87 research outputs found
Structure function of the UV variability of Q0957+561
We present a detailed structure function analysis of the UV variability of
Q0957+561. From new optical observations, we constructed normalized structure
functions of the quasar luminosity at restframe wavelengths of 2100 and 2600
\AA. Old optical records also allow the structure function to be obtained at
2100 \AA, but 10 years ago in the observer's frame. These three structure
functions are then compared to predictions of both simple and relatively
sophisticated (incorporating two independent variable components) Poissonian
models. We do not find clear evidence of a chromatic mechanism of variability.
From the recent data, 100-d time-symmetric and 170-d time-asymmetric flares
are produced at both restframe wavelengths. Taking into account measurements of
time delays and the existence of an EUV/radio jet, reverberation is probably
the main mechanism of variability. Thus, two types of EUV/X-ray fluctuations
would be generated within or close to the jet and later reprocessed by the disc
gas in the two emission rings. The 100-d time-symmetric shots are also
responsible for most of the 2100 \AA variability detected in the old
experiment. However, there is no evidence of asymmetric shots in the old UV
variability. If reverberation is the involved mechanism of variability, this
could mean an intermittent production of high-energy asymmetric fluctuations.
The old records are also consistent with the presence of very short-lifetime
(10 d) symmetric flares, which may represent additional evidence of time
evolution. We also discuss the quasar structure that emerges from the
variability scenario.Comment: 7 pages, 4 figures. Accepted for publication in A&A (based on the
brightness records at http://arxiv.org/abs/0810.4619
Gravitationally lensed QSOs in the ISSIS/WSO-UV era
Gravitationally lensed QSOs (GLQs) at redshift z = 1-2 play a key role in
understanding the cosmic evolution of the innermost parts of active galaxies
(black holes, accretion disks, coronas and internal jets), as well as the
structure of galaxies at intermediate redshifts. With respect to studies of
normal QSOs, GLQ programmes have several advantages. For example, a monitoring
of GLQs may lead to unambiguous detections of intrinsic and extrinsic
variations. Both kinds of variations can be used to discuss central engines in
distant QSOs, and mass distributions and compositions of lensing galaxies. In
this context, UV data are of particular interest, since they correspond to
emissions from the immediate surroundings of the supermassive black hole. We
describe some observation strategies to analyse optically bright GLQs at z of
about 1.5, using ISSIS (CfS) on board World Space Observatory-Ultraviolet.Comment: 7 pages, 4 figures, Accepted for publication in Astrophysics & Space
Scienc
Spike-Train Responses of a Pair of Hodgkin-Huxley Neurons with Time-Delayed Couplings
Model calculations have been performed on the spike-train response of a pair
of Hodgkin-Huxley (HH) neurons coupled by recurrent excitatory-excitatory
couplings with time delay. The coupled, excitable HH neurons are assumed to
receive the two kinds of spike-train inputs: the transient input consisting of
impulses for the finite duration (: integer) and the sequential input
with the constant interspike interval (ISI). The distribution of the output ISI
shows a rich of variety depending on the coupling strength and the
time delay. The comparison is made between the dependence of the output ISI for
the transient inputs and that for the sequential inputs.Comment: 19 pages, 4 figure
Galaxy Number Counts and Implications for Strong Lensing
We compare galaxy number counts in HST/ACS fields containing
moderate-redshift (0.2<z<1.0) strong gravitational lenses with those in two
control samples: (1) the first square degree of the COSMOS survey, comprising
259 ACS fields and (2) 20 "pure parallel" fields randomly located on the sky.
Through a Bayesian analysis we determine the expectation values (mu_0) and
confidence levels of the underlying number counts for a range of apertures and
magnitude bins. Our analysis has produced the following results: (i) We infer
that our control samples are not consistent, with the number counts in the
COSMOS sample being significantly higher than in the pure parallel sample for
21 <= F814W <= 23. This result matches those found in previous analyses of
COSMOS data using different techniques. (ii) We find that small-size apertures,
centered on strong lenses, are overdense compared with randomly placed
apertures in the control samples, even compared to the COSMOS sample.
Correcting for the local clustering of elliptical galaxies, based on the
average two-point correlation function reduces this overdensity to the 1-2
sigma level. Thus, the overdensity of galaxies seen along a typical line of
sight to a lens can be explained mostly by the natural clustering of galaxies,
rather than being due to lenses lying along otherwise biased lines of sight.
However, a larger sample of lenses is needed to see if the remaining bias
persists when the lens-field uncertainties are smaller. (iii) There is
considerable scatter in the lines of sight to _individual_ lens systems, but
quantities that are linearly dependent on the external convergence (e.g., H_0)
should become unbiased if the extra galaxies that cause the bias can be
accounted for in the lens models either through direct modeling or via an
informed prior on the external convergence. The number counts can used to set
such an informed prior.Comment: Modified to match the version accepted for publication in MNRAS. 15
Pages, 10 figure
Cosmological distance indicators
We review three distance measurement techniques beyond the local universe:
(1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and
(3) HI intensity mapping. We describe the principles and theory behind each
method, the ingredients needed for measuring such distances, the current
observational results, and future prospects. Time delays from strongly lensed
quasars currently provide constraints on with < 4% uncertainty, and with
1% within reach from ongoing surveys and efforts. Recent exciting discoveries
of strongly lensed supernovae hold great promise for time-delay cosmography.
BAO features have been detected in redshift surveys up to z <~ 0.8 with
galaxies and z ~ 2 with Ly- forest, providing precise distance
measurements and with < 2% uncertainty in flat CDM. Future BAO
surveys will probe the distance scale with percent-level precision. HI
intensity mapping has great potential to map BAO distances at z ~ 0.8 and
beyond with precisions of a few percent. The next years ahead will be exciting
as various cosmological probes reach 1% uncertainty in determining , to
assess the current tension in measurements that could indicate new
physics.Comment: Review article accepted for publication in Space Science Reviews
(Springer), 45 pages, 10 figures. Chapter of a special collection resulting
from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in
the Space Ag
Dendritic Spikes Amplify the Synaptic Signal to Enhance Detection of Motion in a Simulation of the Direction-Selective Ganglion Cell
The On-Off direction-selective ganglion cell (DSGC) in mammalian retinas responds most strongly to a stimulus moving in a specific direction. The DSGC initiates spikes in its dendritic tree, which are thought to propagate to the soma with high probability. Both dendritic and somatic spikes in the DSGC display strong directional tuning, whereas somatic PSPs (postsynaptic potentials) are only weakly directional, indicating that spike generation includes marked enhancement of the directional signal. We used a realistic computational model based on anatomical and physiological measurements to determine the source of the enhancement. Our results indicate that the DSGC dendritic tree is partitioned into separate electrotonic regions, each summing its local excitatory and inhibitory synaptic inputs to initiate spikes. Within each local region the local spike threshold nonlinearly amplifies the preferred response over the null response on the basis of PSP amplitude. Using inhibitory conductances previously measured in DSGCs, the simulation results showed that inhibition is only sufficient to prevent spike initiation and cannot affect spike propagation. Therefore, inhibition will only act locally within the dendritic arbor. We identified the role of three mechanisms that generate directional selectivity (DS) in the local dendritic regions. First, a mechanism for DS intrinsic to the dendritic structure of the DSGC enhances DS on the null side of the cell's dendritic tree and weakens it on the preferred side. Second, spatially offset postsynaptic inhibition generates robust DS in the isolated dendritic tips but weak DS near the soma. Third, presynaptic DS is apparently necessary because it is more robust across the dendritic tree. The pre- and postsynaptic mechanisms together can overcome the local intrinsic DS. These local dendritic mechanisms can perform independent nonlinear computations to make a decision, and there could be analogous mechanisms within cortical circuitry
Membranes with the Same Ion Channel Populations but Different Excitabilities
Electrical signaling allows communication within and between different tissues and is necessary for the survival of multicellular organisms. The ionic transport that underlies transmembrane currents in cells is mediated by transporters and channels. Fast ionic transport through channels is typically modeled with a conductance-based formulation that describes current in terms of electrical drift without diffusion. In contrast, currents written in terms of drift and diffusion are not as widely used in the literature in spite of being more realistic and capable of displaying experimentally observable phenomena that conductance-based models cannot reproduce (e.g. rectification). The two formulations are mathematically related: conductance-based currents are linear approximations of drift-diffusion currents. However, conductance-based models of membrane potential are not first-order approximations of drift-diffusion models. Bifurcation analysis and numerical simulations show that the two approaches predict qualitatively and quantitatively different behaviors in the dynamics of membrane potential. For instance, two neuronal membrane models with identical populations of ion channels, one written with conductance-based currents, the other with drift-diffusion currents, undergo transitions into and out of repetitive oscillations through different mechanisms and for different levels of stimulation. These differences in excitability are observed in response to excitatory synaptic input, and across different levels of ion channel expression. In general, the electrophysiological profiles of membranes modeled with drift-diffusion and conductance-based models having identical ion channel populations are different, potentially causing the input-output and computational properties of networks constructed with these models to be different as well. The drift-diffusion formulation is thus proposed as a theoretical improvement over conductance-based models that may lead to more accurate predictions and interpretations of experimental data at the single cell and network levels
The Cognitive Impact of the ANK3 Risk Variant for Bipolar Disorder: Initial Evidence of Selectivity to Signal Detection during Sustained Attention
BACKGROUND: Abnormalities in cognition have been reported in patients with Bipolar Disorder (BD) and their first degree relatives, suggesting that susceptibility genes for BD may impact on cognitive processes. Recent genome-wide genetic studies have reported a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of sodium gated ion channels. Since ANK3 influences the efficiency of transmission of neuronal impulses, allelic variation in this gene may have widespread cognitive effects. Preclinical data suggest that this may principally apply to sequential signal detection, a core process of sustained attention. METHODOLOGY/PRINCIPAL FINDINGS: One hundred and eighty-nine individuals of white British descent were genotyped for the ANK3 rs10994336 polymorphism and received diagnostic interviews and comprehensive neurocognitive assessment of their general intellectual ability, memory, decision making, response inhibition and sustained attention. Participants comprised euthymic BD patients (n = 47), their unaffected first-degree relatives (n = 75) and healthy controls (n = 67). The risk allele T was associated with reduced sensitivity in target detection (p = 0.0004) and increased errors of commission (p = 0.0018) during sustained attention regardless of diagnosis. We found no effect of the ANK3 genotype on general intellectual ability, memory, decision making and response inhibition. CONCLUSIONS/SIGNIFICANCE: Our results suggest that allelic variation in ANK3 impacts cognitive processes associated with signal detection and this mechanism may relate to risk for BD. However, our results require independent replication and confirmation that ANK3 (rs10994336) is a direct functional variant
A Computational Study on the Role of Gap Junctions and Rod Ih Conductance in the Enhancement of the Dynamic Range of the Retina
Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation in the first processing stages. In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current Ih on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results show that for realistic values of Ih conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII coupling is less relevant to dynamic range amplification in comparison with receptor coupling. Furthermore, a plot of the retina output response versus input intensity for the optimal parameter configuration is well fitted by a power law with exponent . The results are consistent with predictions of more theoretical works and suggest that the earliest expression of gap junctions along the rod pathways, together with appropriate values of rod Ih conductance, has the highest impact on vertebrate retina dynamic range enhancement
End of Green Sahara amplified mid- to late Holocene megadroughts in mainland Southeast Asia
Between 5 and 4 thousand years ago, crippling megadroughts led to the disruption of ancient civilizations across parts of Africa and Asia, yet the extent of these climate extremes in mainland Southeast Asia (MSEA) has never been defined. This is despite archeological evidence showing a shift in human settlement patterns across the region during this period. We report evidence from stalagmite climate records indicating a major decrease of monsoon rainfall in MSEA during the mid- to late Holocene, coincident with African monsoon failure during the end of the Green Sahara. Through a set of modeling experiments, we show that reduced vegetation and increased dust loads during the Green Sahara termination shifted the Walker circulation eastward and cooled the Indian Ocean, causing a reduction in monsoon rainfall in MSEA. Our results indicate that vegetation-dust climate feedbacks from Sahara drying may have been the catalyst for societal shifts in MSEA via ocean-atmospheric teleconnections
- …