Inter-firm R&D networks in the global pharmaceutical biotechnology industry during 1985 - 1998: A conceptual and empirical analysis

This paper analyses a large database on inter-firm R&D cooperation formed in the pharmaceutical biotechnology industry during the period 1985 - 1998. The results indicate that network size largely grows, whereas the density of the network declines during the periods. In the network analysis that emphasizes individual structural positions, the empirical results show that small biotechnological companies had a crucial bridging role for the large pharmaceutical firms in the second half of the 1980s. In the 1990s, the bridge role of biotechnology companies became less important and established pharmaceutical companies developed into dominant start players with many collaborators while holding central roles in the research network. The current analysis also shows that degree-based and betweenness-based network centralization are both low implying that the overall positional advantages are relatively equally distributed in the inter-firm R&D network of the pharmaceutical biotechnology industry. --R&D networks,pharmaceutical biotechnology,network analysis,conceptual centrality,network visualization software

Nuruosmaniye Camii

Taha Toros Arşivi, Dosya No: 102-Camilerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Transonic cryogenic test section for the Goettingen tube facility

The design of modern aircraft requires the solution of problems related to transonic flow at high Reynolds numbers. To investigate these problems experimentally, it is proposed to extend the Ludwieg tube facility by adding a transonic cryogenic test section. After stating the requirements for such a test section, the technical concept is briefly explained and a preliminary estimate of the costs is given

Inter-firm R&D networks in pharmaceutical biotechnology : what determines firm's centrality-based partnering capability?

This paper analyses the inter-firm R&D network formed in the pharmaceutical biotechnology industry during the 1990s from different perspectives: theoretical network formation, firm's structural positions and its collaborations at the entire network level, and the determinants for firm's centrality-based partnering capability. The results indicate that pharmaceutical biotechnology industry has experienced a significant evolutional change in size and structure during 1991-1998. By considering individual structural positions, the descriptive statistics show that in the 1990s, established pharmaceutical companies developed into dominant star players with multiple partnerships while holding central roles in the R&D network. In the network analysis that emphasized aggregate network level, the degree-based and betweenness-based network centralization were not high implying that the distribution of overall positional advantages in the pharmaceutical biotechnology industry is, to a large degree, not unequal and even though most firms in this sector are linked to the R&D network, some of them are more active than others. The current analysis also shows that firm's efficiency, firm's dependency on its complementary resources and firm's experiences at managing partnerships are important determinants for firm's centrality-based partnering capability, which has important managerial implications for understanding firm's strategic partnering behaviour

Tor bei der Hagia Sophia

Taha Toros Arşivi, Dosya No: 102-Camilerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033

Inter-firm R&D networks in the global pharmaceutical biotechnology industry during 1985?1998 : a conceptual and empirical analysis

This paper analyses a large database on inter-firm R&D cooperation formed in the pharmaceutical biotechnology industry during the period 1985?1998. The results indicate that network size largely grows, whereas the density of the network declines during the periods. In the network analysis that emphasizes individual structural positions, the empirical results show that small biotechnological companies had a crucial bridging role for the large pharmaceutical firms in the second half of the 1980s. In the 1990s, the bridge role of biotechnology companies became less important and established pharmaceutical companies developed into dominant start players with many collaborators while holding central roles in the research network. The current analysis also shows that degree-based and betweenness-based network centralization are both low implying that the overall positional advantages are relatively equally distributed in the inter-firm R&D network of the pharmaceutical biotechnology industry

Unsafe Sewage Sludge or Beneficial Biosolids?: Liability, Planning, and Management Issues Regarding the Land Application of Sewage Treatment Residuals

Commentators have identified fear of liability as a major deterrent to the widespread land application of sewage sludge. Liability issues regarding land application include not only legal liability, but also market liability as a result of negative public perceptions of the land application of sewage sludge. Under current law, municipal sewage treatment facilities, landowners, farmers, and even lenders are potentially liable for risks arising from sewage sludge application, unless someone else assumes the risk through a clear and legally enforceable mechanism. This article introduces this complex, evolving, and contentious environmental issue. It investigates the various siting and toxic tort liability issues associated with the land application of sewage sludge, and explores some of the risk-sharing mechanisms developed to minimize the liabilities associated with the application of sewage sludge to farmland. It concludes with a recommendation for a public indemnification fund to compensate for losses caused by land application of sewage sludge

Resonant X-ray emission spectroscopy reveals d–d ligand-field states involved in the self-assembly of a square-planar platinum complex

Resonant X-ray Emission Spectroscopy (RXES) is used to characterize the ligand field states of the prototypic self-assembled square-planar complex, [Pt(tpy)Cl]Cl (tpy=2,2′:6′,2′′-terpyridine), and determine the effect of weak metal-metal and π-π interactions on their energy. © 2012 the Owner Societies

Reconstruction of Software Component Architectures and Behaviour Models using Static and Dynamic Analysis

Model-based performance prediction systematically deals with the evaluation of software performance to avoid for example bottlenecks, estimate execution environment sizing, or identify scalability limitations for new usage scenarios. Such performance predictions require up-to-date software performance models. This book describes a new integrated reverse engineering approach for the reconstruction of parameterised software performance models (software component architecture and behaviour)

Probabilistic Routing for On-Street Parking Search

An estimated 30% of urban traffic is caused by search for parking spots [Shoup, 2005]. Suggesting routes along highly probable parking spots could reduce traffic. In this paper, we formalize parking search as a probabilistic problem on a road graph and show that it is NP-complete. We explore heuristics that optimize for the driving duration and the walking distance to the destination. Routes are constrained to reach a certain probability threshold of finding a spot. Empirically estimated probabilities of successful parking attempts are provided by TomTom on a per-street basis. We release these probabilities as a dataset of about 80,000 roads covering the Berlin area. This allows to evaluate parking search algorithms on a real road network with realistic probabilities for the first time. However, for many other areas, parking probabilities are not openly available. Because they are effortful to collect, we propose an algorithm that relies on conventional road attributes only. Our experiments show that this algorithm comes close to the baseline by a factor of 1.3 in our cost measure. This leads to the conclusion that conventional road attributes may be sufficient to compute reasonably good parking search routes