1,851 research outputs found
Thermal Noise Reduction and Absorption Optimisation via Multi-Material Coatings
Future gravitational wave detectors (GWDs) such as Advanced LIGO upgrades and
the Einstein Telescope are planned to operate at cryogenic temperatures using
crystalline silicon (cSi) test-mass mirrors at an operation wavelength of 1550
nm. The reduction in temperature in principle provides a direct reduction in
coating thermal noise, but the presently used coating stacks which are composed
of silica (SiO2) and tantala (Ta2O5) show cryogenic loss peaks which results in
less thermal noise improvement than might be expected. Due to low mechanical
loss at low temperature amorphous silicon (aSi) is a very promising candidate
material for dielectric mirror coatings and could replace Ta2O5. Unfortunately,
such a aSi/SiO2 coating is not suitable for use in GWDs due to high optical
absorption in aSi coatings. We explore the use of a three material based
coating stack. In this multi-material design the low absorbing Ta2O5 in the
outermost coating layers significantly reduces the incident light power, while
aSi is used only in the lower bilayers to maintain low optical absorption. Such
a coating design would enable a reduction of Brownian thermal noise by 25%. We
show experimentally that an optical absorption of only (5.3 +/- 0.4)ppm at 1550
nm should be achievable
a randomized double blind placebo controlled phase 1 study of multiple ascending doses of subcutaneous m1095 an anti interleukin 17a f nanobody in moderate to severe psoriasis
Background Interleukin 17 is involved in the pathogenesis of psoriasis, a chronic debilitating disease. Objectives To evaluate the safety/tolerability, immunogenicity, pharmacokinetics/pharmacodynamics, and efficacy of M1095, an anti–interleukin 17A/F nanobody, in moderate-to-severe plaque psoriasis. Methods This multicenter, double-blind, placebo-controlled dose escalation phase 1 study randomized 44 patients 4:1 to treatment with subcutaneous M1095 (30, 60, 120, or 240 mg) or placebo biweekly for 6 weeks, in 4 ascending dose cohorts. Results The most frequent treatment-emergent adverse events with M1095 were pruritus (n = 4) and headache (n = 3); 2 patients withdrew owing to adverse events (injection site reaction and elevated liver enzyme levels). The terminal half-life of M1095 was 11 to 12 days. The area under the curve/maximum concentration was dose proportional. Of 10 M1095-treated patients positive for antidrug antibodies, 5 showed treatment-emergent antidrug antibody responses. There was no effect on M1095 exposure. Marked decreases in psoriasis inflammatory markers were observed with M1095. By day 85, 100% and 56% of patients receiving M1095, 240 mg, achieved psoriasis area and severity index 90 and 100, respectively. Improvements in static Physician's Global Assessment and affected body surface area were also seen. Limitations Interpretation of efficacy data is limited by the small sample size. Conclusion Multiple subcutaneous doses of M1095 showed a favorable safety profile with dose-dependent improvements in psoriasis
Growth in densely populated Asia: implications for primary product exporters
Economic growth and integration in Asia is rapidly increasing the global economic importance of the region. To the extent that this growth continues and is strongest in natural resource-poor Asian economies, it will add to global demand for imports of primary products, to the benefit of (especially nearby) resource-abundant countries. How will global production, consumption and trade patterns change by 2030 in the course of such economic developments and structural changes? We address this question using the GTAP model and Version 8.1 of the 2007 GTAP database, together with supplementary data from a range of sources, to support projections of the global economy from 2007 to 2030 under various scenarios. Factor endowments and real gross domestic product are assumed to grow at exogenous rates, and trade-related policies are kept unchanged to generate a core baseline, which is compared with an alternative slower growth scenario. We also consider the impact of several policy changes aimed at increasing China's agricultural self-sufficiency relative to the 2030 baseline. Policy implications for countries of the Asia-Pacific region are drawn out in the final section
Accessing Transversity in Double-Spin Asymmetries at the BNL-RHIC
We give upper bounds for transverse double-spin asymmetries in polarized
proton-proton collisions by saturating the positivity constraint for the
transversity densities at a low hadronic resolution scale. We consider prompt
photon, jet, pion, and heavy flavor production at the BNL Relativistic Heavy
Ion Collider (RHIC). Estimates of the expected statistical accuracy for such
measurements are presented, taking into account the acceptance of the RHIC
detectors.Comment: 15 pages, LaTeX, 2 figures as eps file
The Nature of Starbursts : II. The Duration of Starbursts in Dwarf Galaxies
The starburst phenomenon can shape the evolution of the host galaxy and the
surrounding intergalactic medium. The extent of the evolutionary impact is
partly determined by the duration of the starburst, which has a direct
correlation with both the amount of stellar feedback and the development of
galactic winds, particularly for smaller mass dwarf systems. We measure the
duration of starbursts in twenty nearby, ongoing, and "fossil" starbursts in
dwarf galaxies based on the recent star formation histories derived from
resolved stellar population data obtained with the Hubble Space Telescope.
Contrary to the shorter times of 3-10 Myr often cited, the starburst durations
we measure range from 450 - 650 Myr in fifteen of the dwarf galaxies and up to
1.3 Gyr in four galaxies; these longer durations are comparable to or longer
than the dynamical timescales for each system. The same feedback from massive
stars that may quench the flickering SF does not disrupt the overall burst
event in our sample of galaxies. While five galaxies present fossil bursts,
fifteen galaxies show ongoing bursts and thus the final durations may be longer
than we report here for these systems. One galaxy shows a burst that has been
ongoing for only 20 Myr; we are likely seeing the beginning of a burst event in
this system. Using the duration of the starbursts, we calculate that the bursts
deposited 10^(53.9)-10^(57.2) ergs of energy into the interstellar medium
through stellar winds and supernovae and produced 3%-26% of the host galaxy's
mass.Comment: 28 pages, 4 figure
The Evolution of the Stratopause During the 2006 Major Warming: Satellite Data and Assimilated Meteorological Analyses
Microwave Limb Sounder and Sounding of the Atmosphere with Broadband Emission Radiometry data show the polar stratopause, usually higher than and separated from that at midlatitudes, dropping from <55-60 to near 30 km, and cooling dramatically in January 2006 during a major stratospheric sudden warming (SSW). After a nearly isothermal period, a cool stratopause reforms near 75 km in early February, then drops to <55 km and warms. The stratopause is separated in longitude as well as latitude, with lowest temperatures in the transition regions between higher and lower stratopauses. Operational assimilated meteorological analyses, which are not constrained by data at stratopause altitude, do not capture a secondary temperature maximum that overlies the stratopause or the very high stratopause that reforms after the SSW; they underestimate the stratopause altitude variation during the SSW. High-quality daily satellite temperature measurements are invaluable in improving our understanding of stratopause evolution and its representation in models and assimilation systems
The Big Three Perfectionism Scale: A new measure of perfectionism
This article introduces a new measure of dispositional perfectionism: the Big Three Perfectionism Scale (BTPS). The BTPS assesses three higher-order global factors (rigid perfectionism, self-critical perfectionism, narcissistic perfectionism) via 10 lower-order perfectionism facets (self-oriented perfectionism, self-worth contingencies, concern over mistakes, doubts about actions, self-criticism, socially prescribed perfectionism, other-oriented perfectionism, hypercriticism, grandiosity, entitlement). The present investigation examined the structure of the BTPS using exploratory factor analysis in Study 1 (288 undergraduates), and confirmatory factor analyses in Study 2 (352 community adults) and Study 3 (290 undergraduates). Additionally, in Study 3 the relationships among the BTPS, other measures of perfectionism, and the five-factor model of personality were investigated. Overall, findings provide first evidence for the reliability and validity of the BTPS as a multidimensional measure of perfectionism
Understanding consumer demand for new transport technologies and services, and implications for the future of mobility
The transport sector is witnessing unprecedented levels of disruption.
Privately owned cars that operate on internal combustion engines have been the
dominant modes of passenger transport for much of the last century. However,
recent advances in transport technologies and services, such as the development
of autonomous vehicles, the emergence of shared mobility services, and the
commercialization of alternative fuel vehicle technologies, promise to
revolutionise how humans travel. The implications are profound: some have
predicted the end of private car dependent Western societies, others have
portended greater suburbanization than has ever been observed before. If
transport systems are to fulfil current and future needs of different
subpopulations, and satisfy short and long-term societal objectives, it is
imperative that we comprehend the many factors that shape individual behaviour.
This chapter introduces the technologies and services most likely to disrupt
prevailing practices in the transport sector. We review past studies that have
examined current and future demand for these new technologies and services, and
their likely short and long-term impacts on extant mobility patterns. We
conclude with a summary of what these new technologies and services might mean
for the future of mobility.Comment: 15 pages, 0 figures, book chapte
Pattern selection in the absolutely unstable regime as a nonlinear eigenvalue problem: Taylor vortices in axial flow
A unique pattern selection in the absolutely unstable regime of a driven,
nonlinear, open-flow system is analyzed: The spatiotemporal structures of
rotationally symmetric vortices that propagate downstream in the annulus of the
rotating Taylor-Couette system due to an externally imposed axial through-flow
are investigated for two different axial boundary conditions at the in- and
outlet. Unlike the stationary patterns in systems without through-flow the
spatiotemporal structures of propagating vortices are independent of parameter
history, initial conditions, and system's length. They do, however, depend on
the axial boundary conditions, the driving rate of the inner cylinder and the
through-flow rate. Our analysis of the amplitude equation shows that the
pattern selection can be described by a nonlinear eigenvalue problem with the
frequency being the eigenvalue. Approaching the border between absolute and
convective instability the eigenvalue problem becomes effectively linear and
the selection mechanism approaches that one of linear front propagation.
PACS:47.54.+r,47.20.Ky,47.32.-y,47.20.FtComment: 15 pages (LateX-file), 8 figures (Postscript
Social marketing and healthy eating : Findings from young people in Greece
This document is the Accepted Manuscript version. The final publication is available at Springer via http://dx.doi.org/10.1007/s12208-013-0112-xGreece has high rates of obesity and non-communicable diseases owing to poor dietary choices. This research provides lessons for social marketing to tackle the severe nutrition-related problems in this country by obtaining insight into the eating behaviour of young adults aged 18–23. Also, the main behavioural theories used to inform the research are critically discussed. The research was conducted in Athens. Nine focus groups with young adults from eight educational institutions were conducted and fifty-nine participants’ views towards eating habits, healthy eating and the factors that affect their food choices were explored. The study found that the participants adopted unhealthier nutritional habits after enrolment. Motivations for healthy eating were good health, appearance and psychological consequences, while barriers included lack of time, fast-food availability and taste, peer pressure, lack of knowledge and lack of family support. Participants reported lack of supportive environments when deciding on food choices. Based on the findings, recommendations about the development of the basic 4Ps of the marketing mix, as well as of a fifth P, for Policy are proposedPeer reviewe
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