Resección compartimental mediante abordaje quirúrgico modificado en sarcomas de partes blandas del deltoides

Se describe una técnica quirúrgica para la resección radical de sarcomas de partes blandas confinados al compartimento deltoideo en tres pacientes, así como los resultados clínicos y funcionales, además de la evolución oncológica de su patología. Se realiza un abordaje en “Y” que permite la desinserción proximal y distal del deltoides, incluyendo en la pieza tumoral una isla cutánea lateral con la zona de biopsia previa, evitando la necesidad de técnicas de cobertura. No se desarrollaron complicaciones de la herida quirúrgica ni casos de recurrencias locales. Todos los pacientes presentaron un rango de movilidad mínimo de 130º de abducción y una pérdida de fuerza para la abducción y antepulsión. Concluimos que los pacientes con neoplasias malignas confinadas al compartimento deltoideo tratados con la resección radical según la técnica descrita presentan unos resultados funcionales excelentes, en ausencia de lesiones del manguito concomitantes, con un menor riesgo de recidiva local.A surgical technique for radical excision of soft tissue malignant sarcomas is described and functional and oncologic outcomes of this procedure in three patients diagnosed of soft tissue sarcoma are reported. A “Y” approach is used to perform a complete release of deltoid attachments in the scapula, clavicle and proximal humerus. This approach also allows an excision of the biopsy site, avoiding the establishment of large flaps coverage. No local recurrence or surgical wound complications were found. All the patients showed a good range of motion (130º of abduction) but loss of strength in abduction and antepulsion was found. We conclude that patients with malignant soft tissue tumors involving the deltoid muscle which undergo a wide resection of the bump through the previously described technique have an excellent functional outcome with low risk of recurrence, in absence of concomitant rotator cuff injuries

Manejo de la infección protésica de hombro con gran defecto óseo: descripción de un caso complejo

La infección periprotésica de hombro tiene una incidencia de entre el 0.4% al 2.9%; su tratamiento es controvertido y se basa en la experiencia sobre infecciones protésicas de rodilla y cadera. Presentamos el caso de una paciente quien fue tratada mediante recambio en dos tiempos, la cual presentó como complicación añadida un gran defecto óseo metafisodiafisario tratado siguiendo pautas establecidas en la literatura actual, con buen resultado final, valorando aspectos analíticos, radiológicos y clínicosShoulder periprosthetic infection has an incidence of 0.4% to 2.9%; treatment is controversial and is based on the experience of prosthetic hip and knee infections. We report a patient who was treated by two-stage exchange, which added complication presented as a large bone defect treated following guidelines established in the current literature, with good outcome, evaluating blood analysis, radiological and clinical aspects

Modeling the isothermal inactivation curves of Listeria innocua CECT 910 in a vegetable beverage under low-temperature treatments and different pH levels

Thermal inactivation kinetics of Listeria innocua CECT 910 inoculated in a vegetable beverage at three pH conditions (4.25, 4.75, and 5.20), four levels of temperature (50, 55, 60, 65℃), and different treatment times (0–75 min) were obtained. Survival curves did not follow a log-linear relationship and consequently were fitted to various mathematical models: Weibull, Geeraerd, Cerf with shoulder, and the modified Gompertz equation. Results indicated that the best model for the treatment conditions was the modified Gompertz equation, which provides the best goodness-of-fit and the lowest Akaike information criterion value. Sensitivity analysis indicated that the most influential factors affecting the final microbial load were temperature and time in the case of the higher temperature level (65℃) and time in the case of the lower temperature level (50℃).This paper has been partially supported by research grants MTM2013-42323-P and AGL2013-48993-C2-2-R from the Spanish Ministry of Economy and Competiveness.Peer reviewe

Non-bituminous binders formulated with bio-based and recycled materials for energy-efficient roofing applications

Non-bituminous binders have been designed as potential roofing materials with sustainable characteristics. To that end, three bio-based rosin esters (R), a waste cooking oil (O) and a recycled polyethylene from greenhouse agriculture (LDPEr) have been used in their formulations. A comprehensive rheological, microstructural, calorimetric, and technological characterization have been performed on binary (polymer/oil or rosin/oil) and ternary (polymer/rosin/oil) blends, allowing the compatibility among binder compounds to be studied. Additionally, thermal conductivity and solar radiation tests have been conducted on a selected non-bituminous binder and compared with a reference polymer modified bitumen. The formulation composed of 61.0% phenolic-modified rosin, 30.5% oil and 8.5% LDPEr has shown suitable mechanical properties for roofing materials, and has exhibited enhanced energy efficiency derived from its light yellowish to brownish color. Under the experimental radiant flux conditions, surface temperature of the non-bituminous binder was 8 °C lower than that of the black bitumen. Moreover, conduction heat transfer through this roofing material was about 14% lower than that conducted through a bitumen-based membrane with the same thickness. Accordingly, developed binders are expected to behave as reflective building materials aiming to reduce the heat island effects and save energy.This work is part of GreenAsphalt project (ref. 802C1800001), cofunded by FEDER European Programme (80%) and Junta de Andalucía (Consejería de Economía, Conocimiento, Empresas y Unversidades/ Agencia-IDEA), and has been also co-funded by FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento/Project UHU- 1256916. Clara Delgado-S´anchez also acknowledges financial support from Junta de Andalucía through post-doctoral Grant No. DC 01228 (PAIDI 2020), co-funded by the EU Fondo Social Europeo (FSE). Funding for open access charge: Universidad de Huelva / CBUA

Necrosis avascular de cabeza femoral en pacientes con enfermedad de Gaucher tipo I : tratamiento mediante artroplastia total de cadera no cementada

El 80% de los pacientes con enfermedad de Gaucher presentan manifestaciones óseas, siendo la necrosis avascular de la cabeza femoral una de las que mayor limitación produce y la primera causa de intervención quirúrgica osteoarticular. La artroplastia total de cadera cementada ha sido el tratamiento de elección en los casos con mayor deterioro de la articulación, pero sus resultados a medio y largo plazo se han visto ensombrecidos por la elevada tasa de aflojamiento. La terapia enzimática sustitutiva ha disminuido las complicaciones postoperatorias, además de permitir el uso de componentes no cementados con resultados similares a las prótesis implantadas por otros motivos. Presentamos una serie de 5 artroplastias de cadera no cementadas, con un seguimiento medio de 12.4 años (3.4-30), en 4 pacientes con enfermedad de Gaucher tipo I y osteonecrosis de la cabeza femoral. Solo se observó un caso de aflojamiento aséptico a los 18 años de la intervención

Implementation of the AES strategy in a Regional University: the experience of the PACE Program of La Serena University

Avanzar hacia la equidad en el ingreso a la Educación Superior supone un desafío para avanzar en justicia social. En consecuencia, los programas de acompañamiento juegan un rol fundamental para el desarrollo cognitivo, actitudinal – valórico y procedimental, que permiten la inserción efectiva, a fin de lograr las competencias de egreso propuestas en una carrera de pre-grado. Este trabajo pretende presentar el flujo de trabajo utilizado en el Programa de Acompañamiento para la Educación Superior (AES) en el Programa PACE de la Universidad de La Serena, de manera que pueda contribuir a fortalecer la implementación de programas de acompañamiento similar, en alguna (s) de la (s) 31 Instituciones de Educación Superior que ejecutan este Programa en nuestro país, o en su defecto, que estén iniciando un proceso de acompañamiento en alguna Institución de Educación Superior. Una reflexión relevante, es que los programas enfocados en establecer mecanismos de apoyo oportuno a estudiantes que provienen de contextos vulnerables, suponen la entrega de herramientas que promueven la justicia y su propia movilidad social, lo que aumenta las posibilidades de lograr una mejor calidad de vida.Advancing towards equity in the admission to higher education, underlies a challenge to move forward to social justice. As a consequence, transition support programs play a significant role for cognitive, attitudinal, know-how and values development, which allows the effective insertion with the purpose of achieving the graduating competences proposed in an undergraduate degree. This paper, intends to present the work system used in the Accompaniment Program for Higher Education (AHE) within the PACE Program of La Serena University, in a way that may contribute to strengthen the implementation of similar transition support programs, in any of the 31 Institutions of higher education that have implemented this program in Chile, or in any institution which is starting a transition support process. A significant reflection is that programs focused on setting timely supporting mechanisms for students coming from vulnerable contexts involve the delivery of tools that promote justice and their own social mobility, which enhances the possibilities of achieving a better quality of life

Hardware timestamping for image acquisition system based on FlexRIO and IEEE 1588 v2 Standard

Current fusion devices consist of multiple diagnostics and hundreds or even thousands of signals. This situation forces on multiple occasions to use distributed data acquisition systems as the best approach. In this type of distributed systems, one of the most important issues is the synchronization between signals, so that it is possible to have a temporal correlation as accurate as possible between the acquired samples of all channels. In last decades, many fusion devices use different types of video cameras to provide inside views of the vessel during operations and to monitor plasma behavior. The synchronization between each video frame and the rest of the different signals acquired from any other diagnostics is essential in order to know correctly the plasma evolution, since it is possible to analyze jointly all the information having accurate knowledge of their temporal correlation. The developed system described in this paper allows timestamping image frames in a real-time acquisition and processing system using 1588 clock distribution. The system has been implemented using FPGA based devices together with a 1588 synchronized timing card (see Fig.1). The solution is based on a previous system [1] that allows image acquisition and real-time image processing based on PXIe technology. This architecture is fully compatible with the ITER Fast Controllers [2] and offers integration with EPICS to control and monitor the entire system. However, this set-up is not able to timestamp the frames acquired since the frame grabber module does not present any type of timing input (IRIG-B, GPS, PTP). To solve this lack, an IEEE1588 PXI timing device its used to provide an accurate way to synchronize distributed data acquisition systems using the Precision Time Protocol (PTP) IEEE 1588 2008 standard. This local timing device can be connected to a master clock device for global synchronization. The timing device has a buffer timestamp for each PXI trigger line and requires tha- a software application assigns each frame the corresponding timestamp. The previous action is critical and cannot be achieved if the frame rate is high. To solve this problem, it has been designed a solution that distributes the clock from the IEEE 1588 timing card to all FlexRIO devices [3]. This solution uses two PXI trigger lines that provide the capacity to assign timestamps to every frame acquired and register events by hardware in a deterministic way. The system provides a solution for timestamping frames to synchronize them with the rest of the different signals

High Pretransplant BAFF Levels and B-cell Subset Polarized towards a Memory Phenotype as Predictive Biomarkers for Antibody-Mediated Rejection

Antibody-mediated rejection (AbMR) is one of the leading causes of graft loss in kidney transplantation and B cells play an important role in the development of it. A B-cell activating factor (BAFF) is a cytokine involved in B cell ontogeny. Here, we analyzed whether B cell maturation and the e ect of B cell soluble factors, such as BAFF could be involved in AbMR. Serum BAFF levels and B and T cell subpopulations were analyzed 109 kidney transplant patients before transplantation and at 6 and 12 months after kidney transplantation. Pretransplant serum BAFF levels as well as memory B cell subpopulations were significantly higher in those patients who su ered clinical AbMR during the first 12 months after kidney transplantation. Similar results were observed in the prospective analysis of patients with subclinical antibody-mediated rejection detected in the surveillance biopsy performed at 12 months after kidney transplantation. A multivariate analysis confirmed the independent role of BAFF in the development of AbMR, irrespective of other classical variables. Pretransplant serum BAFF levels could be an important non-invasive biomarker for the prediction of the development of AbMR and posttransplant increased serum BAFF levels contribute to AbMR

Preservation of Synchronization Using a Tracy‐Singh Product in the Transformation on Their Linear Matrix

Preservation is related to local asymptotic stability in nonlinear systems by using dynamical systems tools. It is known that a system, which is stable, asymptotically stable, or unstable at origin, through a transformation can remain stable, asymptotically stable, or unstable. Some systems permit partition of its nonlinear equation in a linear and nonlinear part. Some authors have stated that such systems preserve their local asymptotic stability through the transformations on their linear part. The preservation of synchronization is a typical application of these types of tools and it is considered an interesting topic by scientific community. This chapter is devoted to extend the methodology of the dynamical systems through a partition in the linear part and the nonlinear part, transforming the linear part using the Tracy-Singh product in the Jacobian matrix. This methodology preserves the structure of signs through the real part of eigenvalues of the Jacobian matrix of the dynamical systems in their equilibrium points. The principal part of this methodology is that it permits to extend the fundamental theorems of the dynamical systems, given a linear transformation. The results allow us to infer the hyperbolicity, the stability and the synchronization of transformed systems of higher dimension

Síntesis y análisis estructural de la perovskita inorgánico libre de plomo Bi0.5Na0.5TiO3 dopada con praseodimio al 0.4% mol por el método de citratos

Bi0.5Na0.5TiO3 praseodymium doped at 0.4% mol was synthesized by the citrates method, structure characterization show the secondary phase, identifying it in the structural analysis, it was also found that the rhombohedral phase promoted by bismuth as opposed to the cubic phase corresponding to that formed by sodium. These results show the importance of materials science for the design of new functional materials with application in photovoltaic devicesResumen: Se sintetizo el material Bi0.5Na0.5TiO3 dopado con praseodimio al 0.4% mol por el método de citratos, para posteriormente caracterizar su estructura encontrando la presencia de fase secundaria e identificándola en el análisis estructural, asimismo se encontró que predomina la fase romboédrica promovida por el bismuto en contraposición a la fase cubica correspondiente a la formada por el sodio. Estos resultados muestran la importancia de la ciencia de materiales para el diseño de nuevos materiales funcionales con aplicación en dispositivos fotovoltaicos