Multisegment Scheme Applications to Modified Chebyshev Picard Iteration Method for Highly Elliptical Orbits

A modified Chebyshev Picard iteration method is proposed for solving orbit propagation initial/boundary value problems. Cosine sampling techniques, known as Chebyshev-Gauss-Lobatto (CGL) nodes, are used to reduce Runge’s phenomenon that plagues many series approximations. The key benefit of using the CGL data sampling is that the nodal points are distributed nonuniformly, with dense sampling at the beginning and ending times. This problem can be addressed by a nonlinear time transformation and/or by utilizing multiple time segments over an orbit. This paper suggests a method, called a multisegment method, to obtain accurate solutions overall regardless of initial states and albeit eccentricity by dividing the given orbit into two or more segments based on the true anomaly

Variability and the size-luminosity relation of the intermediate mass AGN in NGC 4395

We present the variability study of the lowest-luminosity Seyfert 1 galaxy NGC 4395 based on the photometric monitoring campaigns in 2017 and 2018. Using 22 ground-based and space telescopes, we monitored NGC 4395 with a $\sim$5 minute cadence during a period of 10 days and obtained light curves in the UV, V, J, H, and K/Ks bands as well as the H$\alpha$ narrow-band. The RMS variability is $\sim$0.13 mag on \emph{Swift}-UVM2 and V filter light curves, decreasing down to $\sim$0.01 mag on K filter. After correcting for continuum contribution to the H$\alpha$ narrow-band, we measured the time lag of the H$\alpha$ emission line with respect to the V-band continuum as ${55}^{+27}_{-31}$ to ${122}^{+33}_{-67}$ min. in 2017 and ${49}^{+15}_{-14}$ to ${83}^{+13}_{-14}$ min. in 2018, depending on the assumption on the continuum variability amplitude in the H$\alpha$ narrow-band. We obtained no reliable measurements for the continuum-to-continuum lag between UV and V bands and among near-IR bands, due to the large flux uncertainty of UV observations and the limited time baseline. We determined the AGN monochromatic luminosity at 5100\AA\ $\lambda L_\lambda = \left(5.75\pm0.40\right)\times 10^{39}\,\mathrm{erg\,s^{-1}}$, after subtracting the contribution of the nuclear star cluster. While the optical luminosity of NGC 4395 is two orders of magnitude lower than that of other reverberation-mapped AGNs, NGC 4395 follows the size-luminosity relation, albeit with an offset of 0.48 dex ($\geq$2.5$\sigma$) from the previous best-fit relation of Bentz et al. (2013).Comment: Accepted for publication in ApJ (Feb. 23rd, 2020). 18 pages, 10 figure

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.

Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

The discovery of drivers of cancer has traditionally focused on protein-coding genes1-4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers6,7, raise doubts about others and identify novel candidates, including point mutations in the 5' region of TP53, in the 3' untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Reorientation of Asymmetric Rigid Body Using Two Controls

Most spacecrafts are designed to be maneuvered to achieve pointing goals. This is accomplished usually by designing a three-axis control system, which can achieve arbitrary maneuvers, where the goal is to repoint the spacecraft and match a desired angular velocity at the end of the maneuver. New control laws are required, however, if one of the three-axis control actuators fails. This paper explores suboptimal maneuver strategies when only two control torque inputs are available. To handle this underactuated system control problem, the three-axis maneuver strategy is transformed to two successive independent submaneuver strategies. The first maneuver is conducted on one of the available torque axes. Next, the second maneuver is conducted on the torque available plane using two available control torques. However, the resulting control law is more complicated than the general three-axis control law. This is because an optimal switch time needs to be found for determining the end time for the single-axis maneuver or the start time for the second maneuver. Numerical simulation results are presented that compare optimal maneuver strategies for both nominal and failed actuator cases

Magnetoelectric coupling in micropatterned BaTiO3/CoFe2O4 epitaxial thin film structures: Augmentation and site-dependency

The prominent magnetoelectric (ME) effect in ME composites usually originates from an interfacial strain-mediated coupling between ferroelectric and ferromagnetic components. While ME composite bilayer thin films have been proposed for microdevice applications, the ME coupling is usually diminished because of the substrate clamping effect. Here, we apply simple CMOS/MEMS compatible top-down fabrication techniques to ferroelectric BaTiO3 (BTO) and ferromagnetic CoFe2O4 (CFO) bilayer epitaxial thin films to control the substrate clamping. We found augmented ME coupling in micro-patterned bilayer thin films compared to the as-deposited films due to the reduced substrate clamping. In addition, a site-dependent ME coupling within the microstructure was observed. Larger ME coupling was obtained near the edge of the microstructure, and site-dependent ferroelectric imprints were observed on the micropattern. This can be attributed to the non-uniform substrate clamping across the film, and the strain gradient developed in the BTO layer due to the magnetostriction of CFO. Our findings provide additional insights to the design of micro- and nanoscale devices based on 2–2 ME composite thin films.ISSN:0003-6951ISSN:1077-311