Investigating the effect of joint behavior on the optimum design of steel frames via hunting search algorithm

This study aims to carry out the effect of beam-to-column connections on the minimum weight design of steel plane frames. In the practical analysis of steel frames, end connections are assumed to be either fully restrained or pin-connected. However, experiments reveal that the real behavior is between these extremes and should be taken into account for the realistic design of structures. Hunting search algorithm is used for the automation of optimum design process. It is a numerical optimization method inspired by group hunting of animals such as wolves and lions. It is proven that it is a reliable and efficient technique for obtaining the solution of discrete structural optimization problems. Present design algorithm developed on the basis of hunting search algorithm selects w-sections for the members of semi rigid steel frame from the complete list of w-sections given in LRFD-AISC (Load and Resistance Factor Design, American Institute of Steel Construction). The design constraints are implemented from the specifications of the same code which covers serviceability and strength limitations. The selection of w-sections is carried out such that the design limitations are satisfied and the weight of semi-rigid frame is the minimum. In order to demonstrate its efficiency, three different steel frames are designed by the optimum design algorithm presented. The designs obtained by use of this algorithm are also compared with the ones produced by particle swarm optimization method. © 2018, Hong Kong Institute of Steel Construction. All rights reserved

Investigating the effect of joint behavior on the optimum design of steel frames via hunting search algorithm

This study aims to carry out the effect of beam-to-column connections on the minimum weight design of steel plane frames. In the practical analysis of steel frames, end connections are assumed to be either fully restrained or pin-connected. However, experiments reveal that the real behavior is between these extremes and should be taken into account for the realistic design of structures. Hunting search algorithm is used for the automation of optimum design process. It is a numerical optimization method inspired by group hunting of animals such as wolves and lions. It is proven that it is a reliable and efficient technique for obtaining the solution of discrete structural optimization problems. Present design algorithm developed on the basis of hunting search algorithm selects w-sections for the members of semi rigid steel frame from the complete list of w-sections given in LRFD-AISC (Load and Resistance Factor Design, American Institute of Steel Construction). The design constraints are implemented from the specifications of the same code which covers serviceability and strength limitations. The selection of w-sections is carried out such that the design limitations are satisfied and the weight of semi-rigid frame is the minimum. In order to demonstrate its efficiency, three different steel frames are designed by the optimum design algorithm presented. The designs obtained by use of this algorithm are also compared with the ones produced by particle swarm optimization method. © 2018, Hong Kong Institute of Steel Construction. All rights reserved

Effects of two doses of anti-T lymphocyte globulin-Fresenius given after full-match sibling stem cell transplantation in acute myeloblastic leukemia patients who underwent myeloablative fludarabine/busulfan conditioning

Objective/background: Anti-T lymphocyte globulin Fresenius (rATG-F; ATG-Fresenius) and antithymocyte globulin (thymoglobulin), which are included in transplant protocols, are used to reduce the risk of chronic graft-versus-host disease (cGVHD) or suppress allograft rejection. Available clinical studies have been conducted in heterogenous patient populations and with different administration protocols including stem cell sources. Additionally, the pharmacokinetics of ATG is variable, and the clinically effective dose of rATG-F, in particular, is not exactly known. The aim of the study was to investigate the clinical outcomes of acute myeloid leukemia (AML) patients who underwent hemopoietic peripheral stem cell transplantation from full-matched sibling donors and given two different doses of r-ATG-F. Methods: This was a single-center, retrospective chart review conducted between July 2005 and July 2016. Sixty-nine consecutive AML patients who underwent transplant with fludarabine- and busulfan-based conditioning were included in the study. Patients in Group 1 received 15 mg/kg body weight rATG-F to 2013 (n = 46), and Group 2 received 30 mg/kg of rATG-F dose begining in 2013 to reduce to cGVHD (n = 23). Cyclosporine and methotrexate were used to treat acute GVHD (aGVHD) prophylaxis. Outcome parameters were compared between the groups. Results: Although the recommended dose r-ATG-F had led to a decrease in the cumulative incidence of cGVHD (27 [58.7%] vs. 8 [34.8%]; p =.03), it also increased the infection rate at 1 year (3 [6.5%] vs. 4 [17.4%]; p =.02). The two groups were similar in terms of engraftment time, aGVHD, relapse, nonrelapse mortality, and rATG-F-related toxicity. A Cox regression model revealed that aGVHD III–IV was associated with increased nonrelapse mortality at 1 year (hazard ratio = 18.2; 95% confidence interval, 1.667–199.255; p = <.02). No patients developed rATG-F-related severe adverse events (Common Terminology Criteria grade 4 or 5). Conclusion: Dose difference of rATG-F did not influence survival parameters; however, increasing the dose to 30 mg/kg seems to be effective for reducing cGVHD with an increase in infection rate requiring close monitoring of infections in AML patients who received myeloablative fludarabine/busulfan conditioning. © 2018 King Faisal Specialist Hospital & Research Centr

Wearing class: A study on clothes, bodies and emotions in Turkey

This article examines how cultural capital shapes the ways Turkish women, both religiously covered and not covered, experience their presented self' in social interactions. The analysis draws on 44 in-depth interviews conducted as part of a larger project on embodiment of class in Turkey, using the parts where the interviewees reflect on the repercussions of different clothing and adornment tastes. It approaches clothing as an embodied practice and uses the conceptual tools Bourdieu offers to analyse the link between women's appearance-driven experiences and wider class-cultural processes. Consistent with its theoretical framework, it examines the experiencing of tastes by analysing women's emotions. The analysis demonstrates that, regardless of the volumes of capital they hold, the majority of the sample presume that the dressed body' does have value and enhances or limits opportunities, suggesting the relevance of the term capital' to refer to such embodied competence, as Bourdieu did. Moreover, some of the emotional responses are found to be more common among culturally cultivated interviewees of both Islamic-leaning and secular fractions while others only appear among those having limited access to cultural and economic resources. Interview excerpts show that the aesthetic categorisations made by the culturally advantaged, regardless of their religious orientation, are internalised by those who suffer from such hierarchies most, highlighting the role of class culture-driven symbolic violence in maintaining inequalities. The material is then contextualised within the class dynamics in Turkey, where self-fashioning has remained a value-laden domain since the beginning of the country's top-to-bottom modernisation. Focusing on how tastes are lived in the everyday, this article reveals the subtle processes that manifest and reproduce class privileges and calls for an emphasis on the repercussions of embodying particular tastes, which could enhance our understanding of taste, power and cultural exclusion more directly than interrogations of the correlations between taste and class position

Prevalence of Rheumatoid Arthritis and Spondyloarthritis in Turkey: A Nationwide Study.

OBJECTIVES: This study aims to estimate the prevalence of rheumatoid arthritis (RA) and spondyloarthritis (SpA) in Turkey using the same telephone questionnaire developed for screening RA and SpA in France and used in Serbia and Lithuania. MATERIAL AND METHODS: The study was performed in two steps. In step I, the French questionnaire was translated into Turkish and validated through a group of 200 patients (80 males, 120 females; mean age 44.0±13.1 years; range 19 to 75 years) followed up at the rheumatology departments of University Hospitals in Antalya and Ankara. In step II, the validated Turkish questionnaire was administered face-to-face to randomly selected 4,012 subjects (1,670 males, 2,342 females; mean age 41.5±16.8 years; range 16 to 97 years) by trained general practitioners across the country, in 25 prov- inces for case detection. The subjects who were suspected of having RA or SpA in accordance with the questionnaire were invited to the nearest university hospital for rheumatologic examination in order to confirm the diagnosis. RESULTS: In step II, a total of 25 subjects (2 males, 23 females) were diagnosed as RA. The standardized RA prevalence for the general population of Turkey was calculated as 0.56% (95% confidence interval [CI]; 0.33-0.79), 0.10% (95% CI; -0.05-0.25) for males and 0.89% (95% CI; 0.51-1.27) for females. A total of 18 subjects (3 males, 15 females) were diagnosed as SpA. The standardized SpA prevalence for the general population of Turkey was 0.46% (95% CI; 0.25-0.67), 0.17% (95% CI; -0.03-0.37) for males and 0.65% (95% CI; 0.32-0.98) for females. The prevalence of RA was highest in the Northern region (2.00%) and the prevalence of SpA was highest in the Central region (1.49%). CONCLUSION: The prevalences of RA and SpA in Turkey are close to each other and there are significant inter-regional variations in prevalences of both RA and SpA

Prevalence of rheumatoid arthritis and spondyloarthritis in Turkey: A nationwide study

Objectives: This study aims to estimate the prevalence of rheumatoid arthritis (RA) and spondyloarthritis (SpA) in Turkey using the same telephone questionnaire developed for screening RA and SpA in France and used in Serbia and Lithuania. Material and methods: The study was performed in two steps. In step I, the French questionnaire was translated into Turkish and validated through a group of 200 patients (80 males, 120 females; mean age 44.0±13.1 years; range, 19 to 75 years) followed up at the rheumatology departments of University Hospitals in Antalya and Ankara. In step II, the validated Turkish questionnaire was administered face-to-face to randomly selected 4,012 subjects (1,670 males, 2,342 females; mean age 41.5±16.8 years; range, 16 to 97 years) by trained general practitioners across the country, in 25 provinces for case detection. The subjects who were suspected of having RA or SpA in accordance with the questionnaire were invited to the nearest university hospital for rheumatologic examination in order to confirm the diagnosis. Results: In step II, a total of 25 subjects (2 males, 23 females) were diagnosed as RA. The standardized RA prevalence for the general population of Turkey was calculated as 0.56% (95% confidence interval [CI]; 0.33-0.79), 0.10% (95% CI;-0.05-0.25) for males and 0.89% (95% CI; 0.51-1.27) for females. A total of 18 subjects (3 males, 15 females) were diagnosed as SpA. The standardized SpA prevalence for the general population of Turkey was 0.46% (95% CI; 0.25-0.67), 0.17% (95% CI;-0.03-0.37) for males and 0.65% (95% CI; 0.32-0.98) for females. The prevalence of RA was highest in the Northern region (2.00%) and the prevalence of SpA was highest in the Central region (1.49%). Conclusion: The prevalences of RA and SpA in Turkey are close to each other and there are significant inter-regional variations in prevalences of both RA and SpA. © 2018 Turkish League Against Rheumatism. All rights reserved