756 research outputs found
Social psychology:Predicting other people’s attention to understand their mind
Humans are highly social beings who are interested in what others are saying, thinking, and doing. A recent study in the Proceedings of the National Academy of Sciences finds that we can easily tell whether a person’s pattern of attention is natural or artificially manipulated
Sur les arthromyodysplasies chez le veau
Giroud A., Gueguen L. Sur les arthromyodysplasies chez le veau. In: Bulletin de l'Académie Vétérinaire de France tome 126 n°10, 1973. pp. 443-446
Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
Cancer stem cells (CSCs) are thought to be partially responsible for cancer resistance to current therapies and tumor recurrence. Dichloroacetate (DCA), a compound capable of shifting metabolism from glycolysis to glucose oxidation, via an inhibition of pyruvate dehydrogenase kinase was used. We show that DCA is able to shift the pyruvate metabolism in rat glioma CSCs but has no effect in rat neural stem cells. DCA forces CSCs into oxidative phosphorylation but does not trigger the production of reactive oxygen species and consecutive anti-cancer apoptosis. However, DCA, associated with etoposide or irradiation, induced a Bax-dependent apoptosis in CSCs in vitro and decreased their proliferation in vivo. The former phenomenon is related to DCA-induced Foxo3 and p53 expression, resulting in the overexpression of BH3-only proteins (Bad, Noxa, and Puma), which in turn facilitates Bax-dependent apoptosis. Our results demonstrate that a small drug available for clinical studies potentiates the induction of apoptosis in glioma CSCs
Novel transcriptomic panel identifies histologically active eosinophilic oesophagitis.
Eosinophilic oesophagitis (EoE) is characterised by symptoms of esophageal dysfunction and oesinophil tissue infiltration. The EoE Diagnostic Panel (EDP) can distinguish between active and non-active EoE using a set of 77 genes. Recently, the existence of distinct EoE variants featuring symptoms similar to EoE, such as oesophageal dysfunction but lacking eosinophil infiltration, had been determined.
We used oesophageal biopsies from patients with histologically active (n=10) and non-active EoE (n=9) as well as from healthy oesophageal controls (n=5) participating in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) and analysed the gene expression profile in these biopsies by total RNA-sequencing (RNA-seq). Moreover, we employed the publicly accessible RNA-seq dataset (series GSE148381) as reported by Greuter et al, encompassing a comprehensive genomic profile of patients presenting with EoE variants.
A novel, diagnostic gene expression panel that can effectively distinguish patients with histologically active conventional EoE from patients with EoE in histological remission and control individuals, and from three newly discovered EoE variants was identified. Histologically Active EoE Diagnostic Panel (HAEDP) consists of 53 genes that were identified based on differential expression between histologically active EoE, histological remission and controls (p≤0.05). By combining the HAEDP with EDP, we expanded our knowledge about factors that may contribute to the inflammation in EoE and improved our understanding of the underlying mechanisms of the disease. Conversely, we suggested a compact group of genes common to both HAEDP and EDP to create a reliable diagnostic tool that might enhance the accuracy of EoE diagnosis.
We identified a novel set of 53 dysregulated genes that are closely associated with the histological inflammatory activity of EoE. In combination with EDP, our new panel might be a valuable tool for the accurate diagnosis of patients with EoE as well as for monitoring their disease course
Use of multi-sources 10-years quantitative precipitation estimation re-analyses in a lumped rainfall-runoff model
International audienceL'objectif principal de ce projet est de produire une base de donnée de référence couvrant une période de 10 ans pour l'estimation quantitative de lames d'eaux précipitées (LEP). L'objectif est d'utiliser de façon optimale l'ensemble des informations disponibles (radars, pluviomètres horaires et journaliers, données atellite....) afin d'obtenir la meilleure estimation possible de la pluie précipitée. La base de données résultante sera une série de LPE horaire, de 1km2, associée a une estimation des incertitudes sur l'ensemble du territoire français. Cela sera une référence commune pour les hydrologues, permettant des applications telles que le calage des paramètres de modèles, l'evaluation de la valeur ajoutée d'une entrée spatio-temporelle haute résolution pour les modèles hydrologiques ect... / This project main objective is to produce a 10-year reference database of Quantitative Precipitation Estimations (QPE). The objective is to make use optimally at any time of all the available information (radars, hourly and daily rain gauges, satellite data, etc) to obtain the best possible surface precipitation estimation. The resulting data base, will consist of hourly, 1km² gridded QPE and associated estimation uncertainties over the entire French territory. This will represent a common reference for hydrologists useful for various applications such as the calibration of the hydrological model parameters, the assessment of the the added value of high space-time resolution input for hydrological models, etc
The XMM-LSS catalogue: X-ray sources and associated optical data. Version I
Following the presentation of the XMM-LSS X-ray source detection package by
Pacaud et al., we provide the source lists for the first 5.5 surveyed square
degrees. The catalogues pertain to the [0.5-2] and [2-10] keV bands and contain
in total 3385 point-like or extended sources above a detection likelihood of 15
in either band. The agreement with deep logN-logS is excellent. The main
parameters considered are position, countrate, source extent with associated
likelihood values. A set of additional quantities such as astrometric
corrections and fluxes are further calculated while errors on the position and
countrate are deduced from simulations. We describe the construction of the
band-merged catalogue allowing rapid sub-sample selection and easy
cross-correlation with external multi-wavelength catalogues. A small optical
CFHTLS multi-band subset of objects is associated wich each source along with
an X-ray/optical overlay. We make the full X-ray images available in FITS
format. The data are available at CDS and, in a more extended form, at the
Milan XMM-LSS database.Comment: 13 pages, 7 figures and 11 tables (fig. 1 and 6 are enclosed in
reduced resolution), MNRAS Latex, accepted by MNRA
The XMM-LSS Survey: A well controlled X-ray cluster sample over the D1 CFHTLS area
We present the XMM-LSS cluster catalogue corresponding to the CFHTLS D1 area.
The list contains 13 spectroscopically confirmed, X-ray selected galaxy
clusters over 0.8 deg2 to a redshift of unity and so constitutes the highest
density sample of clusters to date. Cluster X-ray bolometric luminosities range
from 0.03 to 5x10^{44} erg/s. In this study, we describe our catalogue
construction procedure: from the detection of X-ray cluster candidates to the
compilation of a spectroscopically confirmed cluster sample with an explicit
selection function. The procedure further provides basic X-ray products such as
cluster temperature, flux and luminosity. We detected slightly more clusters
with a (0.5-2.0 keV) X-ray fluxes of >2x10^{-14} erg/s/cm^{-2} than we expected
based on expectations from deep ROSAT surveys. We also present the
Luminosity-Temperature relation for our 9 brightest objects possessing a
reliable temperature determination. The slope is in good agreement with the
local relation, yet compatible with a luminosity enhancement for the 0.15 < z<
0.35 objects having 1 < T < 2 keV, a population that the XMM-LSS is identifying
systematically for the first time. The present study permits the compilation of
cluster samples from XMM images whose selection biases are understood. This
allows, in addition to studies of large-scale structure, the systematic
investigation of cluster scaling law evolution, especially for low mass X-ray
groups which constitute the bulk of our observed cluster population. All
cluster ancillary data (images, profiles, spectra) are made available in
electronic form via the XMM-LSS cluster database.Comment: 12 pages 5 figures, MNRAS accepted. The paper with full resolution
cluster images is available at
http://vela.astro.ulg.ac.be/themes/spatial/xmm/LSS/rel_pub_e.htm
On morphological hierarchical representations for image processing and spatial data clustering
Hierarchical data representations in the context of classi cation and data
clustering were put forward during the fties. Recently, hierarchical image
representations have gained renewed interest for segmentation purposes. In this
paper, we briefly survey fundamental results on hierarchical clustering and
then detail recent paradigms developed for the hierarchical representation of
images in the framework of mathematical morphology: constrained connectivity
and ultrametric watersheds. Constrained connectivity can be viewed as a way to
constrain an initial hierarchy in such a way that a set of desired constraints
are satis ed. The framework of ultrametric watersheds provides a generic scheme
for computing any hierarchical connected clustering, in particular when such a
hierarchy is constrained. The suitability of this framework for solving
practical problems is illustrated with applications in remote sensing
Biodiesel production from jatropha seeds: Solvent extraction and in situ transesterification in a single step
The objective of this study was to investigate solvent extraction and in situ transesterification in a single step to allow direct production of biodiesel from jatropha seeds. Experiments were conducted using milled jatropha seeds, and n-hexane as extracting solvent. The influence of methanol to seed ratio (2:1–6:1), amount of alkali (KOH) catalyst (0.05–0.1 mol/L in methanol), stirring speed (700–900 rpm), temperature (40–60 °C) and reaction time (3–5 h) was examined to define optimum biodiesel yield and biodiesel quality after water washing and drying. When stirring speed, temperature and reaction time were fixed at 700 rpm, 60 °C and 4 h respectively, highest biodiesel yield (80% with a fatty acid methyl ester purity of 99.9%) and optimum biodiesel quality were obtained with a methanol to seed ratio of 6:1 and 0.075 mol/L KOH in methanol. Subsequently, the influence of stirring speed, temperature and reaction time on biodiesel yield and biodiesel quality was studied, by applying the randomized factorial experimental design with ANOVA (F-test at p = 0.05), and using the optimum values previously found for methanol to seed ratio and KOH catalyst level. Most experimental runs conducted at 50 °C resulted to high biodiesel yields, while stirring speed and reaction time did not give significantly effect. The highest biodiesel yield (87% with a fatty acid methyl ester purity of 99.7%) was obtained with a methanol to seed ratio of 6:1, KOH catalyst of 0.075 mol/L in methanol, a stirring speed of 800 rpm, a temperature of 50 °C, and a reaction time of 5 h. The effects of stirring speed, temperature and reaction time on biodiesel quality were not significant. Most of the biodiesel quality obtained in this study conformed to the Indonesian Biodiesel Standard
The XMM Large Scale Structure Survey: Properties and Two-Point Angular Correlations of Point-like Sources
We analyze X-ray sources detected over 4.2 pseudo-contiguous sq. deg. in the
0.5-2 keV and 2-10 keV bands down to fluxes of 2x10^{-15} and 8x10^{-15}
erg/s/cm^2 respectively, as part of the XMM Large Scale Structure Survey. The
logN-logS in both bands shows a steep slope at bright fluxes, but agrees well
with other determinations below ~2x10^{-14} erg/s/cm^2. The detected sources
resolve close to 30 per cent of the X-ray background in the 2-10 keV band. We
study the two-point angular clustering of point sources using nearest
neighbours and correlation function statistics and find a weak, positive signal
for ~1130 sources in the 0.5-2 keV band, but no correlation for ~400 sources in
the 2-10 keV band below scales of 100 arcsec. A sub-sample of ~200 faint
sources with hard X-ray count ratios, that is likely to be dominated by
obscured AGN, does show a positive signal with the data allowing for a large
scaling of the angular correlation length, but only at the ~2 (3) sigma level,
based on re-sampling (Poisson) statistics. We discuss possible implications and
emphasize the importance of wider, complete surveys in order to fully
understand the large scale structure of the X-ray sky.Comment: A&A in press; High resolution version at
http://www-xray.ast.cam.ac.uk/~pg/publications.htm
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