Complications leading to hospitalization due to consumption of anti-TB drugs in patients with tuberculosis in Gorgan, Iran (2007-12)

Background and Objective: Anti tuberculosis drugs therapy is the most effective method for controling the tuberculosis (TB). Early detection and appropriate treatment can prevent the TB-drug resistance. This study was carried out to determine the complications leading to hospitalization due to consumption of anti-TB drugs in patients with tuberculosis. Methods: In this descriptive-analytic study, 1550 records of patients with TB in urban and rural health centers of Gorgan, north of Iran were assessed during 2007-12. Checklist consists of demographic and clinical data for each patient was recorded in a questionare. Results: 44 cases experienced the complications of anti-TB drugs. 27 (61.4%) of cases with complications were women. 77.3% and 22.7% of patients affected with pulmonary and extra pulmonary tuberculosis,respectively. 38.6% of patients were diabetic. The hepatic complication was seen in 37 cases (84.1%). Skin and other complications were seen in 5 and 2 cases, respectively. There was not any relationship between drug complications and other disases. Conclusion: Hepatic damage is the most common complication leading to hospitalization in tuberculosis patients using anti-TB drugs. Keywords: Tuberculosis, Anti-TB drug, Live

A branch-and-bound algorithm for checkerboard extraction in camera-laser calibration

We address the problem of camera-to-laserscanner calibration using a checkerboard and multiple imagelaser scan pairs. Distinguishing which laser points measure the checkerboard and which lie on the background is essential to any such system. We formulate the checkerboard extraction as a combinatorial optimization problem with a clear cut objective function. We propose a branch-and-bound technique that deterministically and globally optimizes the objective. Unlike what is available in the literature, the proposed method is not heuristic and does not require assumptions such as constraints on the background or relying on discontinuity of the range measurements to partition the data into line segments. The proposed approach is generic and can be applied to both 3D or 2D laser scanners as well as the cases where multiple checkerboards are present. We demonstrate the effectiveness of the proposed approach by providing numerical simulations as well as experimental results.Alireza Khosravian, Tat-Jun Chin, Ian Rei

Outlier-robust manifold pre-integration for INS/GPS fusion

We tackle the INS/GPS sensor fusion problem for pose estimation, particularly in the common setting where the INS components (IMU and magnetometer) function at much higher frequencies than GPS, and where the magnetometer and GPS are prone to giving erroneous measurements (outliers) due to magnetic disturbances and glitches. Our main contribution is a novel non-linear optimization framework that (1) fuses preintegrated IMU and magnetometer measurements with GPS, in a manner that respects the manifold structure of the state space; and (2) supports the usage of robust norms and efficient large scale optimization to effectively mitigate the effects of outliers. Through extensive experiments, we demonstrate the superior accuracy and robustness of our approach over filtering methods (which are customarily applied in the target setting) with minimal impact to computational efficiency. Our work further illustrates the strength of optimization approaches in state estimation problems and paves the way for their adoption in the control and navigation communities.Shin-Fang Ch'ng, Alireza Khosravian, Anh-Dzung Doan and Tat-Jun Chi

A discrete-time attitude observer on SO(3) for vision and GPS fusion

This paper proposes a discrete-time geometric attitude observer for fusing monocular vision with GPS velocity measurements. The observer takes the relative transformations obtained from processing monocular images with any visual odometry algorithm and fuses them with GPS velocity measurements. The objectives of this sensor fusion are twofold; first to mitigate the inherent drift of the attitude estimates of the visual odometry, and second, to estimate the orientation directly with respect to the North-East-Down frame. A key contribution of the paper is to present a rigorous stability analysis showing that the attitude estimates of the observer converge exponentially to the true attitude and to provide a lower bound for the convergence rate of the observer. Through experimental studies, we demonstrate that the observer effectively compensates for the inherent drift of the pure monocular vision based attitude estimation and is able to recover the North-East-Down orientation even if it is initialized with a very large attitude error.Alireza Khosravian, Tat-Jun Chin, Ian Reid, Robert Mahon

Association between (GT)n repeats in heme oxygenase-1 gene promoter and 3-year survival of patients with acute leukemia: A controlled, cross-sectional study

Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance is remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. HO-1 expression levels are related to (GT)n microsatellite polymorphisms in the location of its promoter.This study designed to compare allelic frequencies of (GT)n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls. Indeed, 3-year disease-free survival was also evaluated. Materials and Methods: Sixty-three patients with acute leukemia and 70 healthy infants were included in this study. We used patient�s medical records to collect data about survival after chemotherapy. The number of GT repeats in HO-1 promoter was determined by an ABI 3100 sequencer. Results: The HO-1 GT repeats ranged from 14 to 34 with peaks at 27 repeats in both cases and controls. Children with longer alleles ((GT)n � 27) had enhanced 3-year survival rate after treatment with chemotherapy or radiotherapy (P<0.05). Conclusion: Although no significant differences were observed between leukemia patients and controls regarding allelic frequency, we found elevated frequency of �LL� genotype in leukemia patients with good prognosis and 3-year surveillance. Radiotherapy and chemotherapy might elevate the expression levels of HO-1 with subsequent increased resistance of leukemia patients to therapy. © 2018, Tehran University of Medical Sciences (TUMS). All rights reserved

Association between (GT)n repeats in heme oxygenase-1 gene promoter and 3-year survival of patients with acute leukemia: A controlled, cross-sectional study

Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance is remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. HO-1 expression levels are related to (GT)n microsatellite polymorphisms in the location of its promoter.This study designed to compare allelic frequencies of (GT)n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls. Indeed, 3-year disease-free survival was also evaluated. Materials and Methods: Sixty-three patients with acute leukemia and 70 healthy infants were included in this study. We used patient�s medical records to collect data about survival after chemotherapy. The number of GT repeats in HO-1 promoter was determined by an ABI 3100 sequencer. Results: The HO-1 GT repeats ranged from 14 to 34 with peaks at 27 repeats in both cases and controls. Children with longer alleles ((GT)n � 27) had enhanced 3-year survival rate after treatment with chemotherapy or radiotherapy (P<0.05). Conclusion: Although no significant differences were observed between leukemia patients and controls regarding allelic frequency, we found elevated frequency of �LL� genotype in leukemia patients with good prognosis and 3-year surveillance. Radiotherapy and chemotherapy might elevate the expression levels of HO-1 with subsequent increased resistance of leukemia patients to therapy. © 2018, Tehran University of Medical Sciences (TUMS). All rights reserved

Association between (GT)n repeats in heme oxygenase-1 gene promoter and 3-year survival of patients with acute leukemia: A controlled, cross-sectional study

Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance is remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. HO-1 expression levels are related to (GT)n microsatellite polymorphisms in the location of its promoter.This study designed to compare allelic frequencies of (GT)n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls. Indeed, 3-year disease-free survival was also evaluated. Materials and Methods: Sixty-three patients with acute leukemia and 70 healthy infants were included in this study. We used patient�s medical records to collect data about survival after chemotherapy. The number of GT repeats in HO-1 promoter was determined by an ABI 3100 sequencer. Results: The HO-1 GT repeats ranged from 14 to 34 with peaks at 27 repeats in both cases and controls. Children with longer alleles ((GT)n � 27) had enhanced 3-year survival rate after treatment with chemotherapy or radiotherapy (P<0.05). Conclusion: Although no significant differences were observed between leukemia patients and controls regarding allelic frequency, we found elevated frequency of �LL� genotype in leukemia patients with good prognosis and 3-year surveillance. Radiotherapy and chemotherapy might elevate the expression levels of HO-1 with subsequent increased resistance of leukemia patients to therapy. © 2018, Tehran University of Medical Sciences (TUMS). All rights reserved

A numerical study of fractional relaxation–oscillation equations involving ψ-Caputo fractional derivative

We provide a numerical method to solve a certain class of fractional differential equations involving ψ -Caputo fractional derivative. The considered class includes as particular case fractional relaxation–oscillation equations. Our approach is based on operational matrix of fractional integration of a new type of orthogonal polynomials. More precisely, we introduce ψ -shifted Legendre polynomial basis, and we derive an explicit formula for the ψ -fractional integral of ψ -shifted Legendre polynomials. Next, via an orthogonal projection on this polynomial basis, the problem is reduced to an algebraic equation that can be easily solved. The convergence of the method is justified rigorously and confirmed by some numerical experiments.publishe

Nutrition state of science and dementia prevention: Recommendations of the Nutrition for Dementia Prevention Working Group

Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations