Substantial spatial variation in glacial erosion rates in the Dronning Maud Land Mountains, East Antarctica

The coast-parallel Dronning Maud Land (DML) mountains represent a key nucleation site for the protracted glaciation of Antarctica. Their evolution is therefore of special interest for understanding the formation and development of the Antarctic ice sheet. Extensive glacial erosion has clearly altered the landscape over the past 34 Myr. Yet, the total erosion still remains to be properly constrained. Here, we investigate the power of low-temperature thermochronology in quantifying glacial erosion in-situ. Our data document the differential erosion along the DML escarpment, with up to c. 1.5 and 2.4 km of erosion in western and central DML, respectively. Substantial erosion at the escarpment foothills, and limited erosion at high elevations and close to drainage divides, is consistent with an escarpment retreat model. Such differential erosion suggests major alterations of the landscape during 34 Myr of glaciation and should be implemented in future ice sheet models.publishedVersio

The brittle evolution of Western Norway – A space-time model based on fault mineralizations, K–Ar fault gouge dating and paleostress analysis

Basement fracture and fault patterns on passive continental margins control the onshore landscape and offshore distribution of sediment packages and fluid pathways. In this study, we decipher the spatial-temporal evolution of brittle faults and fractures in the northern section of the passive margin of Western Norway by combining field observations of fault mineralizations and K–Ar fault gouge dating with different paleostress approaches, resulting in the following model: (1) High-T fault mineralizations indicate Silurian NW-SE compression followed by NW-SE extension in the Early to Mid-Devonian. (2) Epidote, chlorite and quartz fault mineralizations indicate a dominant strike-slip stress field in the Late Devonian to early Carboniferous. (3) E-W extensional stress fields which could be related to Permo-Triassic or Late Jurassic rifting are not prominent in our data set. (4) K–Ar fault gouge ages indicate two extensive faulting events under a WNW-ESE transtensional stress regime with related precipitation of zeolite and calcite in the mid (123-115 Ma) and late (86-77 Ma) Cretaceous. Our results show that the brittle architecture of the study area is dominated by reactivation of ductile precursors and newly formed strike-slip faults, which is different from the dip-slip dominated brittle architecture of the southern section of the West Norway margin.publishedVersio

Basement provenance revealed by U-Pb detrital zircon ages: A tale of African and European heritage in Tuscany, Italy

A new data set of ca. 500 LA-ICP-MS U-Pb detrital zircon ages for six metasedimentary units from the Tuscan basement (Apuan Alps, Monti Pisani, Monticiano-Roccastrada), along with a precise SHRIMP U-Pb crystallization age of a metavolcanic unit (Apuan Alps) have been collected to determine their depositional ages and provenance. These results have been integrated with the recently published ca. 900 U-Pb detrital zircon ages from Elba Island to draw a complete picture of the Paleozoic journey of the Tuscan basement. A major change in the sources supplying sediments to the Tuscan basins is shown to occur during this journey. Detrital zircon ages of early Cambrian to middle Ordovician metasediments mirror those of coeval northern Africa sediments: most samples were sourced in western Africa, while one sample is derived material from central northern Africa. The Tuscan block was therefore located at the peri-Gondwana margin, close to central northern Africa. The prominent mid-Ordovician magmatic arc activity (ca. 460. Ma) at the northern Gondwana margin and its detritus, characterise the zircon age distribution of Ordovician and Silurian volcano-sedimentary rocks, that were therefore generated at the northernmost Gondwana margin during subduction and subsequent initial Paleotethys rifting. The Carboniferous-Permian metasediments are dominated by populations of Ordovician and Variscan-age zircons, with a minor occurrence of Neoarchean and Paleoproterozoic zircons that is best explained by recycling of European Neoproterozoic-Cambrian metasediments. In summary, the main sources supplying the Tuscan basins were located in northern Africa throughout Cambrian-Ordovician times, shifting to the volcanic arc active at the northern Gondwana margin during the middle Ordovician. During Variscan and post-Variscan times, detrital zircon sources were mostly located in European terrains, witnessing the shift of Tuscany from Africa to Europe

From widespread faulting to localised rifting: Evidence from K-Ar fault gouge dates from the Norwegian North Sea rift shoulder

Although seismic and stratigraphic well information put tight constraints on rift basin evolution, eroded rift shoulders commonly expose polydeformed prerift basement whose deformation history may be difficult to constrain. In this work, we apply K-Ar dating of fault gouge samples from 18 faults to explore the brittle deformation of the well-exposed eastern rift margin to the northern North Sea rift. We find evidence of clay gouge formation since the Late Devonian, with distinct Permian and Jurassic fault activity peaks that closely match early stages of the two well-established North Sea rift phases. A marked decay in fault density away from the rift margin confirms a close relationship between rifting and onshore faulting. The results show that initial rift-related extension affected a much wider area than the resulting offshore rift. Hence our data support a rift model where strain is initially distributed over a several 100 km wide region, as a prelude to the development of the ~150–200 km wide Permo-Triassic northern North Sea rift as defined by large marginal faults. Towards the end of the second rift phase, strain localises even more strongly to the 25–50 km wide Viking Graben. Interestingly, a period of early widespread extension is seen for both phases of North Sea rifting and may be a general characteristic of continental rifting. The documented prerift faulting and fracturing of the basement since the Devonian weakened the basement and probably facilitated the widespread initial extension that subsequently localised to form the northern North Sea rift, with further localisation to its relatively narrow central part (Viking Graben).publishedVersio

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome

Acute megakaryoblastic leukaemia (AMKL) is associated with poor prognosis. Limited information is available on its cytogenetics, molecular genetics and clinical outcome. We performed genetic analyses, evaluated prognostic factors and the value of allogeneic haematopoietic stem cell transplantation (allo-HSCT) in a homogenous adult AMKL patient cohort. We retrospectively analysed 38 adult patients with AMKL (median age: 58 years, range: 21–80). Most received intensive treatment in AML Cooperative Group (AMLCG) trials between 2001 and 2016. Cytogenetic data showed an accumulation of adverse risk markers according to ELN 2017 and an unexpected high frequency of structural aberrations on chromosome arm 1q (33%). Most frequently, mutations occurred in TET2 (23%), TP53 (23%), JAK2 (19%), PTPN11 (19%) and RUNX1 (15%). Complete remission rate in 33 patients receiving intensive chemotherapy was 33% and median overall survival (OS) was 33 weeks (95% CI: 21–45). Patients undergoing allo-HSCT (n = 14) had a superior median OS (68 weeks; 95% CI: 11–126) and relapse-free survival (RFS) of 27 weeks (95% CI: 4–50), although cumulative incidence of relapse after allo-HSCT was high (62%). The prognosis of AMKL is determined by adverse genetic risk factors and therapy resistance. So far allo-HSCT is the only potentially curative treatment option in this dismal AML subgroup

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

The patho-mechanism of somatic driver mutations in cancer usually involves transcription, but the proportion of mutations and wild-type alleles transcribed from DNA to RNA is largely unknown. We systematically compared the variant allele frequencies of recurrently mutated genes in DNA and RNA sequencing data of 246 acute myeloid leukaemia (AML) patients. We observed that 95% of all detected variants were transcribed while the rest were not detectable in RNA sequencing with a minimum read-depth cut-off (10x). Our analysis focusing on 11 genes harbouring recurring mutations demonstrated allelic imbalance (AI) in most patients. GATA2, RUNX1, TET2, SRSF2, IDH2, PTPN11, WT1, NPM1 and CEBPA showed significant AIs. While the effect size was small in general, GATA2 exhibited the largest allelic imbalance. By pooling heterogeneous data from three independent AML cohorts with paired DNA and RNA sequencing (N = 253), we could validate the preferential transcription of GATA2-mutated alleles. Differential expression analysis of the genes with significant AI showed no significant differential gene and isoform expression for the mutated genes, between mutated and wild-type patients. In conclusion, our analyses identified AI in nine out of eleven recurrently mutated genes. AI might be a common phenomenon in AML which potentially contributes to leukaemogenesis.Peer reviewe

Substantial spatial variation in glacial erosion rates in the Dronning Maud Land Mountains, East Antarctica

The coast-parallel Dronning Maud Land (DML) mountains represent a key nucleation site for the protracted glaciation of Antarctica. Their evolution is therefore of special interest for understanding the formation and development of the Antarctic ice sheet. Extensive glacial erosion has clearly altered the landscape over the past 34 Myr. Yet, the total erosion still remains to be properly constrained. Here, we investigate the power of low-temperature thermochronology in quantifying glacial erosion in-situ. Our data document the differential erosion along the DML escarpment, with up to c. 1.5 and 2.4 km of erosion in western and central DML, respectively. Substantial erosion at the escarpment foothills, and limited erosion at high elevations and close to drainage divides, is consistent with an escarpment retreat model. Such differential erosion suggests major alterations of the landscape during 34 Myr of glaciation and should be implemented in future ice sheet models