Anatomizing the Library: Virtual Anatomy Table Services in an Academic Library

A growing number of academic, medical, and health sciences libraries are adopting 3D virtual anatomy tables (also known as virtual dissection tables) to support active learning initiatives within their anatomy educational communities. This article explores the implementation and management practices of virtual anatomy table (VAT) services offered by an academic library within a large public land-grant university system. The authors will share details surrounding their library\u27s virtual anatomy table acquisition process and the development of VAT services for anatomy learners and instructors on their campus. This article will also discuss their VAT operational challenges arising from the COVID-19 pandemic and highlight plans for VAT services at their library

A Preliminary Inquiry into the Use and Management of 3D Virtual Anatomy Tables within Libraries

This preliminary study explored the use and management practices of 3D virtual anatomy tables (VATs) currently owned by libraries to support their learning communities. This study also examined how libraries have adapted their VAT services during the COVID-19 pandemic. We sent an IRB-approved 15-question survey to members of 46 library-focused email listservs to assess the use and management practices of VATs among libraries. We analyzed the survey results within Qualtrics\u27 default report feature to perform basic calculations and generate visualizations related to the survey data. We received 31 completed surveys, with 23% of those respondents reporting that they were from libraries that owned a virtual anatomy table at any point in time. Respondents from libraries with virtual anatomy tables shared insights into how their libraries offered VAT-related services for their users, how they offered VAT services before and during the COVID-19 pandemic, details regarding their VAT cleaning practices, and what notable challenges they faced while providing VAT services before and during the pandemic. This survey will provide libraries with initial data regarding how other libraries with virtual anatomy tables provide VAT services for their library users and help inform the authors\u27 future research on this topic

Anatomage Table 6

Anatomage Table 6, which launched in the fall of 2018, is the latest software for users of the Anatomage Virtual Dissection Table. Anatomage Table 6 comprises numerous virtual anatomy dissection and study tools for use by anatomy students and instructors. This review provides an overview and assessment of Anatomage Table 6’s primary tools and advanced navigation features

POC in LIS Cohorts

According to ALA Diversity Counts Survey (2012), librarians of color (African American, Asian American/Pacific Islander, Native American including Alaska Native, Two or more races, and Latino) made up only 12% of the profession. Building community in the form of cohorts is a vital opportunity that allows librarians of color to connect with one another and provide support while navigating a profession that is predominantly white. In this presentation, the panelists will discuss different types of cohorts that exist in POC in LIS circles. We conclude by presenting a call to action and ask participants how they might define a cohort, to identify cohorts they may be currently part of, and encourage those to consider creating cohorts of their own in and outside of their respective institutions. Our panel format will include a 45-minute informative discussion followed by a 15-minute Q&A

Haplotype Mapping of a Diploid Non-Meiotic Organism Using Existing and Induced Aneuploidies

Haplotype maps (HapMaps) reveal underlying sequence variation and facilitate the study of recombination and genetic diversity. In general, HapMaps are produced by analysis of Single-Nucleotide Polymorphism (SNP) segregation in large numbers of meiotic progeny. Candida albicans, the most common human fungal pathogen, is an obligate diploid that does not appear to undergo meiosis. Thus, standard methods for haplotype mapping cannot be used. We exploited naturally occurring aneuploid strains to determine the haplotypes of the eight chromosome pairs in the C. albicans laboratory strain SC5314 and in a clinical isolate. Comparison of the maps revealed that the clinical strain had undergone a significant amount of genome rearrangement, consisting primarily of crossover or gene conversion recombination events. SNP map haplotyping revealed that insertion and activation of the UAU1 cassette in essential and non-essential genes can result in whole chromosome aneuploidy. UAU1 is often used to construct homozygous deletions of targeted genes in C. albicans; the exact mechanism (trisomy followed by chromosome loss versus gene conversion) has not been determined. UAU1 insertion into the essential ORC1 gene resulted in a large proportion of trisomic strains, while gene conversion events predominated when UAU1 was inserted into the non-essential LRO1 gene. Therefore, induced aneuploidies can be used to generate HapMaps, which are essential for analyzing genome alterations and mitotic recombination events in this clonal organism

Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection

HIV is a major driver of tuberculosis (TB) reactivation. Depletion of CD4+ T cells is assumed to be the basis behind TB reactivation in individuals with latent tuberculosis infection (LTBI) coinfected with HIV. Nonhuman primates (NHPs) coinfected with a mutant simian immunodeficiency virus (SIVΔGY) that does not cause depletion of tissue CD4+ T cells during infection failed to reactivate TB. To investigate the contribution of CD4+ T cell depletion relative to other mechanisms of SIV-induced reactivation of LTBI, we used CD4R1 antibody to deplete CD4+ T cells in animals with LTBI without lentiviral infection. The mere depletion of CD4+ T cells during LTBI was insufficient in generating reactivation of LTBI. Instead, direct cytopathic effects of SIV resulting in chronic immune activation, along with the altered effector T cell phenotypes and dysregulated T cell homeostasis, were likely mediators of reactivation of LTBI. These results revealed important implications for TB control in HIV-coinfected individuals

Methane Emission From a Cool Brown Dwarf

© 2024, The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Beyond our solar system, aurorae have been inferred from radio obser- vations of isolated brown dwarfs (e.g. [1]; [2]). Within our solar system, giant planets have auroral emission with signatures across the electromag- netic spectrum including infrared emission of H3+ and methane. Isolated brown dwarfs with auroral signatures in the radio have been searched for corresponding infrared features but have only had null detections (e.g. [3]). CWISEP J193518.59-154620.3. (W1935 for short) is an isolated brown dwarf with a temperature of ∼482 K. Here we report JWST observations of strong methane emission from W1935 at 3.326 microns. Atmospheric mod- eling leads us to conclude that a temperature inversion of ∼300 K centered at 1-10 millibar replicates the feature. This represents an atmospheric tem- perature inversion for a Jupiter-like atmosphere without irradiation from a host star. A plausible explanation for the strong inversion is heating by auroral processes, although other internal and/or external dynamical pro- cesses cannot be ruled out. The best fit model rules out the contribution of H3+ emission which is prominent in solar system gas giants, however this is consistent with rapid destruction of H3+ at the higher pressure where the W1935 emission originates (e.g. [4]).Peer reviewe

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

A Multi-Institutional Meningioma MRI Dataset for Automated Multi-Sequence Image Segmentation

Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and longitudinal treatment monitoring. However, automated, objective, and quantitative tools for non-invasive assessment of meningiomas on multi-sequence MR images are not available. Here we present the BraTS Pre-operative Meningioma Dataset, as the largest multi-institutional expert annotated multilabel meningioma multi-sequence MR image dataset to date. This dataset includes 1,141 multi-sequence MR images from six sites, each with four structural MRI sequences (T2-, T2/FLAIR-, pre-contrast T1-, and post-contrast T1-weighted) accompanied by expert manually refined segmentations of three distinct meningioma sub-compartments: enhancing tumor, non-enhancing tumor, and surrounding non-enhancing T2/FLAIR hyperintensity. Basic demographic data are provided including age at time of initial imaging, sex, and CNS WHO grade. The goal of releasing this dataset is to facilitate the development of automated computational methods for meningioma segmentation and expedite their incorporation into clinical practice, ultimately targeting improvement in the care of meningioma patients

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population