Evaluating Acute Interstitial Nephritis Rates in Renal Biopsies (Single Center Study)

Aim:We aimed to evaluate the prevalence and clinicopathological features of acute interstitial nephritis in patients undergoing renal biopsy.Materials and Methods:A total of 1048 native kidney biopsies performed between 2010 and 2018 in the Nephrology Clinic of Katip Celebi University Atatürk Training and Research Hospital were reviewed retrospectively. The records of 42 patients with histopathological diagnosis of acute interstitial nephritis were screened. Medical history, clinical, laboratory and pathological findings, all treatments and results of all patients with acute interstitial nephritis were recorded.Results:The prevalence of acute interstitial nephritis in all renal biopsies was found 4%. We found that the most common cause of acute interstitial nephritis was non-steroid anti-inflammatory drugs (40.5% in 17 patients). Thirty patients (71.4%) received steroid treatment, among them renal function improved in 17 patients (56%). There was no significant difference between the groups receiving end not receiving steroid therapy in terms of complete recovery of renal function (p>0.05). During admission, 12 patients (28.6%) required acute hemodialysis and all of these patients received steroid treatment. A total of eight patients (19.0%) remained in the chronic hemodialysis program. Overall eight patients (19%) died due to acute interstitial nephritis during the follow-up.Conclusion:The prevalence and the most common etiologic factors of acute interstitial nephritis were found similar to literature. In particular, non-steroidal anti-inflammatory drugs took the first place. Therefore, the history of the drug should be questioned well in all patients. Firstly, the underlying etiologic cause of acute interstitial nephritis should be corrected

Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis

The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while endometriosis occurs in only 10% of cases; it also does not explain the endometriotic foci distant from the pelvis, nor explains the cases of endometriosis in male patients. The immunological alterations of the peritoneal fluid explains the effects of disease, such as the inhibition of the physiological processes of cytolysis, but does not explain the cause. There is evidence to support the hypothesis that ectopic müllerian remnants of the endometrium, endocervix and endosalpinx are items from the genital ridge leaked during organogenesis. It is known that tissues derived from coelomatic epithelial and mesenchymal cells have the potential to metaplastically differentiate into epithelium and stroma. In addition, the phenotype of the ectopic endometrial cells is significantly different from those ectopic. There is scientific evidence that, during organogenesis, the genes of the Homeobox and Wingless family play a fundamental role in the differentiation of the ducts of Muller and development of the anatomical structure of the urogenital tract. We present here a hypothesis that deregulation of genes and the Wnt signaling pathway Wnt/β-catenin leads to aberrations and deregulation within the mesoderm, thus, may cause aberrant placement of stem cells. In addition, immune cells, adhesion molecules, extracellular matrix metalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment, creating the conditions for differentiation, adhesion, proliferation and survival of ectopic endometrial cells

Turist rehberliği uygulama gezisi üzerine karşılaştırmalı bir araştırma

2012 yılında yürürlüğe giren Profesyonel Turist Rehberliği Meslek Kanunu öncesinde üniversitelerden tarafından Kültür ve Turizm Bakanlığı kontrolünde gerçekleştirilen uygulama gezisi, meslek kanunu uyarınca Turist Rehberleri Birliği (TUREB) tarafından yürütülmektedir. Bu çalışma Türkiye’de turizm rehberliği mesleki kabul şartlarından biri olan zorunlu yurtiçi uygulama gezisinin hedef, ilke, işlev ve müfredatının paydaşlar tarafından değerlendirilmesini amaçlamaktadır. Nitel bir araştırma modeli olarak tasarlanan çalışmada, birbirinden farklı oluşturulan yarı yapılandırılmış görüşme formları TUREB yetkilileri ve akademisyenlere yöneltilmiştir. Ulaşılan bulgular ışığında iki paydaş arasında gereken iletişimin gerçekleşmediği ve kimi konularda görüşler örtüşürken, kimi konularda fikir ayrılıkları olduğu görülmüştür. Gezi müfredatı ve planlama sürecine dahil birtakım önerilerde bulunulmuş ve paydaşlar arası iletişimin sağlanması amaçlanmıştır.The practice tour, which was held by universities before the Professional Tourist Guidance Occupational Law that went into effect in 2012, is currently held by the Union of Tour Guides (TUREB) in accordance with the law. This study aims the assessment of the objectives, principles and curriculum of the compulsory domestic practice tour which is one of the occupational requirements for tour guiding in Turkey. In the study, designed as a quantitative research, two different semi-structured interview forms were addressed to TUREB officers and academicians. As a result of the findings reached, it has been revealed that the necessary communication between two partners have not been created and some of their views overlap while others are in contrast. Some suggestions have been made on the tour curriculum and planning process, and communication between partners was aimed to be established

Effect of breast-feeding duration on bone mineral density in postmenopausal women

YÖK Tez No: 195242[Özet Yok

Anemia, celiac disease and low bone mass

WOS: 000312831000002PubMed: 23260220