Coexistence of Paramagnetic-Charge-Ordered and Ferromagnetic-Metallic Phases in La0.5Ca0.5MnO3 evidenced by ESR

Throughout a complete Electron Spin Resonance (ESR) and magnetization study of La0.5Ca0.5MnO3, we discuss about the nature of the complex phase-segregated state established in this compound below T~210 K. Between TN<T<TC, the ESR spectra shows two lines characteristic of two different magnetic phases. From the resonance field (Hr) derived for each line we argue that the incommensurate-charge-ordering phase (ICO) which coexists with ferromagnetic-metallic (FMM) clusters in this temperature interval, is mainly paramagnetic and not antiferromagnetic. The FMM/ICO ratio can be tuned with a relatively small field, which suggests that the internal energy associated with those phases is very similar. Below TN, there is an appreciable FM contribution to the magnetization and the ESR spectra indicates the presence of FM clusters in an antiferromagnetic matrix (canted). Our results show that ESR could be a very useful tool to investigate the nature of the phase-separated state now believed to play a fundamental role in the physics of mixed valent manganites.Comment: 6 pages, 6 figure

Intellectual disability and ageing: a new challenge for the twenty-first century

[Resumen] OBJETIVO: Mediante el presente trabajo se pretende conocer las características de la población con retraso mental que ha supera- do la edad de 45 años. MÉTODO: Estudio descriptivo de carácter transversal, entre una muestra representativa de 189 personas mayores de 45 años, con certificado de minusvalía que acredite la discapacidad psíquica, seleccionadas aleatoriamente entre las institucionalizadas en los centros de la comunidad autónoma gallega. La herramienta para recoger la información ha sido un cuestionario de elaboración propia, debidamente contrastado. RESULTADOS: El 60% de los entrevistados reside con sus familias, con las que mantienen una relación calificada como buena en el 49,7% de los casos. El 48,7% presenta un coeficiente intelectual con un retraso moderado, y profundo en el 36,5%; no se conoce el origen del retraso mental en el 42,85% de los casos. CONCLUSIONES: Las necesidades detectadas en la calidad asistencial llevan a concluir la urgencia de actuar sobre los recursos, equipamientos y el grado de especialización de los profesionales implicados, sin obviar a las familias, que constituyen el verdadero soporte asistencial.[Abstract] OBJECTIVE: The aim of this study was to determine the characteristics of adults with intellectual disability who survive for more than45 years. METHODS: We performed a cross-sectional, descriptive study of a representative sample of 189 individuals aged more than 45 years with certified intellectual disability. The subjects were randomly selected from individuals attending centres of the Autonomous Community of Galicia in Spain. The instrument used to gather information was a specifically-designed and validated questionnaire. RESULTS: Sixty percent of subjects lived with their families, with whom 49.7% reported a good relationship. The degree of intellectual disability was moderate in 49.7% and severe in 36.5%. Aetiology was unknown in 42.5%. CONCLUSIONS: Shortfalls detected in the quality of care indicate that urgent action should be taken to improve resources and the degree of specialisation among staff, as well as to aid families, who provide the main support to individuals with mental disability

Papel del logopeda en un centro gerontológico de estancias diurnas

[Resumen] El aumento de población anciana en nuestra sociedad es un hecho que ha provocado la aparición de nuevos recursos socio-sanitarios que cubran sus necesidades. El Centro Gerontológico de Estancias Diurnas es un servicio multidisciplinar diurno que se ocupa de la atención social y sanitaria, con actuación terapéutica y preventiva, de los mayores facilitando la vida laboral de las personas que se ocupan ordinariamente de su cuidado. Los centros de día deben proporcionar una atención integral debiendo, por tanto, estar constituidos por un equipo profesional multidisciplinar en el que la figura del logopeda esté presente desarrollando una labor específica. Parece, por tanto, interesante delimitar las funciones básicas a desempeñar, los trastornos más comunes susceptibles de intervención, así como, algunas directrices a tener en cuenta.[Abstract] The increase of the senior population in our society is an event that has provoked the appeareance of a new sort of social and sanitary recource, a structure that has to be concerned with the needs of this population. The gerontologic day-center is in brief a multidisciplinar service, that works during day time, treating the social and sanitary occupation of our elder with both therapeutic and preventive acts. This to provide a normal working life for the people who are usually taking care of these people. Day-centers have to answer these needs with a complete service, and for that reason they have to apile to a multidisciplinar staff in wich the speech-therapist develops a specific role. It seems though interesting to define the basic functions that a professional speech-therapist has to perform, such as the most common disorders capable of treatment and general intervention, as well derectives to bear in mind

Field campaign on pressure on the crown wall at the outer port of Punta Langosteira breakwater

[Abstract:] Punta Langosteira port, located in A Coruña (Spain), was monitored during the winters of 2017 and 2018, measuring wave pressure in the crown wall structure. Furthermore, the metocean variables were measured on a buoy located very close to the breakwater. This paper presents the real pressures measured at the crown wall of the breakwater during different storm events. These values are compared with the results of the application of state-of-the-art equations for the calculation of pressures on crown walls. The results obtained show the behaviour of the pressures with a crown wall fully protected by the armour, as is the case of Langosteira breakwater. Finally, several conclusions are made on the methodology for measuring the pressures using physical models and the relevance of the armour roughness.Fundação para a Ciência e a Tecnologia (FCT); PTDC/ECI-EGC/31090/201

The SAMI Galaxy Survey: Stellar population radial gradients in early-type galaxies

We study the internal radial gradients of the stellar populations in a sample comprising 522 early-type galaxies (ETGs) from the SAMI (Sydney- AAO Multi-object Integral field spectrograph) Galaxy Survey. We stack the spectra of individual spaxels in radial bins, and derive basic stellar population properties: total metallicity ([Z/H]), [Mg/Fe], [C/Fe] and age. The radial gradient ($\nabla$) and central value of the fits (evaluated at R$_e$/4) are compared against a set of six possible drivers of the trends. We find that velocity dispersion ($\sigma$) - or, equivalently gravitational potential - is the dominant driver of the chemical composition gradients. Surface mass density is also correlated with the trends, especially with stellar age. The decrease of $\nabla$[Mg/Fe] with increasing $\sigma$ is contrasted by a rather shallow dependence of $\nabla$[Z/H] with $\sigma$ (although this radial gradient is overall rather steep). This result, along with a shallow age slope at the massive end, imposes stringent constraints on the progenitors of the populations that contribute to the formation of the outer envelopes of ETGs. The SAMI sample is split between a 'field' sample and a cluster sample. Only weak environment-related differences are found, most notably a stronger dependence of central total metallicity ([Z/H]$_{e4}$) with $\sigma$, along with a marginal trend of $\nabla$[Z/H] to steepen in cluster galaxies, a result that is not followed by [Mg/Fe]. The results presented here serve as constraints on numerical models of the formation and evolution of ETGs.Comment: 14 pages, 9 figures, 3 tables. Submitted to MNRA

Reconstructing the impact of human activities in a NW Iberian Roman mining landscape for the last 2500 years

This article was made available through the Brunel Open Access Publishing Fund.Little is known about the impact of human activities during Roman times on NW Iberian mining landscapes beyond the geomorphological transformations brought about by the use of hydraulic power for gold extraction. We present the high-resolution pollen record of La Molina mire, located in an area intensely used for gold mining (Asturias, NW Spain), combined with other proxy data from the same peat core to identify different human activities, evaluate the strategies followed for the management of the resources and describe the landscape response to human disturbances. We reconstructed the timing and synchronicity of landscape changes of varying intensity and form occurred before, during and after Roman times. An open landscape was prevalent during the local Late Iron Age, a period of relatively environmental stability. During the Early Roman Empire more significant vegetation shifts took place, reflected by changes in both forest (Corylus and Quercus) and heathland cover, as mining/metallurgy peaked and grazing and cultivation increased. In the Late Roman Empire, the influence of mining/metallurgy on landscape change started to disappear. This decoupling was further consolidated in the Germanic period (i.e., Visigothic and Sueve domination of the region), with a sharp decrease in mining/metallurgy but continued grazing. Although human impact was intense in some periods, mostly during the Early Roman Empire, forest regeneration occurred afterwards: clearances were local and short-lived. However, the Roman mining landscape turned into an agrarian one at the onset of the Middle Ages, characterized by a profound deforestation at a regional level due to a myriad of human activities that resulted in an irreversible openness of the landscape. © 2014 The Authors

EP05.02-003 Durvalumab after Chemoradiotherapy (CRT) in Unresectable Stage III NSCLC. Comparative Study of Two Cohorts in the Real-World Setting

[EN] Introduction: Durvalumab is the new standard of care for unresectable locally advanced NSCLC, with PD-L1 _1% and who did not have progression after CRT treatment in the European Union. Our study compares the effectiveness and the frequency of radiation pneumonitis in patients treated with concurrent CRT with or without durvalumab consolidation during the same period in real clinical practice. Methods: A single-center retrospective study. 71 treated patients with unresectable stage III NSCLC were included between March 2018 and December 2021, 37 with CRT followed by durvalumab and 34 with CRT alone. Real-world progression-free survival (rwPFS) and real-world overall survival (rwOS) were calculated since the date of the end CRT. Propensity score matching (PSM) 1:1 was used to account for differences in baseline characteristics. Results: Median age was 67 years (range 46-82). 25.4% of the patients were _75 years old. 78.9% were men and 53.5% former smokers. 54.9% had squamous histology and 28%, 51% and 21% stage IIIA, IIIB and IIIC disease, respectively. The most used scheme was carboplatinpaclitaxel (43.7%), receiving induction chemotherapy in up to 54.9% of patients. 73.2% received between 60-66 Gy doses of radiotherapy. Median time from end of CRT to onset durvalumab was 44 days (range 13-120) with a median of 14 infusions (range 6-27). Of the 34 patients without durvalumab treatment, the expression PD-L1 <1% (58.8%) was the most frequent cause for rejecting consolidation therapy. After PSM analysis, patients distributions were well balanced. With a median follow-up of 19.7 months (range 1.4-36.6); median rw-PFS was 9.3 months (95% CI, 5-13.5) without durvalumab and 17 months (95% CI, 11-22.9) with durvalumab (p¼0.013). Median rw-OS was 19.3 months (95% CI, 3.8-34.8) without durvalumab and 29.9 months (95% CI, 23.3-36.6) with durvalumab (p¼0.241) with a rw-OS% at 6, 18 and 24 months of 90%, 62% and 49% vs 100%, 86% and 74%, respectively. The rate of radiation pneumonitis was more frequent with durvalumab consolidation (56.8% against 44.1%), (p¼0.346), especially within 3 months after CRT. G3 pneumonitis was only observed in the consolidation therapy. Conclusions: Our results demonstrate the effectiveness of durvalumab consolidation after CRT in real-world patients with unresectable stage III NSCLC. Further sample and longer follow-up are required to obtain more accurate results. Active surveillance and appropriate management for radiation pneumonitis are needed, in especially in candidates for consolidation treatmentS

EP05.02-002 Who Benefits More of Durvalumab after Chemoradiotherapy (CRT) in Real-World Patients with Locally Advanced Non-Small-Cell Lung Cancer (NSCLC)?

[EN] Introduction: Durvalumab received EMA approval as consolidation therapy (CT) for unresectable stage III NSCLC with PD-L1 _1% and who did not have progression after CRT. Our objective was to analyze in real clinical practice the effectiveness of durvalumab and explore the clinical factors that may be associated with the benefit from CT. Methods: Retrospective study was made at Hospital of Leon (Spain), including 37 patients with locally advanced NSCLC treated with durvalumab after CRT treatment between March 2018 and october 2021 (40.5% patients were included in the durvalumab early access program). The neutrophil-to-lymphocyte ratio (NLR) could identified after CRT as a factor that may be benefit from durvalumab. Results: Median age was 67 years (range 46-82 years). 40.5% of patients were _70 years old. 78.4% were male and 51.4% smokers. 54% had non-squamous histology. PD-L1 expression was <1% in 5% and not available in 8% patients. 2.7% ROS1 rearrangements, 5.4% KRAS mutations and not available in 43.2% patients. Stage IIIA, IIIB, IIIC disease were 24.3%, 54.1% and 21.6%, respectively. Median time from end of CRT to onset durvalumab was 44 days (range 13-120 days). Overall median CT duration was 214.8 days (range 69-399 days) with a median of 14 infusions (range 6-27 infusions). With a median follow up of 19.7 months (range 1.4-34.9 months); 67.6% had stopped CT: 37.8% due to completing treatment, 16.2% disease progression, 10.8% adverse event and 2.7% due to COVID19 infection. Median real-world progressionfree survival (rwPFS) was 17 months (95% CI, 11-23). Median realworld overall survival (rwOS) was 29.9 months (95% CI, 23.3-36.6). % rwOS at 6, 18 and 24 months were 100%, 86.9% and 74.5%, respectively. For patients with post-CRT NLR not exceeding the cohort median value of 6, receipt of durvalumab was associated with an improvement in rwOS (median not reached vs 25.7 months; p¼0.025). 56.8% patients had any grade of radiation pneumonitis (median time from CRT start: 119 days [range 36-241 days]). Of these, 19% patients developed worsening of radiation pneumonitis with durvalumab. 54,1% developed immune-mediated toxicity, mostly G1-2 (85.1%). Conclusions: Our results demonstrate the effectiveness of durvalumab consolidation in this patients population in a real-life setting. We identified low NLR after CRT as a potentially predictive factor for the benefit of CT in locally advanced NSCLC.S

Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation

Aims: Adiposity plays a key role in the pathogenesis of atrial fibrillation (AF). Our aim was to study the sex differences in adipokines levels according to AF burden. Methods and results: Two independent cohorts of patients were studied: (i) consecutive patients with AF undergoing catheter ablation (n = 217) and (ii) a control group (n = 105). (i) Adipokines, oxidative stress, indirect autonomic markers, and leucocytes mRNA levels were analysed; (ii) correlation between biomarkers was explored with heatmaps and Kendall correlation coefficients; and (iii) logistic regression and random forest model were used to determine predictors of AF recurrence after ablation. Our results showed that: (i) fatty acid-binding protein 4 (FABP4) and leptin levels were higher in women than in men in both cohorts (P < 0.01). In women, FABP4 levels were higher on AF cohort (20 ± 14 control, 29 ± 18 paroxysmal AF and 31 ± 17 ng/mL persistent AF; P < 0.01). In men, leptin levels were lower on AF cohort (22 ± 15 control, 13 ± 16 paroxysmal AF and 13 ± 11 ng/mL persistent AF; P < 0.01). (ii) In female with paroxysmal AF, there was a lower acetylcholinesterase and higher carbonic anhydrase levels with respect to men (P < 0.05). (iii) Adipokines have an important role on discriminate AF recurrence after ablation. In persistent AF, FABP4 was the best predictor of recurrence after ablation (1.067, 95% confidence interval 1-1.14; P = 0.046). Conclusion: The major finding of the present study is the sex-based differences of FABP4 and leptin levels according to AF burden. These adipokines are associated with oxidative stress, inflammatory and autonomic indirect markers, indicating that they may play a role in AF perpetuation.This study was supported by projects (PI16/01282 and PI18/01584) integrated in the Plan Estatal de I+D+I 2016–2019 and cofounded by ISCIII-Subdirección General de Evaluación y Fomento de la Investigación del Fondo Europeo de Desarrollo Regional (FEDER). J.N.L.-C. and M.R.-M. were a recipient of a Sociedade Galega de Cardioloxía (SOGACAR) research grant. D.d.G.-C. was a recipient of a Juan de la Cierva-Incorporación grant from the Ministry of Science Innovation and Universities (IJCI-2016-29393). CIBER Cardiovascular (CB16/11/00403 to V.Ll.-C. and D.d.G.-C.) is a project from Carlos III Health Institute.Peer reviewe

Complemento de la anatomía digital a la enseñanza clásica

Objetivos: Investigar cual es el estado actual del uso de anatomía 3D, en los aspectos relacionados al proceso enseñanza-aprendizaje. Materiales y métodos: Mediante un formulario online se realizó una encuesta dirigida a docentes y estudiantes de ciencias de la salud.Facultad de Ciencias Médica