Structure function of the UV variability of Q0957+561

We present a detailed structure function analysis of the UV variability of Q0957+561. From new optical observations, we constructed normalized structure functions of the quasar luminosity at restframe wavelengths of 2100 and 2600 \AA. Old optical records also allow the structure function to be obtained at 2100 \AA, but 10 years ago in the observer's frame. These three structure functions are then compared to predictions of both simple and relatively sophisticated (incorporating two independent variable components) Poissonian models. We do not find clear evidence of a chromatic mechanism of variability. From the recent data, 100-d time-symmetric and 170-d time-asymmetric flares are produced at both restframe wavelengths. Taking into account measurements of time delays and the existence of an EUV/radio jet, reverberation is probably the main mechanism of variability. Thus, two types of EUV/X-ray fluctuations would be generated within or close to the jet and later reprocessed by the disc gas in the two emission rings. The 100-d time-symmetric shots are also responsible for most of the 2100 \AA variability detected in the old experiment. However, there is no evidence of asymmetric shots in the old UV variability. If reverberation is the involved mechanism of variability, this could mean an intermittent production of high-energy asymmetric fluctuations. The old records are also consistent with the presence of very short-lifetime (10 d) symmetric flares, which may represent additional evidence of time evolution. We also discuss the quasar structure that emerges from the variability scenario.Comment: 7 pages, 4 figures. Accepted for publication in A&A (based on the brightness records at http://arxiv.org/abs/0810.4619

Gravitationally lensed QSOs in the ISSIS/WSO-UV era

Gravitationally lensed QSOs (GLQs) at redshift z = 1-2 play a key role in understanding the cosmic evolution of the innermost parts of active galaxies (black holes, accretion disks, coronas and internal jets), as well as the structure of galaxies at intermediate redshifts. With respect to studies of normal QSOs, GLQ programmes have several advantages. For example, a monitoring of GLQs may lead to unambiguous detections of intrinsic and extrinsic variations. Both kinds of variations can be used to discuss central engines in distant QSOs, and mass distributions and compositions of lensing galaxies. In this context, UV data are of particular interest, since they correspond to emissions from the immediate surroundings of the supermassive black hole. We describe some observation strategies to analyse optically bright GLQs at z of about 1.5, using ISSIS (CfS) on board World Space Observatory-Ultraviolet.Comment: 7 pages, 4 figures, Accepted for publication in Astrophysics & Space Scienc

Spike-Train Responses of a Pair of Hodgkin-Huxley Neurons with Time-Delayed Couplings

Model calculations have been performed on the spike-train response of a pair of Hodgkin-Huxley (HH) neurons coupled by recurrent excitatory-excitatory couplings with time delay. The coupled, excitable HH neurons are assumed to receive the two kinds of spike-train inputs: the transient input consisting of $M$ impulses for the finite duration ($M$: integer) and the sequential input with the constant interspike interval (ISI). The distribution of the output ISI $T_{\rm o}$ shows a rich of variety depending on the coupling strength and the time delay. The comparison is made between the dependence of the output ISI for the transient inputs and that for the sequential inputs.Comment: 19 pages, 4 figure

Galaxy Number Counts and Implications for Strong Lensing

We compare galaxy number counts in HST/ACS fields containing moderate-redshift (0.2<z<1.0) strong gravitational lenses with those in two control samples: (1) the first square degree of the COSMOS survey, comprising 259 ACS fields and (2) 20 "pure parallel" fields randomly located on the sky. Through a Bayesian analysis we determine the expectation values (mu_0) and confidence levels of the underlying number counts for a range of apertures and magnitude bins. Our analysis has produced the following results: (i) We infer that our control samples are not consistent, with the number counts in the COSMOS sample being significantly higher than in the pure parallel sample for 21 <= F814W <= 23. This result matches those found in previous analyses of COSMOS data using different techniques. (ii) We find that small-size apertures, centered on strong lenses, are overdense compared with randomly placed apertures in the control samples, even compared to the COSMOS sample. Correcting for the local clustering of elliptical galaxies, based on the average two-point correlation function reduces this overdensity to the 1-2 sigma level. Thus, the overdensity of galaxies seen along a typical line of sight to a lens can be explained mostly by the natural clustering of galaxies, rather than being due to lenses lying along otherwise biased lines of sight. However, a larger sample of lenses is needed to see if the remaining bias persists when the lens-field uncertainties are smaller. (iii) There is considerable scatter in the lines of sight to _individual_ lens systems, but quantities that are linearly dependent on the external convergence (e.g., H_0) should become unbiased if the extra galaxies that cause the bias can be accounted for in the lens models either through direct modeling or via an informed prior on the external convergence. The number counts can used to set such an informed prior.Comment: Modified to match the version accepted for publication in MNRAS. 15 Pages, 10 figure

Cosmological distance indicators

We review three distance measurement techniques beyond the local universe: (1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and (3) HI intensity mapping. We describe the principles and theory behind each method, the ingredients needed for measuring such distances, the current observational results, and future prospects. Time delays from strongly lensed quasars currently provide constraints on $H_0$ with < 4% uncertainty, and with 1% within reach from ongoing surveys and efforts. Recent exciting discoveries of strongly lensed supernovae hold great promise for time-delay cosmography. BAO features have been detected in redshift surveys up to z <~ 0.8 with galaxies and z ~ 2 with Ly-$\alpha$ forest, providing precise distance measurements and $H_0$ with < 2% uncertainty in flat $\Lambda$CDM. Future BAO surveys will probe the distance scale with percent-level precision. HI intensity mapping has great potential to map BAO distances at z ~ 0.8 and beyond with precisions of a few percent. The next years ahead will be exciting as various cosmological probes reach 1% uncertainty in determining $H_0$, to assess the current tension in $H_0$ measurements that could indicate new physics.Comment: Review article accepted for publication in Space Science Reviews (Springer), 45 pages, 10 figures. Chapter of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Ag

Dendritic Spikes Amplify the Synaptic Signal to Enhance Detection of Motion in a Simulation of the Direction-Selective Ganglion Cell

The On-Off direction-selective ganglion cell (DSGC) in mammalian retinas responds most strongly to a stimulus moving in a specific direction. The DSGC initiates spikes in its dendritic tree, which are thought to propagate to the soma with high probability. Both dendritic and somatic spikes in the DSGC display strong directional tuning, whereas somatic PSPs (postsynaptic potentials) are only weakly directional, indicating that spike generation includes marked enhancement of the directional signal. We used a realistic computational model based on anatomical and physiological measurements to determine the source of the enhancement. Our results indicate that the DSGC dendritic tree is partitioned into separate electrotonic regions, each summing its local excitatory and inhibitory synaptic inputs to initiate spikes. Within each local region the local spike threshold nonlinearly amplifies the preferred response over the null response on the basis of PSP amplitude. Using inhibitory conductances previously measured in DSGCs, the simulation results showed that inhibition is only sufficient to prevent spike initiation and cannot affect spike propagation. Therefore, inhibition will only act locally within the dendritic arbor. We identified the role of three mechanisms that generate directional selectivity (DS) in the local dendritic regions. First, a mechanism for DS intrinsic to the dendritic structure of the DSGC enhances DS on the null side of the cell's dendritic tree and weakens it on the preferred side. Second, spatially offset postsynaptic inhibition generates robust DS in the isolated dendritic tips but weak DS near the soma. Third, presynaptic DS is apparently necessary because it is more robust across the dendritic tree. The pre- and postsynaptic mechanisms together can overcome the local intrinsic DS. These local dendritic mechanisms can perform independent nonlinear computations to make a decision, and there could be analogous mechanisms within cortical circuitry

Membranes with the Same Ion Channel Populations but Different Excitabilities

Electrical signaling allows communication within and between different tissues and is necessary for the survival of multicellular organisms. The ionic transport that underlies transmembrane currents in cells is mediated by transporters and channels. Fast ionic transport through channels is typically modeled with a conductance-based formulation that describes current in terms of electrical drift without diffusion. In contrast, currents written in terms of drift and diffusion are not as widely used in the literature in spite of being more realistic and capable of displaying experimentally observable phenomena that conductance-based models cannot reproduce (e.g. rectification). The two formulations are mathematically related: conductance-based currents are linear approximations of drift-diffusion currents. However, conductance-based models of membrane potential are not first-order approximations of drift-diffusion models. Bifurcation analysis and numerical simulations show that the two approaches predict qualitatively and quantitatively different behaviors in the dynamics of membrane potential. For instance, two neuronal membrane models with identical populations of ion channels, one written with conductance-based currents, the other with drift-diffusion currents, undergo transitions into and out of repetitive oscillations through different mechanisms and for different levels of stimulation. These differences in excitability are observed in response to excitatory synaptic input, and across different levels of ion channel expression. In general, the electrophysiological profiles of membranes modeled with drift-diffusion and conductance-based models having identical ion channel populations are different, potentially causing the input-output and computational properties of networks constructed with these models to be different as well. The drift-diffusion formulation is thus proposed as a theoretical improvement over conductance-based models that may lead to more accurate predictions and interpretations of experimental data at the single cell and network levels

The Cognitive Impact of the ANK3 Risk Variant for Bipolar Disorder: Initial Evidence of Selectivity to Signal Detection during Sustained Attention

BACKGROUND: Abnormalities in cognition have been reported in patients with Bipolar Disorder (BD) and their first degree relatives, suggesting that susceptibility genes for BD may impact on cognitive processes. Recent genome-wide genetic studies have reported a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of sodium gated ion channels. Since ANK3 influences the efficiency of transmission of neuronal impulses, allelic variation in this gene may have widespread cognitive effects. Preclinical data suggest that this may principally apply to sequential signal detection, a core process of sustained attention. METHODOLOGY/PRINCIPAL FINDINGS: One hundred and eighty-nine individuals of white British descent were genotyped for the ANK3 rs10994336 polymorphism and received diagnostic interviews and comprehensive neurocognitive assessment of their general intellectual ability, memory, decision making, response inhibition and sustained attention. Participants comprised euthymic BD patients (n = 47), their unaffected first-degree relatives (n = 75) and healthy controls (n = 67). The risk allele T was associated with reduced sensitivity in target detection (p = 0.0004) and increased errors of commission (p = 0.0018) during sustained attention regardless of diagnosis. We found no effect of the ANK3 genotype on general intellectual ability, memory, decision making and response inhibition. CONCLUSIONS/SIGNIFICANCE: Our results suggest that allelic variation in ANK3 impacts cognitive processes associated with signal detection and this mechanism may relate to risk for BD. However, our results require independent replication and confirmation that ANK3 (rs10994336) is a direct functional variant

A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the Dynamic Range of the Retina

Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation in the first processing stages. In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current Ih on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results show that for realistic values of Ih conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII coupling is less relevant to dynamic range amplification in comparison with receptor coupling. Furthermore, a plot of the retina output response versus input intensity for the optimal parameter configuration is well fitted by a power law with exponent . The results are consistent with predictions of more theoretical works and suggest that the earliest expression of gap junctions along the rod pathways, together with appropriate values of rod Ih conductance, has the highest impact on vertebrate retina dynamic range enhancement

End of Green Sahara amplified mid- to late Holocene megadroughts in mainland Southeast Asia

Between 5 and 4 thousand years ago, crippling megadroughts led to the disruption of ancient civilizations across parts of Africa and Asia, yet the extent of these climate extremes in mainland Southeast Asia (MSEA) has never been defined. This is despite archeological evidence showing a shift in human settlement patterns across the region during this period. We report evidence from stalagmite climate records indicating a major decrease of monsoon rainfall in MSEA during the mid- to late Holocene, coincident with African monsoon failure during the end of the Green Sahara. Through a set of modeling experiments, we show that reduced vegetation and increased dust loads during the Green Sahara termination shifted the Walker circulation eastward and cooled the Indian Ocean, causing a reduction in monsoon rainfall in MSEA. Our results indicate that vegetation-dust climate feedbacks from Sahara drying may have been the catalyst for societal shifts in MSEA via ocean-atmospheric teleconnections