Introduction: Burnout is one of the most important indicators for evaluating the psychological conditions of staff. This study was conducted aimed to determine burnout of nurses in Imam Reza Hospital of Kermanshah University of Medical Sciences. Methods: This cross-sectional study was conducted with participation of 216 nurses Imam Reza Hospital of Kermanshah University of Medical Sciences. Maslach Burnout Inventory (MBI) was used for data gathering. The validity and reliability of the Persian version of MBI has been approved. The data were analyzed with AMOS22 as well as SPSS-21 using T-test, one way ANOVA, and Chi-square. Results: 58.6 (n= 127) of the participants were female and 41.4 (n= 89) male. 42.6 of nurses have reported very high levels of emotional exhaustion, 46.8 percent have expressed a high level of depersonalization, and 40.4 percent have reported an average level of lack of personal accomplishment. Conclusion: Considering high level of three dimensions of burnout we suggest that periodic examinations be performed in relation to burnout for nurses and hospital administrators should provide education, counseling, and clinical services for their employees
