Planificación docente y evaluación del Practicum de la licenciatura de veterinaria en la Granja Docente Veterinaria de Murcia. Póster

[SPA]Este trabajo expone la planificación, desarrollo y evaluación del Practicum de la licenciatura de Veterinaria en su rotación por la Granja Docente Veterinaria (GDV) con el nuevo modelo de aprendizaje englobado en el Espacio Europeo de Educación Superior. Los alumnos al finalizar el segundo ciclo de la Licenciatura de Veterinaria de Murcia realizan el Practicum mediante rotaciones por Organismos Públicos y Privados para certificar la adquisición de las competencias adquiridas durante la licenciatura. Para el acercamiento al mundo laboral de la Producción Animal una de estas rotaciones se desarrolla en la GDV. La organización de la asignatura implica a un elevado número de profesionales cada uno de ellos con funciones claramente definidas. A los alumnos divididos en pequeños grupos, se les facilitan diferentes herramientas (TIC, tutorías, ABP…) y trabajan de forma activa y autónoma para la resolución de las tareas propuestas y consecución de los objetivos inicialmente marcados. Al finalizar, los alumnos tras una tutoría, son evaluados con distintos instrumentos desde distintas perspectivas en su rotación por la GDV. Así mismo, los alumnos evalúan el desarrollo del Practicum por la GDV y en definitiva consideran satisfactorio el nuevo modelo de aprendizaje. [ENG]This paper describes the planning, development and evaluation of the Practicum of the Veterinary degree in the Veterinary Teaching Farm (GDV) with the new learning model fell within the European Higher Education Area. At the end of the second cycle of Murcia Veterinary Degree students complete the Practicum rotations through public and private agencies to certify the acquisition of skills acquired during the degree. For the approach to employment of Animal Production one of these rotations is developed in the GDV. The organization of the subject involves a large number of professionals each with clearly defined functions. Students in small groups, are provided with different tools (TIC, tutorials, ABP ...) and work proactively and autonomously. At the end, they have tutorials with professionals tutors to solve the proposed tasks and objectives initially set. Upon completion, students are evaluated with different instruments. Also, students evaluate the development of the GDV Practicum and are satisfied with the new learning model.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C-Substituted Piperazines

Piperazine rings are essential motifs frequently found in commercial drugs. However, synthetic methodologies are mainly limited to N-substituted piperazines, preventing structural diversity. Disclosed herein is a straightforward catalytic method for the synthesis of complex C-substituted piperazines based on an uncommon head-to-head coupling of easily prepared imines. This 100% atom-economic process allows the selective formation of a sole diastereoisomer, a broad substrate scope, and a good functional group tolerance employing a bench-stable iridium catalyst under mild reaction conditions. Key to the success is the addition of N-oxides to the reaction mixture, as they notably enhance the catalytic activity and selectivity

EXANET: Herramienta para fomentar el aprendizaje autónomo y auto-evaluación en contextos presenciales y virtuales

[SPA]El objetivo del trabajo es presentar y evaluar la herramienta EXANET del módulo docente en la plataforma de campus virtual de la Universidad de Murcia (SUMA 2.0). Dicha herramienta ha sido utilizada durante el desarrollo de las sesiones prácticas de la asignatura Nutrición Animal de la Licenciatura de Veterinaria durante los cursos académicos 2009/2010 y 2010/2011. Exanet ha sido utilizado como herramienta complementaria y de apoyo para fomentar el aprendizaje autónomo de los alumnos, y proporcionar información sobre sus progresos para preparar la evaluación del módulo de prácticas del primer y segundo cuatrimestre. Se han diseñado un total de 18 pruebas de auto-evaluación a partir de una base de datos de preguntas para cada bloque de contenidos (análisis químicos, microscopía de piensos, valoración nutritiva y legislación, formulación y alimentación práctica). Cada prueba constaba de 10 preguntas y era de carácter mixto, con preguntas tipo test y de emparejamiento de términos, además de la inclusión de imágenes. En la configuración de las pruebas virtuales, se especificó el inicio y tiempo máximo de resolución de cada examen, con la posibilidad de su corrección inmediata y su repetición tras dicha corrección. La herramienta ha sido utilizada por más del 90% de los alumnos en prácticas, accediendo una media de 3 veces por prueba. Los alumnos han valorado la incorporación de la herramienta de auto-evaluación como buena (49%) o muy buena (47%), y más del 20% no ha encontrado ningún inconveniente para su realización. Los resultados nos indican que EXANET ha sido una experiencia de innovación educativa válida y positiva. [ENG]The aim of this paper is to present and evaluate EXANET as a tool in the Virtual Campus of the University of Murcia (SUMA 2.0). This tool has been used for the practical sessions in the subject “Animal Nutrition” of the Veterinary Medicine degree during the academic years 2009/2010 and 2010/2011. EXANET has been used as a complement and support to encourage independent student learning, and to provide information about the progress in preparing the assessment of the practical sessions of the first and second term. We have designed a total of 18 self-assessment tests from a database of questions designed for each block of content (chemical analysis, feed microscopy, nutritive evaluation and legislation, feed formulation and practical feeding). Each test consisted of 10 questions, which could be multiple choice, matching words, or image identification. In the configuration of each virtual test was specified the start time and maximum resolution time, with the possibility of immediate correction and repetition after correction. The tool has been used by more than 90% of students, and, on average, they performed 3 times each test. Students have appreciated the inclusion of this self-assessment tool as good (49%) or very good (47%), and more than 20% of them did not find any drawback to its implementation. The results indicate that EXANET has been an innovative and positive educational experience.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

Origin and driving mechanisms of marine litter in the shelf-incised Motril, Carchuna, and Calahonda canyons (northern Alboran Sea)

Introduction and methodsMarine litter density, distribution and potential sources, and the impact on canyon seafloor habitats were investigated in the Motril, Carchuna and Calahonda canyons, located along the northern margin of the Alboran Sea. During the ALSSOMAR-S2S oceanographic survey carried out in 2019, canyon floor imagery was collected by a Remotely Operated Vehicle along 5 km in the Motril Canyon, 10 km in the Carchuna Canyon, and 3 km in Calahonda Canyon, together with 41 surficial sediment samples. Additionally, coastal uses, maritime traffic and fishing activity data were analyzed. A 50 m resolution multibeam bathymetry served as base map. ResultsIn the Motril and Calahonda canyons, the density of marine litter was low and the material was dispersed, very degraded and partially buried. In contrast, the Carchuna Canyon contained a greater amount and variety of litter. The Carchuna Canyon thalweg exhibited a density of marine litter up to 8.66 items center dot 100 m(-1), and litter hotspots with a density of up to 42 items center dot m(2) are found along the upper reaches of the canyon thalweg. DiscussionLow litter abundances found in the studied canyons most likely reflect low population densities and the absence of direct connections with streams in the nearby coasts. The high shelf incision of the Carchuna Canyon and its proximity to the coastline favor littoral sediment remobilization and capture as well as the formation of gravity flows that transport the marine litter along the thalweg toward the distal termination of the channel. Litter hotspots are favored by the canyon morphology and the occurrence of rocky outcrops. Most debris is of coastal origin and related to beach occupation and agricultural practices in the adjacent coastal plain. A third origin was represented by fishing gear in the study area. Fishing activity may be producing an impact through physical damage to the skeletons of the colonial scleractinians located in the walls of the Carchuna Canyon. In contrast, the Motril and Calahonda canyons can be considered passive systems that have mainly acted as depositional sinks in the recent past, as evidenced by buried marine litter.18-ESMARES2-CIRCA project of the Instituto Español de Oceanografıa; DL57/2016/CP1361/CT0009info:eu-repo/semantics/publishedVersio

Enzyme replacement therapy for the treatment of Hunter disease: A systematic review with narrative synthesis and meta-analysis

Background: In the last 10 years enzyme replacement therapy (ERT) has become an alternative for the treatment of patients with Hunter disease (HD). Nevertheless, the information regarding efficacy and safety is scarce and mainly based on the pivotal trials. This scarcity is especially evident for adults and severe forms of HD. Methods: A systematic review of publications in the electronic databases PUBMED, EMBASE and Cochrane Central was undertaken. Clinical trials and observational studies were included. The data about efficacy and security were retrieved and analysed with Review Manager version 5.3. Results: 677 records were found, 559 remaining after the removal of duplicates. By title and abstract review, 427 were excluded. Full reading of the rest was made (122 publications) and 42 were finally included. It was not possible to perform meta-analysis of all the endpoints due to high heterogeneity in the reporting and measuring of variables in each publication. Eight clinical trials were included, 6 with high risk of bias. The quality of the other studies was low in 12%, average in 68% and good in 21%. Main findings were: a reduction in the elimination of glycosaminoglycans (GAG) in urine in all the studies (26/26), decrease in liver and spleen size (18/18), increase of 52.59 m (95% CI, 36, 42-68.76, p < .001) in the 6-min walk test (TM6M), increase in forced vital capacity (FVC) of 9.59% (95% CI 4.77-14.51, p < .001), reduction of the left ventricular mass index of 3.57% (95% CI 1.2-5.93) and reduction in mortality (OR) of 0.44 (0.27-0.71). Discussion: The data suggests a clear and consistent effect of ERT in HD reducing the accumulation of GAGs in the body, demonstrated by the reduction of its urinary excretion, as well as by the reduction of its deposits (spleen, liver and heart). Likewise, there is an improvement in physical and respiratory function. In addition, a reduction in mortality has been observed. Lack of studies, small size of the samples, and methodological deficiencies are the main limitations to establish definite conclusions. Conclusions: The data suggests that ERT is effective and safe in the treatment of HD. There is a need to evaluate patient-centred outcomes and the impact on quality of life

Short–term effects of air pollution and noise on emergency hospital admissions in Madrid and economic assessment

The aim of this study was to study the effect of air pollution and noise has on the population in Madrid Community (MAR) in the period 2013–2018, and its economic impact

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

BACKGROUND: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However, no longitudinal study has investigated the association between CLOCK gene variation and T2D or CVD incidence. Moreover, although in a previous work we detected a gene-diet interaction between the CLOCK-rs4580704 (C > G) single nucleotide polymorphism (SNP) and monounsaturated (MUFA) intake on insulin resistance, no interventional study has analyzed gene-diet interactions on T2D or CVD outcomes. METHODS: We analyzed the association between the CLOCK-rs4580704 SNP and incidence of T2D and CVD longitudinally in 7098 PREDIMED trial (ISRCTN35739639) participants after a median 4.8-year follow-up. We also examined modulation by Mediterranean diet (MedDiet) intervention (high in MUFA) on these associations. RESULTS: We observed a significant association between the CLOCK-rs4580704 SNP and T2D incidence in n = 3671 non-T2D PREDIMED participants, with variant allele (G) carriers showing decreased incidence (dominant model) compared with CC homozygotes (HR: 0.69; 95 % CI 0.54-0.87; P = 0.002). This protection was more significant in the MedDiet intervention group (HR: 0.58; 95 % CI 0.43-0.78; P < 0.001) than in the control group (HR: 0.95; 95 % CI 0.63-1.44; P = 0.818). Moreover, we detected a statistically significant interaction (P = 0.018) between CLOCK-rs4580704 SNP and T2D status on stroke. Thus, only in T2D subjects was CLOCK-rs4580704 SNP associated with stroke risk, G-carriers having decreased risk (HR: 0.61; 95 % CI 0.40-0.94; P = 0.024 versus CC) in the multivariable-adjusted model. CONCLUSIONS: In agreement with our previous results showing a protective effect of the G-allele against hyperglycemia, we extended our findings by reporting a novel association with lower T2D incidence and also suggesting a dietary modulation. Moreover, we report for the first time an association between a CLOCK polymorphism and stroke in T2D subjects, suggesting that core clock genes may significantly contribute to increased CVD risk in T2D

Análisis de la utilidad de las herramientas docentes del Campus Virtual SUMA de la Universidad de Murcia percibida por los alumnos de Veterinaria. Póster

[SPA]En el marco de la Educación Superior, los Entornos Virtuales de Aprendizaje (EVA) son ampliamente utilizados como una de las herramientas de las Tecnologías de Información y Comunicación (TIC) usadas como soporte para la enseñanza virtual, mixta (blended) y presencial. La Universidad de Murcia ha desarrollado su propio entorno (EVA) denominado SUMA (Servicios de la Universidad de Murcia Abierta). El objetivo del presente trabajo fue evaluar la utilidad de las herramientas docentes implementadas por SUMA desde el punto de vista del estudiante de Veterinaria (Universidad de Murcia). Este estudio fue realizado durante el curso académico 2009/2010, llevándose a cabo una encuesta entre los estudiantes de la carrera de Veterinaria. Una muestra aleatoria de 177 encuestas fue obtenida para este estudio. Los datos fueron analizados utilizando el paquete estadístico SPSS. Las herramientas docentes “Llamamiento a exámenes”, “Contenidos” y “Tablón de anuncios de la asignatura” obtuvieron un valor de utilidad igual o mayor a 5, en una escala de Likert (de 1 a 6), en más de un 75% de los casos evaluados. Por otra parte, las herramientas que recibieron menor puntuación fueron el “Chat” y los “Foros”. [ENG]In the framework of Higher Education, the Virtual Learning Environments (VLEs) are widely used as an Information and Communication Tool (ICTs) for supporting the virtual, blended and face-to-face teachinglearning process. The University of Murcia has developed its own VLE, named Services of the Open University of Murcia (SUMA). The aim of this study was to evaluate the utility of the teaching tools provided by SUMA, from the veterinary students’ point of view (University of Murcia). To carry out this research, during the academic year 2009/2010, a survey was conducted among the students of the Veterinary Degree. A random sampling was conducted, obtaining a sample of 177 surveys. Data analysis was performed using several statistical tests using the SPSS software package. The teaching tools “Exams Notice Board”, “Content Delivery System” and “Subject Notice Board” got a value equal or higher than 5, in a Likert Scale of utility (1 to 6) in more than the 75% of the cases. On the other hand, the tools with lower score were “Chats” and “Forums”.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

Short-term impact of noise, other air pollutants and meteorological factors on emergency hospital mental health admissions in the Madrid region

A number of environmental factors, such as air pollution, noise in urbanised settings and meteorological-type variables, may give rise to important effects on human health. In recent years, many studies have confirmed the relation between various mental disorders and these factors, with a possible impact on the increase in emergency hospital admissions due to these causes. The aim of this study was to analyse the impact of a range of environmental factors on daily emergency hospital admissions due to mental disorders in the Madrid Autonomous Region (MAR), across the period 2013–2018

Niveles plasmáticos de oxitocina bajo condiciones de estrés y prosociabilidad en el trastorno bipolar: un estudio longitudinal

La oxitocina es un neuropéptido sintetizado en los núcleos paraventricular y supraóptico del hipotálamo que regula diferentes aspectos de la cognición social, la generación de confianza y la conducta de apego. Existe un funcionamiento deficiente en la depresión, asociado a aislamiento social. La manía bipolar se caracteriza por una marcada pro-sociabilidad, facilidad para generar comunicación y conductas de apego, promiscuidad sexual y aumento del discurso verbal. Objetivos: 1. comparar los niveles plasmáticos de OXT bajo condiciones de estrés en pacientes diagnosticados de trastorno bipolar en las fases de manía, eutimia y depresión; 2. Analizar la asociación entre los niveles de OXT bajo condiciones de estrés y la prosociabilidad (medida a través de la cognición social y la valencia positiva a estímulos sociales) en el trastorno bipolar, así como entre niveles de OXT e intensidad sintomática; 3. Comparar los niveles de OXT y vasopresina (AVP) bajo condiciones de estrés en pacientes con trastorno bipolar en fase de manía, eutimia y depresión.Instituto de Salud Carlos III2022-2