon the “State of the Art in Energy Efficiency in Europe” published separately by the AGREE consortium (Gołaszewski et al. 2012), which shows the status quo of energy use and possible energy efficiency measures in agriculture across different production systems and regions in Europe. This report presents an economic and environmental analysis based on in-depth case studies which show the potential for, and constraints on, energy efficiency measures in agriculture with respect to the specific environments in Europe

Photocatalytic Decomposition of Formic Acid on Mo2C-Containing Catalyst

Soluble components in the peripheral blood from experimental exposure of 14 healthy subjects to filtered air and wood smoke. Samples were collected before (pre), at 24 h and 44 h after exposure, to air and wood smoke. Data are given as medians with interquartile range. (DOCX 62 kb

Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions

Background: Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses to combustion particles include oxidative stress and inflammatory signalling. Objectives: To provide a molecular link between the chemical and physical characteristics of ship emission particles and the cellular responses they elicit and to identify potentially harmful fractions in shipping emission aerosols. Methods: Through an air-liquid interface exposure system, we exposed human lung cells under realistic in vitro conditions to exhaust fumes from a ship engine running on either common heavy fuel oil (HFO) or cleaner-burning diesel fuel (DF). Advanced chemical analyses of the exhaust aerosols were combined with transcriptional, proteomic and metabolomic profiling including isotope labelling methods to characterise the lung cell responses. Results: The HFO emissions contained high concentrations of toxic compounds such as metals and polycyclic aromatic hydrocarbon, and were higher in particle mass. These compounds were lower in DF emissions, which in turn had higher concentrations of elemental carbon (“soot”). Common cellular reactions included cellular stress responses and endocytosis. Reactions to HFO emissions were dominated by oxidative stress and inflammatory responses, whereas DF emissions induced generally a broader biological response than HFO emissions and affected essential cellular pathways such as energy metabolism, protein synthesis, and chromatin modification. Conclusions: Despite a lower content of known toxic compounds, combustion particles from the clean shipping fuel DF influenced several essential pathways of lung cell metabolism more strongly than particles from the unrefined fuel HFO. This might be attributable to a higher soot content in DF. Thus the role of diesel soot, which is a known carcinogen in acute air pollution-induced health effects should be further investigated. For the use of HFO and DF we recommend a reduction of carbonaceous soot in the ship emissions by implementation of filtration devices

Comparative analysis of muon-capture and 0νββ-decay matrix elements

Average matrix elements of ordinary muon capture (OMC) to the intermediate nuclei of neutrinoless double beta (0νββ) decays of current experimental interest are computed and compared with the corresponding energy and multipole decompositions of 0νββ-decay nuclear matrix elements (NMEs). The present OMC computations are performed using the Morita-Fujii formalism by extending the original formalism beyond the leading order. The 0νββ NMEs include the appropriate short-range correlations, nuclear form factors, and higher-order nucleonic weak currents. The nuclear wave functions are obtained in extended no-core single-particle model spaces using the spherical version of the proton-neutron quasiparticle random-phase approximation with two-nucleon interactions based on the Bonn one-boson-exchange G matrix. Both the OMC and 0νββ processes involve 100-MeV-range momentum exchanges and hence similarities could be expected for both processes in the feeding of the 0νββ intermediate states. These similarities may help improve the accuracy of the 0νββ NME calculations by using the data from the currently planned OMC experiments.peerReviewe

Muon-capture strength functions in intermediate nuclei of 0νββ decays

Capture rates of ordinary muon capture (OMC) to the intermediate nuclei of neutrinoless double beta (0νββ) decays of current experimental interest are computed. The corresponding OMC (capture-rate) strength functions have been analyzed in terms of multipole decompositions. The computed low-energy OMC-rate distribution to 76 As is compared with the available data of Zinatulina et al. [Phys. Rev. C 99, 024327 (2019)]. The present OMC computations are performed using the Morita-Fujii formalism by extending the original formalism beyond the leading order. The participant nuclear wave functions are obtained in extended no-core single-particle model spaces using the spherical version of proton-neutron quasiparticle random-phase approximation (pnQRPA) with two-nucleon interactions based on the Bonn one-boson-exchange G matrix. The Hamiltonian parameters are taken from our earlier work [Jokiniemi et al., Phys. Rev. C 98, 024608 (2018)], except for A = 82 nuclei for which the parameters were determined in this work. Both the OMC and 0νββ decays involve momentum exchanges of the order of 100 MeV and thus future measurements of the OMC strength functions for 0νββ daughter nuclei help trace the in-medium renormalization of the weak axial couplings with the aim to improve the accuracy of the 0νββ-decay nuclear matrix elements.peerReviewe

Strong dependence between phytoplankton and water chemistry in a large temperate lake: spatial and temporal perspective

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