Inhibitory Effects of Lidocaine and Mexiletine on Vasorelaxation Mediated by Adenosine Triphosphate-sensitive K ؉ Channels and the Role of Kinases in the Porcine Coronary Artery

Background: Effects of antiarrhythmic drugs on coronary vasodilation mediated by K ؉ channels have not been studied

Fermi super-Tonks-Girardeau state for attractive Fermi gases in an optical lattice

We demonstrate that a kind of highly excited state of strongly attractive Hubbard model, named of Fermi super-Tonks-Girardeau state, can be realized in the spin-1/2 Fermi optical lattice system by a sudden switch of interaction from the strongly repulsive regime to the strongly attractive regime. In contrast to the ground state of the attractive Hubbard model, such a state is the lowest scattering state with no pairing between attractive fermions. With the aid of Bethe-ansatz method, we calculate energies of both the Fermi Tonks-Girardeau gas and the Fermi super-Tonks-Girardeau state of spin-1/2 ultracold fermions and show that both energies approach to the same limit as the strength of the interaction goes to infinity. By exactly solving the quench dynamics of the Hubbard model, we demonstrate that the Fermi super-Tonks-Girardeau state can be transferred from the initial repulsive ground state very efficiently. This allows the experimental study of properties of Fermi super-Tonks-Girardeau gas in optical lattices.Comment: 7 pages, 7 figure

All-optical formation of a Bose-Einstein condensate for applications in scanning electron microscopy

We report on the production of a F=1 spinor condensate of 87Rb atoms in a single beam optical dipole trap formed by a focused CO2 laser. The condensate is produced 13mm below the tip of a scanning electron microscope employing standard all-optical techniques. The condensate fraction contains up to 100,000 atoms and we achieve a duty cycle of less than 10s.Comment: 5 pages, 4 figure

A resonant-term-based model including a nascent disk, precession, and oblateness: application to GJ 876

Investigations of two resonant planets orbiting a star or two resonant satellites orbiting a planet often rely on a few resonant and secular terms in order to obtain a representative quantitative description of the system's dynamical evolution. We present a semianalytic model which traces the orbital evolution of any two resonant bodies in a first- through fourth-order eccentricity or inclination-based resonance dominated by the resonant and secular arguments of the user's choosing. By considering the variation of libration width with different orbital parameters, we identify regions of phase space which give rise to different resonant ''depths,'' and propose methods to model libration profiles. We apply the model to the GJ 876 extrasolar planetary system, quantify the relative importance of the relevant resonant and secular contributions, and thereby assess the goodness of the common approximation of representing the system by just the presumably dominant terms. We highlight the danger in using ''order'' as the metric for accuracy in the orbital solution by revealing the unnatural libration centers produced by the second-order, but not first-order, solution, and by demonstrating that the true orbital solution lies somewhere ''in-between'' the third- and fourth-order solutions. We also present formulas used to incorporate perturbations from central-body oblateness and precession, and a protoplanetary or protosatellite thin disk with gaps, into a resonant system. We quantify these contributions to the GJ 876 system, and thereby highlight the conditions which must exist for multi-planet exosystems to be significantly influenced by such factors. We find that massive enough disks may convert resonant libration into circulation; such disk-induced signatures may provide constraints for future studies of exoplanet systems.Comment: 39 pages of body text, 21 figures, 5 tables, 1 appendix, accepted for publication in Celestial Mechanics and Dynamical Astronom

Wnt signalling and cancer stem cells

[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefly reviewed.Ministerio de Ciencia e Innovación; SAF2008-0060

A Pre-Landing Assessment of Regolith Properties at the InSight Landing Site

This article discusses relevant physical properties of the regolith at the Mars InSight landing site as understood prior to landing of the spacecraft. InSight will land in the northern lowland plains of Mars, close to the equator, where the regolith is estimated to be ≥3--5 m thick. These investigations of physical properties have relied on data collected from Mars orbital measurements, previously collected lander and rover data, results of studies of data and samples from Apollo lunar missions, laboratory measurements on regolith simulants, and theoretical studies. The investigations include changes in properties with depth and temperature. Mechanical properties investigated include density, grain-size distribution, cohesion, and angle of internal friction. Thermophysical properties include thermal inertia, surface emissivity and albedo, thermal conductivity and diffusivity, and specific heat. Regolith elastic properties not only include parameters that control seismic wave velocities in the immediate vicinity of the Insight lander but also coupling of the lander and other potential noise sources to the InSight broadband seismometer. The related properties include Poisson’s ratio, P- and S-wave velocities, Young’s modulus, and seismic attenuation. Finally, mass diffusivity was investigated to estimate gas movements in the regolith driven by atmospheric pressure changes. Physical properties presented here are all to some degree speculative. However, they form a basis for interpretation of the early data to be returned from the InSight mission.Additional co-authors: Nick Teanby and Sharon Keda

Search for astrophysical electron antineutrinos in Super-Kamiokande with 0.01wt% gadolinium-loaded water

We report the first search result for the flux of astrophysical electron antineutrinos for energies O(10) MeV in the gadolinium-loaded Super-Kamiokande (SK) detector. In June 2020, gadolinium was introduced to the ultra-pure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection and higher signal efficiency thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd with a $22.5\times552$ $\rm kton\cdot day$ exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure-water ($22.5 \times 2970 \rm kton\cdot day$) owing to the enhanced neutron tagging