Carlos Solchaga y los retos de la economía española

La consolidación definitiva del proceso democrático en España comienza en 1982 con la llegada al gobierno del PSOE. Marca el inicio de un proceso de importantes transformaciones políticas, económicas y sociales que han tenido influencia en los más de cuarenta años de democracia española. El protagonista de este trabajo es Carlos Solchaga, en el cual analizo la gestión que realizó durante el tiempo que estuvo como ministro de Industria y como ministro de Economía y Hacienda en cinco pilares: tipo de cambio, inflación, hacienda, reconversión industrial y desempleo.The definitive consolidation of the democratic process in Spain begins in 1982 with the arrival of the PSOE government. It marks the beginning of a process of important political, economic and social transformations that have influenced the more than forty years of Spanish democracy. The protagonist of this work is Carlos Solchaga, in which I analyze the management carried out during the time he remains as Minister of Industry and as Minister of Economy and Finance in five pillars: exchange rate, inflation, finance, industrial restructuring and unemployment.Departamento de Fundamentos del Análisis Económico e Historia e Instituciones EconómicasGrado en Economí

Immunogenetic characterization of clonal plasma cells in systemic light-chain amyloidosis

This study was supported by the Centro de Investigación Biomédica en Red—Área de Oncología—del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369; and CB16/12/00489), Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS No. PI13/02196), Asociación Española Contra el Cáncer (GCB120981SAN and the Accelerator Award), CRIS against Cancer foundation grant 2014/0120, and the Black Swan Research Initiative of the International Myeloma Foundation.Peer reviewe

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

Although light-chain amyloidosis (AL) and multiple myeloma (MM) are characterized by tumor plasma cell (PC) expansion in bone marrow (BM), their clinical presentation differs. Previous attempts to identify unique pathogenic mechanisms behind such differences were unsuccessful, and no studies have investigated the differentiation stage of tumor PCs in patients with AL and MM. We sought to define a transcriptional atlas of normal PC development in secondary lymphoid organs (SLOs), peripheral blood (PB), and BM for comparison with the transcriptional programs (TPs) of tumor PCs in AL, MM, and monoclonal gammopathy of undetermined significance (MGUS). Based on bulk and single-cell RNA sequencing, we observed 13 TPs during transition of normal PCs throughout SLOs, PB, and BM. We further noted the following: CD39 outperforms CD19 to discriminate newborn from long-lived BM-PCs; tumor PCs expressed the most advantageous TPs of normal PC differentiation; AL shares greater similarity to SLO-PCs whereas MM is transcriptionally closer to PB-PCs and newborn BM-PCs; patients with AL and MM enriched in immature TPs had inferior survival; and protein N-linked glycosylation–related TPs are upregulated in AL. Collectively, we provide a novel resource to understand normal PC development and the transcriptional reorganization of AL and other monoclonal gammopathies

Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma

On behalf of the PETHEMA/GEM Cooperative Group.Risk of developing myelodysplastic syndrome (MDS) is significantly increased in both multiple myeloma (MM) and monoclonal gammopathy of undetermined significance, suggesting that it is therapy independent. However, the incidence and sequelae of dysplastic hematopoiesis at diagnosis are unknown. Here, we used multidimensional flow cytometry (MFC) to prospectively screen for the presence of MDS-associated phenotypic alterations (MDS-PA) in the bone marrow of 285 patients with MM enrolled in the PETHEMA/GEM2012MENOS65 trial (#NCT01916252). We investigated the clinical significance of monocytic MDS-PA in a larger series of 1252 patients enrolled in 4 PETHEMA/GEM protocols. At diagnosis, 33 (11.6%) of 285 cases displayed MDS-PA. Bulk and single-cell–targeted sequencing of MDS recurrently mutated genes in CD34+ progenitors (and dysplastic lineages) from 67 patients revealed clonal hematopoiesis in 13 (50%) of 26 cases with MDS-PA vs 9 (22%) of 41 without MDS-PA; TET2 and NRAS were the most frequently mutated genes. Dynamics of MDS-PA at diagnosis and after autologous transplant were evaluated in 86 of 285 patients and showed that in most cases (69 of 86 [80%]), MDS-PA either persisted or remained absent in patients with or without MDS-PA at diagnosis, respectively. Noteworthy, MDS-associated mutations infrequently emerged after high-dose therapy. Based on MFC profiling, patients with MDS-PA have altered hematopoiesis and T regulatory cell distribution in the tumor microenvironment. Importantly, the presence of monocytic MDS-PA at diagnosis anticipated greater risk of hematologic toxicity and was independently associated with inferior progression-free survival (hazard ratio, 1.5; P = .02) and overall survival (hazard ratio, 1.7; P = .01). This study reveals the biological and clinical significance of dysplastic hematopoiesis in newly diagnosed MM, which can be screened with moderate sensitivity using cost-effective MFC.Peer reviewe

Presentation of the final prototype to the "Chem-E-Car" Competition at the 10th World Congress of Chemical Engineering

El proyecto consistió en la presentación del prototipo Chem-E-Car desarrollado en la UCM en la competición mundial que se celebró durante el transcurso del Congreso Mundial de Ingeniería Química (Barcelona, 30 septiembre-2 de octubre de 2017).The project consisted of the presentation of the Chem-E-Car prototype developed at the UCM in the world competition held during the World Congress of Chemical Engineering (Barcelona, September 30-October 2, 2017).Depto. de Ingeniería Química y de MaterialesFac. de Ciencias QuímicasFALSEsubmitte

Espacios y destinos turísticos en tiempos de globalización y crisis

2 volúmenesXII Coloquio de Geografía del Turismo, Ocio y Recreación de la Asociación de Geógrafos Españoles. Colmenarejo (Madrid), del 17 al 19 de junio de 2010.Este libro ha sido editado con la colaboración económica del Ministerio de Ciencia e Innovación (ref. CS02010-10416-E)