The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019

Background Health-care needs change throughout the life course. It is thus crucial to assess whether health systems provide access to quality health care for all ages. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019), we measured the Healthcare Access and Quality (HAQ) Index overall and for select age groups in 204 locations from 1990 to 2019. Methods We distinguished the overall HAQ Index (ages 0–74 years) from scores for select age groups: the young (ages 0–14 years), working (ages 15–64 years), and post-working (ages 65–74 years) groups. For GBD 2019, HAQ Index construction methods were updated to use the arithmetic mean of scaled mortality-to-incidence ratios (MIRs) and risk-standardised death rates (RSDRs) for 32 causes of death that should not occur in the presence of timely, quality health care. Across locations and years, MIRs and RSDRs were scaled from 0 (worst) to 100 (best) separately, putting the HAQ Index on a different relative scale for each age group. We estimated absolute convergence for each group on the basis of whether the HAQ Index grew faster in absolute terms between 1990 and 2019 in countries with lower 1990 HAQ Index scores than countries with higher 1990 HAQ Index scores and by Socio-demographic Index (SDI) quintile. SDI is a summary metric of overall development. Findings Between 1990 and 2019, the HAQ Index increased overall (by 19·6 points, 95% uncertainty interval 17·9–21·3), as well as among the young (22·5, 19·9–24·7), working (17·2, 15·2–19·1), and post-working (15·1, 13·2–17·0) age groups. Large differences in HAQ Index scores were present across SDI levels in 2019, with the overall index ranging from 30·7 (28·6–33·0) on average in low-SDI countries to 83·4 (82·4–84·3) on average in high-SDI countries. Similarly large ranges between low-SDI and high-SDI countries, respectively, were estimated in the HAQ Index for the young (40·4–89·0), working (33·8–82·8), and post-working (30·4–79·1) groups. Absolute convergence in HAQ Index was estimated in the young group only. In contrast, divergence was estimated among the working and post-working groups, driven by slow progress in low-SDI countries. Interpretation Although major gaps remain across levels of social and economic development, convergence in the young group is an encouraging sign of reduced disparities in health-care access and quality. However, divergence in the working and post-working groups indicates that health-care access and quality is lagging at lower levels of social and economic development. To meet the needs of ageing populations, health systems need to improve health-care access and quality for working-age adults and older populations while continuing to realise gains among the young

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

BURNOUT AMONG NURSES WORKING IN IMAM REZA HOSPITAL, KERMANSHAH 2015

Introduction: Burnout is one of the most important indicators for evaluating the psychological conditions of staff. This study was conducted aimed to determine burnout of nurses in Imam Reza Hospital of Kermanshah University of Medical Sciences. Methods: This cross-sectional study was conducted with participation of 216 nurses Imam Reza Hospital of Kermanshah University of Medical Sciences. Maslach Burnout Inventory (MBI) was used for data gathering. The validity and reliability of the Persian version of MBI has been approved. The data were analyzed with AMOS22 as well as SPSS-21 using T-test, one way ANOVA, and Chi-square. Results: 58.6 (n= 127) of the participants were female and 41.4 (n= 89) male. 42.6 of nurses have reported very high levels of emotional exhaustion, 46.8 percent have expressed a high level of depersonalization, and 40.4 percent have reported an average level of lack of personal accomplishment. Conclusion: Considering high level of three dimensions of burnout we suggest that periodic examinations be performed in relation to burnout for nurses and hospital administrators should provide education, counseling, and clinical services for their employees

SELF-EFFICACY OF YOUNG ADULTS ACROSS STAGES OF WATERPIPE CESSATION-A MODEL-BASED CROSS-SECTIONAL STUDY

BACKGROUND The aim of the study is to determine self-efficacy of young adults across stages of waterpipe cessation. MATERIALS AND METHODS This cross-sectional study was conducted with participation of 1012 students from Shahid Beheshti University in Iran. Data was collected within two months from May to July 2016 using a self-administered questionnaire that consisted of three parts including demographic variables, stages of change for waterpipe cessation (derived from Prochaska and DiClemente), and self-efficacy. Validity and reliability of questionnaire was assessed and approved by appropriate methods. Data was analysed by SPSS 19 using chi-square, t-test, ANOVA, and Univariate test. RESULTS The mean age of participants in this study was 21.37 +/- 2.76 years. Out of 1012 students, 345 participants (34.1 ) had a history of waterpipe smoking at least once. In addition, current waterpipe smoking in students was 26.28. Overall 267 students (77.4) were categorised in passive stages (precontemplation, contemplation and preparation) and 78 students (22.6) in active stages of waterpipe cessation (action and maintenance). The mean score of self-efficacy had a significant relationship with stages of change (p<.001), gender (p=007), residence status (p=.013), and the type of smoking (p=.041). CONCLUSION Considering the high prevalence of waterpipe smoking in students, negative intention toward cessation, and low self-efficacy for waterpipe smoking cessation amongst students, we suggest informative interventions about hazards of waterpipe smoking to be done to increase self-efficacy and resistance to peer pressure

Development and implementation of a nonlocal and nonlinear implicit electrolyte model

We have developed and implemented an implicit electrolyte model in the Vienna Ab initio Simulation Package (VASP) that includes nonlinear dielectric and ionic responses as well as a nonlocal definition of the cavities defining the spatial regions where these responses can occur. The implementation into the existing VASPsol code is numerically efficient and exhibits robust convergence, requiring computational effort only slightly higher than the original self-consistent continuum solvation (SCCS) model. The nonlinear+nonlocal model is able to reproduce the characteristic `double hump' shape observed experimentally for the differential capacitance of an electrified metal interface while preventing the `leakage' of the electrolyte into regions of space too small to contain a single water molecule or solvation ion. The model also gives a reasonable prediction of molecular solvation free energies as well as the self-ionization free energy of water and the absolute electron chemical potential of the standard hydrogen electrode. All of this, combined with the additional ability to run constant potential density functional theory calculations, should enable the routine computation of activation barriers for electrocatalytic processes

RELATIONSHIP BETWEEN THE MANAGERIAL SKILLS WITH THE EFFECTIVENESS OF MANAGERS

Introduction: Each manager needs a set of skills for effective management. This study was conducted aimed to investigate Relationship between the managerial skills with the effectiveness of managers. Methods: this cross-sectional study was conducted with the participation of 190 employees of Kermanshah University of medical sciences in 2015. We used to questionnaire for data gathering including questionnaire of managerial skills and questionnaire of managers effectiveness. Data was analyzed using the software AMOS 22 as well as SPSS 21. Results: there were positive and direct relationships between managerial, technical, human, and perceptual skills with effectiveness of managers. The higher relationship with effectiveness belonged to technical skill (r=.965). Conclusion: Given that managers in medical sciences universities have expertise in medical sciences, academic qualifications, and sufficient experience we suggest that to be implemented training, practical, and complementary courses about management skills for them

A novel and sensitive method for the determination of vitamin B2 (Riboflavin) in urine and pharmaceutical samples using an aqueous two-phase extraction

A novel, simple, and more sensitive spectrophotometric procedure has been developed for the determination of vitamin B(riboflavin) by an aqueous two-phase extraction (ATPE). An ATPE is formed mostly by water and does not require an organic solvent. Other ATPE components used in this study were the polymer, polyethylene glycol (PEG), and some salts such as NaOand NaO The method is based on the interaction between vitamin B(riboflavin) and sodium sulfate (NaO in an acidic medium (pH 6.4). The influences of effective parameters such as salt (type and concentration), polyethylene glycol (molecular weight and concentration), temperature, centrifuging time, and pH of the sample solution were studied and optimized. The linear range was 1.3-320 ng/mL (R 2 = 0.9991; n = 10) with the relative standard deviation (RSD) for 60 ng/mL 3.68. The limit of detection (LOD) calculated from three times of standard deviation of blank were 0.2 ng/mL and recoveries from analysis of real samples between 94.82 and 103.98 were obtained for the determination of vitamin B(riboflavin) in urine and pharmaceutical samples. © 2013 Sabah Shiri et al