Creating a Reproducible Metadata Transformation Pipeline Using Technology Best Practices

Over the course of two years, a team of librarians and programmers from LSU Libraries migrated the 186 collections of the Louisiana Digital Library from OCLC\u27s CONTENTdm platform over to the open-source Islandora platform. Early in the process, the team understood the value of creating a reproducible metadata transformation pipeline, because there were so many unknowns at the beginning of the process along with the certainty that mistakes would be made. This presentation will describe how the team used innovative and collaborative tools, such as Trello, Ansible, Vagrant, VirtualBox, git and GitHub to accomplish the task

Morphological characterisation of diesel soot in oil and the associated extraction dependence

The size and morphology of soot particles and agglomerates extracted from lubricating oil drawn from the sump of a diesel engine have been investigated and compared using Transmission Electron Microscopy (TEM) and Nanoparticle Tracking Analysis (NTA). Samples were prepared for electron microscopy imaging by both centrifugation and solvent extraction to investigate the impact of these procedures on the morphological characteristics, such as skeleton length and width and circularity, of the obtained soot. It was shown that centrifugation increases the extent of agglomeration within the sample, with 15% of the agglomerates above 200 nm compared to only 11% in the solvent extracted soot. It was also observed that the width of centrifugation extracted soot was typically 10 nm to 20 nm larger than that of solvent extracted soot, suggesting that centrifugation forces the individual agglomerate chains together. Moreover, centrifugation fails to extract a large percentage of particles below 50 nm, with only 4% of the agglomerates smaller than 50 nm in the centrifugation extracted soot, whereas agglomerates in this size range accounted for 19 % using solvent extraction. As TEM represents a comparatively time and cost expensive characterisation tool, unsuitable for high throughput testing required by industry, NTA was explored as a low cost, rapid alternative method for measuring particle size. It was found that results generated by NTA, within the limits of detection, correlated well with those obtained using TEM. This correlative electron microscopy and light scattering approach was further used to appraise the morphological characteristics of two commercial sources of carbon black (CB), enabling the selection of the most suitable soot surrogate, essential for the further development of oils with optimised functional properties

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

Onchocerciasis, commonly known as river blindness, is caused by the filarial nematode Onchocerca volvulus and is transmitted by a blackfly vector. Over 37 million people are thought to be infected, with over 90 million at risk. Infection predominantly occurs in sub-Saharan Africa. Foci also exist in the Arabian Peninsula and Central and South America. Ivermectin, the sole pharmaceutical available for mass chemotherapy, has been used on a community basis for annual or semi-annual treatment since 1987. Multiple treatments with ivermectin kill the microfilariae that are responsible for the pathology of onchocerciasis. More importantly, ivermectin suppresses the reproductive activity of the adult female worms, thus delaying or preventing the repopulation of the skin with new microfilariae and thereby reducing transmission. This study extends earlier reports of sub-optimal responses to ivermectin by examining repopulation levels of microfilaria one year after treatment, worm burdens per nodule, the age structure of adult female worms recovered from nodules, and the reproductive status of adult female worms 90 days after ivermectin treatment. In some communities which have shown a pattern of sub-optimal response to treatment, the data is consistent with an emergence of ivermectin non response or resistance manifested by a loss of the effect of ivermectin on the suppression of parasite reproduction

The Mock LISA Data Challenges: from Challenge 3 to Challenge 4

The Mock LISA Data Challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of one or more datasets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants analyze the datasets and report best-fit solutions for the source parameters. Here we present the results of the third challenge, issued in Apr 2008, which demonstrated the positive recovery of signals from chirping Galactic binaries, from spinning supermassive--black-hole binaries (with optimal SNRs between ~ 10 and 2000), from simultaneous extreme-mass-ratio inspirals (SNRs of 10-50), from cosmic-string-cusp bursts (SNRs of 10-100), and from a relatively loud isotropic background with Omega_gw(f) ~ 10^-11, slightly below the LISA instrument noise.Comment: 12 pages, 2 figures, proceedings of the 8th Edoardo Amaldi Conference on Gravitational Waves, New York, June 21-26, 200

Getting Ready for LISA: The Data, Support and Preparation Needed to Maximize US Participation in Space-Based Gravitational Wave Science

The NASA LISA Study Team was tasked to study how NASA might support US scientists to participate and maximize the science return from the Laser Interferometer Space Antenna (LISA) mission. LISA is gravitational wave observatory led by ESA with NASA as a junior partner, and is scheduled to launch in 2034. Among our findings: LISA science productivity is greatly enhanced by a full-featured US science center and an open access data model. As other major missions have demonstrated, a science center acts as both a locus and an amplifier of research innovation, data analysis, user support, user training and user interaction. In its most basic function, a US Science Center could facilitate entry into LISA science by hosting a Data Processing Center and a portal for the US community to access LISA data products. However, an enhanced LISA Science Center could: support one of the parallel independent processing pipelines required for data product validation; stimulate the high level of research on data analysis that LISA demands; support users unfamiliar with a novel observatory; facilitate astrophysics and fundamental research; provide an interface into the subtleties of the instrument to validate extraordinary discoveries; train new users; and expand the research community through guest investigator, postdoc and student programs. Establishing a US LISA Science Center well before launch can have a beneficial impact on the participation of the broader astronomical community by providing training, hosting topical workshops, disseminating mock catalogs, software pipelines, and documentation. Past experience indicates that successful science centers are established several years before launch; this early adoption model may be especially relevant for a pioneering mission like LISA.Comment: 93 pages with a lovely cover page thanks to Bernard Kelly and Elizabeth Ferrar

Do Cochrane summaries help student midwives understand the findings of Cochrane systematic reviews: the BRIEF randomised trial.

BackgroundAbstracts and plain language summaries (PLS) are often the first, and sometimes the only, point of contact between readers and systematic reviews. It is important to identify how these summaries are used and to know the impact of different elements, including the authors’ conclusions. The trial aims to assess whether (a) the abstract or the PLS of a Cochrane Review is a better aid for midwifery students in assessing the evidence, (b) inclusion of authors’ conclusions helps them and (c) there is an interaction between the type of summary and the presence or absence of the conclusions.MethodsEight hundred thirteen midwifery students from nine universities in the UK and Ireland were recruited to this 2 × 2 factorial trial (abstract versus PLS, conclusions versus no conclusions). They were randomly allocated to one of four groups and asked to recall knowledge after reading one of four summary formats of two Cochrane Reviews, one with clear findings and one with uncertain findings. The primary outcome was the proportion of students who identified the appropriate statement to describe the main findings of the two reviews as assessed by an expert panel.ResultsThere was no statistically significant difference in correct response between the abstract and PLS groups in the clear finding example (abstract, 59.6 %; PLS, 64.2 %; risk difference 4.6 %; CI −0.2 to 11.3) or the uncertain finding example (42.7 %, 39.3 %, −3.4 %, −10.1 to 3.4). There was no significant difference between the conclusion and no conclusion groups in the example with clear findings (conclusions, 63.3 %; no conclusions, 60.5 %; 2.8 %; −3.9 to 9.5), but there was a significant difference in the example with uncertain findings (44.7 %; 37.3 %; 7.3 %; 0.6 to 14.1, p = 0.03). PLS without conclusions in the uncertain finding review had the lowest proportion of correct responses (32.5 %). Prior knowledge and belief predicted student response to the clear finding review, while years of midwifery education predicted response to the uncertain finding review.ConclusionsAbstracts with and without conclusions generated similar student responses. PLS with conclusions gave similar results to abstracts with and without conclusions. Removing the conclusions from a PLS with uncertain findings led to more problems with interpretatio