Redes sociales y el desarrollo empresarial, en el contexto del COVID-19

Currently, social networks constitute, without a doubt, one of the most indispensable tools in business development, a situation that has been evidenced in the last decade. In the context of COVID-19, digital media has been instrumental in preventing companies from succumbing to a deadly recession. Through the digital transformation, these companies have seen a competitive advantage in order to remain operational and continue to generate profitability. However, this pandemic has transformed the world mainly as we develop commerce, having its greatest impact on marketing, which had to be innovated in order to satisfy the needs of a society that had to be confined. Keywords: Social networks, digital transformation, social networks and companies, digital marketing.Las redes sociales en la actualidad constituyen, sin lugar a duda, una de las herramientas más indispensables en el desarrollo empresarial, situación que ha quedado evidenciada en la última década. Dentro del contexto del COVID-19, los medios digitales de difusión han sido fundamental para que las empresas no sucumban en una recesión letal. Mediante la transformación digital estas sociedades han visto una ventaja competitiva para poder mantenerse operativas y seguir generando rentabilidad. No obstante, esta pandemia ha transformado el mundo principalmente como desarrollamos el comercio, teniendo su mayor impacto en el marketing, que tuvo de innovarse para poder satisfacer las necesidades de una sociedad que tuvo que confinarse. Palabras claves: Redes sociales, transformación digital, redes sociales y empresas, marketing digital. ABSTRACT Currently, social networks constitute, without a doubt, one of the most indispensable tools in business development, a situation that has been evidenced in the last decade. In the context of COVID-19, digital media has been instrumental in preventing companies from succumbing to a deadly recession. Through the digital transformation, these companies have seen a competitive advantage in order to remain operational and continue to generate profitability. However, this pandemic has transformed the world mainly as we develop commerce, having its greatest impact on marketing, which had to be innovated in order to satisfy the needs of a society that had to be confined. Keywords: Social networks, digital transformation, social networks and companies, digital marketing

Effect of dietary organic selenium on muscle proteolytic activity and water-holding capacity in pork

This study evaluates the effect of dietary selenium (Se) supplementation source (organic, Se-enriched yeast; SY vs. inorganic, sodium selenite; SS), dose (0.2: L vs. 0.4: H mg/kg) and the combination of Se and vitamin E (VITE + SS) for 26 days on drip loss, TBARS, colour changes, myofibrillar protein pattern and proteolysis in pork. The lowest water losses were observed in the SY-H group when compared to the others. SY-H and VITE + SS groups presented lower myofibrillar protein hydrolysis/oxidation. VITE + SS supplementation also resulted in higher PRO, TRP and PHE content at days 2 and 7, whereas the SY group showed increased GLY and CAR and tended to have higher TAU and ANS at day 2. The myofibrillar fragmentation index was not modified by the dietary treatment; however, at day 8, it tended to be higher in groups supplemented with SeY and VITE + SS. The results of the present study might indicate a possible relation between muscle proteolysis and water loss.This research was supported by projects CDTI IDI-20111017 and S2013/ABI-2913-MEDGAN-CAM.Peer reviewe

Experience with the use of Rituximab for the treatment of rheumatoid arthritis in a tertiary Hospital in Spain: RITAR study

There is evidence supporting that there are no relevant clinical differences between dosing rituximab 1000 mg or 2000 mg per cycle in rheumatoid arthritis (RA) patients in clinical trials, and low-dose cycles seem to have a better safety profile. Our objective was to describe the pattern of use of rituximab in real-life practice conditions. Methods: Rituximab for RA in clinical practice (RITAR) study is a retrospective cohort study from 2005 to 2015. Eligibility criteria were RA adults treated with rituximab for active articular disease. Response duration was the main outcome defined as months elapsed from the date of rituximab first infusion to the date of flare. A multivariable analysis was performed to determine the variables associated with response duration. Results: A total of 114 patients and 409 cycles were described, 93.0% seropositive and 80.7% women. Rituximab was mainly used as second-line biological therapy. On demand retreatment was used in 94.6% of cases versus fixed 6 months retreatment in 5.4%. Median response duration to on demand rituximab cycles was 10 months (interquartile range, 7–13). Multivariable analysis showed that age older than 65 years, number of rituximab cycles, seropositivity, and first- or second-line therapy were associated with longer response duration. The dose administered at each cycle was not significantly associated with response duration. Conclusions: Our experience suggests that 1000 mg rituximab single infusion on demand is a reasonable schedule for long-term treatment of those patients with good response after the first cycles, especially in seropositive patients and when it is applied as a first- or second-line biological therap

Fatty acid composition of different adipose tissues in heavy pigs

Forty-seven castrated male Duroc x (Landrace x Large White) pigs were used to determine fatty acids compositions from different adipose tissues. The outer subcutaneous backfat layer had a lower proportion of saturated and higher monounsaturated and polyunsaturated fatty acids than the inner laver. Liver fat had the highest proportion of poiyunsaturated fatty acids. Intramuscular fat followed by subcutaneous backfat had the highest monounsaturation indexes. Moreover, omental and hepatic fat had the highest amount of n-3 fatty acids. In conclusion, the fatty acid profile was depended on fat location, with intramuscular and outer backfat the most beneficial from the point of view of nutrition and health

Efecto del sexo sobre la calidad de la canal, de la carne y de la grasa de cerdos pesados

España es el primer país productor de jamón a escala mundial. La base animal de la producción de jamón y de otros productos elaborados son cerdos pesados que se sacrifican, generalmente, con pesos superiores a 105 kg. Dentro del escenario productivo del cerdo blanco mejorado, nuestro país cuenta con una Especialidad Tradicional Garantizada (ETG) denominada Jamón Serrano, una Denominación de Origen (Jamón y Paleta de Teruel) y una Indicación Geográfica Protegida (Jamón de Trévelez) amparadas por unas exigencias de calidad que no todos los animales satisfacen

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism.

Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness. This experiment was conducted to investigate gene expression differences, transcriptional regulation and genetic polymorphisms that could be associated with the observed phenotypic differences between IB and IBxDU pigs. Nine IB and 10 IBxDU pigs were slaughtered at birth. Morphometric measures and blood samples were obtained and samples from Biceps femoris muscle were employed for compositional and transcriptome analysis by RNA-Seq technology. Phenotypic differences were evident at this early age, including greater body size and weight in IBxDU and greater Biceps femoris intramuscular fat and plasma cholesterol content in IB newborns. We detected 149 differentially expressed genes between IB and IBxDU neonates (p < 0.01 and Fold-Change > 1. 5). Several were related to adipose and muscle tissues development (DLK1, FGF21 or UBC). The functional interpretation of the transcriptomic differences revealed enrichment of functions and pathways related to lipid metabolism in IB and to cellular and muscle growth in IBxDU pigs. Protein catabolism, cholesterol biosynthesis and immune system were functions enriched in both genotypes. We identified transcription factors potentially affecting the observed gene expression differences. Some of them have known functions on adipogenesis (CEBPA, EGRs), lipid metabolism (PPARGC1B) and myogenesis (FOXOs, MEF2D, MYOD1), which suggest a key role in the meat quality differences existing between IB and IBxDU hams. We also identified several polymorphisms showing differential segregation between IB and IBxDU pigs. Among them, non-synonymous variants were detected in several transcription factors as PPARGC1B and TRIM63 genes, which could be associated to altered gene function. Taken together, these results provide information about candidate genes, metabolic pathways and genetic polymorphisms potentially involved in phenotypic differences between IB and IBxDU pigs associated to meat quality and production traits

Efecto del sexo y la inclusión de glicerol en el pienso sobre la distribución de ácidos grasos en el triglicérido en ganado porcino

Concentration of C16:0 was higher and C18:1 y C18:2 lower in boars than in gilts in the subcutaneous fat of hams. Dietary inclusion of glycerol decrease C18:2 and PUFA concentration, thus decreasing fat unsaturation. Saturated fatty acids are concentrated in the external position of the triglyceride (Sn-1,3), while PUFA and MUFA are located preferentially in the inner position (Sn-2). No interaction was observed between position and either sex or dietary treatment. The PUFA/SAT index was affected by position, sex and dietary treatment, However, rations in which MUFA were involved were not significant. The C18:0/C18:2 index showed an interaction dietary treatment*position, in which the ratio is increased by dietary glycerol only in the Sn-1,3 position.Los machos castrados tuvieron una concentración más alta de C16:0 y más baja de C18:1 y C18:2 en la grasa subcutánea del jamón. La inclusión de glicerol en el pienso durante la fase de acabado produce una menor concentración de C18:2, del total de PUFA y, en consecuencia, una menor insaturación de la grasa. Los ácidos grasos saturados se concentraron especialmente en las posiciones externas (Sn-1,3), mientras que los MUFA y PUFA lo hicieron preferentemente en la posición central (Sn-2). No se observaron interacciones de la posición de los ácidos grasos individuales debidas al sexo o a la alimentación. La relación PUFA/SAT resultó significativa respecto a la posición, el sexo y la alimentación. Sin embargo, los índices en los que participan los MUFA son mucho más constantes e independientes del sexo y la alimentación. El cociente C18:0/C18:2 muestra una interacción glicerol*posición, de modo que dicho cociente aumenta específicamente en la posición 1,3 cuando los cerdos reciben glicerol, pero no se afecta (o lo hace con muy poca intensidad) en la posición 2

Efecto de la densidad en cebo sobre el rendimiento productivo, la composición de la carne y el perfil de ácidos grasos de cerdos sacrificados con 110 kg de peso

El número de cerdos por cuadra y la densidad influyen sobre el rendimiento productivo (Edmons et al., 1998). Además, la densidad de cría puede afectar a la calidad de la canal y de la carne (Estevez et al., 2003), ya que una reducción del espacio disponible da lugar a peleas y mordeduras de colas. Sin embargo, la producción de carne por m 2 aumenta con la densidad con un mejor aprovechamiento de la superficie disponible. Por otro lado, la densidad podría afectar de distinto modo a hembras (HE) y a machos castrados (MC) debido posiblemente al menor consumo voluntario de pienso de las HE. A este particular, Hamilton et al. (2003) observaron que a altas densidades de cría las HE fueron relativamente más magras mientras que los MC eran relativamente más grasos. Cambios en la densidad de cría, pueden afectar a la composición en ácidos grasos de la canal debido a cambios en el consumo y a la utilización del alimento (Nürnberg et al., 1998). El objetivo de este estudio fue comparar el efecto de la densidad de cebo de HE y MC con alto potencial de crecimiento, sobre el rendimiento productivo y la composición de la carne y el perfil de ácidos grasos en cerdos de 19 a 109 kg PV