427 research outputs found
Liver Transplantation in an Adult with Citrullinaemia Type 2
Citrullinaemia is a urea cycle defect that results from a deficiency of the enzyme arginosuccinate synthetase. Type 1 disease is diagnosed in childhood, whereas Type 2 disease is adult onset. We report the outcome of a patient with citrullinemia Type 2 who received a liver transplant at our center and the implications of this diagnosis in liver transplantation
Body mass and geographic distribution determined the evolution of the wing flight-feather molt strategy in the Neornithes lineage
The evolutionary history of many organisms is characterized by major changes in morphology and distribution. Specifically, alterations of body mass and geographic distribution may profoundly influence organismal life-history traits. Here, we reconstructed the evolutionary history of flight-feather molt strategy using data from 1,808 Neornithes species. Our analysis suggests that the ancestral molt strategy of first-year birds was partial or entirely absent, and that complete wing flight-feather molt in first-year birds first evolved in the late Eocene and Oligocene (25–40 Ma), at least 30 Myr after birds first evolved. Complete flight-feather molt occurred mainly at equatorial latitudes and in relatively low body mass species, following a diversification of body mass within the lineage. We conclude that both body mass and geographic distribution shaped the evolution of molt strategies and propose that the evolutionary transition towards complete juvenile molt in the Neornithes is a novel, relatively late adaptation
Phase diagram of the ferroelectric-relaxor (1-x)PbMg(1/3)Nb(2/3)O3-xPbTiO3
Synchrotron x-ray powder diffraction measurements have been performed on
unpoled ceramic samples of (1-x)PbMg(1/3)Nb(2/3)O3-xPbTiO3 (PMN-xPT) with 30%<=
x<= 39% as a function of temperature around the morphotropic phase boundary
(MPB), which is the line separating the rhombohedral and tetragonal phases in
the phase diagram. The experiments have revealed very interesting features
previously unknown in this or related systems. The sharp and well-defined
diffraction profiles observed at high and intermediate temperatures in the
cubic and tetragonal phases, respectively, are in contrast to the broad
features encountered at low temperatures. These peculiar characteristics, which
are associated with the monoclinic phase of MC-type previously reported by Kiat
et al and Singh et al., can only be interpreted as multiple coexisting
structures with MC as the major component. An analysis of the diffraction
profiles has allowed us to properly characterize the PMN-xPT phase diagram and
to determine the stability region of the monoclinic phase, which extends from
x= 31% to x= 37% at 20 K. The complex lansdcape of observed phases points to an
energy balance between the different PMN-xPT phases which is intrinsically much
more delicate than that of related systems such as PbZr(1-x)TixO3 or
(1-x)PbZn(1/3)Nb(1/3)O3-xPbTiO3. These observations are in good accord with an
optical study of x= 33% by Xu et al., who observed monoclinic domains with
several different polar directions coexisting with rhombohedral domains, in the
same single crystal.Comment: REVTeX4, 11 pages, 10 figures embedde
A combined theoretical and experimental study of the low temperature properties of BaZrO3
Low temperature properties of BaZrO3 are revealed by combining experimental
techniques (X-ray diffraction, neutron scattering and dielectric measurements)
with theoretical first-principles-based methods (total energy and linear
response calculations within density functional theory, and effective
Hamiltonian approaches incorporating/neglecting zero-point phonon vibrations).
Unlike most of the perovskite systems, BaZrO3 does not undergo any
(long-range-order) structural phase transition and thus remains cubic and
paraelectric down to 2 K, even when neglecting zero-point phonon vibrations. On
the other hand, these latter pure quantum effects lead to a negligible thermal
dependency of the cubic lattice parameter below ~ 40 K. They also affect the
dielectricity of BaZrO3 by inducing an overall saturation of the real part of
the dielectric response, for temperatures below ~ 40 K. Two fine structures in
the real part, as well as in the imaginary part, of dielectric response are
further observed around 50-65 K and 15 K, respectively. Microscopic origins
(e.g., unavoidable defects and oxygen octahedra rotation occurring at a local
scale) of such anomalies are suggested. Finally, possible reasons for the facts
that some of these dielectric anomalies have not been previously reported in
the better studied KTaO3 and SrTiO3 incipient ferroelectrics are also
discussed.Comment: 8 pages, 5 figures, submitted to Physical Review
Low temperature superlattice in monoclinic PZT
TEM has shown that the strongly piezoelectric material Pb(Zr0.52Ti0.48)O3
separates into two phases at low temperatures. The majority phase is the
monoclinic phase previously found by x-ray diffraction. The minority phase,
with a nanoscale coherence length, is a slightly distorted variant of the first
resulting from the anti-phase rotation of the oxygen octahedra about [111].
This work clears up a recent controversy about the origin of superlattice peaks
in these materials, and supports recent theoretical results predicting the
coexistence of ferroelectric and rotational instabilities.Comment: REVTeX4, 4 eps figures embedded. JPG version of figs. 2&4 is also
include
Effects of a portion design plate on food group guideline adherence among hospital staff
Food group guideline adherence is vital to prevent obesity and diabetes. Various studies have demonstrated that environmental variables influence food intake behaviour. In the present study we examined the effect of a portion design plate with food group portion guidelines demarcated by coloured lines (ETE Plate™).
A two-group quasi-experimental design was used to measure proportions of carbohydrate, vegetable and protein portions and user experience in a hospital staff lounge setting in Singapore. Lunch was served on the portion design plate before 12.15 hours. For comparison, a normal plate (without markings) was used after 12.15 hours. Changes in proportions of food groups from 2 months before the introduction of the design plate were analysed in a stratified sample at baseline (859 subjects, all on normal plates) to 1, 3 and 6 months after (in all 1016 subjects on the design plate, 968 subjects on the control plate).
A total of 151 participants were asked about their experiences and opinions. Between-group comparisons were performed using ___t___ tests. Among those served on the portion design plate at 6 months after its introduction, the proportion of vegetables was 4·71 % (P < 0·001) higher and that of carbohydrates 2·83 % (P < 0·001) lower relative to the baseline. No significant change was found for proteins (−1·85 %).
Over 6 months, we observed different change patterns between the different food group proportions. While participants were positive about the portion design plate, they did not think it would influence their personal behaviour. A portion design plate might stimulate food group guideline adherence among hospital staff and beyond
Evidence for and phases in the morphotropic phase boundary region of : A Rietveld study
We present here the results of the room temperature dielectric constant
measurements and Rietveld analysis of the powder x-ray diffraction data on
(PMN-PT) in the composition range
to show that the morphotropic phase boundary (MPB)
region contains two monoclinic phases with space groups Cm (or type) and
Pm (or type) stable in the composition ranges and
, respectively. The structure of PMN-PT in the
composition ranges 0.26, and is found to be
rhombohedral (R3m) and tetragonal (P4mm), respectively. These results are
compared with the predictions of Vanderbilt & Cohen's theory.Comment: 20 pages, 11 pdf figure
Landau model for uniaxial systems with complex order parameter
We study the Landau model for uniaxial incommensurate-commensurate systems of
the I class by keeping Umklapp terms of third and fourth order in the expansion
of the free energy. It applies to systems in which the soft mode minimum lies
between the corresponding commensurate wave numbers. The minimization of the
Landau functional leads to the sine-Gordon equation with two nonlinear terms,
equivalent to the equation of motion for the well-known classical mechanical
problem of two mixing resonances. We calculate the average free energies for
periodic, quasiperiodic and chaotic solutions of this equation, and show that
in the regime of finite strengths of Umklapp terms only periodic solutions are
absolute minima of the free energy, so that the phase diagram contains only
commensurate configurations. The phase transitions between neighboring
configurations are of the first order, and the wave number of ordering goes
through harmless staircase with a finite number of steps. These results are the
basis for the interpretation of phase diagrams for some materials from the I
class of incommensurate-commensurate systems, in particular of those for
ABX and BCCD compounds. Also, we argue that chaotic barriers which
separate metastable periodic solutions represent an intrinsic mechanism for
observed memory effects and thermal hystereses.Comment: 12 pages, 14 figures, LaTeX, to be published in Phys. Rev.
Plant-based meat analogues (PBMAs) and their effects on cardiometabolic health: An 8-week randomized controlled trial comparing PBMAs with their corresponding animal-based foods.
BACKGROUND: With the growing popularity of plant-based meat analogues (PBMAs), an examination of their effects on health is warranted in an Asian population. OBJECTIVE: This research investigated the impact of consuming an omnivorous animal-based meat diet (ABMD) compared to a PBMAs diet (PBMD) on cardiometabolic health among adults with elevated risk of diabetes in Singapore. METHODS: In an 8-week parallel design randomized controlled trial, participants (n=89) were instructed to substitute habitual protein-rich foods with fixed quantities of either PBMAs (n=44) or their corresponding animal-based meats (n=45; 2.5 servings daily) maintaining intake of other dietary components. LDL-cholesterol served as primary outcome, while secondary outcomes included other cardiometabolic disease-related risk factors (e.g. glucose, fructosamine), dietary data, and within a sub-population, ambulatory blood pressure measurements (n=40) at baseline and post-intervention, as well as a 14-day continuous glucose monitor (glucose homeostasis-related outcomes; n=37). RESULTS: Data from 82 participants (ABMD:42, PBMD:40) were examined. Using linear mixed-effects model, there were significant interaction (time × treatment) effects for dietary trans-fat (increased in ABMD), dietary fiber, sodium and potassium (all increased in PBMD; PInteraction<0.001). There were no significant effects on the lipoprotein profile, including LDL-cholesterol. Diastolic blood pressure (DBP) was lower in the PBMD group (PInteraction=0.041) although the nocturnal DBP markedly increased in ABMD (+3.2% mean) and was reduced in PBMD (-2.6%; PInteraction=0.017). Fructosamine (PTime=0.035) and homeostatic model assessment for β-cell function were improved at week 8 (PTime=0.006) in both groups. Glycemic homeostasis was better regulated in the ABMD than PBMD groups as evidenced by interstitial glucose time in range (ABMD median: 94.1% (Q1:87.2%, Q3:96.7%); PBMD: 86.5% (81.7%, 89.4%); P=0.041). The intervention had no significant effect on the other outcomes examined. CONCLUSIONS: A plant-based meat analogues diet did not show widespread cardiometabolic health benefits compared with omnivorous diets over 8 weeks. The composition of PBMAs may need to be considered in future trials. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ TRIAL REGISTRATION NUMBER: NCT05446753
Cellular Robustness Conferred by Genetic Crosstalk Underlies Resistance against Chemotherapeutic Drug Doxorubicin in Fission Yeast
10.1371/journal.pone.0055041PLoS ONE81
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