Design Library Solution Patterns in SysML for Concept Design and Simulation

AbstractObject-oriented models in the Systems Modeling Language (SysML) are developed in this paper to support the concept development phase within engineering design. Generic libraries in SysML for functions, according to the functional basis, and structural components, are presented in previous work by the authors. This paper extends this work and proposes the use of multi-solution patterns in SysML that combine a new behavior simulation library together with the previous generic libraries describing functions and components. These patterns capture coherent solutions to known problems that can be reused in concept design with the aim to save modeling effort. Since they are based on solution-neutral functions, they also offer multiple potential solutions at once. The new behavior simulation library and solution patterns are demonstrated in this paper using a 3D printer case study with two different kinematic solutions

Schizophrenic patients in forensic and general psychiatry – a comparison

In Nordrhein-Westfalen ist die Zahl männlicher schizophrener Patienten, die infolge gewalttätiger Delikte gemäß § 63 des Strafgesetzbuchs untergebracht werden, in den letzten Jahren dramatisch gestiegen. Da etwa zwei Drittel der forensischen Patienten in der Allgemeinpsychiatrie vorbehandelt wurden, sind einige Forscher der Meinung, dass es sich bei den forensischen Patienten um eine besonders komplex gestörte Patientengruppe mit einer Reihe von Risikomerkmalen handelt, die in der Allgemeinpsychiatrie unzureichend vorbehandelt wurde. Vor diesem Hintergrund zielt die vorliegende Arbeit darauf ab, allgemeinpsychiatrische und forensische schizophrene Patienten hinsichtlich ihrer Behandlungsvorgeschichte und bestimmter Risikomerkmale zu vergleichen. Es wurden jeweils 72 männliche schizophrene Patienten der Allgemeinpsychiatrie und forensischen Psychiatrie anhand eines standardisierten Interviews zu ihrer psychiatrischen Vorbehandlung und zu ihrer Delinquenzvorgeschichte befragt. Die Behandlungsvorgeschichte wurde anhand von Arztbriefen und Angaben ambulanter Vorbehandler rekonstruiert. Die selbstberichtete Vorstrafenbelastung wurde mit Bundeszentralregister-Auszügen verglichen. Die Ergebnisse dieser Arbeit zeigen, dass sich die forensischen Patienten von den allgemeinpsychiatrischen Patienten durch eine geringere Einbindung in das psychiatrische Versorgungsnetzwerk, eine geringe medikamentöse Compliance, mehr Zwangsbehandlungen wegen Fremdaggressivität, mehr Behandlungsschwierigkeiten und mehr gewalttätige Verhaltensweisen während stationärer Vorbehandlungen unterscheiden. Die forensischen Patienten wiesen mehr Vorstrafen auf und waren häufiger wegen eines Gewaltdeliktes vorbestraft. Hinsichtlich weiterer wesentlicher Risikomerkmale (komorbide Sucht, Alter, Bildung, Störungen des Sozialverhaltens, antisoziale Persönlichkeitsstörung, Gewalt- und Missbrauchserfahrungen) waren die beiden Gruppen jedoch vergleichbar. Für schizophrene Patienten mit einer komorbiden Suchtdiagnose, gewalttätigen Vordelikten und gewalttätigen Verhaltensweisen während stationärer Voraufenthalte sollte vor der Entlassung aus der Allgemeinpsychiatrie eine Anbindung an das ambulante Versorgungsnetzwerk vorbereitet werden und eine besonders intensive Nachbetreuung erfolgen.The number of schizophrenic patients admitted to forensic hospitals according to section 63 of the German Criminal Code has increased continuously over the past years. Prior to admission to a forensic ward, two thirds of schizophrenic patients have been admitted to a general psychiatric institution at least once. Among other factors, forensic admission is seen as a consequence of insufficient pretreatment in general psychiatry. This study aims to identify differences regarding the history of treatment of forensic and general psychiatric patients diagnosed with schizophrenia. The matched samples include 72 male patients from forensic wards and 72 male patients from general psychiatry diagnosed with schizophrenia. The history of psychiatric treatment was reconstructed by interviewing the patients as well as the outpatient psychiatrists and by analyzing these patients’ medical records. Both groups showed similar risk factors, however, forensic patients had a higher number of previous convictions and were convicted more often for violent offences. Furthermore, the data indicate that forensic patients are less integrated into psychiatric care and showed a lower rate of treatment compliance prior to admission to a forensic ward. The results provide support for the arrangement of an intensive outpatient aftercare, especially for schizophrenic patients with comorbid substance abuse disorders and previous convictions for violent offences

Circulating Tumor DNA in Patients with Renal Cell Carcinoma. A Systematic Review of the Literature

CONTEXT: Over the past decade there has been increasing interest in the potential of liquid biopsies and systematic biomarkers in the diagnosis and management of kidney cancer, as they may provide a tool for early detection of disease and monitoring of treatment response. OBJECTIVE: To identify and summarize relevant published data on circulating tumor DNA (ctDNA) in patients with renal cell carcinoma (RCC). EVIDENCE ACQUISITION: We performed a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement of studies identified in PubMed, MEDLINE, EMBASE, and Cochrane Library up to January 15, 2021. Two reviewers independently screened all articles and performed the data extraction. EVIDENCE SYNTHESIS: Nineteen studies investigating ctDNA in RCC (1237 patients) were included and analyzed in the final review. The study size and design varied widely, and the studies were divided into five groups according to the method used for ctDNA detection. The outcome data included (1) the sensitivity/specificity if available; (2) the method used for ctDNA detection; and (3) the main findings in the studies. CONCLUSIONS: The studies highlight that the level of ctDNA in RCC appears to be low. Studies using multiple methods for ctDNA detection indicate that tumor-guided analysis improves the ctDNA detection rate and suggest that cell-free methylated DNA immunoprecipitation and high-throughput sequencing may be a very sensitive method for ctDNA detection in RCC. PATIENT SUMMARY: We systematically reviewed the literature to identify all relevant studies investigating circulating tumor DNA in patients with kidney cancer to investigate its use and potential in this highly malignant disease. We found that the level of circulating tumor DNA is low in kidney cancer and that very sensitive methods have to be used for detection in this disease

Moyo Vol. I N 1

JDB, Greek to Me . 1. Hood, Richard. Hood Advocates Off-Campus Living . 3. Rinehart, Dawn. Beta Press Biggio on Plan B . 10. Boyden, Ode on a Grecian Turn: An Interview with President Michele T. Myers . 6. Rogers, Kirstin. The Social Auction . 11. Bosari, David. Bosari on Brotherhood . 13. Mason, Amy. A Pledge in a Sea of Screaming Girls . 13. Kruse, Kristina. Kruse, Urges Thinking Hard . 14. O\u27Hare, Kimberly. Never Uncertain . 15. Howard, Tressie. D.U.\u27s New Face from Bucknell . 15. Pryor, Derrick. AΦA: A Fraternity of a Different Color . 16. Norpell, Bradley F. The Year of 1950: Looking Back on Fraternity Life . 18. Rogers, Kirstin. Freshman Lambert Co-Authors Book . 19. Bergstrom, Ida. Defending the System . 20. Bristow, Vernall. Meding D.U.\u27s Broken Reputation . 20

Ecosystem services mapping and assessment for policy- and decision-making: Lessons learned from a comparative analysis of European case studies

This paper analyses and compares a set of case studies on ecosystem services (ES) mapping and assessment with the purpose of formulating lessons learned and recommendations. Fourteen case studies were selected during the EU Horizon 2020 “Coordination and Support Action” ESMERALDA to represent different policy- and decision-making processes throughout the European Union, across a wide range of themes, biomes and scales. The analysis is based on a framework that addresses the key steps of an ES mapping and assessment process, namely policy questions, stakeholder identification and involvement, application of mapping and assessment methods, dissemination and communication and implementation. The analysis revealed that most case studies were policy-orientated or gave explicit suggestions for policy implementation in different contexts, including urban, rural and natural areas. Amongst the findings, the importance of starting stakeholder engagement early in the process was confirmed in order to generate interest and confidence in the project and to increase their willingness to cooperate. Concerning mapping and assessment methods, it was found that the integration of methods and results is essential for providing a comprehensive overview from different perspectives (e.g. social, economic). Finally, lessons learned for effective implementation of ES mapping and assessment results are presented and discussed

Data-driven analysis of interactions between people with dementia and a tablet device

Abstract In the project I-CARE a technical system for tablet devices is developed that captures the personal needs and skills of people with dementia. The system provides activation content such as music videos, biographical photographs and quizzes on various topics of interest to people with dementia, their families and professional caregivers. To adapt the system, the activation content is adjusted to the daily condition of individual users. For this purpose, emotions are automatically detected through facial expressions, motion, and voice. The daily interactions of the users with the tablet devices are documented in log files which can be merged into an event list. In this paper, we propose an advanced format for event lists and a data analysis strategy. A transformation scheme is developed in order to obtain datasets with features and time series for popular methods of data mining. The proposed methods are applied to analysing the interactions of people with dementia with the I-CARE tablet device. We show how the new format of event lists and the innovative transformation scheme can be used to compress the stored data, to identify groups of users, and to model changes of user behaviour. As the I-CARE user studies are still ongoing, simulated benchmark log files are applied to illustrate the data mining strategy. We discuss possible solutions to challenges that appear in the context of I-CARE and that are relevant to a broad range of applications.</jats:p