A Managerial View of Translational Medicine

Translational Medicine principal goal is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. In order to achieve this purpose, translational medicine calls for a synergy between epidemiology, basic research and clinical trials, and is strongly based upon innovation management and research development in medicine. For this reason a managerial view of translational medicine is particularly prolific in terms of insights for researchers and clinicians who place efforts to improve health service

Toward Open Integrated Access and Backhaul with O-RAN

Millimeter wave (mmWave) communications has been recently standardized for use in the fifth generation (5G) of cellular networks, fulfilling the promise of multi-gigabit mobile throughput of current and future mobile radio network generations. In this context, the network densification required to overcome the difficult mmWave propagation will result in increased deployment costs. Integrated Access and Backhaul (IAB) has been proposed as an effective mean of reducing densification costs by deploying a wireless mesh network of base stations, where backhaul and access transmissions share the same radio technology. However, IAB requires sophisticated control mechanisms to operate efficiently and address the increased complexity. The Open Radio Access Network (RAN) paradigm represents the ideal enabler of RAN intelligent control, but its current specifications are not compatible with IAB. In this work, we discuss the challenges of integrating IAB into the Open RAN ecosystem, detailing the required architectural extensions that will enable dynamic control of 5G IAB networks. We implement the proposed integrated architecture into the first publiclyavailable Open-RAN-enabled experimental framework, which allows prototyping and testing Open-RAN-based solutions over end-to-end 5G IAB networks. Finally, we validate the framework with both ideal and realistic deployment scenarios exploiting the large-scale testing capabilities of publicly available experimental platforms

An Experimental mmWave Channel Model for UAV-to-UAV Communications

Unmanned Aerial Vehicle (UAV) networks can provide a resilient communication infrastructure to enhance terrestrial networks in case of traffic spikes or disaster scenarios. However, to be able to do so, they need to be based on high-bandwidth wireless technologies for both radio access and backhaul. With this respect, the millimeter wave (mmWave) spectrum represents an enticing solution, since it provides large chunks of untapped spectrum that can enable ultra-high data-rates for aerial platforms. Aerial mmWave channels, however, experience characteristics that are significantly different from terrestrial deployments in the same frequency bands. As of today, mmWave aerial channels have not been extensively studied and modeled. Specifically, the combination of UAV micro-mobility (because of imprecisions in the control loop, and external factors including wind) and the highly directional mmWave transmissions require ad hoc models to accurately capture the performance of UAV deployments. To fill this gap, we propose an empirical propagation loss model for UAV-to-UAV communications at 60 GHz, based on an extensive aerial measurement campaign conducted with the Facebook Terragraph channel sounders. We compare it with 3GPP channel models and make the measurement dataset publicly available.Comment: 7 pages, 7 figures, 3 tables. Please cite it as M. Polese, L. Bertizzolo, L. Bonati, A. Gosain, T. Melodia, An Experimental mmWave Channel Model for UAV-to-UAV Communications, in Proc. of ACM Workshop on Millimeter-Wave Networks and Sensing Systems (mmNets), London, UK, Sept. 202

Emergence in marketing: an institutional and ecosystem framework

Many core marketing concepts (e.g., markets, relationships, customer experience, brand meaning, value) concern phenomena that are difficult to understand using linear and dyadic approaches, because they are emergent. That is, they arise, often unpredictably, from interactions within complex and dynamic contexts. This paper contributes to the marketing discipline through an explication of the concept of emergence as it applies to marketing theory. We accomplish this by first drawing on the existing literature on emergence in philosophy, sociology, and the theory of complex adaptive systems, and then link and extend this understanding to marketing using the theoretical framework of service-dominant (S-D) logic, particularly as enhanced by its service-ecosystems and institutionalization perspectives. Our work recognizes both emergence and institutionalization as integral or interrelated processes in the creation, maintenance, and disruption of markets and marketing phenomena. We conclude by discussing implications for marketing research and practice

The CMS RPC gas gain monitoring system: an overview and preliminary results

The status of the CMS RPC Gas Gain Monitoring (GGM) system developed at the Frascati Laboratory of INFN (Istituto Nazionale di Fisica Nucleare) is reported on. The GGM system is a cosmic ray telescope based on small RPC detectors operated with the same gas mixture used by the CMS RPC system. The GGM gain and efficiency are continuously monitored on-line, thus providing a fast and accurate determination of any shift in working point conditions. The construction details and the first result of GGM commissioning are described.Comment: 8 pages, 9 figures, uses lnfprepCMS.sty, presented by L. Benussi at RPC07, Mumbai, INDIA 200

Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation.

It has been shown that γδ T cells protect against the formation of squamous cell carcinoma (SCC) in several models. However, the role of γδ T cells in human papillomavirus (HPV)-associated uterine cervical SCC, the third-leading cause of death by cancer in women, is unknown. Here, we investigated the impact of γδ T cells in a transgenic mouse model of carcinogenesis induced by HPV16 oncoproteins. Surprisingly, γδ T cells promoted the development of HPV16 oncoprotein-induced lesions. HPV16 oncoproteins induced a decrease in epidermal Skint1 expression and the associated antitumor Vγ5 <sup>+</sup> γδ T cells, which were replaced by γδ T-cell subsets (mainly Vγ6 <sup>+</sup> γδ <sup>low</sup> CCR2 <sup>+</sup> CCR6 <sup>-</sup> ) actively producing IL-17A. Consistent with a proangiogenic role, γδ T cells promoted the formation of blood vessels in the dermis underlying the HPV-induced lesions. In human cervical biopsies, IL-17A <sup>+</sup> γδ T cells could only be observed at the cancer stage (SCC), where HPV oncoproteins are highly expressed, supporting the clinical relevance of our observations in mice. Overall, our results suggest that HPV16 oncoproteins induce a reorganization of the local epithelial-associated γδ T-cell subpopulations, thereby promoting angiogenesis and cancer development

Sleeve Gastrectomy-Induced Body Mass Index Reduction Increases the Intensity of Taste Perception’s and Reduces Bitter-Induced Pleasantness in Severe Obesity

Background: The sense of taste is involved in food behavior and may drive food choices, likely contributing to obesity. Differences in taste preferences have been reported in normal-weight as compared to obese subjects. Changes in taste perception with an increased sweet-induced sensitivity have been reported in surgically treated obese patients, but data regarding the perception of basic tastes yielded conflicting results. We aimed to evaluate basic taste identification, induced perception, and pleasantness in normal-weight controls and obese subjects before and after bariatric surgery. Methods: Severe obese and matched normal weight subjects underwent a standardized spit test to evaluate sweet, bitter, salty, umami, and sour taste identification, induced perception, and pleasant-ness. A subset of obese subjects were also studied before and 12 months after sleeve gastrectomy. Results: No significant differences in basic taste-induced perceptions were observed, although a higher number of controls correctly identified umami than did obese subjects. Sleeve-gastrectomy-induced weight loss did not affect the overall ability to correctly identify basic tastes but was associated with a significant increase in taste intensities, with higher scores for sour and bitter, and a significantly reduced bitter-induced pleasantness. Conclusions: The perception of basic tastes is similar in normal-weight and severely obese subjects. Sleeve-gastrectomy-induced weight loss significantly increases basic taste-induced intensity, and selectively reduces bitter-related pleasantness without affecting the ability to identify the tastes. Our findings reveal that taste perception is influenced by body mass index changes, likely supporting the hypothesis that centrally mediated mechanisms modulate taste perception in severe obesity

Gas Analysis and Monitoring Systems for the RPC Detector of CMS at LHC

The Resistive Plate Chambers (RPC) detector of the CMS experiment at the LHC proton collider (CERN, Switzerland) will employ an online gas analysis and monitoring system of the freon-based gas mixture used. We give an overview of the CMS RPC gas system, describe the project parameters and first results on gas-chromatograph analysis. Finally, we report on preliminary results for a set of monitor RPC.Comment: 9 pages, 8 figures. Presented by Stefano Bianco (Laboratori Nazionali di Frascati dell'INFN) at the IEEE NSS, San Diego (USA), October 200

I Say “no”. You Say “it Isn't”. About a New Understanding of the Concept of Negation

Introduction: In our opinion there is still confusion about the exact meaning of the term negation. As a consequence of this the importance of negation in the psychotherapeutic work is until now underestimated. Objectives For psychiatrists who work according to Fagioli's human birth theory the concept of negation is fundamental. Negation is a notion that refers to unconscious reality. Aims: The task of the psychiatrist is to identify and to interpret the negation in the deformed dream images during the psychotherapeutic process. Methods: In contrast to an intentional lie, which is communicated through verbal speech, negation corresponds to unconscious thoughts, which we can find in dreams. During sleep a transformation occurs, language is altered and expressed through images. Negation deforms the image. This deformation of the image happens in an unconscious process. This negation distorts the reality of the patient and his ability to interact with the other. Corresponding the relationship will be aggressive/destructive. The only way to identify this deformation is dream interpretation. Results: Through this therapeutic process the patient will be able to intuit and realize instead of negate the positive qualities of the other and integrate these into his reality. Only human interaction that is free from negation enable the patient to overcome the ideo-affective splitting, which allows recovery of positive affects and the possibility of developing evolutive relationships. Conclusions: Only a clarification of the term negation allows a psychotherapeutic process with the aim of developing evolutive relationships

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE